TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism
Open accessAbstract
The most effective immunological adjuvants contain microbial products, such as TLR agonists, which bind to conserved pathogen recognition receptors. These activate dendritic cells (DCs) to become highly effective APCs. We assessed whether TLR ligand-treated DCs can enhance the otherwise defective response of aged naive CD4 T cells. In vivo administration of CpG, polyinosinic-polycytidylic acid, and Pam(3)CSK(4) in combination with Ag resulted in the increased expression of costimulatory molecules and MHC class II by DCs, increased serum levels of the inflammatory cytokines IL-6 and RANTES, and increased cognate CD4 T cell responses in young and aged mice. We show that, in vitro, preactivation of DCs by TLR ligands makes them more efficient APCs for aged naive CD4 T cells. After T-DC interaction, there are enhanced production of inflammatory cytokines, particularly IL-6, and greater expansion of the aged T cells, resulting from increased proliferation and greater effector survival with increased levels of Bcl-2. TLR preactivation of both bone marrow-derived and ex vivo DCs improved responses. IL-6 produced by the activated DCs during cognate T cell interaction was necessary for enhanced aged CD4 T cell expansion and survival. These studies suggest that some age-associated immune defects may be overcome by targeted activation of APCs by TLR ligands.
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Development and identification of appropriate adjuvants and cytokines might effectively remedy defects in T cell functions from older adults, both directly and by better activation of DCs.
“The development an identification of appropriate adjuvants and cytokines might effectively remedy defects in T cell functions from older adults, both directly and by better activation of DCs (214–216).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [215]
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Cites
Fiore, A. E., Shay, D. K., Broder, K., Iskander, J. K., Uyeki, T. M., Mootrey, G., Bresee, J. S., & Cox, N. S. (2001) · PsycEXTRA Dataset · doi:10.1037/e548312006-001 · Cited by 5,006 · see citing works
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777 · see citing works
Interleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1001 · Cited by 3,933 · see citing works
Lutz, M. B., Kukutsch, N. A., Ogilvie, A. L. J., Rößner, S., Koch, F., Romani, N., & Schuler, G. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00204-x · Cited by 2,972 · see citing works
Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works
Donnelly, C. A., Ghani, A. C., Leung, G. M., Hedley, A. J., Fraser, C., Riley, S., Abu-Raddad, L. J., Ho, L.-M., Thach, T.-Q., Chau, P., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13410-1 · Cited by 940 · see citing works
The two faces of IL-6 on Th1/Th2 differentiation
Diehl, S. A., & Rincón, M. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00210-9 · Cited by 873 · see citing works
Prevention and Control of Influenza
(1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-4-560 · Cited by 809 · see citing works
Agrawal, S., Agrawal, A., Doughty, B. L., Gerwitz, A., Blenis, J., Dyke, T. E. V., & Pulendran, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.4984 · Cited by 726 · see citing works
Davis, H. L., Weeranta, R., Waldschmidt, T. J., Tygrett, L. T., Schorr, J., & Krieg, A. Μ. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.2.870 · Cited by 676 · see citing works
Cutting edge: impaired toll-like receptor expression and function in aging
Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4697 · Cited by 626 · see citing works
The Role of CD40 Ligand in Costimulation and T‐Cell Activation
Grewal, I. S., & Flavell, R. A. (1996) · Immunological Reviews · doi:10.1111/j.1600-065x.1996.tb00921.x · Cited by 450 · see citing works
SERIOUS MORBIDITY AND MORTALITY ASSOCIATED WITH INFLUENZA EPIDEMICS
GLEZEN, W. P. (1982) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036250 · Cited by 449 · see citing works
Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works
Means, T. K., Hayashi, F., Smith, K. D., Aderem, A. A., & Luster, A. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5165 · Cited by 411 · see citing works
Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
KRIEG, A. M. (2008) · Oncogene · doi:10.1038/sj.onc.1210911 · Cited by 389 · see citing works
Toll-Like Receptor Ligands Directly Promote Activated CD4+ T Cell Survival
Gelman, A. E., Zhang, J., Choi, Y., & Turka, L. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6065 · Cited by 386 · see citing works
Triggering TLR signaling in vaccination
van Duin, D., Medzhitov, R. M., & Shaw, A. C. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.11.005 · Cited by 364 · see citing works
Mechanisms of stimulation of the immune response by aluminum adjuvants
HogenEsch, H. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00169-x · Cited by 358 · see citing works
Age-Associated Defect in Human TLR-1/2 Function
van Duin, D., Mohanty, S., Thomas, V., Ginter, S., Montgomery, R. R., Fikrig, E., Allore, H. G., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.970 · Cited by 352 · see citing works
Toll-like receptors and dendritic cells: for whom the bug tolls
Sousa, C. R. E. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.10.004 · Cited by 341 · see citing works
A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity
Scott, B., Liblau, R., Degermann, S., Marconi, L. A., Ogata, L., Caton, A. J., McDevitt, H. O., & Lo, D. D. (1994) · Immunity · doi:10.1016/1074-7613(94)90011-6 · Cited by 338 · see citing works
Yoshikawa, T. T., & Schmader, K. E. (2001) · Clinical Infectious Diseases · doi:10.1086/320169 · Cited by 335 · see citing works
CD4 Effector T Cell Subsets in the Response to Influenza
Román, E., Miller, E., Harmsen, A. G., Wiley, J., von Andrian, U. H., Huston, G. E., & Swain, S. L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021052 · Cited by 327 · see citing works
Self-citationKuchen, S., Robbins, R., Sims, G. P., Sheng, C., Phillips, T. M., Lipsky, P. E., & Ettinger, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5886 · Cited by 326 · see citing works
Modulating vaccine responses with dendritic cells and Toll‐like receptors
Pulendran, B. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00144.x · Cited by 323 · see citing works
Respiratory Syncytial Virus Pneumonia among the Elderly: An Assessment of Disease Burden
Han, L. L., Alexander, J. P., & Anderson, L. J. (1999) · The Journal of Infectious Diseases · doi:10.1086/314567 · Cited by 302 · see citing works
Datta, S. K., Redecke, V., Prilliman, K. R., Takabayashi, K., Corr, M., Tallant, T. C., DiDonato, J. A., Dziarski, R., Akira, S., Schoenberger, S. P., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4102 · Cited by 300 · see citing works
Brown, D. M., Dilzer, A. M., Meents, D. L., & Swain, S. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2888 · Cited by 282 · see citing works
Self-citationTLR‐mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells
Barr, T. A., Brown, S. L., Ryan, G. A., Zhao, J., & Gray, D. (2007) · European Journal of Immunology · doi:10.1002/eji.200636483 · Cited by 281 · see citing works
Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses
Eaton, S. M., Burns, E. M., Kusser, K. L., Randall, T. D., & Haynes, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041395 · Cited by 279 · see citing works
Ichinohe, T., Watanabe, I., Ito, S., Fujii, H., Moriyama, M., Tamura, S., Takahashi, H., Sawa, H., Chiba, J., Kurata, T., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.2910-2919.2005 · Cited by 272 · see citing works
Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2433717100 · Cited by 270 · see citing works
Self-citationBoehmer, E. D., Góral, J., Faunce, D. E., & Kovacs, E. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0803389 · Cited by 266 · see citing works
How Do Adjuvants Work? Important Considerations for New Generation Adjuvants
McKee, A. S., Munks, M. W., & Marrack, P. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.003 · Cited by 262 · see citing works
Antigen-independent changes in naive CD4 T cells with aging.
Linton, P. J., Haynes, L., Klinman, N. R., & Swain, S. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.1891 · Cited by 248 · see citing works
Self-citationHaynes, L., Linton, P., Eaton, S. M., Tonkonogy, S. L., & Swain, S. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.1013 · Cited by 248 · see citing works
Self-citationImmunosenescence and germinal center reaction
Zheng, B. Q., Han, S., Takahashi, Y., & Kelsoe, G. H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01028.x · Cited by 229 · see citing works
Immunological adjuvants promote activated T cell survival via induction of Bcl-3
Mitchell, T. C., Hildeman, D. A., Kedl, R. M., Teague, T. K., Schaefer, B. C., White, J., Zhu, Y., Kappler, J. W., & Marrack, P. (2001) · Nature Immunology · doi:10.1038/87692 · Cited by 221 · see citing works
Proietti, E., Bracci, L., Puzelli, S., Pucchio, T. D., Sestili, P., Vincenzi, E. D., Venditti, M., Capone, I., Seif, I., Maeyer, E. D., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.375 · Cited by 218 · see citing works
Cutting Edge: TLR2 Directly Triggers Th1 Effector Functions
Imanishi, T., Hara, H., Suzuki, S., Suzuki, N., Akira, S., & Saito, T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6715 · Cited by 200 · see citing works
Dubey, C., Croft, M., & Swain, S. L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.8.3280 · Cited by 196 · see citing works
Self-citationRhee, E. G., Méndez, S., Shah, J. A., Wu, C. Y., Kirman, J. R., Turon, T. N., Davey, D. F., Davis, H. L., Klinman, D. M., Coler, R. N., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020147 · Cited by 171 · see citing works
Why Aging T Cells Fail: Implications for Vaccination
Haynes, L., & Swain, S. L. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.003 · Cited by 169 · see citing works
Self-citationTsukamoto, H., Clise-Dwyer, K., Huston, G. E., Duso, D. K., Buck, A. L., Johnson, L. L., Haynes, L., & Swain, S. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910139106 · Cited by 166 · cited 1× · see citing works
“However, effectors “rescued” by exogenous IL-2 did not become functional memory CD4 T cells (13, 21).”
BackgroundSelf-citationInflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo
Haynes, L., Eaton, S. M., Burns, E. M., Rincon, M., & Swain, S. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5194 · Cited by 162 · see citing works
Self-citationLundberg, A. M., Drexler, S. K., Monaco, C. G., Williams, L. M., Sacre, S. M., Feldmann, M., & Foxwell, B. M. J. (2007) · Blood · doi:10.1182/blood-2007-02-072934 · Cited by 155 · see citing works
Recommendations of the Advi sory Committee on Immunization Practices
anning, S. E. M., Rupprecht, C. E., Fishbein, D. B., Hanlon, C. A., Lumlertdacha, B., Meltzer, I., Jenkins, S. R., Sun, B., & Hull, H. F. (2008) · Cited by 141 · see citing works
IL-6 Increases Primed Cell Expansion and Survival
Rochman, I., Paul, W., & Ben-Sasson, S. (2005) · Journal of Immunology · doi:10.4049/jimmunol.174.8.4761 · Cited by 138 · see citing works
Powell, T. J., Strutt, T. M., Reome, J. B., Hollenbaugh, J. A., Roberts, A. D., Woodland, D. L., Swain, S. L., & Dutton, R. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.1030 · Cited by 130 · see citing works
Self-citationToll‐Like Receptors in Older Adults
van Duin, D., & Shaw, A. C. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01300.x · Cited by 129 · see citing works
Immune response modifiers – mode of action
Schiller, M., Metze, D., Luger, T. A., Grabbe, S., & Gunzer, M. (2006) · Experimental Dermatology · doi:10.1111/j.0906-6705.2006.00414.x · Cited by 116 · see citing works
Human and mouse plasmacytoid dendritic cells
Hochrein, H., O’Keeffe, M. A., & Wagner, H. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00748-6 · Cited by 114 · see citing works
Age‐related changes in antibody repertoire: contribution from T cells
Song, H., Price, P. W., & Černý, J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01027.x · Cited by 109 · see citing works
Anderson, L. M., Shinn, C., St, C. J., Fullilove, M. T., Scrimshaw, S. C. M., Fielding, J. E., Normand, J., Sanchez-Way, R., & Richardson, T. (2002) · PsycEXTRA Dataset · doi:10.1037/e548532006-001 · Cited by 107 · see citing works
Homeostasis and the age-associated defect of CD4 T cells
Swain, S. L., Clise-Dwyer, K., & Haynes, L. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.007 · Cited by 107 · see citing works
Self-citationMurine myeloid dendritic cell‐dependent toll‐like receptor immunity is preserved with aging
Tesar, B. M., Walker, W. E., Unternaehrer, J., Joshi, N. S., Chandele, A., Haynes, L., Kaech, S. M., & Goldstein, D. R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00245.x · Cited by 93 · see citing works
Katz, J. M., Plowden, J., Renshaw‐Hoelscher, M., Lu, X., Tumpey, T. M., & Sambhara, S. R. (2004) · Immunologic Research · doi:10.1385/ir:29:1-3:113 · Cited by 88 · see citing works
Cui, Z., & Qiu, F. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0114-6 · Cited by 81 · see citing works
Tritel, M., Stoddard, A. M., Flynn, B. J., Darrah, P. A., Wu, C. Y., Wille, U., Shah, J. A., Huang, Y., Xu, L., Betts, M. R., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2538 · Cited by 76 · see citing works
Clise-Dwyer, K., Huston, G. E., Buck, A. L., Duso, D. K., & Swain, S. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1321 · Cited by 65 · see citing works
Self-citationProinflammatory Adjuvants Enhance the Cognate Helper Activity of Aged CD4 T Cells
Maue, A. C., Eaton, S. M., Lanthier, P. A., Sweet, K. B., Blumerman, S. L., & Haynes, L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804226 · Cited by 64 · see citing works
CD8 T cell memory development: CD4 T cell help is appreciated
Khanolkar, A., Badovinac, V. P., & Harty, J. T. (2007) · Immunologic Research · doi:10.1007/s12026-007-0081-4 · Cited by 63 · see citing works
Important infections in elderly persons.
Yoshikawa, T. T. (1981) · PubMed · Cited by 46 · see citing works
Eaton, S. M., Maue, A. C., Swain, S. L., & Haynes, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4825 · Cited by 45 · see citing works
Self-citationEvidence for a Role for Notch Signaling in the Cytokine-Dependent Survival of Activated T Cells
Bheeshmachar, G., Purushotaman, D., Sade, H., Gunasekharan, V., Rangarajan, A., & Sarin, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5041 · Cited by 41 · see citing works
Impact of Post-Thymic Cellular Longevity on the Development of Age-Associated CD4+ T Cell Defects
Jones, S. C., Clise-Dwyer, K., Huston, G. E., Dibble, J. P., Eaton, S. M., Haynes, L., & Swain, S. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4465 · Cited by 30 · see citing works
Self-citationVremec, D. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-421-0_14 · Cited by 20 · see citing works
Functionally Diverse Subsets in CD4 T Cell Responses Against Influenza
Strutt, T. M., McKinstry, K. K., & Swain, S. L. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9266-4 · Cited by 19 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Slavich, G. M., & Sacher, J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05326-9 · Cited by 383 · see citing works
Emerging Concepts and Technologies in Vaccine Development
Brisse, M. E., Vrba, S. M., Kirk, N. M., Liang, Y., & Ly, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583077 · Cited by 325 · see citing works
The Confluence of Sex Hormones and Aging on Immunity
Gubbels Bupp, M. R., Potluri, T., Fink, A. L., & Klein, S. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01269 · Cited by 277 · see citing works
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses
Ugolini, M., Gerhard, J., Burkert, S., Jensen, K. J., Georg, P., Ebner, F., Volkers, S. M., Thada, S., Dietert, K., Bauer, L. L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0068-4 · Cited by 162 · see citing works
Ling, G. S., Bennett, J., Woollard, K. J., Szajna, M., Fossati‐Jimack, L., Taylor, P. R., Scott, D. M., Franzoso, G., Cook, H. T., & Botto, M. (2014) · Nature Communications · doi:10.1038/ncomms4039 · Cited by 151 · see citing works
McElhaney, J. E., Kuchel, G. A., Zhou, X., Swain, S. L., & Haynes, L. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00041 · Cited by 139 · see citing works
Self-citationImpact of aging on antigen presentation cell function of dendritic cells
Wong, C. K., & Goldstein, D. R. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.016 · Cited by 129 · see citing works
Induction of Intestinal Th17 Cells by Flagellins From Segmented Filamentous Bacteria
Wang, Y., Yin, Y., Chen, X., Zhao, Y., Wu, Y., Li, Y., Wang, X., Chen, H., & Xiang, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02750 · Cited by 130 · see citing works
Behzad, H., Huckriede, A. L. W., Haynes, L., Gentleman, B., Coyle, K. M., Wilschut, J., Kollmann, T. R., Reed, S. G., & McElhaney, J. E. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir769 · Cited by 128 · see citing works
Role of IL‐6 in dendritic cell functions
Xu, Y.-D., Cheng, M., Shang, P., & Yang, Y.-Q. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0621-616rr · Cited by 93 · see citing works
Alghamri, M. S., McClellan, B. L., Hartlage, C. S., Haase, S., Faisal, S. M., Thalla, R., Dabaja, A. A., Banerjee, K., Carney, S. V., Mujeeb, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.680021 · Cited by 89 · see citing works
Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging
Silva-Cayetano, A., Fra-Bidó, S., Robert, P. A., Innocentin, S., Burton, A. R., Watson, E. M., Lee, J. L., Webb, L. M. C., Foster, W. S., McKenzie, R. C. J., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01519-9 · Cited by 90 · see citing works
Targeting immunosenescence and inflammaging: advancing longevity research
Nguyen, T. Q. T., & Cho, K. A. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01527-9 · Cited by 94 · see citing works
Keilich, S. R., Bartley, J. M., & Haynes, L. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103992 · Cited by 88 · see citing works
Vaccine development: Current trends and technologies
Poria, R., Kala, D., Nagraik, R., Walia, Y., Dhir, S., Singh, B., Kaushik, N. K., Noorani, M. S., Kaushal, A., & Gupta, S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122331 · Cited by 83 · see citing works
Flagellin Induces Antibody Responses through a TLR5- and Inflammasome-Independent Pathway
López-Yglesias, A. H., Zhao, X., Quarles, E. K., Lai, M. A., VandenBos, T., Strong, R. K., & Smith, K. D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301893 · Cited by 69 · see citing works
Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects
Haynes, L., & Swain, S. L. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.001 · Cited by 65 · see citing works
Self-citationImmunostimulatory Properties of Lipid Modified CpG Oligonucleotides
Yu, C., An, M., Li, M., & Liu, H. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00335 · Cited by 51 · see citing works
CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent
Zhang, W., Brahmakshatriya, V., & Swain, S. L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.002 · Cited by 49 · see citing works
Self-citationSong, L., Xiong, D., Kang, X., Yang, Y., Wang, J., Guo, Y., Xu, H., Chen, S., Peng, D., Pan, Z., et al. (2015) · BMC Biotechnology · doi:10.1186/s12896-015-0195-z · Cited by 46 · see citing works
Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection
Paquette, S. G., Huang, S. S. H., Banner, D., Xu, L., Leon, A. J., Kelvin, A. A., & Kelvin, D. J. (2014) · Virology · doi:10.1016/j.virol.2014.07.013 · Cited by 45 · see citing works
Brahmakshatriya, V., Kuang, Y., Devarajan, P., Xia, J., Zhang, W., Vong, A. M., & Swain, S. L. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601119 · Cited by 43 · see citing works
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Devarajan, P., Bautista, B., Vong, A. M., McKinstry, K. K., Strutt, T. M., & Swain, S. L. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00136 · Cited by 41 · see citing works
Self-citationBhattacharya, P., Dey, R., Dagur, P. K., Joshi, A. B., Ismail, N., Gannavaram, S., Debrabant, A., Akue, A. D., KuKuruga, M. A., Selvapandiyan, A., et al. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004963 · Cited by 34 · see citing works
Xie, G., Luo, H., Pang, L., Peng, B., Winkelmann, E., McGruder, B., Hesse, J., Whiteman, M. C., Campbell, G. A., Milligan, G. N., et al. (2015) · Journal of Virology · doi:10.1128/jvi.02488-15 · Cited by 35 · see citing works
Phenotype and functions of conventional dendritic cells are not compromised in aged mice
Tan, S., Cavanagh, L. L., d'Advigor, W., Shackel, N. A., Groth, B. F. D. S., & Weninger, W. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2011.104 · Cited by 32 · see citing works
Vaccine strategies to enhance immune responses in the aged
Lefebvre, J. S., & Haynes, L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.014 · Cited by 31 · see citing works
Effect of polysaccharides from a Korean ginseng berry on the immunosenescence of aged mice
Kim, M., Yi, Y., Kim, J., Han, S. Y., Kim, S. H., Seo, D. B., Cho, J. Y., & Shin, S. S. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.04.014 · Cited by 29 · see citing works
Zhou, X., Hopkins, J. W., Wang, C., Brahmakshatriya, V., Swain, S. L., Kuchel, G. A., Haynes, L., & McElhaney, J. E. (2016) · Oncotarget · doi:10.18632/oncotarget.10047 · Cited by 28 · see citing works
Self-citationElderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation
Gardner, J. K., Cornwall, S. M. J., Musk, A. W., Alvarez, J., Mamotte, C. D. S., Jackaman, C., Nowak, A. K., & Nelson, D. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195313 · Cited by 26 · see citing works
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Strutt, T. M., McKinstry, K. K., Kuang, Y., Finn, C. M., Hwang, J. H., Dhume, K., Sell, S., & Swain, S. L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600033 · Cited by 21 · see citing works
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Abolhalaj, M., Askmyr, D., Sakellariou, C. A., Lundberg, K., Greiff, L., & Lindstedt, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-26193-y · Cited by 19 · see citing works
Kugler‐Umana, O., Zhang, W., Kuang, Y., Liang, J., Castonguay, C. H., Tonkonogy, S. L., Marshak‐Rothstein, A., Devarajan, P., & Swain, S. L. (2022) · Aging Cell · doi:10.1111/acel.13705 · Cited by 16 · see citing works
Self-citationCarabelli, J., Prato, C. A., Sanmarco, L. M., Aoki, M. P., Campetella, O., & Tribulatti, M. V. (2018) · Immunology · doi:10.1111/imm.12980 · Cited by 16 · see citing works
Huang, C., Zhang, C., Sheng, J., Wang, D., Zhao, Y., Qian, L., Xie, L. Y., & Meng, Z. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.717319 · Cited by 15 · see citing works
Kilgore, J. A., Dolman, N. J., & Davidson, M. W. (2014) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy1232s67 · Cited by 14 · see citing works
Devarajan, P., Jones, M. C., Kugler‐Umana, O., Vong, A. M., Xia, J., & Swain, S. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00596 · Cited by 15 · see citing works
Self-citationXia, J., Kuang, Y., Liang, J., Jones, M., & Swain, S. L. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000597 · Cited by 14 · see citing works
Self-citationKugler‐Umana, O., Devarajan, P., & Swain, S. L. (2020) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2020034934 · Cited by 10 · see citing works
Self-citationActivation of immune checkpoint OX40 inhibits HBV replication in a mouse model
Zhan, M., Zhong, S., Niu, J., & Gao, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114120 · Cited by 6 · see citing works
Golub, O., Kilgore, J. A., & Dolman, N. J. (2023) · Current Protocols · doi:10.1002/cpz1.754 · Cited by 4 · see citing works
Swain, S. L., Kugler‐Umana, O., & Tonkonogy, S. L. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.701900 · Cited by 3 · see citing works
Self-citationZhan, M., Gao, X., Wang, C., Peng, F., Wang, X., Xu, H., & Niu, J. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i7.1619 · Cited by 2 · see citing works
(2021) · Frontiers research topics · doi:10.3389/978-2-88966-718-5 · Cited by 3 · see citing works
Pattern Recognition Receptors and Aging
Shalaby, K. H. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_8 · Cited by 1 · see citing works
López-Yglesias, A. H. (2014) · ResearchWorks at the University of Washington (University of Washington)
Immune Modulation By Amphiphilic Oligonucleotides
Yu, C. (2019) · Human Biology
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_10
Zhu, Y., Wei, L., Zwygart, A. C., Gaínza, P., Khac, Q. O., Olgiati, F., Kurum, A., Tang, L., Correia, B. E., Tapparel, C., et al. (2024) · Small · doi:10.1002/smll.202307709
Monteiro, F. R., Nardy, A., Paixão, V., do Amaral, J. B., Amirato, G. R., Santos, C. A. F., Furtado, G. E., Rodrigues, F., COELHO, P. M. D. S. C., Santos, J. M. B., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7085263/v1
Mathematical model for immune checkpoint inhibitors with delayed responses
Zheng, C. Y., Rose, D., & Kim, P. (2026) · Mathematical Modelling of Natural Phenomena · doi:10.1051/mmnp/2026004
Ontiveros-Padilla, L. A., Ehrenzeller, S. A., Murphy, C. T., Middleton, D. D., Williamson, G. L., Lopez, A. M., Bachelder, E. M., & Ainslie, K. M. (2026) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2026.100679
Cosentino, L. (2012) · Bradford Scholars (University of Bradford)
- Authors
- Jones, S. C., Brahmakshatriya, V., Huston, G., Dibble, J., & Swain, S. L.
- Affiliations
- Trudeau Institute (US)
- ORCID
- Swain, Susan L
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12-01
- Volume
- 185
- Issue
- 11
- Pages
- 6783-6794
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3375592
- OpenAlex
- W2105541044
- Cited by
- 54
- References
- 69
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01AG021600, R37AG025805, F32AG027641, AG021600, AG025805)
- National Institute of Allergy and Infectious Diseases (P01AI046530)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- TLR agonists, dendritic cells, immunosenescence, interleukin-6, immunoadjuvant, CpG, polyinosinic-polycytidylic acid, Pam3CSK4, antigen-presenting cells, T cell proliferation, T cell survival, Bcl-2, RANTES, costimulatory molecules, MHC class II
- MeSH terms
- Amino Acid Sequence, Animals, Antigen-Presenting Cells, Cell Communication, Cell Survival, Cells, Cultured, Dendritic Cells, Ligands, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, CD4-Positive T-Lymphocytes, Interleukin-6, Resting Phase, Cell Cycle, Cellular Senescence, Coculture Techniques, Cell Proliferation, Toll-Like Receptors, Mice
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