The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
IgH Chain Class Switch Recombination: Mechanism and Regulation
Open accessAbstract
IgH class switching occurs rapidly after activation of mature naive B cells, resulting in a switch from expression of IgM and IgD to expression of IgG, IgE, or IgA; this switch improves the ability of Abs to remove the pathogen that induces the humoral immune response. Class switching occurs by a deletional recombination between two switch regions, each of which is associated with a H chain constant region gene. Class switch recombination (CSR) is instigated by activation-induced cytidine deaminase, which converts cytosines in switch regions to uracils. The uracils are subsequently removed by two DNA-repair pathways, resulting in mutations, single-strand DNA breaks, and the double-strand breaks required for CSR. We discuss several aspects of CSR, including how CSR is induced, CSR in B cell progenitors, the roles of transcription and chromosomal looping in CSR, and the roles of certain DNA-repair enzymes in CSR.
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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
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Mechanism and Regulation of Class Switch Recombination
Stavnezer, J., Guikema, J. E. J., & Schrader, C. E. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090248 · Cited by 1,132
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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
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R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
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Li, Y., Jin, L., & Chen, T. (2020) · BioMed Research International · doi:10.1155/2020/2032057 · Cited by 336
Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway
Stinson, B. M., & Loparo, J. J. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-080320-110356 · Cited by 223
Structural principles of B cell antigen receptor assembly
Dong, Y., Pi, X., Bartels-Burgahn, F., Saltukoglu, D., Liang, Z., Yang, J., Alt, F. W., Reth, M., & Wu, H. (2022) · Nature · doi:10.1038/s41586-022-05412-7 · Cited by 82
Zhao, H., Hartono, S. R., de Vera, K. M. F., Yu, Z., Satchi, K., Zhao, T., Sciammas, R., Sanz, L., Chédin, F., & Barlow, J. (2022) · eLife · doi:10.7554/elife.78917 · Cited by 18
Metadata
- Authors
- Stavnezer, J., & Schrader, C. E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-12-01
- Volume
- 193
- Issue
- 11
- Pages
- 5370-5378
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1913397935
- Cited by
- 296
- References
- 123
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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