Cited by 129Microbial Metabolites in Food BiotechnologyInfant Nutrition and HealthGut microbiota and health

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Mechanisms underlying immune effects of dietary oligosaccharides

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Jeurink, Prescilla V, van Esch, Betty CAM, Rijnierse, Anneke, Garssen, Johan, Knippels, Léon MJ·2013·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.112.038596

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Abstract

The WHO refers to human milk as the nutritional gold standard for term infants. Human milk contains many immunomodulatory compounds, including oligosaccharides. Human-milk oligosaccharides can serve as prebiotics because the nondigestible oligosaccharides present in human milk show a clear bifidogenic effect on the gut microbiota. Dietary oligosaccharide structures that have prebiotic effects similar to human-milk oligosaccharides include galacto-oligosaccharides, fructo-oligosaccharides, and pectin-derived acidic oligosaccharides. Both animal studies and human clinical trials showed that dietary intervention with these dietary oligosaccharides in early life could lead to the prevention of atopic dermatitis, food allergy, and allergic asthma. The immune-modulating effects of these oligosaccharides are likely assisted via alteration of the intestinal microbiota or in a microbiota-independent manner by direct interaction on immune cells or both. In this review, an overview of the prebiotic role of dietary oligosaccharides on the microbiota and the microbiota-independent immune modulation by these prebiotics is provided. In addition, recent publications that report on the pathways by which the oligosaccharides might exert their direct immunomodulatory effect are summarized.

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Authors: Jeurink, P. V., van Esch, B. C., Rijnierse, A., Garssen, J., & Knippels, L. M.
Affiliations: Utrecht University (NL)
ORCID: Rijnierse, Anneke
Garssen, Johan
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2013-08
Volume: 98
Issue: 2
Pages: 572S-577S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.112.038596
OpenAlex: W2146896376
Cited by: 129
References: 82
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 14 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 14 · 2014: 10 · 2013: 4
FWCI: 12.21
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3490 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Danone
Universiteit Utrecht
Top Institute Pharma (T1-214)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: dietary oligosaccharides, human milk oligosaccharides, prebiotics, gut microbiota, immunomodulation, galactooligosaccharides, fructooligosaccharides, atopic dermatitis, food allergy, allergic asthma, early life nutrition
MeSH terms: Animals, Asthma, Clinical Trials as Topic, Dermatitis, Atopic, Diet, Food Hypersensitivity, Humans, Immunologic Factors, Infant, Milk, Human, Oligosaccharides, Trisaccharides, Probiotics, Models, Animal, Gastrointestinal Tract, Metagenome, Prebiotics

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