Cited by 288Fatty Acid Research and HealthAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Chronic Administration of Docosahexaenoic Acid Ameliorates the Impairment of Spatial Cognition Learning Ability in Amyloid β–Infused Rats

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Hashimoto, Michio, Tanabe, Yoko, Fujii, Yoshimi, Kikuta, Toshihiko, Shibata, Hitoshi, Shido, Osamu·2005·The Journal of Nutrition

Abstract

We investigated whether administration of docosahexaenoic acid (DHA), a major (n-3) fatty acid of the brain, ameliorates the impairment of learning ability in an animal model of Alzheimer's disease (AD), rats infused with amyloid-beta (Abeta) peptide (1-40) into the cerebral ventricle. Inbred 3rd generation male rats (20 wk old) fed a fish oil-deficient diet were randomly divided into 4 groups: a vehicle group, an Abeta peptide-infused group (Abeta group), a DHA group, and an Abeta + DHA group. A mini-osmotic pump filled with Abeta peptide or vehicle was implanted in the rats, and they were tested for learning ability-related reference and working memory in an 8-arm radial maze. The rats were then orally fed DHA dissolved in 5% gum Arabic solution at 300 mg/(kg . d) (DHA and Abeta + DHA groups) or vehicle alone (vehicle and Abeta groups) and tested again for learning ability. DHA administered for 12 wk significantly reduced the increase in the number of reference and working memory errors in the Abeta-infused rats, and increased both the cortico-hippocampal level of DHA and the molar ratio of DHA/arachidonic acid, suggesting an amelioration of the impaired spatial cognition learning ability. Furthermore, DHA suppressed the increases in the levels of lipid peroxide and reactive oxygen species in the cerebral cortex and the hippocampus of Abeta-infused rats, suggesting that DHA increases antioxidative defenses. DHA is thus a possible therapeutic agent for ameliorating learning deficiencies due to Alzheimer's disease.

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  1. Suzuki, H., Morikawa, Y. & Takahashi, H. (2001) Effect of DHA sup- plementation on intelligence and visual activity in the elderly. In: Fatty Acids and Lipids-New Findings (Hamazaki T. & Okuyama H., eds.). World Rev. Nutr. Diet. 88: 68 -71. Karger, Basel, Switzerland.

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Authors
Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., & Shido, O.
Affiliations
Shimane University (JP)
Corresponding author
Hashimoto, Michio
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2005-03
Volume
135
Issue
3
Pages
549-555
ISSN
0022-3166 (ISSN-L)
OpenAlex
W2111757144
Cited by
288
References
46
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 7 · 2016: 20 · 2015: 25 · 2014: 18 · 2013: 13 · 2012: 17
FWCI
18.59
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
docosahexaenoic acid, Alzheimer's disease, amyloid-beta, spatial learning, memory impairment, omega-3 fatty acids, hippocampus, cerebral cortex, oxidative stress, lipid hydroperoxides, antioxidant defense, reference memory, working memory, 8-arm radial maze
MeSH terms
Alzheimer Disease, Animals, Cognition, Disease Models, Animal, Docosahexaenoic Acids, Learning, Space Perception, Amyloid beta-Peptides, Rats, Wistar, Reactive Oxygen Species, Rats

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