Cited by 349Microbial Metabolites in Food BiotechnologyGut microbiota and healthProbiotics and Fermented Foods

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A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults

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Vulevic, Jelena, Juric, Aleksandra, Tzortzis, George, Gibson, Glenn R.·2013·The Journal of Nutrition

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Abstract

Metabolic syndrome is a set of disorders that increases the risk of developing cardiovascular disease. The gut microbiota is altered toward a less beneficial composition in overweight adults and this change can be accompanied by inflammation. Prebiotics such as galactooligosaccharides can positively modify the gut microbiota and immune system; some may also reduce blood lipids. We assessed the effect of a galactooligosaccharide mixture [Bi2muno (B-GOS)] on markers of metabolic syndrome, gut microbiota, and immune function in 45 overweight adults with ≥3 risk factors associated with metabolic syndrome in a double-blind, randomized, placebo (maltodextrin)-controlled, crossover study (with a 4-wk wash-out period between interventions). Whole blood, saliva, feces, and anthropometric measurements were taken at the beginning, wk 6, and end of each 12-wk intervention period. Predominant groups of fecal bacteria were quantified and full blood count, markers of inflammation and lipid metabolism, insulin, and glucose were measured. B-GOS increased the number of fecal bifidobacteria at the expense of less desirable groups of bacteria. Increases in fecal secretory IgA and decreases in fecal calprotectin, plasma C-reactive protein, insulin, total cholesterol (TC), TG, and the TC:HDL cholesterol ratio were also observed. Administration of B-GOS to overweight adults resulted in positive effects on the composition of the gut microbiota, the immune response, and insulin, TC, and TG concentrations. B-GOS may be a useful candidate for the enhancement of gastrointestinal health, immune function, and the reduction of metabolic syndrome risk factors in overweight adults.

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Authors: Vulevic, J., Juric, A., Tzortzis, G., & Gibson, G. R.
Affiliations: University of Reading (GB)
Corresponding author: Vulevic, Jelena
ORCID: Vulevic, Jelena
Gibson, Glenn R.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2013-03
Volume: 143
Issue: 3
Pages: 324-331
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.112.166132
OpenAlex: W2145232186
Cited by: 349
References: 52
Citations by year: 2026: 19 · 2025: 20 · 2024: 20 · 2023: 10 · 2022: 36 · 2021: 32 · 2020: 31 · 2019: 31 · 2018: 34 · 2017: 33 · 2016: 30 · 2015: 22 · 2014: 18 · 2013: 11
FWCI: 24.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3624 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Clasado Ltd
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: galactooligosaccharides, prebiotics, metabolic syndrome, overweight adults, gut microbiota, secretory IgA, calprotectin, C-reactive protein, inflammation, insulin, lipid metabolism, cholesterol, triglycerides, TC/HDL-C ratio, immune function
MeSH terms: Adult, Bacteria, Bifidobacterium, C-Reactive Protein, Double-Blind Method, Feces, Female, Galactose, Humans, Immunoglobulin A, Immunity, Inflammation, Insulin, Lipids, Male, Middle Aged, Oligosaccharides, Risk Factors, Biomarkers, Cross-Over Studies, Metabolic Syndrome, Leukocyte L1 Antigen Complex, Overweight, Metagenome, Prebiotics

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A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults

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