The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.
Nutritional Supplements in Support of Resistance Exercise to Counter Age-Related Sarcopenia
Open accessAbstract
Age-related sarcopenia, composed of myopenia (a decline in muscle mass) and dynapenia (a decline in muscle strength), can compromise physical function, increase risk of disability, and lower quality of life in older adults. There are no available pharmaceutical treatments for this condition, but evidence shows resistance training (RT) is a viable and relatively low-cost treatment with an exceptionally positive side effect profile. Further evidence suggests that RT-induced increases in muscle mass, strength, and function can be enhanced by certain foods, nutrients, or nutritional supplements. This brief review focuses on adjunctive nutritional strategies, which have a reasonable evidence base, to enhance RT-induced gains in outcomes relevant to sarcopenia and to reducing risk of functional declines.
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“PS in combination with resistance-type MSE has been identified as an efficient intervention for LM and strength gain in elderly individuals [11,13,15,19,59,64].”
In the citing paper
“As such, the anti-inflammatory effects of n-3 PUFAs on skeletal muscle may be most beneficial to older individuals suffering from sarcopenia [32,50,51] and may complement other strategies, such as exercise and protein supplementation, to combat sarcopenia.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [51]
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Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · cited 1×
“This effect is associated with the ability of Leu to activate mTORC1, which subsequently targets downstream signaling protein kinases such as 4E binding protein 1 (4EBP1) and p70S6K1, both of which facilitate translation initiation and stimulation of MPS (81).”
BackgroundCruz-Jentoft, A. J., Landi, F., Schneider, S. M., Zuniga, C., Arai, H., Boirie, Y., Chen, L.-K., Fielding, R. A., Martin, F. C., Michel, J.-P., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu115 · Cited by 1,963
Progressive resistance strength training for improving physical function in older adults
Liu, C.-J., & Latham, N. K. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002759.pub2 · Cited by 1,258
Houston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132
Branched-Chain Amino Acid Metabolism
Harper, A. E., Miller, R. H., & Block, K. P. (1984) · Annual Review of Nutrition · doi:10.1146/annurev.nu.04.070184.002205 · Cited by 1,011
Moore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973
Self-citationKatsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Cited by
Sorted by citations
Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms
Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., & Toedebusch, R. G. (2017) · Physiological Reviews · doi:10.1152/physrev.00019.2016 · Cited by 696
Zhuang, C., Huang, D., Pang, W., Zhou, C.-J., Wang, S.-L., Lou, N., Ma, L., Yu, Z., & Shen, X. (2016) · Medicine · doi:10.1097/md.0000000000003164 · Cited by 471
Sarcopenia and Postoperative Complication Risk in Gastrointestinal Surgical Oncology
Simonsen, C., de Heer, P., Bjerre, E. D., Suetta, C., Højman, P., Pedersen, B. K., Svendsen, L. B., & Christensen, J. F. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002679 · Cited by 385
Verlaan, S., Ligthart-Melis, G. C., Wijers, S. L. J., Cederholm, T., Maier, A. B., & de van der Schueren, M. A. E. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.12.074 · Cited by 246
Traylor, D. A., Gorissen, S. H. M., & Phillips, S. M. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy003 · Cited by 243
Metadata
- Authors
- Phillips, S. M.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Phillips, Stuart M
- ORCID
- Phillips, Stuart M
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 6
- Issue
- 4
- Pages
- 452-460
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC4496741
- OpenAlex
- W2170406844
- Cited by
- 144
- References
- 102
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 14 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 29 · 2017: 17 · 2016: 14 · 2015: 1
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP- 123296)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, resistance training, dietary supplements, myopenia, dynapenia, muscle mass, muscle strength, older adults, functional decline
- MeSH terms
- Aged, Aging, Creatine, Diet, Dietary Proteins, Female, Humans, Leucine, Male, Quality of Life, Valerates, Fatty Acids, Omega-3, Muscle, Skeletal, Dietary Supplements, Muscle Strength, Resistance Training, Sarcopenia
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