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Cited by 277T-cell and B-cell ImmunologySex and Gender in HealthcareEstrogen and related hormone effects

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The Confluence of Sex Hormones and Aging on Immunity

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Gubbels Bupp, Melanie R., Potluri, Tanvi, Fink, Ashley L., Klein, Sabra L.·2018·Frontiers in Immunology
DOI 10.3389/fimmu.2018.01269PMC PMC5994698
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Abstract

The immune systems of post-pubescent males and females differ significantly with profound consequences to health and disease. In many cases, sex-specific differences in the immune responses of young adults are also apparent in aged men and women. Moreover, as in young adults, aged women develop several late-adult onset autoimmune conditions more frequently than do men, while aged men continue to develop many cancers to a greater extent than aged women. However, sex differences in the immune systems of aged individuals have not been extensively investigated and data addressing the effectiveness of vaccinations and immunotherapies in aged men and women are scarce. In this review, we evaluate age- and sex hormone-related changes to innate and adaptive immunity, with consideration about how this impacts age- and sex-associated changes in the incidence and pathogenesis of autoimmunity and cancer as well as the efficacy of vaccination and cancer immunotherapy. We conclude that future preclinical and clinical studies should consider age and sex to better understand the ways in which these characteristics intersect with immune function and the resulting consequences for autoimmunity, cancer, and therapeutic interventions.

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  • The rate of "inflammaging" is also greater in men, driving a gap in male and female life expectancies.

    “The rate of “inflammaging” is also greater in men [33–35], driving a gap in male and female life expectancies.”

    From Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients (2024) · cites this paper as [33]

    The Introduction (page unavailable) says aged females may be more inflammation-prone than aged males, and the section on age-related innate immunity reports higher inflammatory-protein concentrations in aged females. The paper does say women live longer and that some aspects of adaptive immune aging may progress faster in men, but it does not attribute the life-expectancy gap to a greater rate of inflammaging in men. (LLM, conf=0.84)

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Metadata

Authors
Gubbels Bupp, M. R., Potluri, T., Fink, A. L., & Klein, S. L.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2018-06-04
Volume
9
Pages
1269-1269
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2018.01269
PMC
PMC5994698
OpenAlex
W2806351344
Cited by
277
References
46
Citations by year
2026: 25 · 2025: 26 · 2024: 40 · 2023: 32 · 2022: 41 · 2021: 52 · 2020: 36 · 2019: 20 · 2018: 3
FWCI
2.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Allergy and Infectious Diseases (HHSN272201400007C)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords
sex hormones, aging, sex differences in immunity, innate immunity, adaptive immunity, autoimmune disease, cancer, vaccination efficacy, cancer immunotherapy, menopause
MeSH terms
Aging, Animals, Humans, Immune System, Immunity, Immunity, Innate, Immunologic Surveillance, Sex Factors, Gonadal Steroid Hormones, Autoimmunity, Host-Pathogen Interactions, Adaptive Immunity

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