Associations between n−3 PUFA concentrations and cognitive function after recovery from late-life depression
Open accessAbstract
Background Lower concentrations of n-3 PUFAs have been reported to be associated with cognitive impairment and dementia, but also with depression-itself a potential risk factor for cognitive decline.Objective The aims of this study were to investigate associations between n-3 PUFA concentrations in erythrocyte membrane or plasma and cognitive function in an at-risk sample of older people with previous major depression and to explore specificity with respect to cognitive domains.Design A cross-sectional sample of 132 eligible participants who had recovered from major depression (mean ± SD age: 67.8 ± 6.6 y) were enrolled from outpatient psychiatric services. A series of cognitive tests and a structured questionnaire were administered. Fasting blood samples were collected for n-3 PUFA measurements.Results Higher EPA and total n-3 PUFA concentrations and a lower ratio of arachidonic acid to EPA in erythrocyte membranes were associated with a higher cognitive composite score: independent of age and sex, but no longer significant after adjustment for education. No associations were found with plasma concentrations of any fatty acid. Considering individual cognitive tests, the strongest and most consistent correlations were found between immediate recall and concentrations of total n-3 PUFAs and α-linolenic acid (ALA) in erythrocytes, which were observed only in participants with recurrent depression.Conclusions Total erythrocyte n-3 PUFA concentrations are positively associated with cognitive function, particularly immediate recall, in older people with previous depression. Lower concentrations of n-3 PUFAs or ALA in erythrocyte membranes may be good predictors for cognitive impairment in older people with previous recurrent depression.
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In a separate cross-sectional investigation on individuals recovered from major depressive disorder (n = 132), plasma concentrations of n-3 polyunsaturated fatty acids correlated positively with neurocognitive performance.
“Additionally, in a separate cross-sectional investigation on individuals recovered from MDD (n = 132), plasma concentrations of n-3 PUFAs correlated positively with neurocognitive performance [141].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [141]
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Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
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- Authors
- Chiu, C.-C., Frangou, S., Chang, C.-J., Chiu, W.-C., Liu, H.-C., Sun, I.-W., Liu, S.-I., Lu, M.-L., Chen, C.-H., Huang, S.-Y., Dewey, M. E., & Stewart, R.
- Affiliations
- Taipei Municipal YangMing Hospital (TW)
- Cathay General Hospital (TW)
- Taipei City Hospital (TW)
- Mackay Memorial Hospital (TW)
- Taipei Medical University (TW)
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 95
- Issue
- 2
- Pages
- 420-427
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2105573194
- Cited by
- 47
- References
- 54
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- omega-3 fatty acids, cognitive function, geriatric depression, major depressive disorder, recurrent depression, erythrocyte membrane fatty acids, plasma fatty acids, alpha-linolenic acid, eicosapentaenoic acid, immediate recall, cognitive impairment, older adults, cognitive decline
- MeSH terms
- Aged, Cognition, Cognition Disorders, Cross-Sectional Studies, Depression, Major Depressive Disorder, Depressive Disorder, Major, Educational Status, Erythrocyte Membrane, Female, Humans, Male, Middle Aged, Nutritional Status, Surveys and Questionnaires, Mental Recall, Recurrence, Risk Factors, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Arachidonic Acid, alpha-Linolenic Acid
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