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Mechanisms underlying immune effects of dietary oligosaccharides
Open accessAbstract
The WHO refers to human milk as the nutritional gold standard for term infants. Human milk contains many immunomodulatory compounds, including oligosaccharides. Human-milk oligosaccharides can serve as prebiotics because the nondigestible oligosaccharides present in human milk show a clear bifidogenic effect on the gut microbiota. Dietary oligosaccharide structures that have prebiotic effects similar to human-milk oligosaccharides include galacto-oligosaccharides, fructo-oligosaccharides, and pectin-derived acidic oligosaccharides. Both animal studies and human clinical trials showed that dietary intervention with these dietary oligosaccharides in early life could lead to the prevention of atopic dermatitis, food allergy, and allergic asthma. The immune-modulating effects of these oligosaccharides are likely assisted via alteration of the intestinal microbiota or in a microbiota-independent manner by direct interaction on immune cells or both. In this review, an overview of the prebiotic role of dietary oligosaccharides on the microbiota and the microbiota-independent immune modulation by these prebiotics is provided. In addition, recent publications that report on the pathways by which the oligosaccharides might exert their direct immunomodulatory effect are summarized.
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“Prebiotic fibers have been shown to have beneficial effects on immune function (Jeurink et al., 2013)(de Kivit et al., 2011)(van Hoffen et al., 2009), bowel motility and constipation (Meksawan et al., 2014) (Scholtens et al., 2014) (Rasmussen et al., 2014) that might be very relevant for inflammation and GI-related symptoms in PD.”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Jeurink et al., 2013
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Metadata
- Authors
- Jeurink, P. V., van Esch, B. C., Rijnierse, A., Garssen, J., & Knippels, L. M.
- Affiliations
- Utrecht University (NL)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 98
- Issue
- 2
- Pages
- 572S-577S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2146896376
- Cited by
- 129
- References
- 82
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 14 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 14 · 2014: 10 · 2013: 4
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danone
- Universiteit Utrecht
- Top Institute Pharma (T1-214)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- dietary oligosaccharides, human milk oligosaccharides, prebiotics, gut microbiota, immunomodulation, galactooligosaccharides, fructooligosaccharides, atopic dermatitis, food allergy, allergic asthma, early life nutrition
- MeSH terms
- Animals, Asthma, Clinical Trials as Topic, Dermatitis, Atopic, Diet, Food Hypersensitivity, Humans, Immunologic Factors, Infant, Milk, Human, Oligosaccharides, Trisaccharides, Probiotics, Models, Animal, Gastrointestinal Tract, Metagenome, Prebiotics
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