The DOI matches its Crossref record; 371 of the 373 references it cites were found in a registry or an index.
Nutritionally Mediated Programming of the Developing Immune System
Open accessAbstract
A growing body of evidence highlights the importance of a mother's nutrition from preconception through lactation in programming the emerging organ systems and homeostatic pathways of her offspring. The developing immune system may be particularly vulnerable. Indeed, examples of nutrition-mediated immune programming can be found in the literature on intra-uterine growth retardation, maternal micronutrient deficiencies, and infant feeding. Current models of immune ontogeny depict a "layered" expansion of increasingly complex defenses, which may be permanently altered by maternal malnutrition. One programming mechanism involves activation of the maternal hypothalamic-pituitary-adrenal axis in response to nutritional stress. Fetal or neonatal exposure to elevated stress hormones is linked in animal studies to permanent changes in neuroendocrine-immune interactions, with diverse manifestations such as an attenuated inflammatory response or reduced resistance to tumor colonization. Maternal malnutrition may also have a direct influence, as evidenced by nutrient-driven epigenetic changes to developing T regulatory cells and subsequent risk of allergy or asthma. A 3rd programming pathway involves placental or breast milk transfer of maternal immune factors with immunomodulatory functions (e.g. cytokines). Maternal malnutrition can directly affect transfer mechanisms or influence the quality or quantity of transferred factors. The public health implications of nutrition-mediated immune programming are of particular importance in the developing world, where prevalent maternal undernutrition is coupled with persistent infectious challenges. However, early alterations to the immune system, resulting from either nutritional deficiencies or excesses, have broad relevance for immune-mediated diseases, such as asthma, and chronic inflammatory conditions like cardiovascular disease.
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“Maternal malnutrition can have adverse implications for the neonate, and it has been demonstrated that neonatal immune responses may be modulated by the nutrition of a mother during gestation (108).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [108]
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“Interestingly, non-pregnant individuals with infectious diseases such as HIV have been shown to have significantly higher levels of galactose-deficient IgG than healthy controls.”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [108]
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Cites
3 retracted
In utero supplementation with methyl donors enhances allergic airway disease in mice
Hollingsworth, J. W., Maruoka, S., Boon, K., Garantziotis, S., Li, Z., Tomfohr, J. K., Bailey, N., Potts, E. N., Whitehead, G. S., Brass, D. M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87742 · Cited by 424
RetractedIn utero supplementation with methyl donors enhances allergic airway disease in mice
Hollingsworth, J. W., Maruoka, S., Boon, K., Garantziotis, S., Li, Z., Tomfohr, J. K., Bailey, N., Potts, E. N., Whitehead, G. S., Brass, D. M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34378 · Cited by 331
RetractedRetracted: Maternal and early life stress effects on immune function: relevance to immunotoxicology
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Cited by
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The Intestinal Microbiome in Early Life: Health and Disease
Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024
Immune Dysfunction as a Cause and Consequence of Malnutrition
Bourke, C. D., Berkley, J. A., & Prendergast, A. J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.003 · Cited by 771
Basha, S., Surendran, N., & Pichichero, M. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.942288 · Cited by 513
How nutrition and the maternal microbiota shape the neonatal immune system
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Impact of Childhood Malnutrition on Host Defense and Infection
Ibrahim, M. K., Zambruni, M., Melby, C. L., & Melby, P. C. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00119-16 · Cited by 382
Metadata
- Authors
- Palmer, A. C.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Palmer, Amanda C.
- ORCID
- Palmer, Amanda C.
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 2
- Issue
- 5
- Pages
- 377-395
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC3183589
- OpenAlex
- W2168523800
- Cited by
- 198
- References
- 373
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 18 · 2021: 20 · 2020: 10 · 2019: 15 · 2018: 10 · 2017: 17 · 2016: 22 · 2015: 19 · 2014: 20 · 2013: 11 · 2012: 5
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- United States Agency for International Development (GHS-A-00-03-00019-00)
- Bill and Melinda Gates Foundation (GHS-A-00-03-00019-00)
- Procter and Gamble
- Johns Hopkins University
- Johns Hopkins Bloomberg School of Public Health
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- immune programming, maternal nutrition, maternal malnutrition, fetal programming, immune ontogeny, hypothalamic-pituitary-adrenal axis, stress hormones, neuroendocrine-immune interaction, epigenetic regulation, regulatory T cells, placental transfer, breast milk, cytokines, micronutrient deficiency, fetal growth restriction, infant feeding, immune-mediated diseases
- MeSH terms
- Animals, Breast Feeding, Female, Fetal Growth Retardation, Humans, Immune System, Lactation, Maternal-Fetal Exchange, Nutritional Status, Pregnancy, Maternal Nutritional Physiological Phenomena, Malnutrition, Nutrition Therapy
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