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Cited by 295

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

Open access
Tate, Michelle D, Deng, Yi-Mo, Jones, Jessica E, Anderson, Gary P, Brooks, Andrew G, Reading, Patrick C·2009·The Journal of Immunology
DOI 10.4049/jimmunol.0902497
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Abstract

The clinical response to influenza infection ranges from mild disease to severe pneumonia and it remains unclear whether the inflammatory response to infection is protective or pathogenic. We have defined a novel role for neutrophils in ameliorating lung injury during influenza infection, thereby limiting development of severe disease. Infection of neutrophil-depleted mice with influenza virus HKx31 (H3N2) led to rapid weight loss, pneumonia, and death. Neutropenia was associated with enhanced virus replication in the respiratory tract; however, viral titers were declining at the time of death, leading us to investigate other factors contributing to mortality. In addition to thymic atrophy, lymphopenia, and viremic spread, depletion of neutrophils led to exacerbated pulmonary inflammation, edema, and respiratory dysfunction. Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease.

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Metadata

Authors
Tate, M. D., Deng, Y.-M., Jones, J. E., Anderson, G. P., Brooks, A. G., & Reading, P. C.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2009-12-01
Volume
183
Issue
11
Pages
7441-7450
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.0902497
OpenAlex
W2103293702
Cited by
295
References
64
FWCI
11.72
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

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