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Cited by 156Diabetes and associated disordersInfant Nutrition and HealthDiabetes Management and Research

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Infant feeding and the risk of type 1 diabetes

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Knip, Mikael, Virtanen, Suvi M, Åkerblom, Hans K·2010·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.2010.28701cPMC PMC6443298
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Abstract

Type 1 diabetes is generally considered to be a chronic, immune-mediated disease with a subclinical prodrome during which beta cell autoimmunity becomes overt disease at a variable rate in genetically susceptible individuals. Accumulated evidence supports a critical role of environmental factors in its development. Prospective birth cohort studies show that the first signs of beta cell autoimmunity may be initiated during the first year of life. This implies that risk factors for beta cell autoimmunity and type 1 diabetes must be operative in infancy. Early nutrition provides essential exogenous exposures in that period. This article discusses the role of factors related to infant nutrition in the development of beta cell autoimmunity and type 1 diabetes and the potential mechanistic pathways involved. So far, no specific dietary factor has been shown to be an unequivocal risk factor for beta cell autoimmunity or type 1 diabetes, and there are a number of contradictory observations with regard to the effect of various foods. This may reflect geographic and cultural differences in infant-feeding practices. Most studies suggest that the early introduction of complex foreign proteins may be a risk factor for beta cell autoimmunity, and a pilot intervention trial has implied that weaning to a highly hydrolyzed formula may decrease the risk of beta cell autoimmunity. Lack of vitamin D supplementation and accelerated growth might increase the risk of type 1 diabetes. Additional wor…

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Metadata

Authors
Knip, M., Virtanen, S. M., & Åkerblom, H. K.
Affiliations
University of Helsinki (FI)
Corresponding author
Knip, Mikael
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2010-05
Volume
91
Issue
5
Pages
1506S-1513S
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.2010.28701c
PMC
PMC6443298
OpenAlex
W2138015526
Cited by
156
References
0
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 12 · 2016: 10 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 15
FWCI
9.90
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
NIH
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 1 diabetes, infant feeding, islet autoimmunity, infant nutrition, hydrolyzed formula, weaning, vitamin D supplementation, infant growth, environmental risk factors, dietary risk factors
MeSH terms
Breast Feeding, Cell Membrane Permeability, Diabetes Mellitus, Type 1, Female, Finland, Humans, Infant, Infant Food, Infant Nutritional Physiological Phenomena, Intestinal Absorption, Polymorphism, Genetic, Rickets, Risk Factors, Vitamin D, Vitamin D Deficiency, Incidence, Receptors, Calcitriol, Developed Countries, Dietary Supplements, Insulin-Secreting Cells

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