The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults
Open accessAbstract
Metabolic syndrome is a set of disorders that increases the risk of developing cardiovascular disease. The gut microbiota is altered toward a less beneficial composition in overweight adults and this change can be accompanied by inflammation. Prebiotics such as galactooligosaccharides can positively modify the gut microbiota and immune system; some may also reduce blood lipids. We assessed the effect of a galactooligosaccharide mixture [Bi2muno (B-GOS)] on markers of metabolic syndrome, gut microbiota, and immune function in 45 overweight adults with ≥3 risk factors associated with metabolic syndrome in a double-blind, randomized, placebo (maltodextrin)-controlled, crossover study (with a 4-wk wash-out period between interventions). Whole blood, saliva, feces, and anthropometric measurements were taken at the beginning, wk 6, and end of each 12-wk intervention period. Predominant groups of fecal bacteria were quantified and full blood count, markers of inflammation and lipid metabolism, insulin, and glucose were measured. B-GOS increased the number of fecal bifidobacteria at the expense of less desirable groups of bacteria. Increases in fecal secretory IgA and decreases in fecal calprotectin, plasma C-reactive protein, insulin, total cholesterol (TC), TG, and the TC:HDL cholesterol ratio were also observed. Administration of B-GOS to overweight adults resulted in positive effects on the composition of the gut microbiota, the immune response, and insulin, TC, and TG concentrations. B-GOS may be a useful candidate for the enhancement of gastrointestinal health, immune function, and the reduction of metabolic syndrome risk factors in overweight adults.
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Metadata
- Authors
- Vulevic, J., Juric, A., Tzortzis, G., & Gibson, G. R.
- Affiliations
- University of Reading (GB)
- Corresponding author
- Vulevic, Jelena
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 143
- Issue
- 3
- Pages
- 324-331
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2145232186
- Cited by
- 349
- References
- 52
- Citations by year
- 2026: 19 · 2025: 20 · 2024: 20 · 2023: 10 · 2022: 36 · 2021: 32 · 2020: 31 · 2019: 31 · 2018: 34 · 2017: 33 · 2016: 30 · 2015: 22 · 2014: 18 · 2013: 11
- FWCI
- 24.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Clasado Ltd
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- galactooligosaccharides, prebiotics, metabolic syndrome, overweight adults, gut microbiota, secretory IgA, calprotectin, C-reactive protein, inflammation, insulin, lipid metabolism, cholesterol, triglycerides, TC/HDL-C ratio, immune function
- MeSH terms
- Adult, Bacteria, Bifidobacterium, C-Reactive Protein, Double-Blind Method, Feces, Female, Galactose, Humans, Immunoglobulin A, Immunity, Inflammation, Insulin, Lipids, Male, Middle Aged, Oligosaccharides, Risk Factors, Biomarkers, Cross-Over Studies, Metabolic Syndrome, Leukocyte L1 Antigen Complex, Overweight, Metagenome, Prebiotics
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