The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Habitual coffee consumption and risk of hypertension: a systematic review and meta‐analysis of prospective observational studies
Open accessAbstract
Background In 2 meta-analyses of randomized controlled trials, increased coffee intake was associated with slightly higher blood pressure. However, these trials were short in duration (<85 d).Objective We conducted a systematic review and meta-analyses of long-term prospective studies that examined the association of habitual coffee consumption with risk of hypertension.Design We searched electronic databases (MEDLINE, EMBASE, Agricola, and Cochrane Library) through August 2009 with the use of a standardized protocol. Eligible studies were prospective cohort trials that examined the association of coffee consumption with incident hypertension or blood pressure.Results From 6 prospective cohort studies, a total of 172,567 participants and 37,135 incident hypertension cases were included. Mean follow-up ranged from 6.4 to 33.0 y. Compared with the lowest consumption [<1 cup (≈237 mL)/d], the pooled relative risks (RRs) for hypertension were 1.09 (95% CI: 1.01, 1.18) for the next higher category (1-3 cups/d), 1.07 (95% CI: 0.96, 1.20) for the second highest category (3-5 cups/d), and 1.08 (95% CI: 0.96, 1.21) for the highest category (>5 cups/d). A dose-response meta-analysis showed an inverse "J-shaped" curve (P for quadratic term < 0.001) with hypertension risk increasing up to 3 cups/d (RR for comparison of 3 with 0 cups/d: 1.07; 95% CI: 0.97, 1.20) and decreasing with higher intakes (RR for comparison of 6 with 0 cups/d: 0.99; 95% CI: 0.89, 1.10).Conclusion The results suggest that habitual coffee consumption of >3 cups/d was not associated with an increased risk of hypertension compared with <1 cup/d; however, a slightly elevated risk appeared to be associated with light-to-moderate consumption of 1 to 3 cups/d.
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“Compared with the reference category, the pooled RRs (95 % CI) for hypertension were 1.09 (1.01-1.18)for the low category (one to three cups per day)”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Zhang et al., 2011
In the citing paper
“In a dose-response meta-analysis, the best-fitting model showed an inverse “J-shaped” curve (p for quadratic term < 0.001), with the risk of hypertension increasing up to three cups per day (RR for the comparison of three cups with zero cups per day: 1.07, 95 % CI = 0.97-1.20)and decreasing with higher intake (RR for the comparison of six cups with zero cups per day: 0.99, 95 % CI = 0.89-1.10).”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Zhang et al., 2011
In the citing paper
“Long-term heavy coffee consumption has been associated with a slightly elevated risk of hypertension,40 and a higher level of plasma homocysteine.41, 42”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [40]
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Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,698
Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353
Salvini, S., Hunter, D. J., SAMPSON, L., Stampfer, M. J., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.4.858 · Cited by 1,038
COLDITZ, G. A., MARTIN, P., STAMPFER, M. J., WILLETT, W. C., SAMPSON, L., ROSNER, B., HENNEKENS, C. H., & SPEIZER, F. E. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114319 · Cited by 992
Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review
van Dam, R. M., & Hu, F. B. (2005) · JAMA · doi:10.1001/jama.294.1.97 · Cited by 662
Coffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490 · cited 2×
“Because the Australia study used residuals of BP in their regression models (16) and the Amsterdam Growth and Health Longitudinal Study in the Netherlands used mean arterial BP [arterial BP = (2 · DBP + SBP)/3] in the analyses (14), we conducted a meta-analysis for a pooled estimation.”
BackgroundNoordzij, M., Uiterwaal, C. S., Arends, L. R., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000166828.94699.1d · Cited by 376
Coffee, caffeine and blood pressure: a critical review
Nurminen, M.-L., Niittynen, L., Korpela, R., & Vapaatalo, H. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600899 · Cited by 351
Jee, S. H., He, J., Whelton, P. K., Suh, I., & Klag, M. J. (1999) · Hypertension · doi:10.1161/01.hyp.33.2.647 · Cited by 276
Cited by
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Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Poole, R., Kennedy, O. J., Roderick, P., Fallowfield, J. A., Hayes, P. C., & Parkes, J. (2017) · BMJ · doi:10.1136/bmj.j5024 · Cited by 835
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613
“Two systematic reviews and meta-analyses of prospective cohort studies have addressed the association between coffee consumption and the risk of incident hypertension (Zhang et al., 2011; Steffen et al., 2012).”
BackgroundDing, M., Bhupathiraju, S. N., Satija, A., van Dam, R. M., & Hu, F. B. (2014) · Circulation · doi:10.1161/circulationaha.113.005925 · Cited by 565
Mesas, A. E., Leon-Muñoz, L. M., Rodriguez-Artalejo, F., & Lopez-Garcia, E. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.016667 · Cited by 350
Antihypertensive effects and mechanisms of chlorogenic acids
Zhao, Y., Wang, J., Ballèvre, O. P., Luo, H., & Zhang, W. (2011) · Hypertension Research · doi:10.1038/hr.2011.195 · Cited by 306
Metadata
- Authors
- Zhang, Z., Hu, G., Caballero, B., Appel, L., & Chen, L.
- Affiliations
- Michigan State University (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 93
- Issue
- 6
- Pages
- 1212-1219
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2165238637
- Cited by
- 166
- References
- 36
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 19 · 2022: 11 · 2021: 14 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 10 · 2016: 16 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- coffee consumption, hypertension, blood pressure, dose-response relationship, J-curve, hypertension incidence, habitual dietary intake, prospective cohort
- MeSH terms
- Coffee, Feeding Behavior, Humans, Hypertension, Prospective Studies, Risk Factors
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