Regulation of IFN Consensus Sequence Binding Protein Expression in Murine Macrophages
Abstract
Recent work has demonstrated that the transcription factor, IFN consensus sequence binding protein (ICSBP), plays a critical role in the capacity of mice to control infection with Toxoplasma gondii and Leishmania major, agents that require highly activated macrophages for their elimination. In this report the regulation of ICSBP mRNA and protein were analyzed in murine macrophages stimulated with LPS and/or IFN-γ. Like induction of leishmaniacidal activity, LPS and IFN-γ synergize to induce ICSBP mRNA and protein. Deletion analysis of the ICSBP promoter identified regions that were IFN-γ responsive, regions that mediate the ability of LPS and IFN-γ to activate this promoter synergistically, as well as regions that normally repress ICSBP transcription. Finally, exogenous expression of ICSBP, found in previous studies to down-regulate MHC I gene expression, failed to repress basal or IFN-γ-induced ICSBP transcription. This demonstrates that ICSBP can selectively suppress the expression of IFN-responsive genes. These findings extend in a significant way our understanding of the regulation of ICSBP by LPS and IFN-γ and provide important clues as to its role in macrophage activation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ICSBP and IRF-1 levels were enhanced after IFNγ treatment.
“levels of ICSBP and IRF-1 were enhanced after IFN𝛄 treatment (compare -and + input lanes in Fig. 1B), consistent with IFN𝛄 induction of the IRF proteins (22, 53).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [22]
ICSBP is strongly induced in macrophages upon IFNγ stimulation.
“In macrophages ICSBP is strongly induced upon IFN𝛄 stimulation (22).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [22]
TEL recruitment and the resultant transcriptional repression are not likely to be immediate responses to IFNγ but rather delayed events that follow initial activation of transcription.
“Given that TEL recruitment is dependent on ICSBP, whose expression is increased following IFN𝛄 treatment (22), TEL recruitment and the resultant transcriptional repression are not likely to be immediate responses to IFN𝛄 but rather delayed events that follow initial activation of transcription”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [22]
ICSBP/IRF-8 is an IFN-γ-inducible transcription factor of the IRF family that regulates transcription through multiple target DNA elements, including ISRE, EICE, and GAS.
“Interferon (IFN) consensus sequence binding protein (ICSBP)/IFN regulatory factor (IRF)-8 is an IFN g -inducible transcription factor of the IRF family and regulates transcription through multiple target DNA elements, such as IFN-stimulated response element (ISRE), Ets/IRF composite element, and IFNg activation site (GAS).”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [13]
LPS also induces ICSBP, albeit to a lesser degree, and synergizes with IFN-γ in macrophages.
“Lipopolysaccharide (LPS) also induces ICSBP, albeit to a lesser degree, and synergizes with IFNg in macrophages. (13-15)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [13]
ICSBP is expressed in hematopoietic cells, including monocyte/macrophage lineage, B lymphocytes, and activated T lymphocytes, and is inducible by IFN-γ in these cells.
“ICSBP is expressed in the hematopoietic cells, including cells of the monocyte/macrophage lineage, B lymphocytes, and activated T lymphocytes, and is inducible by IFNg in these cells, suggesting its role in immune cells. (6,9-13)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [13]
Cites
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,673 · see citing works
Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179 · see citing works
Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014 · see citing works
Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., & Taniguchi, T. (1988) · Cell · doi:10.1016/s0092-8674(88)91307-4 · Cited by 977 · see citing works
Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., & Taniguchi, T. (1989) · Cell · doi:10.1016/0092-8674(89)90107-4 · Cited by 957 · see citing works
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843 · see citing works
Schindler, C., Fu, X.-Y., Improta, T., Aebersold, R. H., & Darnell, J. E., Jr. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7836 · Cited by 647 · see citing works
Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644 · see citing works
Self-citationLorsbach, R. B., Murphy, W. J., Lowenstein, C. J., Snyder, S. H., & Russell, S. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53940-5 · Cited by 619 · see citing works
Fu, X.-Y., Schindler, C., Improta, T., Aebersold, R. H., & Darnell, J. E., Jr. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7840 · Cited by 532 · see citing works
Friedman, R. L., & Stark, G. R. (1985) · Nature · doi:10.1038/314637a0 · Cited by 491 · see citing works
Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., & Darnell, J. E., Jr. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8555 · Cited by 490 · see citing works
The growing family of interferon regulatory factors
Nguyen, H., Hiscott, J., & Pitha, P. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00019-1 · Cited by 480 · see citing works
Role of interferon regulatory factor 1 in induction of nitric oxide synthase.
Martin, E., Nathan, C. F., & Xie, Q. W. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.977 · Cited by 477 · see citing works
Tanaka, N., Kawakami, T., & Taniguchi, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4531 · Cited by 406 · see citing works
Harada, H., Willison, K. R., Sakakibara, J., Miyamoto, M., Fujita, T., & Taniguchi, T. (1990) · Cell · doi:10.1016/0092-8674(90)90163-9 · Cited by 368 · see citing works
Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W. H., Marks, M. S., Levi, B. Z., Flanagan, J. R., Appella, E., & Ozato, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3743 · Cited by 356 · see citing works
Self-citationPongubala, J. M., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., & Atchison, M. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.368 · Cited by 354 · see citing works
Macrophage Tumor Killing: Influence of the Local Environment
Hibbs, J. B., Taintor, R. R., Chapman, H. A., & Weinberg, J. B. (1977) · Science · doi:10.1126/science.327547 · Cited by 337 · see citing works
Gao, J., Morrison, D. C., Parmely, T. J., Russell, S. W., & Murphy, W. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1226 · Cited by 303 · see citing works
Chemical, Physical, and Biological Properties of a Lipopolysaccharide from Escherichia coli K-235 *
McIntire, F. C., Sievert, H. W., Barlow, G. H., Finley, R. A., & Lee, A. Y. (1967) · Biochemistry · doi:10.1021/bi00860a011 · Cited by 247 · see citing works
Ohmori, Y., & Hamilton, T. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53303-2 · Cited by 245 · see citing works
Reis, L. F. L., Harada, H., Wolchok, J. D., Taniguchi, T., & Vilček, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05041.x · Cited by 243 · see citing works
Brass, A. L., Kehrli, E., Eisenbeis, C. F., Storb, U., & Singh, H. (1996) · Genes & Development · doi:10.1101/gad.10.18.2335 · Cited by 242 · see citing works
Beutler, B., Tkacenko, V., Milsark, I. W., Krochin, N., & Cerami, A. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.5.1791 · Cited by 235 · see citing works
Gao, J., Filla, M. B., Fultz, M. J., Vogel, S. N., Russell, S. W., & Murphy, W. J. (1998) · PubMed · Cited by 225 · see citing works
Self-citationScharton-Kersten, T., Contursi, C., Masumi, A., Sher, A., & Ozato, K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1523 · Cited by 217 · see citing works
Self-citationGao, J., Filla, M. B., Fultz, M. J., Vogel, S. N., Russell, S. W., & Murphy, W. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4803 · Cited by 203 · see citing works
Self-citationLack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid Leukemias
Schmidt, M., Nagel, S., Proba, J., Thiede, C., Ritter, M., Waring, J. F., Rosenbauer, F., Huhn, D., Wittig, B., Horak, I., et al. (1998) · Blood · doi:10.1182/blood.v91.1.22 · Cited by 199 · see citing works
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588 · Cited by 192 · see citing works
Self-citationNelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588-599.1993 · Cited by 192 · see citing works
Self-citationActivation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2
Vaughan, P. S., Aziz, F., van Wijnen, A. J., Wu, S., Harada, H., Taniguchi, T., Soprano, K. J., Stein, J. L., & Stein, G. S. (1995) · Nature · doi:10.1038/377362a0 · Cited by 189 · see citing works
Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma.
Pace, J. L., Russell, S. W., Schreiber, R. D., Altman, A., & Katz, D. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.12.3782 · Cited by 184 · see citing works
Functional characterization of a stable, noncytolytic stage of macrophage activation in tumors.
Russell, S. W., Doe, W. F., & McIntosh, A. T. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.146.6.1511 · Cited by 184 · see citing works
Kanno, Y., Kozak, C. A., Schindler, C., Driggers, P. H., Ennist, D. L., Gleason, S. L., Darnell, J. E., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3951 · Cited by 180 · see citing works
Self-citationEklund, E. A., Jalava, A., & Kakar, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13957 · Cited by 176 · see citing works
Bovolenta, C., Driggers, P. H., Marks, M. S., Medin, J. A., Politis, A. D., Vogel, S. N., Levy, D. E., Sakaguchi, K., Appella, E., & Coligan, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5046 · Cited by 167 · see citing works
Self-citationGiese, N. A., Gabriele, L., Doherty, T. M., Klinman, D. M., Tadesse-Heath, L., Contursi, C., Epstein, S. L., & Morse, H. C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1535 · Cited by 160 · see citing works
Meltzer, M. S. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.1.179 · Cited by 154 · see citing works
Weisz, A., Marx, P., Sharf, R., Appella, E., Driggers, P. H., Ozato, K., & Levi, B. Z. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74081-2 · Cited by 152 · see citing works
Self-citationTanaka, N., Kawakami, T., & Taniguchi, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4531-4538.1993 · Cited by 131 · see citing works
Macrophage-Pathogen Interactions
Zwilling, B. S., & Eisenstein, T. K. (1993) · Medical Entomology and Zoology · Cited by 120 · see citing works
Nelson, N., Kanno, Y., Hong, C., Contursi, C., Fujita, T., Fowlkes, B. J., O’Connell, E., Hu-Li, J., Paul, W. E., Jankovic, D., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3711 · Cited by 110 · see citing works
Self-citationPU.1 Recruits a Second Nuclear Factor to a Site Important for Immunoglobulin κ 3' Enhancer Activity
Pongubala, J. M. R., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., & Atchison, M. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.368-378.1992 · Cited by 105 · see citing works
Sharf, R., Azriel, A., Lejbkowicz, F., Winograd, S. S., Ehrlich, R., & Levi, B.-Z. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13063 · Cited by 100 · see citing works
PU.1 can participate in an active enhancer complex without its transcriptional activation domain
Pongubala, J. M. R., & Atchison, M. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.127 · Cited by 86 · see citing works
Barber, S. A., Fultz, M. J., Salkowski, C. A., & Vogel, S. N. (1995) · Infection and Immunity · doi:10.1128/iai.63.2.601-608.1995 · Cited by 84 · see citing works
Self-citationActivation of transcription factors by interferon-alpha in a cell-free system.
David, M., & Larner, A. (1992) · Science · doi:10.1126/science.1496402 · Cited by 74 · see citing works
Politis, A. D., Sivo, J., Driggers, P. H., Ozato, K., & Vogel, S. N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.3.801 · Cited by 68 · see citing works
Self-citationPolitis, A. D., Ozato, K., Coligan, J. E., & Vogel, S. N. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2270 · Cited by 61 · see citing works
Self-citationHunninghake, G. W., Monks, B. G., Geist, L. J., Monick, M. M., Monroy, M. A., Stinski, M. F., Webb, A. C., Dayer, J. M., Auron, P. E., & Fenton, M. J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3439 · Cited by 59 · see citing works
Self-citationMacrophage activation: a riddle of immunological resistance.
Rm, C., Da, L., Green, S. J., Nacy, C. A., Ah, F., & Meltzer, M. S. (1994) · PubMed · Cited by 44 · see citing works
Buras, J. A., Monks, B. G., & Fenton, M. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.9.4444 · Cited by 39 · see citing works
Self-citationPaclitaxel (Taxol)-Induced Killing ofLeishmania majorin Murine Macrophages
Doherty, T. M., Sher, A., & Vogel, S. N. (1998) · Infection and Immunity · doi:10.1128/iai.66.9.4553-4556.1998 · Cited by 21 · see citing works
Self-citationHunninghake, G. W., Monks, B. G., Geist, L. J., Monick, M. M., Monroy, M. A., Stinski, M. F., Webb, A. C., Dayer, J., Auron, P. E., & Fenton, M. J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3439-3448.1992 · Cited by 19 · see citing works
Self-citationThe molecular biology of macrophage activation.
Paulnock, D. M. (1994) · PubMed · Cited by 18 · see citing works
Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid Leukemias
Schmidt, M., Nagel, S., Proba, J., et al. (1998) · Blood · doi:10.1182/blood.v91.1.22.22_22_29 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Negishi, H., Taniguchi, T., & Yanai, H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028423 · Cited by 447 · see citing works
Xu, H., Zhu, J., Smith, S. M., Foldi, J., Zhao, B., Chung, A. Y., Outtz, H. H., Kitajewski, J., Shi, C., Weber, S., et al. (2012) · Nature Immunology · doi:10.1038/ni.2304 · Cited by 437 · see citing works
Self-citationGrajales‐Reyes, G. E., Iwata, A., Albring, J. C., Wu, X., Tussiwand, R., Wumesh, K. C., Kretzer, N. M., Briseño, C. G., Durai, V., Bagadia, P., et al. (2015) · Nature Immunology · doi:10.1038/ni.3197 · Cited by 398 · see citing works
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis
Zhao, B., Takami, M., Yamada, A., Wang, X., Koga, T., Hu, X., Tamura, T., Ozato, K., Choi, Y., Ivashkiv, L. B., et al. (2009) · Nature Medicine · doi:10.1038/nm.2007 · Cited by 313 · see citing works
Self-citationICSBP Directs Bipotential Myeloid Progenitor Cells to Differentiate into Mature Macrophages
Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T., & Ozato, K. (2000) · Immunity · doi:10.1016/s1074-7613(00)00016-9 · Cited by 305 · see citing works
Self-citationBancerek, J., Poss, Z. C., Steinparzer, I., Sedlyarov, V., Pfaffenwimmer, T., Mikulic, I., Dölken, L., Strobl, B., Müller, M., Taatjes, D. J., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.017 · Cited by 297 · see citing works
Kong, H. J., Anderson, D. E., Lee, C. H., Jang, M. K., Tamura, T., Tailor, P. B., Cho, H. K., Cheong, J., Xiong, H., Morse, H. C., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.26 · Cited by 207 · see citing works
Self-citationWang, I.-M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., & Ozato, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.271 · Cited by 187 · see citing works
Self-citationReview: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells
Tamura, T., & Ozato, K. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452755 · Cited by 183 · see citing works
Self-citationJAK-STAT Signaling Mediates Gangliosides-induced Inflammatory Responses in Brain Microglial Cells
Kim, O. S., Park, E. J., Joe, E.-H., & Jou, I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203885200 · Cited by 158 · see citing works
Meraro, D., Hashmueli, S., Koren, B., Azriel, A., Oumard, A., Kirchhoff, S., Hauser, H., Nagulapalli, S., Atchison, M. L., & Levi, B.-Z. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6468 · Cited by 147 · see citing works
Immune cell-specific amplification of interferon signaling by the IRF-4/8-PU. 1 complex
Kanno, Y., Levi, B.-Z., Tamura, T., & Ozato, K. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.770 · Cited by 128 · see citing works
Self-citationSalem, S., Salem, D., & Gros, P. (2020) · Human Genetics · doi:10.1007/s00439-020-02154-2 · Cited by 124 · see citing works
IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice
Salkowski, C. A., Kopydlowski, K., Blanco, J., Cody, M. J., McNally, R., & Vogel, S. N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1529 · Cited by 119 · see citing works
Self-citationLehtonen, A., Veckman, V., Nikula, T., Lahesmaa, R., Kinnunen, L., Matikainen, S., & Julkunen, I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6570 · Cited by 112 · see citing works
Cyclooxygenase-2 Expression in Macrophages: Modulation by Protein Kinase C-α
Giroux, M., & Descoteaux, A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3985 · Cited by 114 · see citing works
TRIM21 – A potential novel therapeutic target in cancer
Alomari, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105443 · Cited by 110 · see citing works
Marecki, S., Atchison, M. L., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2713 · Cited by 87 · see citing works
Self-citationIRF‐8/ICSBP and IRF‐1 cooperatively stimulate mouse IL‐12 promoter activity in macrophages
Masumi, A., Tamaoki, S., Wang, I., Ozato, K., & Komuro, K. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03556-1 · Cited by 87 · see citing works
Self-citationTsujimura, H., Nagamura‐Inoue, T., Tamura, T., & Ozato, K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1261 · Cited by 82 · see citing works
Self-citationKim, Y.-M., Im, J. Y., Han, S. H., Kang, H. S., & Choi, I. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3198 · Cited by 77 · see citing works
PU.1/Interferon Regulatory Factor Interactions; Mechanisms of Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:33:2:127 · Cited by 74 · see citing works
Self-citationA Role for IFN-αβ in Virus Infection-Induced Sensitization to Endotoxin
Doughty, L., Nguyen, K. B., Durbin, J. E., & Biron, C. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2658 · Cited by 73 · see citing works
Kuwata, T., Gongora, C., Kanno, Y., Sakaguchi, K., Tamura, T., Kanno, T., Basrur, V., Martinez, R., Appella, E., Golub, T., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7439-7448.2002 · Cited by 69 · see citing works
Self-citationReview: The Role of IRF-4 in Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452737 · Cited by 67 · see citing works
Self-citationTargeted in vivo expression of IFN-γ-inducible protein 10 induces specific antitumor activity
Yang, X., Chu, Y., Wang, Y., Zhang, R., & Xiong, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306212 · Cited by 65 · see citing works
Lehtonen, A., Lund, R., Lahesmaa, R., Julkunen, I., Sareneva, T., & Matikainen, S. (2003) · Cytokine · doi:10.1016/j.cyto.2003.07.001 · Cited by 66 · see citing works
Sala, A., He, J., Laricchia‐Robbio, L., Gorini, S., Iwasaki, A., Braun, M., Yap, G. S., Sher, A., Ozato, K., & Kelsall, B. L. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20080912 · Cited by 55 · see citing works
Self-citationEnhancement of Th1/Th17 inflammation by TRIM21 in Behçet’s disease
Ahn, Y., Hwang, J., Zheng, Z., Bang, D., & Kim, D. Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-03251-5 · Cited by 54 · see citing works
Cramer, L. A., Nelson, S. L., & Klemsz, M. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3190 · Cited by 52 · see citing works
PU.1 and ICSBP control constitutive and IFN-γ-regulatedTlr9gene expression in mouse macrophages
Schroder, K., Lichtinger, M., Irvine, K. M., Brion, K., Trieu, A., Ross, I. L., Ravasi, T., Stacey, K. J., Rehli, M., Hume, D. A., et al. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0107036 · Cited by 51 · see citing works
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity
Lukas, D., Yogev, N., Kel, J. M., Regen, T., Mufazalov, I. A., Tang, Y., Wanke, F., Reizis, B., Müller, W., Kurschus, F. C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615065114 · Cited by 45 · see citing works
Zhu, C., Saberwal, G., Lu, Y., Platanias, L. C., & Eklund, E. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405736200 · Cited by 45 · see citing works
Cohen, H., Azriel, A., Cohen, T., Meraro, D., Hashmueli, S., Bech-Otschir, D., Kraft, R., Dubiel, W., & Levi, B.-Z. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004900200 · Cited by 45 · see citing works
Xiong, H., Li, H., Kong, H. J., Chen, Y., Zhao, J., Xiong, S., Huang, B., Gu, H., Mayer, L., Ozato, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414296200 · Cited by 44 · see citing works
Self-citationKiyomiya, H., Ariyoshi, W., Okinaga, T., Kaneuji, T., Mitsugi, S., Sakurai, T., Habu, M., Yoshioka, I., Tominaga, K., & Nishihara, T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.033 · Cited by 42 · see citing works
Alter-Koltunoff, M., Ehrlich, S., Dror, N., Azriel, A., Eilers, M., Häuser, H., Bowen, H., Barton, C. H., Tamura, T., Ozato, K., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307954200 · Cited by 41 · see citing works
Self-citationHein, J., Kempf, V. A. J., Diebold, J., Bücheler, N., Preger, S., Horak, I., Sing, A., Kramer, U., & Autenrieth, I. B. (2000) · Infection and Immunity · doi:10.1128/iai.68.3.1408-1417.2000 · Cited by 39 · see citing works
Ivashkiv, L. B., Zhao, B., Park‐Min, K., & Takami, M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06217.x · Cited by 35 · see citing works
IFN regulatory factor–8 expression in macrophages governs an antimetastatic program
Twum, D. Y. F., Colligan, S. H., Hoffend, N. C., Katsuta, E., Gomez, E. C., Hensen, M. L., Seshadri, M., Nemeth, M. J., & Abrams, S. I. (2019) · JCI Insight · doi:10.1172/jci.insight.124267 · Cited by 28 · see citing works
León, B. (2025) · Trends in Immunology · doi:10.1016/j.it.2024.12.005 · Cited by 21 · see citing works
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer
Wen, P., Wang, H., Li, Y., Sui, X., Hou, Z., Guo, X., Xue, W., Liu, D.-H., Wang, Y., & Gao, J. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00984-3 · Cited by 20 · see citing works
Korczeniewska, J., & Barnes, B. J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00802-12 · Cited by 21 · see citing works
RetractedTakahashi, K., Sugiyama, T., Tokoro, S., Neri, P., & Mori, H. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.11.004 · Cited by 21 · see citing works
Zhu, X., Chang, M. S., Hsueh, R. C., Taussig, R., Smith, K. D., Simon, M. I., & Choi, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4299 · Cited by 19 · see citing works
Kallies, A., Rosenbauer, F., Scheller, M., Knobeloch, K., & Horak, I. D. (2002) · Blood · doi:10.1182/blood.v99.9.3213 · Cited by 18 · see citing works
Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias
Koenigsmann, J., Rudolph, C., Sander, S., Kershaw, O., Gruber, A. D., Bullinger, L., Schlegelberger, B., & Carstanjen, D. (2009) · Blood · doi:10.1182/blood-2008-05-158485 · Cited by 17 · see citing works
Cao, J., Wang, S., Wei, C., Lin, H., Zhang, C., Gao, Y., Xu, Z., Cheng, Z., Sun, W., & Wang, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107137 · Cited by 10 · see citing works
Bradford, M. A., Schroeder, A., Morse, H. C., Vogel, S. N., & Cowdery, J. S. (2002) · Journal of Biomedical Science · doi:10.1007/bf02254997 · Cited by 10 · see citing works
Self-citationEl género Brucella y su interacción con el sistema mononuclear fagocítico
Aréstegui, M. B., Gualtieri, S. C., Domı́nguez, J., & Scharovsky, O. G. (2001) · Americanae (AECID Library) · Cited by 9 · see citing works
Korczeniewska, J., & Barnes, B. J. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00493-17 · Cited by 7 · see citing works
The Making of a cDC1 : Precision Programming of Progenitor Potential
Murphy, T. L., & MURPHY, K. M. M. (2025) · Immunological Reviews · doi:10.1111/imr.70081 · Cited by 7 · see citing works
Loss of Irf8 does not co-operate with overexpression of BCL-2 in the induction of leukemiasin vivo
Koenigsmann, J., & Carstanjen, D. (2009) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190903296913 · Cited by 5 · see citing works
Sun, H., Li, C. L., Lei, Y., Wang, Y., Li, B., & Ye, J. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110426 · Cited by 4 · see citing works
Watanabe, M., Yasunaga, J., Hussein, O., Tanaka, A., Shichijo, T., Izaki, M., Okamoto, Y., Komohara, Y., & Matsuoka, M. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0306 · Cited by 2 · see citing works
Mechanisms of Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2000) · Cited by 2 · see citing works
Self-citationKim, S. K., Liu, T., Ou, F., Murphy, T. L., & MURPHY, K. M. M. (2024) · Advances in immunology · doi:10.1016/bs.ai.2024.08.001 · Cited by 1 · see citing works
Expression and activation of STAT and IRF family transcription factors in mononuclear leukocytes
Lehtonen, A. (2005) · Työväentutkimus Vuosikirja
TUMOR-BEARING HOST MACROPHAGE DYSFUNCTION: ROLE OF
Martins, R. S. (2001)
The role of Batf2 in LPS/IFNgamma polarized macrophages
Gehman, M. (2015) · UKnowledge (University of Kentucky)
Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions
Martins, R. S. (2001) · VTechWorks (Virginia Tech)
- Authors
- Kantakamalakul, W., Politis, A. D., Marecki, S., Sullivan, T., Ozato, K., Fenton, M. J., & Vogel, S. N.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- Boston University (US)
- National Institutes of Health (US)
- Corresponding author
- Kantakamalakul, Wannee
- Sullivan, Teri
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-06
- Volume
- 162
- Issue
- 12
- Pages
- 7417-7425
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1545447189
- Cited by
- 61
- References
- 54
- Citations by year
- 2025: 4 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 3 · 2013: 1 · 2012: 2
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm057053-04)
- National Institute of General Medical Sciences (GM57053)
- National Institute of Allergy and Infectious Diseases (AI-18797)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- IRF8, macrophages, macrophage activation, LPS, interferon-gamma, transcriptional regulation, promoter analysis, synergistic gene induction, MHC class I expression, Toxoplasma gondii, Leishmania major, innate immunity
- MeSH terms
- Interferon Regulatory Factor-8, Proto-Oncogene Protein Spi-1, Animals, Cell Line, DNA-Binding Proteins, Drug Synergism, Female, Gene Expression Regulation, Interferon-gamma, Lipopolysaccharides, Mice, Inbred C3H, Phosphoproteins, Promoter Regions, Genetic, Proto-Oncogene Proteins, Repressor Proteins, RNA, Messenger, Protein Biosynthesis, Trans-Activators, Consensus Sequence, Sequence Deletion, Macrophages, Peritoneal, Interferon Regulatory Factors, Interferon Regulatory Factor-1, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
