Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome

Barona, Jacqueline; Aristizabal, Juan C.; Blesso, Christopher N.; Volek, Jeff S.; Fernandez, Maria Luz

doi:10.3945/jn.112.162743

Cited by 173Phytochemicals and Antioxidant ActivitiesCardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome

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Barona, Jacqueline, Aristizabal, Juan C., Blesso, Christopher N., Volek, Jeff S., Fernandez, Maria Luz·2012·The Journal of Nutrition

DOI 10.3945/jn.112.162743

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Abstract

We evaluated the effects of grape polyphenols in individuals classified with metabolic syndrome (MetS). Men (n = 24) aged 30-70 y were randomly assigned to consume either a freeze-dried grape polyphenol powder (GRAPE) or a placebo for 30 d in a double-blind, crossover design, separated by a 3-wk washout period. Participants were asked to maintain their usual diet and physical activity during the study and abstain from consuming polyphenol-rich foods. MetS criteria including blood pressure (BP) and markers of vascular endothelial function including brachial artery flow-mediated vasodilation (FMD), plasma total nitrite + nitrate (NOx) to estimate NO production, plasma soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured at the end of each dietary period. Systolic BP (P < 0.0025) and plasma sICAM-1 concentrations (P < 0.025) were lower, whereas the FMD response was higher (P < 0.0001), during the GRAPE compared with the placebo period. In addition, changes in sVCAM-1 concentrations between periods were positively correlated with changes in systolic BP (r = 0.45; P < 0.05). Although NOx concentrations did not differ between periods, changes in systolic BP were negatively correlated with changes in NOx concentrations (r = -0.44; P < 0.05), indicating the vasodilating properties of NO. Other MetS variables did not differ between the GRAPE and placebo periods. These results suggest that GRAPE polyphenols may potentiate vasorelaxation and reduce BP and circulating cell adhesion molecules, resulting in improvements in vascular function.

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The statistical power of the present data was 64 %, lower than the 80 % predicted in the sample size calculation.
“However, this meant that the statistical power of the present data (64 %) was somewhat lower than that predicted (80 %) in the sample size calculation based on a previous study (n 20) (29) .”
From High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women (2015) · cites this paper as [29]
Our findings are consistent with previous studies showing significant elevations in plasma nitrite concentration and reductions in BP following nitrate ingestion.
“our findings are consistent with previous studies showing significant elevations in plasma nitrite concentration and reductions in BP following nitrate ingestion (7,29) .”
From High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women (2015) · cites this paper as [29]

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Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720 · see citing works
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175 · see citing works
Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982 · see citing works
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606 · see citing works
Prevalence of Overweight and Obesity in the United States
Crespo, C. J., & Smit, E. (2003) · Human Kinetics eBooks · doi:10.5040/9781718206601.ch-001 · Cited by 4,382 · see citing works
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · see citing works
The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure
(2004) · PsycEXTRA Dataset · doi:10.1037/e442802008-001 · Cited by 2,882 · see citing works
Endothelial Function: Cardiac Events
Lerman, A., & Zeiher, A. M. (2005) · Circulation · doi:10.1161/01.cir.0000153339.27064.14 · Cited by 1,096 · see citing works
Biological Activities of Polyphenols from Grapes
Xia, E.-Q., Deng, G.-F., Guo, Y.-J., & Li, H.-B. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11020622 · Cited by 1,063 · see citing works
The discovery of nitric oxide and its role in vascular biology
Moncada, S., & Higgs, E. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706458 · Cited by 863 · see citing works
Ultrasound Assessment of Flow-Mediated Dilation
Harris, R. A., Nishiyama, S. K., Wray, D. W., & Richardson, R. S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.150821 · Cited by 671 · see citing works
Endothelial function and dysfunction. Part I
Deanfield, J. E., Donald, A. E., Ferri, C., Giannattasio, C., Halcox, J., Halligan, S., Lerman, A., Mancia, G., Oliver, J. J., Pessina, A. C., et al. (2005) · Journal of Hypertension · doi:10.1097/00004872-200501000-00004 · Cited by 634 · see citing works
Persistent Increase of Prevalence of Metabolic Syndrome Among U.S. Adults: NHANES III to NHANES 1999–2006
Mozumdar, A., & Liguori, G. A. (2010) · Diabetes Care · doi:10.2337/dc10-0879 · Cited by 551 · see citing works
Select Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release
Freedman, J. E., Parker, C., Li, L., Perlman, J. A., Frei, B. B., Ivanov, V. O., Deak, L. R., Iafrati, M. D., & Folts, J. D. (2001) · Circulation · doi:10.1161/01.cir.103.23.2792 · Cited by 476 · see citing works
Recommendations for Blood Pressure Measurement in Humans: An AHA Scientific Statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J. W., Hill, M. N., Jones, D. W., Kurtz, T. W., Sheps, S. G., & Roccella, E. J. (2005) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2005.04377.x · Cited by 435 · see citing works
Vascular Endothelial Function and Hypertension: Insights and Directions
Dharmashankar, K., & Widlansky, M. E. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0150-2 · Cited by 426 · see citing works
Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet
Volek, J. S., Phinney, S. D., Forsythe, C. E., Quann, E. E., Wood, R. J., Puglisi, M. J., Kraemer, W. J., Bibus, D. M., Fernandez, M. L., & Feinman, R. D. (2009) · Lipids · doi:10.1007/s11745-008-3274-2 · Cited by 397 · see citing works
Self-citation
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure
Ward, R. (2011) · Cited by 377 · see citing works
Grape Polyphenols Exert a Cardioprotective Effect in Pre- and Postmenopausal Women by Lowering Plasma Lipids and Reducing Oxidative Stress
Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., & Fernández, M. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.1911 · Cited by 376 · see citing works
Polyphenols, intracellular signalling and inflammation.
Santangelo, C., Varı́, R., Scazzocchio, B., Benedetto, R. D., Filesi, C., & Masella, R. (2007) · PubMed · Cited by 369 · see citing works
Cardioprotective Effects of Dietary Polyphenols
Zern, T. L., & Fernández, M. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2291 · Cited by 367 · see citing works
Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome
Rizza, S., Muniyappa, R., Iantorno, M., Kim, J., Chen, H., Pullikotil, P., Senese, N., Tesauro, M., Lauro, D., Cardillo, C., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2879 · Cited by 324 · see citing works
Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation?
Pyke, K. E., & Tschakovsky, M. E. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01024.2006 · Cited by 312 · see citing works
Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome
Volek, J. S., Fernandez, M. L., Feinman, R. D., & Phinney, S. D. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.02.003 · Cited by 288 · see citing works
Self-citation
Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy
Grundy, S. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2005 · Cited by 287 · see citing works
Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness
Mitchell, G. F., Vita, J. A., Larson, M. G., Parise, H., Keyes, M. J., Warner, E., Vasan, R. S., Levy, D. A., & Benjamin, E. J. (2005) · Circulation · doi:10.1161/circulationaha.105.551168 · Cited by 282 · see citing works
Grapes and Cardiovascular Disease
Dohadwala, M. M., & Vita, J. A. (2009) · Journal of Nutrition · doi:10.3945/jn.109.107474 · Cited by 235 · see citing works
Potential of Flavonoids as Anti-inflammatory Agents: Modulation of Pro- Inflammatory Gene Expression and Signal Transduction Pathways
Tuñón, M. J., García‐Mediavilla, M. V., Sánchez‐Campos, S., & González‐Gallego, J. (2009) · Current Drug Metabolism · doi:10.2174/138920009787846369 · Cited by 227 · see citing works
Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction
Volek, J. S., & Feinman, R. D. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-31 · Cited by 223 · see citing works
Self-citation
Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management
Τζιόμαλος, Κ., Athyros, V. G., Karagiannis, A. I., & Mikhailidis, D. P. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.08.006 · Cited by 177 · see citing works
Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: The Northern Manhattan Study (NOMAS)
Suzuki, T., Hirata, K., Elkind, M. S. V., Jin, Z., Rundek, T., Miyake, Y., Boden-Albala, B. M., Tullio, M. R. D., Sacco, R. L., & Homma, S. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.02.022 · Cited by 162 · see citing works
Grape Polyphenols Decrease Plasma Triglycerides and Cholesterol Accumulation in the Aorta of Ovariectomized Guinea Pigs
Zern, T. L., West, K. L., & Fernández, M. L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2268 · Cited by 147 · see citing works
Biomedical effects of grape products
Vislocky, L. M., & Fernández, M. L. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00335.x · Cited by 146 · see citing works
Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome
Sivaprakasapillai, B., Edirisinghe, I., Randolph, J., Steinberg, F. M., & Kappagoda, T. C. (2009) · Metabolism · doi:10.1016/j.metabol.2009.05.030 · Cited by 140 · see citing works
Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF
Schini‐Kerth, V. B., Auger, C., Kim, J. H., Étienne-Selloum, N., & Chataigneau, T. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0806-4 · Cited by 132 · see citing works
The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial
Ward, N. C., Hodgson, J. M., Croft, K. D., Burke, V., Beilin, L. J., & Puddey, I. B. (2005) · Journal of Hypertension · doi:10.1097/00004872-200502000-00026 · Cited by 124 · see citing works
Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment
Fujitaka, K., Otani, H., Jo, F., Jo, H., Nomura, E., Iwasaki, M., Nishikawa, M., Iwasaka, T., & Das, D. K. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.028 · Cited by 123 · see citing works
Human endothelial dysfunction: EDRFs
Flammer, A. J., & Lüscher, T. F. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0822-4 · Cited by 121 · see citing works
Grape products and cardiovascular disease risk factors
Pérez‐Jiménez, J., & Saura-Calixto, F. D. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408125124 · Cited by 104 · see citing works
Pick your Poiseuille: normalizing the shear stimulus in studies of flow-mediated dilation
Parker, B. A., Trehearn, T. L., & Meendering, J. R. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91302.2009 · Cited by 98 · see citing works
Effect of Muscadine Grape Seed Supplementation on Vascular Function in Subjects with or at Risk for Cardiovascular Disease: A Randomized Crossover Trial
Mellen, P. B., Daniel, K. R., Brosnihan, K. B., Hansen, K. J., & Herrington, D. M. (2010) · Journal of the American College of Nutrition · doi:10.1080/07315724.2010.10719883 · Cited by 90 · see citing works
Pleiotropic Benefit of Monomeric and Oligomeric Flavanols on Vascular Health - A Randomized Controlled Clinical Pilot Study
Weseler, A. R., Ruijters, E. J. B., Drittij-Reijnders, M.-J., Reesink, K. D., Haenen, G. R. M. M., & Bast, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028460 · Cited by 85 · see citing works
Non-Invasive Diagnostic Tools for Investigating Endothelial Dysfunction
Ghiadoni, L., Versari, D., Giannarelli, C., Faita, F., & Taddei, S. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786898761 · Cited by 80 · see citing works
Grape Polyphenols Do Not Affect Vascular Function in Healthy Men
van Mierlo, L. A. J., Zock, P. L., van der Knaap, H. C. M., & Draijer, R. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125518 · Cited by 72 · see citing works
Vasoprotective endothelial effects of a standardized grape product in humans
Chaves, A., Joshi, M. S., Coyle, C. M., Brady, J. E., Dech, S. J., Schanbacher, B. L., Baliga, R. S., Basuray, A., & Bauer, J. A. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.08.004 · Cited by 60 · see citing works
Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults
Kullo, I. J., Malik, A. R., Bielak, L. F., Sheedy, P. F., Turner, S. T., & Peyser, P. A. (2007) · Clinical Science · doi:10.1042/cs20060131 · Cited by 58 · see citing works
Carbohydrate Restriction, as a First-Line Dietary Intervention, Effectively Reduces Biomarkers of Metabolic Syndrome in Emirati Adults
Al‐Sarraj, T., Saadi, H., Calle, M. C., Volek, J. S., & Fernández, M. L. (2009) · Journal of Nutrition · doi:10.3945/jn.109.109603 · Cited by 58 · see citing works
Self-citation
The Metabolic Syndrome
Fernández, M. L. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00325.x · Cited by 54 · see citing works
Carbohydrate restriction as the default treatment for type 2 diabetes and metabolic syndrome
Feinman, R. D., & Volek, J. S. (2008) · Scandinavian Cardiovascular Journal · doi:10.1080/14017430802014838 · Cited by 47 · see citing works
Self-citation
The Metabolic Syndrome
Fernández, M. L. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.jun.s30-s34 · Cited by 45 · see citing works
Evaluation of NOx in the Cardiovascular System. Relationship to NO-Related Compounds In Vivo.
Ishibashi, T., Yoshida, J., & Nishio, M. (1999) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.81.317 · Cited by 27 · see citing works
Endothelial dysfunction evaluated by flow mediated dilation is strongly associated to metabolic syndrome in the elderly
de Matthaeis, A., Greco, A., Serviddio, G., Stramaglia, G., & Vendemiale, G. (2010) · Aging Clinical and Experimental Research · doi:10.1007/bf03337727 · Cited by 16 · see citing works

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Samtiya, M., Aluko, R. E., Dhewa, T., & Moreno‐Rojas, J. M. (2021) · Foods · doi:10.3390/foods10040839 · Cited by 686 · see citing works
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
Rodriguez‐Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J. D., Calani, L., Mena, P. R., Rio, D. D., & Crozier, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1330-7 · Cited by 608 · see citing works
Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review
Amiot, M. J., Riva, C., & Vinet, A. (2016) · Obesity Reviews · doi:10.1111/obr.12409 · Cited by 448 · see citing works
Intake and time dependence of blueberry flavonoid–induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity
Rodriguez‐Mateos, A., Rendeiro, C., Bergillos-Meca, T., Tabatabaee, S., George, T. W., Heiß, C., & Spencer, J. P. E. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.066639 · Cited by 361 · see citing works
Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans
Joseph, S. V., Edirisinghe, I., & Burton‐Freeman, B. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.767221 · Cited by 282 · see citing works
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Costa, C., Tsatsakis, A. M., Mamoulakis, C., Teodoro, M., Briguglio, G., Caruso, E., Tsoukalas, D., Margina, D. M., Dardiotis, E., Kouretas, D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.023 · Cited by 262 · see citing works
Grape Polyphenols’ Effects in Human Cardiovascular Diseases and Diabetes
Rasines-Perea, Z., & Teissèdre, P. (2017) · Molecules · doi:10.3390/molecules22010068 · Cited by 226 · see citing works
Fruit-Derived Polyphenol Supplementation for Athlete Recovery and Performance
Bowtell, J., & Kelly, V. (2019) · Sports Medicine · doi:10.1007/s40279-018-0998-x · Cited by 213 · see citing works
Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials
Chiva‐Blanch, G., & Badimón, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5812401 · Cited by 211 · see citing works
Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence
Aune, D. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz042 · Cited by 215 · see citing works
The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function
Rees, A., Dodd, G. F., & Spencer, J. P. E. (2018) · Nutrients · doi:10.3390/nu10121852 · Cited by 196 · see citing works
Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies
Borgi, L., Muraki, I., Satija, A., Willett, W. C., Rimm, E. B., & Forman, J. P. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06497 · Cited by 178 · see citing works
Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials
Liu, Y., Ma, W., Zhang, P., Shun-chuan, H., & Huang, D. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.03.009 · Cited by 161 · see citing works
Cranberry Juice Consumption Lowers Markers of Cardiometabolic Risk, Including Blood Pressure and Circulating C-Reactive Protein, Triglyceride, and Glucose Concentrations in Adults
Novotny, J. A., Baer, D. J., Khoo, C., Gebauer, S. K., & Charron, C. S. (2015) · Journal of Nutrition · doi:10.3945/jn.114.203190 · Cited by 159 · see citing works
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Andersen, C. J., & Fernández, M. L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9251-y · Cited by 142 · see citing works
Resveratrol, in its natural combination in whole grape, for health promotion and disease management
Singh, C. K., Liu, X., & Ahmad, N. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12798 · Cited by 133 · see citing works
The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Fairlie‐Jones, L., Davison, K., Fromentin, E., & Hill, A. M. (2017) · Nutrients · doi:10.3390/nu9080908 · Cited by 134 · see citing works
A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial
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Asgary, S., Rastqar, A., & Keshvari, M. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1410867 · Cited by 132 · see citing works
Dietary flavonoids and nitrate: effects on nitric oxide and vascular function
Bondonno, C. P., Croft, K. D., Ward, N., Considine, M. J., & Hodgson, J. M. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu014 · Cited by 150 · see citing works
The role of nutraceuticals in the prevention of cardiovascular disease
Sosnowska, B., Penson, P. E., & Banach, M. (2017) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.03.20 · Cited by 113 · see citing works
High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women
Ashworth, A., Mitchell, K., Blackwell, J. R., Vanhatalo, A., & Jones, A. M. (2015) · Public Health Nutrition · doi:10.1017/s1368980015000038 · Cited by 109 · see citing works
Encapsulation of natural active compounds, enzymes, and probiotics for fruit juice fortification, preservation, and processing: An overview
Ephrem, E., Najjar, A., Charcosset, C., & Greige‐Gerges, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.06.021 · Cited by 103 · see citing works
Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
Park, E., Edirisinghe, I., Choy, Y. Y., Waterhouse, A. L., & Burton‐Freeman, B. M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004328 · Cited by 100 · see citing works
Consumption of a Polyphenol-Rich Grape-Wine Extract Lowers Ambulatory Blood Pressure in Mildly Hypertensive Subjects
Draijer, R., de Graaf, Y., Slettenaar, M., de Groot, E., & Wright, C. (2015) · Nutrients · doi:10.3390/nu7053138 · Cited by 95 · see citing works
Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats
Quiñones, M., Guerrero, L., Suárez, M., Pons, Z., Aleixandre, A., Arola, L., & Muguerza, B. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.023 · Cited by 93 · see citing works
Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study
Odai, T., Terauchi, M., Kato, K., Hirose, A., & Miyasaka, N. (2019) · Nutrients · doi:10.3390/nu11122844 · Cited by 94 · see citing works
Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells
Warner, E. F., Zhang, Q., Raheem, S., O’Hagan, D., O'Connell, M. A., & Kay, C. D. (2016) · Journal of Nutrition · doi:10.3945/jn.115.217943 · Cited by 86 · see citing works
Effects of pomegranate supplementation on exercise performance and post-exercise recovery in healthy adults: A systematic review
Ammar, A., Bailey, S. J., Chtourou, H., Trabelsi, K., Turki, M., Hökelmann, A., & Souissi, N. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518002696 · Cited by 81 · see citing works
Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension
Ras, R. T., Zock, P. L., Zebregs, Y. E. M. P., Johnston, N. R., Webb, D. J., & Draijer, R. (2013) · British Journal Of Nutrition · doi:10.1017/s000711451300161x · Cited by 84 · see citing works
Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study
Kuntz, S., Kunz, C., Herrmann, J., Borsch, C., Abel, G., Fröhling, B., Dietrich, H., & Rudloff, S. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001482 · Cited by 84 · see citing works
Effect of grape and other berries on cardiovascular health
Wightman, J. D., & Heuberger, R. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6890 · Cited by 82 · see citing works
A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects
Biesinger, S., Michaels, H. A., Quadros, A., Qian, Y., Rabovsky, A. B., Badger, R. S., & Jalili, T. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.88 · Cited by 81 · see citing works
Potential health benefits of (poly)phenols derived from fruit and 100% fruit juice
Ho, K. K. H. Y., Ferruzzi, M. G., & Wightman, J. D. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz041 · Cited by 81 · see citing works
Antioxidant and Anti-Inflammatory Actions of Polyphenols from Red and White Grape Pomace in Ischemic Heart Diseases
Bocșan, I. C., Măgureanu, D. C., Pop, R. M., Levai, A. M., Macovei, Ș. O., Pătrașca, I. M., Chedea, V. S., & Buzoianu, A. D. (2022) · Biomedicines · doi:10.3390/biomedicines10102337 · Cited by 81 · see citing works
Important Food Sources of Fructose‐Containing Sugars and Incident Hypertension: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies
Liu, Q., Ayoub‐Charette, S., Khan, T. A., Au‐Yeung, F., Blanco Mejia, S., de Souza, R. J., Wolever, T. M. S., Leiter, L. A., Kendall, C. W. C., & Sievenpiper, J. L. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010977 · Cited by 65 · see citing works
Dietary polyphenols and metabolic syndrome among Iranian adults
Sohrab, G., Hosseinpour‐Niazi, S., Hejazi, J., Yuzbashian, E., Mirmiran, P., & Azizi, F. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.787397 · Cited by 76 · see citing works
Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans
Zunino, S. J., Peerson, J. M., Freytag, T. L., Breksa, A. P., Bonnel, E. L., Woodhouse, L. R., & Storms, D. H. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000890 · Cited by 74 · see citing works
Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies
Manolescu, B. N., Oprea, E., Mititelu, M., Ruta, L. L., & FARCASANU, I. C. (2019) · Nutrients · doi:10.3390/nu11071479 · Cited by 74 · see citing works
Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study
Vaisman, N., & Niv, E. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.1000840 · Cited by 73 · see citing works
Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals
Salden, B. N., Troost, F. J., de Groot, E., Stevens, Y., Garcés‐Rimón, M., Possemiers, S., Winkens, B., & Masclee, A. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136960 · Cited by 73 · see citing works
Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials
Kiyimba, T., Yiga, P., Bamuwamye, M., Ogwok, P., der Schueren, B. J. V., & Matthys, C. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.01.002 · Cited by 59 · see citing works
Plant-derived seasonings as sodium salt replacers in food
Taladrid, D., Laguna, L., Bartolomé, B., & Moreno-Arribas, M. V. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.03.002 · Cited by 70 · see citing works
Grape Consumption Increases Anti-Inflammatory Markers and Upregulates Peripheral Nitric Oxide Synthase in the Absence of Dyslipidemias in Men with Metabolic Syndrome
Barona, J., Blesso, C. N., Andersen, C. J., Park, Y., Lee, J., & Fernández, M. L. (2012) · Nutrients · doi:10.3390/nu4121945 · Cited by 68 · see citing works
Self-citation
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
Nurul-Iman, B. S., Kamisah, Y., Jaarin, K., & Qodriyah, H. M. S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/629329 · Cited by 72 · see citing works
Sweet Bing Cherries Lower Circulating Concentrations of Markers for Chronic Inflammatory Diseases in Healthy Humans
Kelley, D. S., Adkins, Y. C., Reddy, A., Woodhouse, L. R., Mackey, B. E., & Erickson, K. L. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171371 · Cited by 65 · see citing works
Effects of chronic consumption of specific fruit (berries, citrus and cherries) on CVD risk factors: a systematic review and meta-analysis of randomised controlled trials
Wang, Y., Lara, J., Haskell‐Ramsay, C. F., & Lodge, J. K. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02299-w · Cited by 62 · see citing works
Carbonyl Stress in Aging Process: Role of Vitamins and Phytochemicals as Redox Regulators
Ergin, V. (2013) · Aging and Disease · doi:10.14336/ad.2013.0400276 · Cited by 59 · see citing works
Potential Factors Influencing the Effects of Anthocyanins on Blood Pressure Regulation in Humans: A Review
Vendrame, S., & Klimis‐Zacas, D. J. (2019) · Nutrients · doi:10.3390/nu11061431 · Cited by 59 · see citing works
Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Li, S., Zhao, P., Tian, H., Chen, L., & Cui, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137665 · Cited by 58 · see citing works
Effects of pomegranate extract on blood flow and running time to exhaustion
Trexler, E. T., Smith‐Ryan, A. E., Melvin, M. N., Roelofs, E. J., & Wingfield, H. L. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0137 · Cited by 56 · see citing works
A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers
Martínez‐Maqueda, D., Zapatera, B., Gallego‐Narbón, A., Vaquero, M. P., Saura-Calixto, F. D., & Pérez‐Jiménez, J. (2018) · Food & Function · doi:10.1039/c8fo01323c · Cited by 55 · see citing works
Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults
Dodd, G. F., Williams, C. M., Butler, L. T., & Spencer, J. P. E. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-180056 · Cited by 54 · see citing works
Fine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular health
Weaver, S. R., Rendeiro, C., McGettrick, H. M., Philp, A., & Lucas, S. J. E. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02247-8 · Cited by 56 · see citing works
A single serving of blueberry (V. corymbosum) modulates peripheral arterial dysfunction induced by acute cigarette smoking in young volunteers: a randomized-controlled trial
Bo’, C. D., Porrini, M., Fracassetti, D., Campolo, J., Klimis‐Zacas, D. J., & Riso, P. (2014) · Food & Function · doi:10.1039/c4fo00570h · Cited by 52 · see citing works
Do grape polyphenols improve metabolic syndrome components? A systematic review
Woerdeman, J., van Poelgeest, E. M., Ket, J. C. F., Eringa, E. C., Serné, E. H., & Smulders, Y. M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.227 · Cited by 50 · see citing works
A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study
Toscano, L. T., Silva, A. S., de França, A. C. L., de Sousa, B. R. V., Filho, É. J. B. D. A., Costa, M. D. S., Biasoto, A. C. T., da Silva, D. F., Sena, K. D. F., Cerqueira, G. S., et al. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02139-6 · Cited by 50 · see citing works
A Larger Body Mass Index is Associated with Increased Atherogenic Dyslipidemia, Insulin Resistance, and Low-Grade Inflammation in Individuals with Metabolic Syndrome
Ebron, K., Andersen, C. J., Aguilar, D., Blesso, C. N., Barona, J., Dugan, C. E., Jones, J. L., Al‐Sarraj, T., & Fernández, M. L. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0053 · Cited by 48 · see citing works
Self-citation
Effects of pomegranate extract on blood flow and vessel diameter after high‐intensity exercise in young, healthy adults
Roelofs, E. J., Smith‐Ryan, A. E., Trexler, E. T., Hirsch, K. R., & Mock, M. G. (2016) · European Journal of Sport Science · doi:10.1080/17461391.2016.1230892 · Cited by 48 · see citing works
The impact of grape seed extract treatment on blood pressure changes
Zhang, H., Liu, S., Li, L., Liu, S., Liu, S., Mi, J., & Tian, G. (2016) · Medicine · doi:10.1097/md.0000000000004247 · Cited by 47 · see citing works
The Acute Effects of Grape Polyphenols Supplementation on Endothelial Function in Adults: Meta-Analyses of Controlled Trials
Li, S., Tian, H., Zhao, H., Chen, L., & Cui, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069818 · Cited by 45 · see citing works
Plant bioactive compounds from Mediterranean diet improve risk factors for metabolic syndrome
Farias‐Pereira, R., Zuk, J. B., & Khavaran, H. (2023) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2023.2232949 · Cited by 45 · see citing works
Polyphenolic bioactives as an emerging group of nutraceuticals for promotion of gut health: A review
Ashwin, K., Pattanaik, A. K., & Howarth, G. S. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101376 · Cited by 48 · see citing works
Acute Effects of Hesperidin in Oxidant/Antioxidant State Markers and Performance in Amateur Cyclists
Martínez-Noguera, F. J., Marín‐Pagán, C., Carlos‐Vivas, J., Rubio‐Arias, J. Á., & Alcaráz, P. E. (2019) · Nutrients · doi:10.3390/nu11081898 · Cited by 42 · see citing works
Plant polyphenols as natural bioactives for alleviating lipid metabolism disorder: Mechanisms and application challenges
Wei, H., Rui, J., Yan, X., Xu, R., Chen, S., Zhang, B., Wang, L., Zhang, Z., Zhu, C., Ma, M., et al. (2025) · Food Research International · doi:10.1016/j.foodres.2025.115682 · Cited by 46 · see citing works
Evaluation of Agraz Consumption on Adipocytokines, Inflammation, and Oxidative Stress Markers in Women with Metabolic Syndrome
Moncada, J. E., Marín-Echeverri, C., Galvis-Pérez, Y., Ciro-Gómez, G. L., Aristizábal, J. C., Blesso, C. N., Fernández, M. L., & Barona-Acevedo, J. (2018) · Nutrients · doi:10.3390/nu10111639 · Cited by 40 · see citing works
Self-citation
Pomegranate Extract Improves Maximal Performance of Trained Cyclists after an Exhausting Endurance Trial: A Randomised Controlled Trial
Torregrosa-García, A., Ávila-Gandía, V., Luque-Rubia, A. J., Abellán-Ruiz, M. S., Querol-Calderón, M., & López-Román, F. J. (2019) · Nutrients · doi:10.3390/nu11040721 · Cited by 40 · see citing works
The effect of grapefruits (Citrus paradisi) on body weight and cardiovascular risk factors: A systematic review and meta-analysis of randomized clinical trials
Onakpoya, I., O’Sullivan, J. W., Heneghan, C. J., & Thompson, M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.901292 · Cited by 38 · see citing works
Effects of Blueberry Consumption on Cardiovascular Health in Healthy Adults: A Cross-Over Randomised Controlled Trial
Wang, Y., Lara, J., Haskell‐Ramsay, C. F., & Lodge, J. K. (2022) · Nutrients · doi:10.3390/nu14132562 · Cited by 36 · see citing works
The effect of acute pomegranate extract supplementation on oxygen uptake in highly-trained cyclists during high-intensity exercise in a high altitude environment
Crum, E. M., Muhamed, A. M. C., Barnes, M. J., & Stannard, S. R. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0172-0 · Cited by 35 · see citing works
The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Tamtaji, O. R., Milajerdi, A., Dadgostar, E., Kolahdooz, F., Chamani, M., Amirani, E., Mirzaei, H., & Asemi, Z. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190513095352 · Cited by 34 · see citing works
Clinical effects of an oral supplement rich in antioxidants on skin radiance in women
Dumoulin, M., Gaudout, D., & Lemaire, B. (2016) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s118920 · Cited by 32 · see citing works
Effects of grape consumption on biomarkers of inflammation, endothelial function, and PBMC gene expression in obese subjects
Bardagjy, A. S., Hu, Q., Giebler, K., Ford, A., & Steinberg, F. M. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.04.003 · Cited by 31 · see citing works
Dietary Flavanols: A Review of Select Effects on Vascular Function, Blood Pressure, and Exercise Performance
Al-Dashti, Y. A., Holt, R. R., Stebbins, C. L., Keen, C. L., & Hackman, R. M. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1451788 · Cited by 33 · see citing works
Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Function
Martelli, A., Flori, L., Gorica, E., Piragine, E., Saviano, A., Annunziata, G., Minno, M. N. D. D., Ciampaglia, R., Calcaterra, I. L., Μaione, F., et al. (2021) · Nutrients · doi:10.3390/nu13051540 · Cited by 31 · see citing works
Natural pomegranate juice reduces inflammation, muscle damage and increase platelets blood levels in active healthy Tunisian aged men
Achraf, A., Chtourou, H., Turki, M., Abdelkarim, O., Ayadi, F. M., Höekelmann, A., Yaich, S., & Souissi, N. (2017) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2017.03.005 · Cited by 28 · see citing works
Changing to a Low-Polyphenol Diet Alters Vascular Biomarkers in Healthy Men after Only Two Weeks
Hurtado‐Barroso, S., Quifer‐Rada, P., de Alvarenga, J. F. R., Pérez-Fernández, S., Tresserra‐Rimbau, A., & Lamuela-Raventós, R. M. (2018) · Nutrients · doi:10.3390/nu10111766 · Cited by 29 · see citing works
Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of Flavonoid-Rich Foods and Lower Blood Pressure
Jennings, A., Koch, M., Bang, C., Franke, A., Lieb, W., & Cassidy, A. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17441 · Cited by 26 · see citing works
Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites
Laudani, S., Godos, J., Domenico, F. M. D., Barbagallo, I. A., Randazzo, C. L., Leggio, G. M., Galvano, F., & Grosso, G. (2023) · Antioxidants · doi:10.3390/antiox12091773 · Cited by 26 · see citing works
Added Sugar Intake is Associated with Blood Pressure in Older Females
Mansoori, S., Kushner, N., Suminski, R. R., Jr., Farquhar, W. B., & Chai, S. C. (2019) · Nutrients · doi:10.3390/nu11092060 · Cited by 25 · see citing works
Effect of Agraz (Vaccinium meridionale Swartz) on High-Density Lipoprotein Function and Inflammation in Women with Metabolic Syndrome
Marín-Echeverri, C., Blesso, C. N., Fernández, M. L., Galvis-Pérez, Y., Ciro-Gómez, G. L., Núñez-Rangel, V., Aristizábal, J. C., & Barona-Acevedo, J. (2018) · Antioxidants · doi:10.3390/antiox7120185 · Cited by 25 · see citing works
Self-citation
Montmorency cherry supplementation attenuates vascular dysfunction induced by prolonged forearm occlusion in overweight, middle-aged men
Bakkar, Z. A., Fulford, J., Gates, P. E., Jackman, S. R., JONES, A. M., Bond, B., & Bowtell, J. L. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00804.2018 · Cited by 24 · see citing works
Pola Konsumsi dengan Terjadinya Sindrom Metabolik
Suhaema, S., & Masthalina, H. (2015) · Kesmas National Public Health Journal · doi:10.21109/kesmas.v9i4.741 · Cited by 23 · see citing works
Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein Function in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Study
Millar, C. L., Duclos, Q., Garcia, C., Norris, G. H., Lemos, B. S., DiMarco, D. M., Fernández, M. L., & Blesso, C. N. (2018) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0052 · Cited by 23 · see citing works
Self-citation
The Role of Plant-Derived Bioactive Compounds in Mitigating Oxidative Stress
TUGEN, A., & Buruleanu, C. L. (2025) · Foods · doi:10.3390/foods15010108 · Cited by 23 · see citing works
The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials
khorasani, S. S., & Hosseinzadeh, M. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003591 · Cited by 20 · see citing works
The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis
Foshati, S., Nouripour, F., Sadeghi, E., & Amani, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105905 · Cited by 21 · see citing works
The effect of whole grape products on blood pressure and vascular function: A systematic review and meta-analysis of randomized controlled trials
Ashoori, M., Soltani, S., Kolahdouz‐Mohammadi, R., Moghtaderi, F., Clayton, Z. S., & Abdollahi, S. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.05.001 · Cited by 20 · see citing works
Winery by-products as a valuable source for natural antihypertensive agents
López‐Fernández‐Sobrino, R., Torres‐Fuentes, C., Bravo, F. I., & Muguerza, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2049202 · Cited by 19 · see citing works
Physico-chemical characterization and antioxidant capacity of the colombian berry (Vaccinium meridionale Swartz) with a high-polyphenol content: potential effects in people with metabolic syndrome
Quiroz, J. Q., Galvis-Pérez, Y., GALEANO-VÁSQUEZ, S., Marín-Echeverri, C., FRANCO-ESCOBAR, C., Ciro-Gómez, G. L., Núñez-Rangel, V., ARISTIZÁBAL-RIVERA, J. C., & Barona-Acevedo, J. (2019) · Food Science and Technology · doi:10.1590/fst.32817 · Cited by 19 · see citing works
Recent Advances in Extraction of Polyphenols by Advanced Extraction Methods
Yendurı, S., Venkatesh, K. V., & Prashant, K. N. (2025) · Phytochemical Analysis · doi:10.1002/pca.70012 · Cited by 20 · see citing works
Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-Hypertension
Robinson, Lu, B., Edirisinghe, I., & Kappagoda, C. T. (2012) · Journal of Pharmacy and Nutrition Sciences · doi:10.6000/1927-5951.2012.02.02.6 · Cited by 18 · see citing works
Bioactivities and mechanisms of dietary proanthocyanidins on blood pressure lowering: A critical review of in vivo and clinical studies
Fan, W., Zong, H., Zhao, T., Deng, J., & Yang, H. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2132375 · Cited by 18 · see citing works
Daily Consumption of Grapefruit for 6 Weeks Reduces Urine F2-Isoprostanes in Overweight Adults with High Baseline Values but Has No Effect on Plasma High-Sensitivity C-Reactive Protein or Soluble Vascular Cellular Adhesion Molecule
Dow, C. A., Wertheim, B. C., Patil, B. S., & Thomson, C. A. (2013) · Journal of Nutrition · doi:10.3945/jn.113.175166 · Cited by 15 · see citing works
Consumption of Aged White Wine under a Veil of Flor Reduces Blood Pressure-Increasing Plasma Nitric Oxide in Men at High Cardiovascular Risk
Roth, I., Casas, R. M., Ribó-Coll, M., & Estruch, R. (2019) · Nutrients · doi:10.3390/nu11061266 · Cited by 15 · see citing works
Chardonnay Marc as a New Model for Upcycled Co-products in the Food Industry: Concentration of Diverse Natural Products Chemistry for Consumer Health and Sensory Benefits
Holt, R. R., Barile, D., Wang, S. C., Munafo, J. P., Arvik, T. J., Li, X., Lee, F., Keen, C. L., Tagkopoulos, I., & Schmitz, H. H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04519 · Cited by 15 · see citing works
Fortification of orange juice with microencapsulated Kocuria flava Y4 towards a novel functional beverage: Biological and quality aspects
Barik, A., Pallavi, P., Sen, S. K., Rajhans, G., Bose, A., & Raut, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17509 · Cited by 14 · see citing works

Grape polyphenols improve blood pressure and vascular function in men with metabolic syndrome
Barona, J., Volek, J. S., & Fernández, M. L. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.385.1
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The Increase in Flow‐Mediated Vasodilation Induced by Grape Polyphenols is Positively Correlated with Increased Expression of Inducible Nitric Oxide (iNOS)
Barona, J., Lee, J., Park, Y., & Fernández, M. L. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.823.22
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Effect of a polyphenoics extracts of Grape Seeds (GSE) on Blood Pressure(BP) in patients with the Metabolic Syndrome (MetS)
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Authors: Barona, J., Aristizabal, J. C., Blesso, C. N., Volek, J. S., & Fernandez, M. L.
Affiliations: University of Connecticut (US)
ORCID: Blesso, Christopher N.
Volek, Jeff S.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2012-09
Volume: 142
Issue: 9
Pages: 1626-1632
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.112.162743
OpenAlex: W2128017243
Cited by: 173
References: 56
Citations by year: 2026: 5 · 2025: 16 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 17 · 2018: 19 · 2017: 11 · 2016: 11 · 2015: 19 · 2014: 8 · 2013: 15 · 2012: 4
FWCI: 10.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3811 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: grape polyphenols, metabolic syndrome, blood pressure, flow-mediated dilation, endothelial function, nitric oxide, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, adhesion molecules, vasorelaxation, men
MeSH terms: Adult, Aged, Blood Pressure, Brachial Artery, Endothelium, Vascular, Freeze Drying, Humans, Male, Middle Aged, Nitrates, Nitrites, Placebos, Vasculitis, Vasodilation, Biomarkers, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Metabolic Syndrome, Vitis, Polyphenols

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Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome

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