Redox Remodeling by Dendritic Cells Protects Antigen-Specific T Cells against Oxidative Stress
Abstract
Microorganisms and microbial products induce the release of reactive oxygen species (ROS) from monocytes and other myeloid cells, which may trigger dysfunction and apoptosis of adjacent lymphocytes. Therefore, T cell-mediated immunity is likely to comprise mechanisms of T cell protection against ROS-inflicted toxicity. The present study aimed to clarify the dynamics of reduced sulfhydryl groups (thiols) in human T cells after presentation of viral and bacterial Ags by dendritic cells (DCs) or B cells. DCs, but not B cells, efficiently triggered intra- and extracellular thiol expression in T cells with corresponding Ag specificity. After interaction with DCs, the Ag-specific T cells acquired the capacity to neutralize exogenous oxygen radicals and resisted ROS-induced apoptosis. Our results imply that DCs provide Ag-specific T cells with antioxidative thiols during Ag presentation, which suggests a novel aspect of DC/T cell cross-talk of relevance to the maintenance of specific immunity in inflamed or infected tissue.
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Antigen processing and presentation is impaired by oxidative stress.
“For example, antigen processing and presentation is impaired by oxidative stress (Martner et al. 2011; Preynat-Seauve et al. 2003)”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Martner et al. 2011
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- Authors
- Martner, A., Aurelius, J., Rydström, A., Hellstrand, K., & Thorén, F. B.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Martner, Anna
- Aurelius, Johan
- Hellstrand, Kristoffer
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12
- Volume
- 187
- Issue
- 12
- Pages
- 6243-6248
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2129125910
- Cited by
- 20
- References
- 32
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- dendritic cells, antigen-presenting cells, oxidative stress, reactive oxygen species, thiols, antioxidant defense, T cell apoptosis, viral antigens, bacterial antigens, B cells, T cell activation
- MeSH terms
- Cell Communication, Cell Membrane, Cells, Cultured, Cytomegalovirus, Dendritic Cells, Enterotoxins, Humans, Intracellular Fluid, Oxidation-Reduction, Sulfhydryl Compounds, T-Lymphocyte Subsets, Antigen Presentation, Oxidative Stress, CD8-Positive T-Lymphocytes, Coculture Techniques, Epitopes, T-Lymphocyte
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