(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights

Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915

Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study

Thota, R. N., Dias, C. B., Abbott, K. A., Acharya, S., & Garg, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-32032-x · Cited by 38

Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial

Hames, K. C., Morgan-Bathke, M. E., Harteneck, D. A., Zhou, L., Port, J. D., Lanza, I. R., & Jensen, M. D. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.148114 · Cited by 40

Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults

Heskey, C. E., Jaceldo‐Siegl, K., Sabaté, J., Fraser, G. E., & Rajaram, S. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.118935 · Cited by 35

Effects of Sweet Cherry Polyphenols on Enhanced Osteoclastogenesis Associated With Childhood Obesity

Corbo, F., Brunetti, G., Crupi, P., Bortolotti, S., Storlino, G., Piacente, L., Carocci, A., Catalano, A. A., Milani, G., Colaianni, G., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01001 · Cited by 33

AdipoGauge software for analysis of biological microscopic images

Yosofvand, M., Liyanage, S., Kalupahana, N. S., Scoggin, S. O., Moustaïd‐Moussa, N., & Moussa, H. M. (2020) · Adipocyte · doi:10.1080/21623945.2020.1787583 · Cited by 31

Influence of genetic variants in FADS2 and ELOVL2 genes on BMI and PUFAs homeostasis in children and adolescents with obesity

Maguolo, A., Zusi, C., Giontella, A., del Giudice, E. M., Tagetti, A., Fava, C., Morandi, A., & Maffeis, C. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00662-9 · Cited by 33

Adipose tissue inflammation linked to obesity: A review of current understanding, therapies and relevance of phyto-therapeutics

Aruwa, C. E., & Sabiu, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23114 · Cited by 34

Schisandra Chinensis Acidic Polysaccharide Improves the Insulin Resistance in Type 2 Diabetic Rats by Inhibiting Inflammation

Qiao, Z., Du, X.-X., Zhuang, W., Yang, S., He, L., Sun, J., Chen, J., & Wang, C. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2019.4469 · Cited by 31

Amelioration of obesity-associated inflammation and insulin resistance in c57bl/6 mice via macrophage polarization by fish oil supplementation

Bashir, S., Sharma, Y., Elahi, A., & Khan, F. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.02.011 · Cited by 30

Fatty acids: Adiposity and breast cancer chemotherapy, a bad synergy?

Mentoor, I., Engelbrecht, A., & Nell, T. A. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.11.009 · Cited by 28

Sandalwood seed oil ameliorates hepatic insulin resistance by regulating the JNK/NF-κB inflammatory and PI3K/AKT insulin signaling pathways

Zhang, H., Gao, X., Li, K., Liu, Y. D., Hettiarachichi, D. S., Sunderland, B., & Li, D. (2021) · Food & Function · doi:10.1039/d0fo03051a · Cited by 29

Effects of dietary n-6:n-3 polyunsaturated fatty acid ratio on cardiac antioxidative status, T-cell and cytokine mRNA expression in the thymus, and blood T lymphocyte subsets of broilers

Chen, W., Wang, J. P., & Huang, Y. (2012) · Livestock Science · doi:10.1016/j.livsci.2012.08.008 · Cited by 27

The Role of Omega-3 Polyunsaturated Fatty Acids Supplementation in Childhood: A Review

Ciccone, M. M., Scicchitano, P., Gesualdo, M., Zito, A., Carbonara, S., Ricci, G., Cortese, F., & Giordano, P. (2013) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/1574890111308010006 · Cited by 28

Maternal and Postnatal Supplementation of Fish Oil Improves Metabolic Health of Mouse Male Offspring

Ramalingam, L., Menikdiwela, K. R., Clevenger, S., Eboh, T., Allen, L., Koboziev, I., Scoggin, S. O., Rashid, A. M., Moussa, H. M., & Moustaïd‐Moussa, N. (2018) · Obesity · doi:10.1002/oby.22319 · Cited by 27

Dietary fish oil supplementation alters liver gene expressions to protect against LPS-induced liver injury in weanling piglets

Zhang, J., Xu, X., Zhu, H., Wang, Y., Hou, Y., & Liu, Y. (2019) · Innate Immunity · doi:10.1177/1753425918821420 · Cited by 26

N-3 Polyunsaturated Fatty Acids, Lipid Microclusters, and Vitamin E

Shaikh, S. R., Wassall, S. R., Brown, D. A., & Kosaraju, R. (2015) · Current topics in membranes · doi:10.1016/bs.ctm.2015.03.003 · Cited by 26

Potential of Nutraceutical Supplementation in the Modulation of White and Brown Fat Tissues in Obesity-Associated Disorders: Role of Inflammatory Signalling

Scarano, F., Gliozzi, M., Zito, M. C., Guarnieri, L., Carresi, C., Macrì, R., Nucera, S., Scicchitano, M., Bosco, F., Ruga, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073351 · Cited by 30

Pentraxin 3 deficiency exacerbates lipopolysaccharide-induced inflammation in adipose tissue

Guo, H., Qiu, X., Deis, J. A., Lin, T., & Chen, X. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0402-4 · Cited by 25

Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis

Zhou, F. J., Yin, M., Liu, Y., Han, X., Guo, J., Ren, C., Wang, W., Huang, W., Zhan, J., & You, Y. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103509 · Cited by 25

Protective effects of eicosapentaenoic acid in adipocyte-breast cancer cell cross talk

Aljawadi, A., Rasha, F. A., Ramalingam, L., Alhaj, S., Moussa, H. M., Gollahon, L., Dharmawardhane, S., & Moustaïd‐Moussa, N. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108244 · Cited by 25

ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

Cao, X., Song, L., & Yang, J. (2021) · Clinical Science · doi:10.1042/cs20200752 · Cited by 24

Resolvin E3 ameliorates high-fat diet-induced insulin resistance via the phosphatidylinositol-3-kinase/Akt signaling pathway in adipocytes

Shimizu, T., Saito, T., Aoki‐Saito, H., Okada, S., Ikeda, H., Fukuda, H., Arai, S., Fujiwara, K., Nakajima, Y., Horiguchi, K., et al. (2022) · Institutional Repositories DataBase (IRDB) · doi:10.1096/fj.202100053r · Cited by 23

A PUFA-rich diet improves fat oxidation following saturated fat-rich meal

Stevenson, J. L., Miller, M. K., Skillman, H. E., Paton, C. M., & Cooper, J. A. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1226-9 · Cited by 23

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

Hassan, E. B., Alderghaffar, M., Wauquier, F., Coxam, V., Demontiero, O., Vogrin, S., Wittrant, Y., & Duque, G. (2019) · Aging · doi:10.18632/aging.102299 · Cited by 23

Marine omega-3 fatty acids prevent myocardial insulin resistance and metabolic remodeling as induced experimentally by high insulin exposure

Franekova, V., Angın, Y., Hoebers, N., Coumans, W. A., Simons, P. J., Glatz, J. F. C., Luiken, J. J. F. P., & Larsen, T. S. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00073.2014 · Cited by 22

Microalgae: Cultivation, Biotechnological, Environmental, and Agricultural Applications

Andrade, D. S., Amaral, H. F., Gavilanes, F. Z., Morioka, L. R. I., Nassar, J. M., de Melo, J. M., da Silva, H. R., & Telles, T. S. (2021) · Environmental and microbial biotechnology · doi:10.1007/978-981-15-8999-7_23 · Cited by 24

High omega-6/omega-3 fatty acid and oxylipin ratio in plasma is linked to an adverse cardiometabolic profile in middle-aged adults

Jurado‐Fasoli, L., Osuna‐Prieto, F. J., Yang, W., Köhler, I., Di, X., Rensen, P. C. N., Castillo, M. J., Martínez‐Téllez, B., & Amaro‐Gahete, F. J. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109331 · Cited by 21

Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning

Kasbi-Chadli, F., Boquien, C., Simard, G., Ulmann, L., Mimouni, V., Leray, V., Meynier, A., Ferchaud‐Roucher, V., Champ, M. M. J., Nguyen, P., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.03.003 · Cited by 21

Dietary and serum n -3 PUFA and polycystic ovary syndrome: a matched case–control study

Lu, L., Li, X., Lv, L., Xu, Y., Wu, B., & Huang, C. (2022) · British Journal of Nutrition · doi:10.1017/s0007114521003007 · Cited by 20

Beneficial Effects of n-3 Fatty Acids on Cardiometabolic and Inflammatory Markers in Type 2 Diabetes Mellitus: A Clinical Trial

Mazaherioun, M., Djalali, M., Koohdani, F., Javanbakht, M. H., Zarei, M., Beigy, M., Ansari, S., Rezvan, N., & Saedisomeolia, A. (2017) · Medical Principles and Practice · doi:10.1159/000484089 · Cited by 20

Hyperbaric Oxygen Therapy and Vascular Complications in Diabetes Mellitus

Resanović, I., Zarić, B. L., Radovanović, J., Sudar-Milovanovic, E. M., Gluvic, Z. M., Jevremović, D., & Isenović, E. R. (2020) · Angiology · doi:10.1177/0003319720936925 · Cited by 20

Correlation of Body Mass Index and Proinflammatory Cytokine Levels with Hematopoietic Stem Cell Mobilization

Wang, T., Liou, Y.-S., Chang, H., Yang, S., Li, C., Wang, J., & Sun, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144169 · Cited by 19

Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women

Albracht‐Schulte, K., Rosairo, S., Ramalingam, L., Wijetunge, S., Ratnayake, C., Kotakadeniya, H. M. S. R. B., Dawson, J., Kalupahana, N. S., & Moustaïd‐Moussa, N. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s203937 · Cited by 23

Bone Marrow Adipose Tissue Quantification by Imaging

Hassan, E. B., Ghasemzadeh, A., Imani, M., Kutaiba, N., Wright, D. K., Sepehrizadeh, T., & Duque, G. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00539-5 · Cited by 20

CXCL2 Impairs Functions of Bone Marrow Mesenchymal Stem Cells and Can Serve as a Serum Marker in High-Fat Diet-Fed Rats

Bi, J., Li, Q., Yang, Z., Cai, L., Lv, T., Yang, X., Yan, L., Liu, X., Wang, Q., Fu, X., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.687942 · Cited by 19

Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition

González-Alonso, A., Ramírez-Tortosa, C. L., Varela‐López, A., Roche, E., Arribas, M. I., Ramírez-Tortosa, M. C., Giampieri, F., Ochoa, J. J., & Quiles, J. L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161023425 · Cited by 19

Untitled work

(2012) · PubMed · Cited by 19

Docosahexaenoic Acid Improves Diabetic Wound Healing in a Rat Model by Restoring Impaired Plasticity of Macrophage Progenitor Cells

Jia, Y., Qiu, S., Xu, J., Kang, Q., & Chai, Y. (2020) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000006739 · Cited by 19

New generation lipid emulsions increase brain DHA and improve body composition, but not short-term neurodevelopment in parenterally-fed preterm piglets

Molina, T. L., Stoll, B., Mohammad, M. A., Mohila, C., Call, L., Cui, L., Guthrie, G. J., Kunichoff, D. F., Lin, S., Welch-Jernigan, R. J., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.031 · Cited by 19

Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions in Polycystic Ovary Syndrome

Albardan, L., Platat, C., & Kalupahana, N. S. (2024) · Nutrients · doi:10.3390/nu16172961 · Cited by 18

Nutrition and Inflammation

Myers, J. L., & Allen, J. C. (2011) · American Journal of Lifestyle Medicine · doi:10.1177/1559827611424259 · Cited by 19

Maternal omega-3 fatty acids and micronutrients modulate fetal lipid metabolism: A review

Khaire, A. A., Kale, A. A., & Joshi, S. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.04.007 · Cited by 19

High fish oil diet promotes liver inflammation and activates the complement system

Jin, H., Yan, C., Xiao, T., Yan, N., Xu, J., Zhou, L., Zhou, X., Shao, Q., & Xia, S. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8687 · Cited by 18

Influence of maternal consumption of different types of fatty acids during pregnancy and lactation on lipid and glucose metabolism of the 21-day-old male offspring in rats

Mennitti, L. V., Oyama, L. M., Santamarina, A. B., do Nascimento, O., & Pisani, L. P. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.07.001 · Cited by 18

A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia

Furse, S., Fernandez‐Twinn, D. S., Beeson, J. H., Chiarugi, D., Ozanne, S. E., & Koulman, A. (2022) · Nutrition and Diabetes · doi:10.1038/s41387-022-00185-4 · Cited by 19

The role of bioactives in energy metabolism and metabolic syndrome

Bordoni, A., Boesch, C., Malpuech‐Brugère, C., Orfila, C., & Tomás‐Cobos, L. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000545 · Cited by 18

Oral ω-3 PUFA supplementation modulates inflammation in adipose tissue depots in morbidly obese women: A randomized trial

Bakker, N., Hickey, M., Shams, R., Rivera, C. F., Vlahos, J., Cense, H. A., Demirkıran, A., Ramkhelawon, B., & Houdijk, A. P. J. (2023) · Nutrition · doi:10.1016/j.nut.2023.112055 · Cited by 26

Impact of combined consumption of fish oil and probiotics on the serum metabolome in pregnant women with overweight or obesity

Mokkala, K., Vahlberg, T. J., Houttu, N., Koivuniemi, E., Lahti, L., & Laitinen, K. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103655 · Cited by 17

Why Have the Benefits of DHA Not Been Borne Out in the Treatment and Prevention of Alzheimer’s Disease? A Narrative Review Focused on DHA Metabolism and Adipose Tissue

Heath, R. J., & Wood, T. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111826 · Cited by 19

Ameliorative potential of omega 3 fatty acids and HMG-CoA reductase inhibitors on experimentally-induced non-alcoholic steatohepatitis

Kabel, A. M., Elmaaboud, M. A. A., & Albarraq, A. A. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.12.003 · Cited by 16

Effect of Dietary Combination of Methionine and Fish Oil on Cellular Immunity and Plasma Fatty Acids in Infectious Bursal Disease Challenged Chickens

Maroufyan, E., Kasim, A., Meng, G. Y., Ebrahimi, M. M., Loh, T. C., Mehrbod, P., Kamalıdehghan, B., & Farjam, A. S. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/531397 · Cited by 16

A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

González‐Hedström, D., Amor, S., de la Fuente‐Fernández, M., Tejera‐Muñoz, A., Priego, T., Martín, A. I., López‐Calderón, A., Inarejos-García, A. M., García-Villalón, Á. L., & Granado, M. (2020) · Antioxidants · doi:10.3390/antiox9060483 · Cited by 17

Effect of poly and mono-unsaturated fatty acids on stability and structure of recombinant S100A8/A9

Asghari, H., Chegini, K. G., Amini, A., & Gheibi, N. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.11.065 · Cited by 16

Polyamine supplementation reduces DNA damage in adipose stem cells cultured in 3-D

Minguzzi, M., Guidotti, S., Platano, D., D’Adamo, S., Cetrullo, S., Assirelli, E., Santi, S., Mariani, E., Trisolino, G., Filardo, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50543-z · Cited by 15

Combined Effects of Eicosapentaenoic Acid and Adipocyte Renin–Angiotensin System Inhibition on Breast Cancer Cell Inflammation and Migration

Rasha, F. A., Kahathuduwa, C. N., Ramalingam, L., Hernandez, A., Moussa, H. M., & Moustaïd‐Moussa, N. (2020) · Cancers · doi:10.3390/cancers12010220 · Cited by 15

α-Linolenic acid rich-chia seed modulates visceral adipose tissue collagen deposition, lipolytic enzymes expression, insulin signaling and GLUT-4 levels in a diet-induced adiposity rodent model

Aiassa, V., Ferreira, M. D. R., Villafañe, N., & D’Alessandro, M. E. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111164 · Cited by 15

Regulation and Functions of the Renin‐Angiotensin System in White and Brown Adipose Tissue

Pahlavani, M., Kalupahana, N. S., Ramalingam, L., & Moustaïd‐Moussa, N. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00776.x · Cited by 14

Steroidogenic Acute Regulatory Protein (StAR) Overexpression Reduces Inflammation and Insulin Resistance in Obese Mice

Qiu, Y., Sui, X., Cao, S., Li, X., Ning, Y., Wang, S., Yin, L., & Zhi, X. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26046 · Cited by 14

Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes

Polus, A., Kieć‐Wilk, B., Raźny, U., Gielicz, A., Schmitz, G., & Dembinska-Kiec, A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.05.002 · Cited by 15

Adipose tissue dysfunction and the pathogenesis of metabolic syndrome

Zhao, D. (2013) · World Journal of Hypertension · doi:10.5494/wjh.v3.i3.18 · Cited by 14

Polyunsaturated Fatty Acids on Cardiovascular Health: Revealing Potentials of Functional Food

Drenjančević, I., Kralik, G., Kralik, Z., Mihalj, M., Stupin, A., Novak, S., & Grčević, M. (2017) · InTech eBooks · doi:10.5772/67033 · Cited by 13

Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig

Walker, M. E., Matthan, N. R., Goldbaum, A. A., Meng, H., Lamon‐Fava, S., Lakshman, S., Jang, S., Molokin, A., Solano-Aguilar, G. I., Urban, J. F., et al. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.04.013 · Cited by 13

Natural Products in the Prevention of Metabolic Diseases: Lessons Learned from the 20th KAST Frontier Scientists Workshop

Baek, S. J., Hammock, B. D., Hwang, I. K., Li, Q. X., Moustaïd‐Moussa, N., Park, Y., Safe, S. H., Suh, N., Yi, S.-S., Zeldin, D. C., et al. (2021) · Nutrients · doi:10.3390/nu13061881 · Cited by 15

Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-κB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis

Cavallo, C., Merli, G., Zini, N., D’Adamo, S., Cattini, L., Guescini, M., Grigolo, B., Martino, A. D., Santi, S., Borzı̀, R. M., et al. (2022) · Stem Cells International · doi:10.1155/2022/9376338 · Cited by 12

Effect of omega-3 fatty acids on haemostatic functions in urocortin-treated obese rats

El-Gendy, A. A., & Abbas, A. M. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0350-3 · Cited by 12

PET/MRI-evaluated brown adipose tissue activity may be related to dietary MUFA and omega-6 fatty acids intake

Maliszewska, K., Adamska-Patruno, E., Miniewska, K., Bauer, W., Mojsak, M. N., & Kretowski, A. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-08125-z · Cited by 15

Streptozotocin‐Induced Diabetes Partially Attenuates the Effects of a High‐Fat Diet on Liver and Brain Fatty Acid Composition in Mice

Levant, B., Ozias, M. K., Guilford, B. L., & Wright, D. E. (2013) · Lipids · doi:10.1007/s11745-013-3817-z · Cited by 12

Polyunsaturated Fatty Acids in Pregnancy and Metabolic Syndrome: A Review

Poniedziałek‐Czajkowska, E., Mierzyński, R., Kimber-Trojnar, Ż., Leszczyńska‐Gorzelak, B., & Oleszczuk, J. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201015666140330195614 · Cited by 12

Early exposure to distinct sources of lipids affects differently the development and hepatic inflammatory profiles of 21-day-old rat offspring

Mennitti, L. V., Oyama, L. M., Santamarina, A. B., do Nascimento, C. O., & Pisani, L. P. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s152326 · Cited by 12

Negative effects on newborn piglets caused by excess dietary tryptophan in the morning in sows

Xu, K., Bai, M., Bin, P., Duan, Y., Wu, X., Liu, H., & Yin, Y. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9514 · Cited by 12

N-3 fatty acids improve body composition and insulin sensitivity during energy restriction in the rat

Guelzim, N., Huneau, J., Mathé, V., Tesseraud, S., Mourot, J., Simon, N., & Hermier, D. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.07.007 · Cited by 13

Effect of n-3 and n-6 Polyunsaturated Fatty Acids on Microsomal P450 Steroidogenic Enzyme Activities and In Vitro Cortisol Production in Adrenal Tissue From Yorkshire Boars

Xie, X., Wang, X., Mick, G. J., Kabarowski, J. H. S., Wilson, L. S., Barnes, S., Walcott, G. P., Luo, X., & McCormick, K. L. (2016) · Endocrinology · doi:10.1210/en.2015-1831 · Cited by 11

The transcriptional regulation of the human angiotensinogen gene after high-fat diet is haplotype-dependent: Novel insights into the gene-regulatory networks and implications for human hypertension

Rana, A., Jain, S., Puri, N., Kaw, M., Sirianni, N., Eren, D., Mopidevi, B., & Kumar, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176373 · Cited by 11

Docosahexaenoic Acid Supplementation is Not Anti- Inflammatory in Adipose Tissue of Healthy Obese Postmenopausal Women

Holt, P. R., Alemán, J. O., Walker, J. M., Jiang, C. S., Liang, Y., de Rosa, J. C., Giri, D. D., Iyengar, N. M., Milne, G. L., Hudis, C. A., et al. (2017) · International Journal Of Nutrition · doi:10.14302/issn.2379-7835.ijn-17-1636 · Cited by 11

Association between plasma phospholipid omega-3 polyunsaturated fatty acids and type 2 diabetes is sex dependent: The Hunter Community Study

Abbott, K. A., Burrows, T. L., Thota, R. N., Alex, A., Acharya, S., Attia, J., McEvoy, M., & Garg, M. L. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.04.007 · Cited by 10

Membrane Disordering by Eicosapentaenoic Acid in B Lymphomas Is Reduced by Elongation to Docosapentaenoic Acid as Revealed with Solid-State Nuclear Magnetic Resonance Spectroscopy of Model Membranes

Harris, M., Kinnun, J. J., Kosaraju, R., Leng, X., Wassall, S. R., & Shaikh, S. R. (2016) · Journal of Nutrition · doi:10.3945/jn.116.231639 · Cited by 10

The effects of Elateriospermum tapos against obese maternal rat in mitigating obesity development among their adult female offspring

Bahari, H., Abidin, A. Z., Balan, S. S., Perumal, K. V., Rosli, N. S., Lotafi, A. A., Danabala, S., Manimaran, M., Shafie, N., Abdullah, M. A., et al. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_142_20 · Cited by 10

Fatty acid desaturation and elongation in mammals

O’Neill, L. M., Miyazaki, M., Bond, L. M., Lewis, S. A., Ding, F., Liu, Z., & Ntambi, J. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824048-9.00014-6 · Cited by 10

Nutritional Status, Selected Nutrients Intake, and Metabolic Disorders in Bariatric Surgery Patients

Boniecka, I., Czerwonogrodzka–Senczyna, A., Jeznach-Steinhagen, A. E., Paśnik, K., Szostak-Węgierek, D. E., & Zeair, S. (2023) · Nutrients · doi:10.3390/nu15112479 · Cited by 10

Maternal C-Peptide and Insulin Sensitivity, but Not BMI, Associate with Fatty Acids in the First Trimester of Pregnancy

Bandres‐Meriz, J., Majali‐Martinez, A., Hoch, D., Morante, M., Glasner, A., van Poppel, M. N. M., Desoyé, G., & Herrera, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910422 · Cited by 10

Aortic cholesterol accumulation correlates with systemic inflammation but not hepatic and gonadal adipose tissue inflammation in low-density lipoprotein receptor null mice

Wang, S. F., Miller, B. B., Matthan, N. R., Göktaş, Z., Wu, D., Reed, D. B., Yin, X., Grammas, P., Moustaïd‐Moussa, N., Shen, C., et al. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.09.002 · Cited by 10

Polyunsaturated fatty acid status at birth, childhood growth, and cardiometabolic risk: a pooled analysis of the MEFAB and RHEA cohorts

Stratakis, N., Gielen, M., Margetaki, K., de Groot, R. H. M., Apostolaki, M., Chalkiadaki, G., Vafeiadi, M., Leventakou, V., Karachaliou, M., Godschalk, R., et al. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0175-1 · Cited by 10

Changes of urine metabolites in response to n-3 fatty acid supplements and their correlation with metabolic risk factors in patients with type 2 diabetes

Ruan, Y., Zheng, J., Ren, Y., Tang, J., Li, J., & Li, D. (2019) · Food & Function · doi:10.1039/c9fo00048h · Cited by 9

Fu Loose Tea Administration Ameliorates Obesity in High-Fat Diet-Fed C57BL/6J Mice: A Comparison with Fu Brick Tea and Orlistat

Yan, L., Wu, F., Wu, D., Zhu, X., Gao, X., Hu, X., Xu, F., Ma, T., Zhao, H., & Cao, W. (2024) · Foods · doi:10.3390/foods13020206 · Cited by 9

Highly purified eicosapentaenoic acid ameliorates cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome

Ito, S., Sano, Y., Nagasawa, K., Matsuura, N., Yamada, Y., Uchinaka, A., Murohara, T., & Nagata, K. (2016) · Obesity Science & Practice · doi:10.1002/osp4.50 · Cited by 9

Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults

Thota, R. N., Rosato, J. I., Burrows, T. L., Dias, C. B., Abbott, K. A., Martins, R. N., & Garg, M. L. (2020) · Nutrients · doi:10.3390/nu12061612 · Cited by 9

Eicosapentaenoic Acid Protects against Metabolic Impairments in the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model

Yavari, M., Ramalingam, L., Harris, B. N., Kahathuduwa, C. N., Chavira, A., Biltz, C., Mounce, L., Maldonado, K. A., Scoggin, S. O., Zu, Y., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.01.030 · Cited by 8

Relationship between Common Dietary Polyphenols and Obesity-Induced Inflammation

Tucakovic, L., Colson, N., & Singh, I. (2015) · Food and public health · doi:10.5923/j.fph.20150503.04 · Cited by 9

Influence of Fatty Acid Desaturase Enzyme-1 Gene (FADS-1) Polymorphism on Serum Polyunsaturated Fatty Acids Levels, Desaturase Enzymes, Lipid Profile, and Glycemic Control Parameters in Newly Diagnosed Diabetic Mellitus Patients

Jarullah, H. H., & Saleh, E. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094015 · Cited by 8

Effect of metformin on Sirtuin-1 disorders associated with diabetes in male rats

Khowailed, E. A., Seddiek, H., Mahmoud, M. M., Rashed, L. A., & Ibrahim, F. E. (2017) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2017.09.002 · Cited by 8

Modulation of Fatty Acid-Related Genes in the Response of H9c2 Cardiac Cells to Palmitate and n-3 Polyunsaturated Fatty Acids

Cetrullo, S., D’Adamo, S., Panichi, V., Borzı̀, R. M., Pignatti, C., & Flamigni, F. (2020) · Cells · doi:10.3390/cells9030537 · Cited by 8

A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice

Dunn, T. N., Keenan, A. H., Thomas, A. P., Newman, J. W. I., & Adams, S. H. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-24 · Cited by 8

Opportunities for probiotics and polyunsaturated fatty acids to improve metabolic health of overweight pregnant women

Mokkala, K., Röytiö, H., Ekblad, U., & Laitinen, K. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0068 · Cited by 8

Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver

Deol, P., Yang, J., Morisseau, C. H. P., Hammock, B. D., & Sladek, F. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00580 · Cited by 8

n-3 Fatty acids preserve muscle mass and insulin sensitivity in a rat model of energy restriction

Galmiche, G., Huneau, J., Mathé, V., Mourot, J., Simon, N., Guillou, C. L., & Hermier, D. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516003111 · Cited by 7

Clinical Effects of Caraway, a Traditional Medicine for Weight Loss

Kazemipoor, M., & Cordell, G. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800874-4.00016-7 · Cited by 7

Liver but not adipose tissue is responsive to the pattern of enteral feeding

Otero, Y. F., Lundblad, T. M., Ford, E. A., House, L. M., & McGuinness, O. P. (2014) · Physiological Reports · doi:10.1002/phy2.250 · Cited by 7

Exploration of the perceived and actual benefits of omega-3 fatty acids and the impact of FADS1 and FADS2 genetic information on dietary intake and blood levels of EPA and DHA

Roke, K. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0700 · Cited by 7

Dietary fish oil ameliorates adipose tissue dysfunction in insulin-resistant rats fed a sucrose-rich diet improving oxidative stress, peroxisome proliferator-activated receptor γ and uncoupling protein 2

Selenscig, D. A., Ferreira, M. D. R., Chicco, A. G., & Lombardo, Y. B. (2018) · Food & Function · doi:10.1039/c7fo01993a · Cited by 7

Anti-Inflammatory probiotic biomarkers in Fermented foods

Ahmed Farid, E., & Ahmed Nancy, C. (2019) · Journal of Clinical Nephrology · doi:10.29328/journal.jcn.1001023 · Cited by 7

REVIEW (n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance:

Insights, M., Kalupahana, N. S., Claycombe, K. J., & Moustaïd‐Moussa, N. (2015)

n-3 PUFA: bioavailability and modulation of adipose tissue function

Kopecký, J., Rossmeisl, M., Flachs, P., Kuda, O., Brauner, P., Jílková, Z. M., Staňková, B., TVRZICKÁ, E., & Bryhn, M. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990231 · Cited by 138

Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans

Huang, C., Chien, Y.-S., Chen, Y.-J., Ajuwon, K. M., Mersmann, H. J., & Ding, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101689 · Cited by 107

Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids

Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 318

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

Martínez‐Fernández, L., Laiglesia, L. M., Huerta, A. E., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.07.003 · Cited by 218