Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages.

Politis, A D; Ozato, K; Coligan, J E; Vogel, S N

doi:10.4049/jimmunol.152.5.2270

Cited by 62interferon and immune responsesCytokine Signaling Pathways and InteractionsImmune Response and Inflammation

Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages.

Politis, A D, Ozato, K, Coligan, J E, Vogel, S N·1994·The Journal of Immunology

DOI 10.4049/jimmunol.152.5.2270

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Abstract

IFNs are well characterized macrophage-activating agents. Their varied effects are largely mediated via the induction of many genes, whose products act in concert to induce macrophage differentiation. Homologous DNA sequences have been found upstream of the promoter in many of these IFN-inducible genes and bind a family of trans-acting proteins. Interferon consensus sequence binding protein (ICSBP) is one member of this family of interferon regulatory factors (IRF) and is structurally related within the DNA-binding domain to the other members, IRF-1, IRF-2, and ISGF3 gamma. ISCBP mRNA levels become elevated in response to IFN-gamma; however, little is known about the regulation of ICSBP expression at the protein level. In this study, anti-ICSBP peptide Abs were used to quantify and localize ICSBP in murine peritoneal exudate macrophages. Western blot analysis of cytoplasmic and nuclear extracts from treated and control cells revealed ICSBP to be induced by IFN-gamma and not by IFN-alpha and to exist primarily in the nucleus. The regulation of ICSBP induction by IFN-gamma was consistent with the characteristics found at the mRNA level; inhibition by IFN-alpha or glucocorticoids and the requirement for protein kinase C (as determined pharmacologically). The time course of IFN-gamma-induced ICSBP showed an induction of protein that required approximately 12 h to reach maximal levels. Induced ICSBP was relatively stable, exhibiting a half-life of approximately 48 h. Indirect immunofluorescence also demonstrated ICSBP to be an IFN-gamma-inducible protein that is strongly localized to the nucleus.

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ICSBP/IRF-8 is an IFN-γ-inducible transcription factor of the IRF family that regulates transcription through multiple target DNA elements, including ISRE, EICE, and GAS.
“Interferon (IFN) consensus sequence binding protein (ICSBP)/IFN regulatory factor (IRF)-8 is an IFN g -inducible transcription factor of the IRF family and regulates transcription through multiple target DNA elements, such as IFN-stimulated response element (ISRE), Ets/IRF composite element, and IFNg activation site (GAS).”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [11]
ICSBP is expressed in hematopoietic cells, including monocyte/macrophage lineage, B lymphocytes, and activated T lymphocytes, and is inducible by IFN-γ in these cells.
“ICSBP is expressed in the hematopoietic cells, including cells of the monocyte/macrophage lineage, B lymphocytes, and activated T lymphocytes, and is inducible by IFNg in these cells, suggesting its role in immune cells. (6,9-13)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [11]

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Authors: Politis, A. D., Ozato, K., Coligan, J. E., & Vogel, S. N.
Affiliations: Uniformed Services University of the Health Sciences (US)
National Institutes of Health (US)
ORCID: Ozato, K
Vogel, S N
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1994-03-01
Volume: 152
Issue: 5
Pages: 2270-2278
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.152.5.2270
OpenAlex: W1585007907
Cited by: 61
References: 0
Citations by year: 2025: 1 · 2024: 2 · 2021: 2 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 2
FWCI: 1.67
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI-18797)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: IRF8, interferon-gamma, peritoneal macrophages, interferon regulatory factors, nuclear translocation, protein stability, protein kinase C, glucocorticoid inhibition, interferon-alpha, macrophage activation, gene expression regulation
MeSH terms: Interferon Regulatory Factor-8, Amino Acid Sequence, Animals, Antibodies, Carrier Proteins, Cell Nucleus, Female, Fluorescent Antibody Technique, Humans, Interferon-gamma, Mice, Inbred C3H, Molecular Sequence Data, Peptide Fragments, Recombinant Proteins, Repressor Proteins, RNA, Messenger, Macrophages, Peritoneal, Interferon Regulatory Factors, Mice, In Vitro Techniques

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Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages.

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