Antigen-Reactive T Cell Enrichment for Direct, High-Resolution Analysis of the Human Naive and Memory Th Cell Repertoire

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

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BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood

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Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude

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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

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Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes

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Direct access to CD4+ T cells specific for defined antigens according to CD154 expression

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Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities

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Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection

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MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen

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A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

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The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude

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Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

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On the Composition of the Preimmune Repertoire of T Cells Specific for Peptide–Major Histocompatibility Complex Ligands

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Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine 5′′-monophosphate decarboxylase

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Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells

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Enumeration of human antigen–specific naive CD8+ T cells reveals conserved precursor frequencies

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A sensitive method for detecting proliferation of rare autoantigen-specific human T cells

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In vitro methods for generating CD8+ T-cell clones for immunotherapy from the naïve repertoire

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Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire

Kwok, W. W., Tan, V., Gillette, L., Littell, C. T., Soltis, M. A., LaFond, R. E., Yang, J., James, E. A., & DeLong, J. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102190 · Cited by 120 · see citing works

MHC Class II Tetramers

Nepom, G. T. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102398 · Cited by 114 · see citing works

Measurement ofCandida-specific blastogenesis: Comparison of carboxyfluorescein succinimidyl ester labelling of T cells, thymidine incorporation, and CD69 expression

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Ultrasensitive Detection and Phenotyping of CD4+ T Cells with Optimized HLA Class II Tetramer Staining

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Characterization of CD4+ T cell subsets in allergy

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Flow cytometric analysis of vaccine responses: how many colors are enough?

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Mapping T cell epitopes by flow cytometry

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Flow Cytometry

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Identification and isolation of murine antigen‐reactive T cells according to CD154 expression

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Ultra‐sensitive class I tetramer analysis reveals previously undetectable populations of antiviral CD8+ T cells

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Positive selection optimizes the number and function of MHCII-restricted CD4 + T cell clones in the naive polyclonal repertoire

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Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

Sato, T., Ishii, N., Murata, K., Kikuchi, K., Nakagawa, S., Ndhlovu, L. C., & Sugamura, K. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200211)32:11 · Cited by 51 · see citing works

Multiparameter Flow Cytometry Monitoring of T Cell Responses

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Negative Selection and Peptide Chemistry Determine the Size of Naive Foreign Peptide–MHC Class II-Specific CD4+ T Cell Populations

Chu, H., Moon, J. J., Kruse, A. C., Pepper, M., & Jenkins, M. K. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002276 · Cited by 43 · see citing works

Antigen-specific cytometry—New tools arrived!

Thiel, A., Scheffold, A., & Radbruch, A. (2004) · Clinical Immunology · doi:10.1016/j.clim.2003.12.017 · Cited by 41 · see citing works

Flow cytometry and the future of vaccine development

Bolton, D. L., & Roederer, M. (2009) · Expert Review of Vaccines · doi:10.1586/erv.09.41 · Cited by 40 · see citing works

Simultaneous Cytometric Analysis of (Auto)antigen-Reactive T and B Cell Proliferation

Schneider, S. M. (2002) · Immunobiology · doi:10.1078/0171-2985-00196 · Cited by 23 · see citing works

Recent Developments in Flow Cytometry

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Untitled work

Rodriguez-Palmero, M. (1999) · doi:10.1002/(sici)1521-4141(199912)29:12

Identification of preexisting adaptive immunity to Cas9 proteins in humans

Charlesworth, C. T., Deshpande, P. S., Dever, D. P., Camarena, J., Lemgart, V. T., Cromer, M. K., Vakulskas, C. A., Collingwood, M. A., Zhang, L., Bode, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0326-x · Cited by 1,093 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

Meckiff, B. J., Ramírez-Suástegui, C., Fajardo, V., Chee, S., Kusnadi, A., Simon, H. A., Eschweiler, S., Grifoni, A., Pelosi, E., Weiskopf, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.001 · Cited by 564 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Cossarizza, A., Chang, H., Radbruch, A., Akdiş, M., Andrä, I., Annunziato, F., Bächer, P., Barnaba, V., Battistini, L., Bauer, W. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646632 · Cited by 572 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

Bacher, P., Hohnstein, T., Beerbaum, E., Röcker, M., Blango, M. G., Kaufmann, S., Röhmel, J., Eschenhagen, P., Grehn, C., Seidel, K., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.041 · Cited by 473 · see citing works

Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

Hegazy, A. N., West, N. R., Stubbington, M. J. T., Wendt, E., Suijker, K. I. M., Datsi, A., This, S., Danne, C., Campion, S., Duncan, S. H., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.047 · Cited by 338 · see citing works

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

Bacher, P., Heinrich, F., Stervbo, U., Nienen, M., Vahldieck, M., Iwert, C., Vogt, K., Kollet, J., Babel, N., Sawitzki, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.050 · Cited by 319 · see citing works

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

Bacher, P., Rosati, E., Esser, D., Martini, G. R., Saggau, C., Schiminsky, E., Dargvainiene, J., Schröder, I., Wieters, I., Khodamoradi, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.016 · Cited by 314 · see citing works

Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines

Becattini, S., Latorre, D., Mele, F., Foglierini, M., Gregorio, C. D., Cassotta, A., Fernandez, B., Kelderman, S., Schumacher, T. N., Corti, D., et al. (2014) · Science · doi:10.1126/science.1260668 · Cited by 314 · see citing works

Gut Mycobiota in Immunity and Inflammatory Disease

Li, X. V., Leonardi, I., & Iliev, I. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.023 · Cited by 246 · see citing works

Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells

Kusnadi, A., Ramírez-Suástegui, C., Fajardo, V., Chee, S., Meckiff, B. J., Simon, H. A., Pelosi, E., Seumois, G., Ay, F., Vijayanand, P., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abe4782 · Cited by 232 · see citing works

Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma

Seumois, G., Ramírez-Suástegui, C., Schmiedel, B. J., Liang, S. Y., Peters, B., Sette, A., & Vijayanand, P. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba6087 · Cited by 208 · see citing works

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

Wolf, D., Gerhardt, T., Winkels, H., Michel, N. A., Pramod, A. B., Ghosheh, Y., Brunel, S., Buscher, K., Miller, J., McArdle, S., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.042863 · Cited by 164 · see citing works

Flow-cytometric analysis of rare antigen-specific T cells

Bacher, P., & Scheffold, A. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22317 · Cited by 155 · see citing works

Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease

Goel, G., Tye–Din, J. A., Qiao, S., Russell, A. K., Mayassi, T., Ciszewski, C., Sarna, V. K., Wang, S., Goldstein, K. E., Dzuris, J. L., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw7756 · Cited by 131 · see citing works

Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi

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Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease

Martini, G. R., Tikhonova, E., Rosati, E., DeCelie, M. B., Sievers, L. K., Tran, F., Lessing, M., Bergfeld, A., Hinz, S., Nikolaus, S., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02556-5 · Cited by 97 · see citing works

Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn’s Disease

Alexander, K. L., Zhao, Q. S., Reif, M. S., Rosenberg, A. F., Mannon, P., Duck, L. W., & Elson, C. O. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.03.064 · Cited by 96 · see citing works

SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking

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T cells specific for post-translational modifications escape intrathymic tolerance induction

Raposo, B., Merky, P., Lundqvist, C., Yamada, H., Urbonaviciute, V., Niaudet, C., Viljanen, J., Kihlberg, J. O., Kyewski, B., Ekwall, O., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02763-y · Cited by 92 · see citing works

Interleukin-17 in Antifungal Immunity

Sparber, F., & LeibundGut‐Landmann, S. (2019) · Pathogens · doi:10.3390/pathogens8020054 · Cited by 86 · see citing works

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes

Cerosaletti, K. M., Barahmand-pour-Whitman, F., Yang, J., DeBerg, H. A., Dufort, M. J., Murray, S. A., Israelsson, E., Speake, C., Gersuk, V. H., Eddy, J. A., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700172 · Cited by 81 · see citing works

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Renand, A., Cervera-Marzal, I., Gil, L., Dong, C., Garcia, A., Kervagoret, E., Aublé, H., Habes, S., Chevalier, C., Vavasseur, F., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.053 · Cited by 80 · see citing works

Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System

Pilli, D., Zou, A., Tea, F., Dale, R. C., & Brilot, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00652 · Cited by 78 · see citing works

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Saggau, C., Bacher, P., Esser, D., Rasa, M., Meise, S., Mohr, N., Kohlstedt, N., Hutloff, A., Schacht, S.-S., Dargvainiene, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.005 · Cited by 79 · see citing works

Efficient Culture of Human Naive and Memory B Cells for Use as APCs

Su, K., Watanabe, A., Yeh, C., Kelsoe, G. H., & Kuraoka, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502193 · Cited by 75 · see citing works

A Mechanistic, Multiscale Mathematical Model of Immunogenicity for Therapeutic Proteins: Part 1—Theoretical Model

Chen, X., Hickling, T. P., & Vicini, P. (2014) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2014.30 · Cited by 75 · see citing works

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

Rao, A., Strauss, O., Kokkinou, E., Bruchard, M., Tripathi, K. P., Schlums, H., Carrasco, A., Mazzurana, L., Kónya, V., Villablanca, E. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15695-x · Cited by 74 · see citing works

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus <i>Aspergillus fumigatus</i>

Voltersen, V., Blango, M. G., Herrmann, S., Schmidt, F., Heinekamp, T., Strassburger, M., Krüger, T., Bacher, P., Lother, J., Weiss, E., et al. (2018) · mBio · doi:10.1128/mbio.01557-18 · Cited by 71 · see citing works

Pulmonary immune responses against Aspergillus fumigatus are characterized by high frequencies of IL-17 producing T-cells

Jolink, H., de Boer, R., Hombrink, P., Jonkers, R. E., van Dissel, J. T., Falkenburg, J. H. F., & Heemskerk, M. H. M. (2017) · Journal of Infection · doi:10.1016/j.jinf.2016.10.010 · Cited by 65 · see citing works

Identification of Immunogenic Antigens from Aspergillus fumigatus by Direct Multiparameter Characterization of Specific Conventional and Regulatory CD4+ T Cells

Bächer, P., Kniemeyer, O., Teutschbein, J., Thön, M., Vödisch, M., Wartenberg, D., Scharf, D. H., Koester-Eiserfunke, N., Schütte, M., Dübel, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400776 · Cited by 61 · see citing works

Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery

Pogorelyy, M. V., Rosati, E., Minervina, A. A., Mettelman, R. C., Scheffold, A., Franke, A., Bächer, P., & Thomas, P. G. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100697 · Cited by 54 · see citing works

The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy

Bächer, P., & Scheffold, A. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.10.016 · Cited by 54 · see citing works

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

de Groot, R., van Loenen, M. M., Guislain, A., Nicolet, B. P., Heeren, J. J. F., Verhagen, O. J. H. M., van den Heuvel, M. M., de Jong, J., Burger, P., van der Schoot, C. E., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1648170 · Cited by 52 · see citing works

Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response

AlJurayyan, A. N., Puksuriwong, S., Ahmed, M. S., Sharma, R. S., Krishnan, M., Sood, S., Davies, K., Rajashekar, D., Leong, S., McNamara, P. S., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00114-18 · Cited by 51 · see citing works

The renaissance of oral tolerance: merging tradition and new insights

Cerovic, V., Pabst, O., & Mowat, A. M. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01077-7 · Cited by 50 · see citing works

Chronic cat allergen exposure induces a TH2 cell–dependent IgG4 response related to low sensitization

Renand, A., Archila, L. D., McGinty, J. W., Wambre, E. R., Robinson, D. M., Hales, B. J., Thomas, W. R., & Kwok, W. W. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.07.031 · Cited by 47 · see citing works

A Novel HLA–DRB1*10:01–Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis

Chemin, K., Pollastro, S., James, E. A., Ge, C., Albrecht, I., Herrath, J., Gerstner, C., Tandre, K., Rizzi, T. S., Rönnblom, L., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39553 · Cited by 47 · see citing works

Fungus-Specific CD4+ T Cells for Rapid Identification of Invasive Pulmonary Mold Infection

Bächer, P., Steinbach, A., Kniemeyer, O., Hamprecht, A. G., Assenmacher, M., Vehreschild, M. J. G. T., Vehreschild, J. J., Brakhage, A. A., Cornely, O. A., & Scheffold, A. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201407-1235le · Cited by 46 · see citing works

FB5P-seq: FACS-Based 5-Prime End Single-Cell RNA-seq for Integrative Analysis of Transcriptome and Antigen Receptor Repertoire in B and T Cells

Attaf, N., Cervera-Marzal, I., Dong, C., Gil, L., Renand, A., Spinelli, L., & Milpied, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00216 · Cited by 45 · see citing works

The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

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Nuclear antigen–reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys

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New technologies for monitoring human antigen-specific T cells and regulatory T cells by flow-cytometry

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Invasive Pulmonary Fungal Infections in Cystic Fibrosis

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Resolvin E1 Regulates Th17 Function and T Cell Activation

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T cell responses to control fungal infection in an immunological memory lens

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A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussis

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T cell immunity to commensal fungi

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Jug r 2–reactive CD4+ T cells have a dominant immune role in walnut allergy

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TCRs with segment TRAV9‐2 or a CDR3 histidine are overrepresented among nickel‐specific CD4+ T cells

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Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases

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Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies

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Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus

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Emerging Fungal Threats in Cystic Fibrosis

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Decreased inflammatory cytokine production of antigen-specific CD4+ T cells in NMDA receptor encephalitis

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Vaccine-Induced Cellular Immunity against Bordetella pertussis: Harnessing Lessons from Animal and Human Studies to Improve Design and Testing of Novel Pertussis Vaccines

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Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

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Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy

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T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

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Competitive fungal commensalism mitigates candidiasis pathology

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Mould‐reactive T cells for the diagnosis of invasive mould infection—A prospective study

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Bioanalysis of Adeno-Associated Virus Gene Therapy Therapeutics: Regulatory Expectations

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Antigen-specific T cells and autoimmunity

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Analysis of the functional WT 1‐specific T‐cell repertoire in healthy donors reveals a discrepancy between CD 4+ and CD 8+ memory formation

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T-cell epitope discovery and single-cell technologies to advance food allergy research

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Activation-induced surface proteins in the identification of antigen-responsive CD4 T cells

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Fungus-Specific CD4 T Cells as Specific Sensors for Identification of Pulmonary Fungal Infections

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Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

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Editorial: Precision Medicine in Chronic Inflammation

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Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting

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The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology

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Crohn’s Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset

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Anti-fungal T cell responses in the lung and modulation by the gut-lung axis

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Resident memory CD4 + T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction

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Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection—A Prospective Pilot Study

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Identification and characterization of antigen-specific CD4+ T cells targeting renally expressed antigens in human lupus nephritis with two independent methods

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In Vitro Monitoring of Human T Cell Responses to Skin Sensitizing Chemicals—A Systematic Review

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Mycobacterium tuberculosis-specific CD4 T-cell scoring discriminates tuberculosis infection from disease

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Flow Cytometric Characterization of Human Antigen-Reactive T-Helper Cells

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A high-sensitivity detection system for monitoring of rare antigen specific naive and memory T helper cells (58.6)

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Flow Cytometric Characterization of Human Antigen-Reactive T-Helper Cells

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Direct access to CD4+ T cells specific for defined antigens according to CD154 expression

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Flow-cytometric analysis of rare antigen-specific T cells

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On-Chip Activation and Subsequent Detection of Individual Antigen-Specific T Cells

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