The DOI matches its Crossref record; 69 of the 94 references it cites were found in a registry or an index.
Biological Significance of Ascorbic Acid (Vitamin C) in Human Health - A Review
Open accessAbstract
The recognition of vitamin C (Ascorbic acid) is associated with history of an unrelenting search for the cause of the ancient hemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radicals` damages. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps fight off infections.
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“Vitamin C is crucial for immune system function [1,2,3,4] and protects against damage from reactive oxygen species [5,6].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [5]
In the citing paper
“Consequently, adequate cell and tissue stores of vitamin C maintain resistance to infections [5].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [5]
Citations
Cites
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BackgroundVitamins E and C, beta-carotene, and other carotenoids as antioxidants
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“radicals released by the body in its fight against the Vitamin C has been shown to improve the effects of infection (Sies and Wilhelm, 1995).”
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Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
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BackgroundInfluentialVitamin C Intake and Mortality among a Sample of the United States Population
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“(Enstrom, 1992).”
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“…(white blood defense against free radicals, athletes who are doing cells) to the lining of blood vessels and thereby reduce intense training may benefit from the addition of the risk of atherosclerosis (Weber, 1996; Lehr, 1995; antioxidant supplements to their diets (Dekkers et al., Heitzer, 1996).”
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“…severity of illnesses (Hemila, 1992). breast, cervix, colon, rectum, esophagus, larynx, lung, Gaby and Singh (1991) reports that in 1981, in one mouth, prostate and stomach (Levine, 1996; Block, study, when 1 g of vitamin C was given intravenously to 1992; Frei, 1994; Block, 1991; Jacobs, 1993).”
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In, S. (2012) · theses.fr (ABES) · doi:10.70675/16aaa0f6zb985z4179z8447z781a508b0a3a · Cited by 1
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Antioksidan Vitaminlerin Periodontal Sağlıktaki Rolü
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“C vitamini hücrelerin DNA’sını serbest radikallerin ve mutajenlerin etkilerinden korur (14) ve birçok hastalık”
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“The reason may be due to the free radicals increase that are generated for the patients suffering from type-2 diabetes (Al-Ramadhan et al., 2015; Iqbal et al., 2004) as well as the increase in lipid peroxidation that is represented accumulation of lipid peroxidation products, which increases the activity of myeloperox…”
BackgroundPeredaran Vitamin C Injeksi Ilegal di Indonesia
Rastika, D. G. B., Triwinanti, N., & Salaffudin, M. G. (2022) · Eruditio Indonesia Journal of Food and Drug Safety · doi:10.54384/eruditio.v2i2.109
Záccari, F., Saadoun, A., & Cabrera, M. C. (2022) · Agrociencia Uruguay · doi:10.31285/agro.25.917 · Cited by 1
“They frequently lose their bioactivity due to high temperatures, exposure to UV rays, air, or contact with other pro-oxidant elements(14)(17).”
BackgroundInfluentialMuhaswitri, C., Dillon, D., & Zaini, J. (2020) · World Nutrition Journal · doi:10.25220//wnj.v04.i1.0007
Adah, C., Tyohemba, L. R., Ikese, C., Ajegi, J. O., & Michael, O. (2020) · doi:10.22271/chemi.2020.v8.i4a.10267
“The consistent consumption of fruits and vegetables has been reported to defend the human body from deteriorative ailments (Iqbal et al. 2004) [22].”
BackgroundBassey, U., Akpanyung, E., Nwaokonko, D. U., & Ndifon, B. T. (2019) · International Journal of Nutrition and Metabolism · doi:10.5897/ijnam2018.0246
“Vitamin C is an established antioxidant which has been shown to scavenge free radicals with resultant reduction in reactive oxygen and nitrogen species in the blood (Iqbal et al., 2004; Adikwu and Deo, 2013).”
BackgroundLeaf and root evaluation of bioactive compounds of different beetroot varieties
Rubóczki, T., & Hájos, M. T. (2018) · Acta Agraria Debreceniensis · doi:10.34101/actaagrar/74/1678
Al-Dohan, J. A., Jawad, M., Al-Rubaye, H., & Haddad, N. (2014) · doi:10.33762/mjbu.2014.103863
“[15] Vitamin C has a maintaining effect on vitamin E so that it is reduced by vitamin C after neutralizing the radicals by vitamin E.”
BackgroundThe Story of Vitamin C and its Versions in Sepsis and COVID-19: Traditional Review
HEMDAN, O. A. M., Sanajou, S., & Baydar, T. (2024) · Journal of Literature Pharmacy Sciences · doi:10.5336/pharmsci.2024-101309
“After that, inside the intestinal cell, ascorbate is oxidized to dehydroascorbic acid (DHA) and is transported to the bloodstream by GLUT 1&2, which is then recycled to ascorbate is a continuous process that plays a vital function in maintaining the homeostasis of vitamin C in the body to support…”
Fabrication of Coaxial Wet-Spun Biofibres Containing Graphene Core
Mirabedini, A. (2018) · Springer theses · doi:10.1007/978-3-319-95378-6_4
Parenting Care Model is a Rehabilition for Learning Disabled Child
Ismail, S. A. B., Ghazali, P., Mamat, M., & Salleh, Z. (2016) · doi:10.21767/2471-299x.1000016
Metadata
- Authors
- Iqbal, K., Khan, A., & Khan Khattak, M. M. A.
- Venue
- Pakistan Journal of Nutrition
- Publisher
- Science Insights
- Published
- 2003-12-15
- Volume
- 3
- Issue
- 1
- Pages
- 5-13
- ISSN
- 1680-5194 (ISSN-L)
- 1994-7984
- OpenAlex
- W2111933236
- Cited by
- 270
- References
- 94
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 23 · 2023: 20 · 2022: 18 · 2021: 23 · 2020: 21 · 2019: 25 · 2018: 15 · 2017: 7 · 2016: 20 · 2015: 19 · 2014: 21 · 2013: 9 · 2012: 13
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Pakistan Journal of Nutrition (publishedVersion, cc-by)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin C, scurvy, connective tissue, bone formation, wound healing, gingival health, folic acid, bile acid synthesis, antioxidants, free radicals, immune system, allergy, infection
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