Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001–2006
Open accessAbstract
Background The effect of assay drifts over time on serum 25-hydroxyvitamin D [25(OH)D] concentrations were not accounted for in previous national survey studies. Thus, previously reported associations between 25(OH)D with cardiometabolic risk factors using data from NHANES were likely over- or underestimated. Moreover, associations between serum 25(OH)D and metabolic syndrome (MetSyn), insulin resistance (IR), and inflammation are unclear in children.Objective The relation between serum 25(OH)D and cardiometabolic risk factors in US children was investigated by using updated 25(OH)D data.Design This study was based on newly updated serum 25(OH)D data, which were released by the National Center for Health Statistics in November 2010. Data from 3 cycles of NHANES (2001-2002, 2003-2004, and 2005-2006) for 5867 adolescents, aged 12-19 y, were used to study the association, by multivariate-adjusted regression, between serum 25(OH)D and prevalence of MetSyn and several cardiometabolic risk factors.Results The likelihood of having MetSyn was significantly higher in the first tertile of serum 25(OH)D than in the third tertile of 25(OH)D (odds ratio: 1.71; 95% CI: 1.11, 2.65; P < 0.01). Waist circumference (P < 0.0001), systolic blood pressure (P = 0.01), and homeostatic model assessment-insulin resistance index (P = 0.001) were inversely related and HDL cholesterol (P < 0.0001) was directly related with serum 25(OH)D. No association was observed between 25(OH)D and C-reactive protein (P = 0.18).Conclusions On the basis of assay-adjusted data, serum 25(OH)D was significantly associated with several cardiometabolic risk factors regardless of obesity. In children, given the negative outcomes associated with poor vitamin D status and MetSyn, consideration of vitamin D supplementation in reversing cardiometabolic risk factors appears to be warranted.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Advanced glycation end products may also be derived from food or tobacco.
“AGE may also be derived from food (454,461) or tobacco (462) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [461]
Cites
1 retracted
RETRACTION: C‐reactive Protein and Metabolic Syndrome in Youth: A Strong Relationship?
Oliveira, A. C., Assis, A. M. O., Adan, L., de Oliveira, N. F., Silva, A. M., & Ladeia, A. M. T. (2008) · Obesity · doi:10.1038/oby.2008.43 · Cited by 41 · see citing works
RetractedMatthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204 · see citing works
Holick, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1678s · Cited by 2,768 · see citing works
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M., & Virtanen, S. M. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06580-1 · Cited by 1,920 · see citing works
Hypovitaminosis D is associated with insulin resistance and β cell dysfunction
Chiu, K. C., Chu, A. Y., Go, V. L. W., & Saad, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.820 · Cited by 1,643 · see citing works
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625 · see citing works
Vitamin D Deficiency in Children and Its Management: Review of Current Knowledge and Recommendations
Misra, M., Pacaud, D., Petryk, A., Collett‐Solberg, P. F., & Kappy, M. S. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1894 · Cited by 1,398 · see citing works
1,25-Dihydroxyvitamin D 3 Receptors in Human Leukocytes
Provvedini, D. M., Cd, T., Deftos, L. J., & Manolagas, S. C. (1983) · Science · doi:10.1126/science.6310748 · Cited by 1,035 · see citing works
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension
Forman, J. P., Giovannucci, E. L., Holmes, M. D., Bischoff-Ferrari, H. A., Tworoger, S. S., Willett, W. C., & Curhan, G. C. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087288 · Cited by 896 · see citing works
Prevalence of Vitamin D Deficiency Among Healthy Adolescents
Gordon, C. M., DePeter, K. C., Feldman, H. A., Grace, E., & Emans, S. J. (2004) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.158.6.531 · Cited by 877 · see citing works
Wood, R. J., Tchack, L., & Taparia, S. (2001) · BMC Physiology · doi:10.1186/1472-6793-1-11 · Cited by 852 · see citing works
Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults
Ford, E. S., Ajani, U. A., McGuire, L. C., & Liu, S. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1228 · Cited by 667 · see citing works
Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared with 2000–2004
Looker, A. C., Pfeiffer, C. M., Lacher, D. A., Schleicher, R. L., Picciano, M. F., & Yetley, E. A. D. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26182 · Cited by 621 · see citing works
Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004
Kumar, J., Muntner, P., Kaskel, F. J., Hailpern, S. M., & Melamed, M. L. (2009) · Pediatrics · doi:10.1542/peds.2009-0051 · Cited by 621 · see citing works
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
Forouhi, N. G., Luan, J., Cooper, A., Boucher, B. J., & Wareham, N. J. (2008) · Diabetes · doi:10.2337/db08-0593 · Cited by 613 · see citing works
Xiang, W., Kong, J., Chen, S., Cao, L., Qiao, G., Zheng, W., Liu, W., Li, X., Gardner, D. G., & Li, Y. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00224.2004 · Cited by 570 · see citing works
Prevalence and Trends of a Metabolic Syndrome Phenotype Among U.S. Adolescents, 1999–2000
Duncan, G. E., Li, S. M., & Zhou, X. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2438 · Cited by 495 · see citing works
Role of Vitamin D in Insulin Secretion and Insulin Sensitivity for Glucose Homeostasis
Alvarez, J. A., & Ashraf, A. P. (2009) · International Journal of Endocrinology · doi:10.1155/2010/351385 · Cited by 484 · see citing works
Alemzadeh, R., Kichler, J., Babar, G., & Calhoun, M. (2008) · Metabolism · doi:10.1016/j.metabol.2007.08.023 · Cited by 419 · see citing works
Calcium-Regulating Hormones in Essential Hypertension
Resnick, L. M., MÜLLER, F. B., & LARAGH, J. H. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-5-649 · Cited by 371 · see citing works
Jablonski, K., Chonchol, M., Pierce, G. L., Walker, A. E., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160929 · Cited by 360 · see citing works
Vitamin D Status and Cardiometabolic Risk Factors in the United States Adolescent Population
Reis, J. P., von Mühlen, D. G., Miller, E. R., Michos, E. D., & Appel, L. J. (2009) · PEDIATRICS · doi:10.1542/peds.2009-0213 · Cited by 359 · see citing works
Mansbach, J. M., Ginde, A. A., & Camargo, C. A. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2041 · Cited by 334 · see citing works
Shea, M. K., Booth, S. L., Massaro, J. M., Jacques, P. F., D'Agostino, R. B., Dawson-Hughes, B., Ordovas, J. M., O'Donnell, C. J., Kathiresan, S., Keaney, J. F., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm306 · Cited by 316 · see citing works
The Metabolic Syndrome and Concentrations of C-Reactive Protein Among U.S. Youth
Ford, E. S., Ajani, U. A., & Mokdad, A. H. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.878 · Cited by 311 · see citing works
Saintonge, S., Bang, H., & Gerber, L. M. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1195 · Cited by 263 · see citing works
Prevalence of Risk Factors for Metabolic Syndrome in Adolescents
Johnson, W. D., Kroon, J. J. M., Greenway, F. L., Bouchard, C., Ryan, D. H., & Katzmarzyk, P. T. (2009) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2009.3 · Cited by 261 · see citing works
Vitamin D: emerging new roles in insulin sensitivity
Teegarden, D., & Donkin, S. S. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409389301 · Cited by 260 · see citing works
Multiple Markers of Inflammation and Weight Status: Cross-sectional Analyses Throughout Childhood
Skinner, A. C., Steiner, M. J., Henderson, F. W., & Perrin, E. M. (2010) · PEDIATRICS · doi:10.1542/peds.2009-2182 · Cited by 237 · see citing works
Increased NF-κB activity in fibroblasts lacking the vitamin D receptor
Sun, J., Kong, J., Duan, Y., Szeto, F. L., Liao, A. P., Madara, J., & Li, Y. C. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00590.2005 · Cited by 231 · see citing works
Ganji, V., Milone, C., Cody, M. M., McCarty, F., & Wang, Y. T. (2010) · International Archives of Medicine · doi:10.1186/1755-7682-3-29 · Cited by 230 · see citing works
Self-citationPrevalence of Vitamin D Insufficiency in Obese Children and Adolescents
Smotkin-Tangorra, M., Purushothaman, R., Gupta, A., Nejati, G., Anhalt, H., & Ten, S. (2007) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2007.20.7.817 · Cited by 219 · see citing works
Vitamin D status and parathyroid hormone in obese children before and after weight loss
Reinehr, T., de Sousa, G., Alexy, U., Kersting, M., & Andler, W. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0188 · Cited by 219 · see citing works
Judd, S. E., Nanes, M. S., Ziegler, T. R., Wilson, P. W. F., & Tangpricha, V. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.136 · Cited by 215 · see citing works
Self-citationReis, J. P., von Mühlen, D. G., & Miller, E. R. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0072 · Cited by 200 · see citing works
Oh, J. Y., & Barrett-Connor, E. L. (2002) · Metabolism · doi:10.1053/meta.2002.29969 · Cited by 189 · see citing works
Goossens, G. H., Blaak, E. E., & van Baak, M. A. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00091.x · Cited by 187 · see citing works
C-reactive protein: a nontraditional serum marker of cardiovascular risk
de Ferranti, S. D., & Rifai, N. (2007) · Cardiovascular Pathology · doi:10.1016/j.carpath.2006.04.006 · Cited by 181 · see citing works
Pittas, A. G., & Dawson‐Hughes, B. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.042 · Cited by 180 · see citing works
Vitamin D deficiency in children and adolescents: Epidemiology, impact and treatment
Huh, S. Y., & Gordon, C. M. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9072-y · Cited by 161 · see citing works
de Ferranti, S. D., Gauvreau, K., Ludwig, D. S., Newburger, J. W., & Rifai, N. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.067181 · Cited by 156 · see citing works
NHANES Monitoring of Serum 25-Hydroxyvitamin D: A Roundtable Summary
Yetley, E. A. D., Pfeiffer, C. M., Schleicher, R. L., Phinney, K. W., Lacher, D. A., Christakos, S., Eckfeldt, J. H., Fleet, J. C., Howard, G., Hoofnagle, A. N., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.110.121483 · Cited by 155 · see citing works
Potenza, M. V., & Mechanick, J. I. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533609342436 · Cited by 145 · see citing works
Reis, A., Hauache, O. M., & Velho, G. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70200-8 · Cited by 139 · see citing works
The impact of vitamin D deficiency on diabetes and cardiovascular risk
Baz-Hecht, M., & Goldfine, A. B. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283372859 · Cited by 135 · see citing works
A cross-sectional study of vitamin D and insulin resistance in children
Kelly, A. T., Brooks, L. J., Dougherty, S., Carlow, D. C., & Zemel, B. S. (2011) · Archives of Disease in Childhood · doi:10.1136/adc.2010.187591 · Cited by 100 · see citing works
Maki, K. C., Rubin, M. R., Wong, L. G., McManus, J. F., Jensen, C. D., Marshall, J. W., & Lawless, A. L. (2009) · Journal of clinical lipidology · doi:10.1016/j.jacl.2009.07.003 · Cited by 93 · see citing works
Hypertension and the Metabolic Syndrome
Morse, S. A., Zhang, R., Thakur, V., & Reisin, E. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00008 · Cited by 87 · see citing works
Spina, C. S., Tangpricha, V., Uskoković, M. R., Adorinic, L., Maehr, H., & Holick, M. F. (2006) · PubMed · Cited by 85 · see citing works
Self-citationVitamin D and cardiometabolic health: a review of the evidence
Muldowney, S., & Kiely, M. E. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000259 · Cited by 66 · see citing works
Gillum, R. F. (2003) · PubMed Central · Cited by 50 · see citing works
Endothelium-derived vasoactive mediators and renal glomerular function.
Ballermann, B. J., & Marsden, P. A. (1991) · PubMed · Cited by 18 · see citing works
C‐Reactive Protein and the Metabolic Syndrome: Useful Addition to the Cardiovascular Risk Profile?
Szmitko, P. E., & Verma, S. (2006) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.0197-3118.2006.05340.x · Cited by 12 · see citing works
Stunff, C. L., Dechartres, A., del Giudice, E. M., Froguel, P., & Bougneres, P. F. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1822 · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Analysis of Association between Vitamin D Deficiency and Insulin Resistance
Szymczak-Pajor, I., & Śliwińska, A. (2019) · Nutrients · doi:10.3390/nu11040794 · Cited by 345 · see citing works
Prevalence of Vitamin D Deficiency Among Overweight and Obese US Children
Turer, C. B., Lin, H., & Flores, G. (2012) · PEDIATRICS · doi:10.1542/peds.2012-1711 · Cited by 302 · see citing works
Gagnon, C., Lu, Z. X., Magliano, D. J., Dunstan, D. W., Shaw, J. E., Zimmet, P., Sikaris, K. A., Ebeling, P. R., & Daly, R. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3187 · Cited by 255 · see citing works
Focus on Vitamin D, Inflammation and Type 2 Diabetes
Chagas, C. E. A., Borges, M. C., Martini, L. A., & Rogero, M. M. (2012) · Nutrients · doi:10.3390/nu4010052 · Cited by 217 · see citing works
Obesity and hypovitaminosis D: causality or casualty?
Migliaccio, S., Nisio, A. D., Mele, C., Scappaticcio, L., Savastano, S., & Colao, A. (2019) · International Journal of Obesity Supplements · doi:10.1038/s41367-019-0010-8 · Cited by 198 · see citing works
Ganji, V., Zhang, X., & Tangpricha, V. (2012) · Journal of Nutrition · doi:10.3945/jn.111.151977 · Cited by 184 · see citing works
Self-citationKelishadi, R., Farajzadegan, Z., & Bahreynian, M. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.886186 · Cited by 162 · see citing works
Icardi, A., Paoletti, E., De Nicola, L., Mazzaferro, S., Russo, R., & Cozzolino, M. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft021 · Cited by 158 · see citing works
Tørris, C., Småstuen, M. C., & Molin, M. (2018) · Nutrients · doi:10.3390/nu10070952 · Cited by 148 · see citing works
Risk Factors in Adolescent Hypertension
Ewald, D. R., & Haldeman, L. A. (2016) · Global Pediatric Health · doi:10.1177/2333794x15625159 · Cited by 145 · see citing works
Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress
Renke, G., Starling-Soares, B., Baesso, T., Petronio, R., Aguiar, D., & Paes, R. (2023) · Nutrients · doi:10.3390/nu15030769 · Cited by 141 · see citing works
Garbossa, S., & Folli, F. B. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9423-2 · Cited by 140 · see citing works
Vitamin D attenuates high fat diet–induced hepatic steatosis in rats by modulating lipid metabolism
Yin, Y., Yu, Z., Xia, M., Luo, X., Lü, X., & Ling, W. (2012) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2012.02706.x · Cited by 130 · see citing works
Kelishadi, R., Salek, S., Salek, M., Hashemipour, M., & Movahedian, M. (2013) · Jornal de Pediatria · doi:10.1016/j.jped.2013.06.006 · Cited by 107 · see citing works
A Genome-Wide Methylation Study of Severe Vitamin D Deficiency in African American Adolescents
Zhu, H., Wang, X., Shi, H., Su, S., Harshfield, G. A., Gutin, B., Snieder, H., & Dong, Y. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.10.059 · Cited by 105 · see citing works
Tabesh, M., Azadbakht, L., Faghihimani, E., Tabesh, M., & Esmaillzadeh, A. (2014) · Diabetologia · doi:10.1007/s00125-014-3313-x · Cited by 98 · see citing works
Vitamin D and the cardiovascular system
Beveridge, L. A., & Witham, M. D. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2281-1 · Cited by 95 · see citing works
Beydoun, M. A., Canas, J. A., Beydoun, H. A., Chen, X., Shroff, M. R., & Zonderman, A. B. (2012) · Journal of Nutrition · doi:10.3945/jn.112.160416 · Cited by 93 · see citing works
Filgueiras, M. D. S., Rocha, N. P., de Novaes, J. F., & Bressan, J. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1546671 · Cited by 88 · see citing works
Nutritional issues in patients with obesity and cirrhosis
Schiavo, L., Busetto, L., Cesaretti, M., Zelber‐Sagi, S., Deutsch, L., & Iannelli, A. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i30.3330 · Cited by 83 · see citing works
Vitamin D Deficiency and the Risk of Preeclampsia and Eclampsia in Bangladesh
Ullah, M., Koch, C. A., Tamanna, S., Rouf, S., & Shamsuddin, L. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1345199 · Cited by 77 · see citing works
Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children
Lee, S. H., Kim, S. M., Park, H. S., Choi, K. M., Cho, G. J., Ko, B. J., & Kim, J. H. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.04.013 · Cited by 76 · see citing works
Vitamin D insufficiency and insulin resistance in obese adolescents
Peterson, C. A., Tosh, A. K., & Belenchia, A. M. (2014) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018814547205 · Cited by 71 · see citing works
Vitamin D status and childhood health
Shin, Y. H., Shin, H. J., & Lee, Y. (2013) · Korean Journal of Pediatrics · doi:10.3345/kjp.2013.56.10.417 · Cited by 71 · see citing works
Wamberg, L., Pedersen, S. B., Rejnmark, L., & Richelsen, B. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0176-5 · Cited by 66 · see citing works
Parikh, S. J., Guo, D.-H., Pollock, N. K., Petty, K., Bhagatwala, J., Gutin, B., Houk, C., Zhu, H., & Dong, Y. (2012) · Diabetes Care · doi:10.2337/dc11-1944 · Cited by 65 · see citing works
Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight
Sisley, S. R., Arble, D. M., Chambers, A. P., Gutiérrez‐Aguilar, R., He, Y., Xu, Y., Gardner, D. G., Moore, D. D., Seeley, R. J., & Sandoval, D. A. (2016) · Diabetes · doi:10.2337/db16-0309 · Cited by 65 · see citing works
Vitamin D status of psychiatric inpatients in New Zealand’s Waikato region
Menkes, D. B., Lancaster, K., Grant, M., Marsh, R. W., Dean, P., & du Toit, S. A. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-68 · Cited by 64 · see citing works
High prevalence of vitamin D insufficiency or deficiency in young adolescents in Korea
Shin, Y. H., Kim, K. E., Lee, C., Shin, H. J., Kang, M. S., Lee, H.-R., & Lee, Y. (2012) · European Journal of Pediatrics · doi:10.1007/s00431-012-1746-0 · Cited by 64 · see citing works
Ganji, V., Tangpricha, V., & Zhang, X. (2020) · Nutrients · doi:10.3390/nu12030730 · Cited by 63 · see citing works
Self-citationKelishadi, R., Ardalan, G., Motlagh, M. E., Shariatinejad, K., Heshmat, R., Poursafa, P., Fakhri, M., Tajadini, M., & Taslimi, M. (2013) · Nutrition · doi:10.1016/j.nut.2013.05.018 · Cited by 61 · see citing works
Nam, G. E., Kim, D., Cho, K. H., Park, Y. G., Han, K., Kim, S. M., Lee, S. H., Ko, B. J., & Kim, M. J. (2012) · Public Health Nutrition · doi:10.1017/s1368980012004855 · Cited by 60 · see citing works
The Association Between Vitamin D and Cardiometabolic Risk Factors in Children
Dolinsky, D. H., Armstrong, S., Mangarelli, C., & Kemper, A. R. (2013) · Clinical Pediatrics · doi:10.1177/0009922812470742 · Cited by 60 · see citing works
Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic rats
Ning, C., Liu, L., Lv, G., Yang, Y., Zhang, Y., Yu, R., Wang, Y., & Zhu, J. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0030-5 · Cited by 55 · see citing works
Hauger, H., Laursen, R. P., Ritz, C., Mølgaard, C., Lind, M. V., & Damsgaard, C. (2020) · European Journal of Nutrition · doi:10.1007/s00394-019-02150-x · Cited by 45 · see citing works
Health Effects Related to Low Vitamin D Concentrations: Beyond Bone Metabolism
Moreno, L. A., Valtueña, J., Pérez-López, F. R., & González‐Gross, M. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000332070 · Cited by 50 · see citing works
Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children
Fu, Z., Xu, C. Y., Shu, Y., Xie, Z., Lu, C., & Mo, X. (2019) · Public Health Nutrition · doi:10.1017/s1368980019001137 · Cited by 50 · see citing works
Vitamin D, Metabolic Dyslipidemia, and Metabolic Syndrome in Rheumatoid Arthritis
Baker, J. F., Mehta, N. N., Baker, D. G., Toedter, G. P., Justine Shults, A., Feldt, J. M. V., & Leonard, M. B. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2012.01.025 · Cited by 49 · see citing works
Öhlund, I., Silfverdal, S., Hernell, O., & Lind, T. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182838e5b · Cited by 45 · see citing works
Corsello, A., Macchi, M., D’Oria, V., Pigazzi, C., Alberti, I., Treglia, G., Cosmi, V. D., Mazzocchi, A., Agostoni, C. V., & Milani, G. P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106793 · Cited by 44 · see citing works
Miñambres, I., Sánchez-Hernández, J., Sánchez‐Quesada, J. L., Rodrı́guez-Espinosa, J., de Leiva, A., & Pérez, A. (2012) · ISRN Endocrinology · doi:10.5402/2012/691803 · Cited by 43 · see citing works
Nutrition in Type 2 Diabetes and the Metabolic Syndrome
Via, M. A., & Mechanick, J. I. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.06.009 · Cited by 43 · see citing works
Low vitamin D is associated with hypertension in paediatric obesity
Kao, K., Abidi, N., Ranasinha, S., Brown, J. J., Rodda, C. P., McCallum, Z., Zacharin, M., Simm, P. J., Magnussen, C. G., & Sabin, M. A. (2015) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.12935 · Cited by 42 · see citing works
Is vitamin D status relevant to metabolic syndrome?
Boucher, B. J. (2012) · Dermato-Endocrinology · doi:10.4161/derm.20012 · Cited by 40 · see citing works
Brzeziński, M., Jankowska, A., Słomińska-Frączek, M., Metelska, P., Wiśniewski, P., Socha, P., & Szlagatys‐Sidorkiewicz, A. (2020) · Nutrients · doi:10.3390/nu12041093 · Cited by 40 · see citing works
Sacheck, J. M., Rompay, M. I. V., Chomitz, V. R., Economos, C. D., Eliasziw, M., Goodman, E., Gordon, C. M., & Holick, M. F. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01179 · Cited by 38 · see citing works
Vitamin D affects insulin sensitivity and β-cell function in obese non-diabetic youths
Corica, D., Zusi, C., Olivieri, F., Marigliano, M., Piona, C. A., Fornari, E., Morandi, A., Corradi, M., del Giudice, E. M., Gatti, D., et al. (2019) · European Journal of Endocrinology · doi:10.1530/eje-19-0369 · Cited by 37 · see citing works
Xiao, P., Dong, H., Li, H., Yan, Y., Cheng, H., Liu, J., Zhao, X., Hou, D., & Mi, J. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000846 · Cited by 37 · see citing works
The Liver in Children With Metabolic Syndrome
D’Adamo, E., Castorani, V., & Nobili, V. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00514 · Cited by 35 · see citing works
Vitamin D deficiency & childhood obesity: a tale of two epidemics.
Peterson, C. A., & Belenchia, A. M. (2014) · Europe PMC (PubMed Central) · Cited by 35 · see citing works
Mitri, J., Nelson, J., Ruthazer, R., Garganta, C. L., Nathan, D. M., Hu, F. B., Dawson‐Hughes, B., & Pittas, A. G. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.293 · Cited by 34 · see citing works
Li, W., Chen, D., Peng, Y., Lu, Z., & Wang, D. (2023) · Obesity · doi:10.1002/oby.23691 · Cited by 33 · see citing works
Association between Vitamin D and Circulating Lipids in Early Childhood
Birken, C. S., Lebovic, G., Anderson, L. N., McCrindle, B. W., Mamdani, M., Kandasamy, S., Khovratovich, M., Parkin, P. C., & Maguire, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131938 · Cited by 32 · see citing works
Rafraf, M., Hasanabad, S. K., & Jafarabadi, M. A. (2013) · Public Health Nutrition · doi:10.1017/s1368980013003340 · Cited by 31 · see citing works
Anapalı, M., Dağıstanlı, F. K., Akdemir, A. S., Aydemir, D., Ulusu, N. N., Ulutin, T., Uysal, Ö., Tanrıverdi, G., & Öztürk, M. (2022) · Histochemistry and Cell Biology · doi:10.1007/s00418-022-02131-y · Cited by 31 · see citing works
Asbaghi, O., Kashkooli, S., Choghakhori, R., Hasanvand, A., & Abbasnezhad, A. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.100124 · Cited by 31 · see citing works
Chung, S. J., Lee, Y. A., Hong, H., Kang, M. J., Kwon, H. J., Shin, C. H., & Yang, S. W. (2013) · Public Health Nutrition · doi:10.1017/s1368980013002334 · Cited by 30 · see citing works
Moore, C. E., & Liu, Y. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.11.003 · Cited by 30 · see citing works
Milagres, L. C., Rocha, N. P., Filgueiras, M. D. S., de Albuquerque, F. M., Castro, A. P. P., Pessoa, M. C., Pelúzio, M. D. C. G., & de Novaes, J. F. (2017) · Public Health Nutrition · doi:10.1017/s136898001700194x · Cited by 30 · see citing works
Tepper, S., Shahar, D. R., Geva, D., & Ish‐Shalom, S. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12650 · Cited by 29 · see citing works
Tomaino, K., Romero, K. M., Robinson, C. L., Baumann, L. M., Hansel, N. N., Pollard, S. L., Gilman, R. H., Mougey, E. B., Lima, J. J., Checkley, W., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpu264 · Cited by 29 · see citing works
Ganji, V., Sukik, A., Alaayesh, H., Rasoulinejad, H., & Shraim, M. (2019) · BioFactors · doi:10.1002/biof.1572 · Cited by 28 · see citing works
Self-citationLow serum 25-hydroxyvitamin D level is associated with obesity and atherogenesis in adolescent boys
Naganuma, J., Koyama, S., Arisaka, O., & Yoshihara, S. (2021) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2142112.056 · Cited by 27 · see citing works
Vitamin D Supplementation Does Not Impact Insulin Resistance in Black and White Children.
Ferira, A. J., Laing, E., Hausman, D., Hall, D., McCabe, G., Martin, B., Gallant, K. H. H., Warden, S., Weaver, C., Peacock, M., et al. (2016) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2015-3687 · Cited by 25 · see citing works
Association of serum vitamin D concentrations with dietary patterns in children and adolescents
Ganji, V., Martineau, B., & FLEIT, W. E. V. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0365-7 · Cited by 27 · see citing works
Self-citationCalcium and vitamin D requirements for optimal bone mass during adolescence
Abrams, S. A. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834b2b01 · Cited by 27 · see citing works
Zheng, J., Imamura, F., Sharp, S. J., van der Schouw, Y. T., Sluijs, I., Gundersen, T. E., Ardanáz, E., Boeing, H., Bonet, C., Gómez, J., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01522 · Cited by 26 · see citing works
Giudici, K. V., Fisberg, R. M., Marchioni, D. M. L., Peters, B. S. E., & Martini, L. A. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1274923 · Cited by 26 · see citing works
Iqbal, A., DAHL, A. R., Lteif, A. N., & Kumar, S. (2017) · Children · doi:10.3390/children4090080 · Cited by 26 · see citing works
Zheng, H., Yin, Z., Luo, X., Zhou, Y., Fei, Z., & Guo, Z. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30317-x · Cited by 25 · see citing works
Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty
Zhao, Y., Long, W., Du, C., Yang, H., Wu, S., Ning, Q., & Luo, X. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0544-5 · Cited by 24 · see citing works
Black, L. J., Burrows, S., Lucas, R. M., Marshall, C. E., Huang, R., Ping‐Delfos, W. C. S., Beilin, L. J., Holt, P. G., Hart, P. H., Oddy, W. H., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001185 · Cited by 24 · see citing works
Szlagatys‐Sidorkiewicz, A., Brzeziński, M., Jankowska, A., Metelska, P., Słomińska-Frączek, M., & Socha, P. (2017) · BMC Pediatrics · doi:10.1186/s12887-017-0851-7 · Cited by 24 · see citing works
Yu, A., Kim, J., Kwon, O., Oh, S., Kim, J.-H., & Yang, Y. J. (2013) · Clinical Nutrition Research · doi:10.7762/cnr.2013.2.2.107 · Cited by 23 · see citing works
Cho, Y., Kim, J. W., Shim, J. O., Yang, H. R., Chang, J. Y., Moon, J. S., & Ko, J. S. (2019) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2019.22.3.233 · Cited by 23 · see citing works
Low serum vitamin D levels increase the mortality of cardiovascular disease in older adults
Yang, J., Ouyang, J., & Huang, J. (2019) · Medicine · doi:10.1097/md.0000000000016733 · Cited by 23 · see citing works
Mousa, H., Islam, N., Ganji, V., & Zughaier, S. M. (2020) · Nutrients · doi:10.3390/nu13010127 · Cited by 22 · see citing works
Self-citationKelishadi, R., Salek, S., Salek, M., Hashemipour, M., & Movahedian, M. (2014) · Jornal de Pediatria (Versão em Português) · doi:10.1016/j.jpedp.2013.06.005 · Cited by 22 · see citing works
Zhu, L., Li, S., Zhong, L., Xu, S., & Zhu, H. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03301-x · Cited by 21 · see citing works
Lee, M., Ebert, J. R., Kadakia, M., Zhang, J., & Czerwinski, S. A. (2016) · American Journal of Human Biology · doi:10.1002/ajhb.22863 · Cited by 21 · see citing works
Moore, C. E., & Liu, Y. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.01.008 · Cited by 21 · see citing works
Alaklabi, A., & Alsharairi, N. A. (2018) · Children · doi:10.3390/children5010011 · Cited by 20 · see citing works
Koçak, F. E., Öztürk, B., Işıklar, Ö. Ö., Genc, O., Ünlü, A., & Altuntaş, İ. (2015) · Biochemia Medica · doi:10.11613/bm.2015.044 · Cited by 20 · see citing works
Vinet, A., Morrissey, C., Pérez‐Martin, A., Goncalves, A., Raverdy, C., Masson, D., Gayrard, S., Carrère, M., Landrier, J., & Amiot, M. J. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.04.025 · Cited by 20 · see citing works
Qorbani, M., Heidari‐Beni, M., Ejtahed, H., Shafiee, G., Goodarzi, F., Zadeh, S. S. T., Khademian, M., Khonsari, N. M., Motlagh, M. E., Asayesh, H., et al. (2021) · BMC Nutrition · doi:10.1186/s40795-021-00477-5 · Cited by 20 · see citing works
Vitamin D status, body composition and hypertensive target organ damage in primary hypertension
Płudowski, P., Jaworski, M., Niemirska, A., Litwin, M., Szalecki, M., Karczmarewicz, E., & Michałkiewicz, J. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.10.026 · Cited by 20 · see citing works
Wood, J., Connor, C. G., Cheng, P., Ruedy, K. J., Tamborlane, W. V., KLINGENSMITH, G. J., Schatz, D., Gregg, B. E., Cengiz, E., Willi, S. M., et al. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12340 · Cited by 20 · see citing works
García‐Bailo, B., Karmali, M. A., Badawi, A. F., & El‐Sohemy, A. (2013) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.826112 · Cited by 19 · see citing works
Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity
Durá-Travé, T., Gallinas-Victoriano, F., Peñafiel-Freire, D. M., Urretavizcaya-Martinez, M., Moreno-González, P., & Chueca-Guindulain, M. J. (2020) · Children · doi:10.3390/children7020010 · Cited by 19 · see citing works
Öhlund, I., Lind, T., Hernell, O., Silfverdal, S., Liv, P., & Åkeson, P. K. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa031 · Cited by 19 · see citing works
Ganji, V., Al-Obahi, A., Yusuf, S., Dookhy, Z., & Shi, Z. (2020) · Scientific Reports · doi:10.1038/s41598-020-67967-7 · Cited by 19 · see citing works
Self-citationVigna, L., Cassinelli, L., Tirelli, A. S., Felicetta, I., Napolitano, F., Tomaino, L., Mutti, M., Barberi, C. E., & Riboldi, L. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1264280 · Cited by 19 · see citing works
Vitamin D Intake and Status in 6-Year-Old Icelandic Children Followed up from Infancy
Þórisdóttir, B., Gunnarsdóttir, I., Steingrímsdóttir, L., Palsson, G. I., Birgisdóttir, B. E., & Þórsdóttir, I. (2016) · Nutrients · doi:10.3390/nu8020075 · Cited by 18 · see citing works
Smith, T. J., Tripkovic, L., Lanham-New, S. A., & Hart, K. H. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117004104 · Cited by 18 · see citing works
Hauger, H., Mølgaard, C., Mortensen, C. G., Ritz, C., Frøkiær, H., Smith, T. J., Hart, K. H., Lanham-New, S. A., & Damsgaard, C. T. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy080 · Cited by 18 · see citing works
Smith, T. J., Tripkovic, L., Hauger, H., Damsgaard, C. T., Mølgaard, C., Lanham-New, S. A., & Hart, K. H. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy079 · Cited by 18 · see citing works
Vitamin D status is associated with early markers of cardiovascular disease in prepubertal children
Nwosu, B. U., Maranda, L., Cullen, K., Ciccarelli, C., & Lee, M. (2013) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2013-0086 · Cited by 18 · see citing works
Association of Vitamin D Status and Metabolic Syndrome Components in Iranian Children
Ghobadi, S., Hassanzadeh-Rostami, Z., Salehi‐Marzijarani, M., & Faghih, S. (2019) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_242_17 · Cited by 17 · see citing works
Sphingolipid serum profiling in vitamin D deficient and dyslipidemic obese dimorphic adults
Al‐Daghri, N. M., Torretta, E., Barbacini, P., Asare, H., Ricci, C., Capitanio, D., Guerini, F. R., Sabico, S., Alokail, M. S., Clerici, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53122-4 · Cited by 17 · see citing works
- Authors
- Ganji, V., Zhang, X., Shaikh, N., & Tangpricha, V.
- Affiliations
- Emory University (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 94
- Issue
- 1
- Pages
- 225-233
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2118926394
- Cited by
- 189
- References
- 59
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 13 · 2018: 14 · 2017: 18 · 2016: 13 · 2015: 12 · 2014: 9 · 2013: 17 · 2012: 30
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- 25-hydroxyvitamin D, vitamin D status, metabolic syndrome, cardiometabolic risk factors, children and adolescents, insulin resistance, waist circumference, systolic blood pressure, HDL cholesterol, C-reactive protein, inflammation, obesity, NHANES, vitamin D supplementation, vitamin D deficiency, vitamin D excess, cardiovascular disease prevention, diabetes prevention
- MeSH terms
- Adolescent, Adult, Cardiovascular Diseases, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Health Surveys, Humans, Insulin Resistance, Cholesterol, HDL, Male, Risk Factors, Time Factors, Vitamin D, Prevalence, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review