IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF- beta and IL-4, and is inhibited by IFN-gamma.

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,263

The immunology of asthma

Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., & Stockinger, B. (2008) · Nature Immunology · doi:10.1038/ni.1659 · Cited by 1,213

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

Liao, W., Lin, J., & Leonard, W. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.004 · Cited by 1,107

Biology and regulation of IL-2: from molecular mechanisms to human therapy

Spolski, R., Li, P., & Leonard, W. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0046-y · Cited by 637

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577

Heterogeneity and plasticity of T helper cells

Zhu, J., & Paul, W. E. (2009) · Cell Research · doi:10.1038/cr.2009.138 · Cited by 592

Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells

Staudt, V., Bothur, E., Klein, M., Lingnau, K., Reuter, S., Grebe, N., Gerlitzki, B., Hoffmann, M., Ulges, A., Taube, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.014 · Cited by 554

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

Knochelmann, H. M., Dwyer, C. J., Bailey, S. R., Amaya, S. M., Elston, D. M., Mazza-McCrann, J. M., & Paulos, C. M. (2018) · Cellular & Molecular Immunology · doi:10.1038/s41423-018-0004-4 · Cited by 535

Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells

Purwar, R., Schlapbach, C., Xiao, S., Kang, H. S., Elyaman, W., Jiang, X., Jetten, A. M., Khoury, S. J., Fuhlbrigge, R. C., Kuchroo, V. K., et al. (2012) · Nature Medicine · doi:10.1038/nm.2856 · Cited by 442

A Brief History of IL-9

Goswami, R., & Kaplan, M. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003049 · Cited by 414

IL-9 as a mediator of Th17-driven inflammatory disease

Nowak, E. C., Weaver, C. T., Turner, H., Begum-Haque, S., Becher, B., Schreiner, B., Coyle, A. J., Kasper, L. H., & Noelle, R. J. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090246 · Cited by 393

The development and in vivo function of T helper 9 cells

Kaplan, M. H., Hufford, M. M., & Olson, M. R. (2015) · Nature Reviews Immunology · doi:10.1038/nri3824 · Cited by 384

New insights into the role of cytokines in asthma

Renauld, J. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.8.577 · Cited by 384

Th9 cells promote antitumor immune responses in vivo

Lu, Y., Hong, S., Li, H., Park, J., Hong, B., Wang, L., Zheng, Y., Liu, Z., Xu, J., He, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65459 · Cited by 361

Heterogeneity of Human CD4 + T Cells Against Microbes

Sallusto, F. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112056 · Cited by 336

Endotoxin exposure in allergy and asthma: Reconciling a paradox

Liu, A. H. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.122157 · Cited by 330

Th9 cells: differentiation and disease

Kaplan, M. H. (2013) · Immunological Reviews · doi:10.1111/imr.12028 · Cited by 340

Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE

Liu, Y., Teige, I., Birnir, B., & Issazadeh‐Navikas, S. (2006) · Nature Medicine · doi:10.1038/nm1402 · Cited by 302

Cellular sources and immune functions of interleukin-9

Noelle, R. J., & Nowak, E. C. (2010) · Nature reviews. Immunology · doi:10.1038/nri2848 · Cited by 312

TGF-β Regulation of T Cells

Chen, W. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-045939 · Cited by 292

Regulation of human helper T cell subset differentiation by cytokines

Schmitt, N., & Ueno, H. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.03.007 · Cited by 261

Lineage-specific Effects of 1,25-Dihydroxyvitamin D3 on the Development of Effector CD4 T Cells

Palmer, M. T., Lee, Y. K., Maynard, C. L., Oliver, J. R., Bikle, D. D., Jetten, A. M., & Weaver, C. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.163790 · Cited by 243

STAT6-dependent regulation of Th9 development

Goswami, R., Jabeen, R., Yagi, R., Pham, D., Zhu, J., Goenka, S., & Kaplan, M. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102840 · Cited by 240

OX40 signaling favors the induction of TH9 cells and airway inflammation

Xiao, X., Balasubramanian, S., Liu, W., Chu, X., Wang, H., Taparowsky, E. J., Fu, Y., Choi, Y., Walsh, M. C., & Li, X. C. (2012) · Nature Immunology · doi:10.1038/ni.2390 · Cited by 233

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

Végran, F., Berger, H., Boidot, R., Mignot, G., Bruchard, M., Dosset, M., Chalmin, F., Rébé, C., Dérangère, V., Ryffel, B., et al. (2014) · Nature Immunology · doi:10.1038/ni.2925 · Cited by 228

Regulation of IL-9 expression by IL-25 signaling

Angkasekwinai, P., Chang, S. H., Thapa, M., Watarai, H., & Dong, C. (2010) · Nature Immunology · doi:10.1038/ni.1846 · Cited by 234

Th9 and allergic disease

Soroosh, P., & Doherty, T. A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03114.x · Cited by 226

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

Licona-Limón, P., Henao‐Mejia, J., Temann, U.-A., Gagliani, N., Licona‐Limón, I., Ishigame, H., Hao, L., Herbert, D. R., & Flavell, R. A. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.020 · Cited by 231

Interleukin‐4 and Interferon‐γ: The Quintessence of a Mutual Antagonistic Relationship

Paludan (1998) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1998.00435.x · Cited by 219

The Common Cytokine Receptor γ Chain Family of CytokinesPreprint

Lin, J., & Leonard, W. J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028449 · Cited by 215

Human T H 9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity

Schlapbach, C., Gehad, A. E., Yang, C., Watanabe, R., Guenova, E., Teague, J. E., Campbell, L., Yawalkar, N., Kupper, T. S., & Clark, R. A. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007828 · Cited by 214

Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4 + T Cells

Wang, Y., Bi, Y., Chen, X., Li, C., Li, Y., Zhang, Z., Wang, J., Lu, Y., Yu, Q., Su, H., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.009 · Cited by 206

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

Johnston, C. J. C., Smyth, D. J., Kodali, R. B., White, M. P. J., Harcus, Y., Filbey, K. J., Hewitson, J. P., Hinck, C. S., Ivens, A., Kemter, A. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01886-6 · Cited by 197

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

Saresella, M., Calabrese, E., Marventano, I., Piancone, F., Gatti, A. V., Alberoni, M., Nemni, R., & Clerici, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.004 · Cited by 194

Th9 cells, new players in adaptive immunity

Schmitt, E., Klein, M., & Bopp, T. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.004 · Cited by 201

Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

Yao, W., Zhang, Y., Jabeen, R., Nguyen, E., Wilkes, D. S., Tepper, R. S., Kaplan, M. H., & Zhou, B. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.007 · Cited by 185

Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells

Elyaman, W., Bassil, R., Bradshaw, E. M., Orent, W., Lahoud, Y., Zhu, B., Radtke, F., Yagita∥, H., & Khoury, S. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.020 · Cited by 175

TGF-β Induces IL-9 Production from Human Th17 Cells

Bériou, G., Bradshaw, E. M., Lozano, E., Costantino, C. M., Hastings, W. D., Orban, T., Elyaman, W., Khoury, S. J., Kuchroo, V. K., Baecher‐Allan, C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000356 · Cited by 176

The mucosal immune system in the oral cavity—an orchestra of T cell diversity

Wu, R.-Q., Zhang, D.-F., Tu, E., Chen, Q.-M., & Chen, W. (2014) · International Journal of Oral Science · doi:10.1038/ijos.2014.48 · Cited by 171

Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis

Singh, T. P., Schön, M. P., Wallbrecht, K., Gruber‐Wackernagel, A., Wang, X., & Wolf, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051752 · Cited by 170

Th9 and other IL-9-producing cells in allergic asthma

Koch, S., Sopel, N., & Finotto, S. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0601-1 · Cited by 162

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

Liao, W., Spolski, R. J., Li, P., Du, N., West, E. E., Ren, M., Mitra, S., & Leonard, W. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301138111 · Cited by 160

Interleukin-9 Enhances Resistance to the Intestinal NematodeTrichuris muris

Faulkner, H., Renauld, J., Snick, J. V., & Grencis, R. K. (1998) · Infection and Immunity · doi:10.1128/iai.66.8.3832-3840.1998 · Cited by 151

Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes

Erpenbeck, V. J., Hohlfeld, J. M., Volkmann, B., Hagenberg, A., Geldmacher, H., Braun, A., & Krug, N. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1485 · Cited by 145

In Activated Mast Cells, IL-1 Up-Regulates the Production of Several Th2-Related Cytokines Including IL-9

Hültner, L., Kölsch, S., Stassen, M., Kaspers, U., Kremer, J.-P., Mailhammer, R., Moeller, J., Broszeit, H., & Schmitt, E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5556 · Cited by 145

Cytokine gene expression profiles during initiation, progression and resolution of periodontitis

Ebersole, J. L., Kirakodu, S. S., Novak, M. J., Stromberg, A. J., Shen, S., Orraca, L., González‐Martínez, J., Burgos, A. G., & González, O. A. (2014) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12286 · Cited by 150

Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells

Zhao, Y., Chu, X., Chen, J., Wang, Y., Gao, S., Jiang, Y., Zhu, X., Tan, G., Zhao, W., Yi, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12368 · Cited by 147

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

Yang, X. O., Zhang, H., Kim, B. S., Niu, X., Peng, J., Chen, Y., Kerketta, R., Lee, Y., Chang, S. H., Corry, D. B., et al. (2013) · Nature Immunology · doi:10.1038/ni.2633 · Cited by 138

Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

Chmelař, J., Kotál, J., Langhansová, H., & Kotsyfakis, M. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00216 · Cited by 131

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

Jones, D. M., Read, K. A., & Oestreich, K. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000612 · Cited by 136

Interleukin 9 and its Receptor: An Overview of Structure and Function

Demoulin, J., & Renauld, J. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043001 · Cited by 131

Cytokines and effector T cell subsets causing autoimmune CNS disease

Petermann, F., & Korn, T. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.064 · Cited by 134

Neutralization of IL-9 Ameliorates Experimental Autoimmune Encephalomyelitis by Decreasing the Effector T Cell Population

Li, H., Nourbakhsh, B., Ćirić, B., Zhang, G., & Rostami, A. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000986 · Cited by 125

IL-9-producing T cells: potential players in allergy and cancer

Angkasekwinai, P., & Dong, C. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0396-0 · Cited by 121

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., Lou, N., Hussain, R., & Nedergaard, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20424-y · Cited by 134

Murine Bone Marrow-Derived Mast Cells as Potent Producers of IL-9: Costimulatory Function of IL-10 and kit Ligand in the Presence of IL-1

Stassen, M., Arnold, M., Hültner, L., Müller, C., Neudörfl, C., Reineke, T., & Schmitt, E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5549 · Cited by 121

Complex interactions of transcription factors in mediating cytokine biology in T cells

Li, P., Spolski, R. J., Liao, W., & Leonard, W. J. (2014) · Immunological Reviews · doi:10.1111/imr.12199 · Cited by 124

Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis

Ma, L., Xue, H.-B., Guan, X.-H., Shu, C.-M., Zhang, J. ‐., & Yu, J. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12198 · Cited by 115

Autoimmunity: increasing suspects in the CD4+ T cell lineup

Palmer, M. T., & Weaver, C. T. (2009) · Nature Immunology · doi:10.1038/ni.1802 · Cited by 117

The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells

Richard, A. C., Tan, C., Hawley, E., Gómez‐Rodríguez, J., Goswami, R., Yang, X., Cruz, A. C., Penumetcha, P., Hayes, E. T., Pelletier, M., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401220 · Cited by 112

From interleukin‐9 to T helper 9 cells

Stassen, M., Schmitt, E., & Bopp, T. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06351.x · Cited by 111

The symphony of the ninth: the development and function of Th9 cells

Jabeen, R., & Kaplan, M. H. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.02.001 · Cited by 112

IL-4: an important cytokine in determining the fate of T cells

Silva‐Filho, J. L., Caruso‐Neves, C., & Pinheiro, A. A. S. (2014) · Biophysical Reviews · doi:10.1007/s12551-013-0133-z · Cited by 111

Smad2/3 and IRF4 Play a Cooperative Role in IL-9–Producing T Cell Induction

Tamiya, T., Ichiyama, K., Kotani, H., Fukaya, T., Sekiya, T., Shichita, T., Honma, K., Yui, K., Matsuyama, T., Nakao, T., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301276 · Cited by 112

IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling

Xue, G., Jin, G., Fang, J., & Lu, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-09401-9 · Cited by 108

Role of IL-9 in the pathophysiology of allergic diseases

GOUNNI, A. S., Kontolemos, M., & Hamid, Q. A. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.114238 · Cited by 105

Th9 cells and IL-9 in autoimmune disorders: Pathogenesis and therapeutic potentials

Deng, Y., Wang, Z., Chang, C., Lu, L., Lau, C. S., & Lu, Q. (2016) · Human Immunology · doi:10.1016/j.humimm.2016.12.010 · Cited by 110

IL-33 Induces IL-9 Production in Human CD4+ T Cells and Basophils

Blom, L. H., Poulsen, B. C., Jensen, B. M., Hansen, A., & Poulsen, L. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021695 · Cited by 102

Nine lives: plasticity among T helper cell subsets

Locksley, R. M. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091442 · Cited by 103

Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity

Kerzerho, J., Maazi, H., Speak, A. O., Szely, N., Lombardi, V., Khoo, B., Geryak, S., Lam, J., Soroosh, P., Snick, J. V., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.09.027 · Cited by 101

IL-36γ signaling controls the induced regulatory T cell–Th9 cell balance via NFκB activation and STAT transcription factors

Harusato, A., Abo, H., Ngo, V. L., Yi, S. W., Mitsutake, K., Osuka, S., Kohlmeier, J. E., Li, J., Gewirtz, A. T., Nusrat, A., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.21 · Cited by 104

Differential Regulatory Capacity of CD25+ T Regulatory Cells and Preactivated CD25+ T Regulatory Cells on Development, Functional Activation, and Proliferation of Th2 Cells

Stassen, M., Jonuleit, H., Müller, C., Klein, M., Richter, C., Bopp, T., Schmitt, S., & Schmitt, E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.267 · Cited by 98

Th9 cells in the pathogenesis of EAE and multiple sclerosis

Elyaman, W., & Khoury, S. J. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0604-y · Cited by 95

IL-9 in Allergic Inflammation

Hauber, H.-P., Bergeron, C., & Hamid, Q. (2004) · International Archives of Allergy and Immunology · doi:10.1159/000078384 · Cited by 90

IL-9 and Th9 cells in health and diseases—From tolerance to immunopathology

Li, J., Chen, S., Xiao, X., Zhao, Y. L., Ding, W., & Li, X. C. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.07.004 · Cited by 92

TH9 cells in anti-tumor immunity

Vargas, T. R., Humblin, É., Végran, F., Ghiringhelli, F., & Apétoh, L. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0599-4 · Cited by 88

Transcriptional and epigenetic networks of helper T and innate lymphoid cells

Shih, H., Sciumè, G., Poholek, A. C., Vahedi, G., Hirahara, K., Villarino, A. V., Bonelli, M. M., Bosselut, R., Kanno, Y., Muljo, S. A., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12208 · Cited by 91

SMAD regulatory networks construct a balanced immune system

Malhotra, N., & Kang, J. (2013) · Immunology · doi:10.1111/imm.12076 · Cited by 92

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

Gómez‐Rodríguez, J., Meylan, F., Handon, R., Hayes, E. T., Anderson, S. M., Kirby, M., Siegel, R. M., & Schwartzberg, P. L. (2016) · Nature Communications · doi:10.1038/ncomms10857 · Cited by 84

Tc9 cells, a new subset of CD8+ T cells, support Th2‐mediated airway inflammation

Visekruna, A., Ritter, J., Scholz, T., Campos, L., Guralnik, A., Poncette, L., Raifer, H., Hagner, S., Garn, H., Staudt, V., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242825 · Cited by 83

Regulating Il9 transcription in T helper cells

Perumal, N. B., & Kaplan, M. H. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.01.006 · Cited by 87

IL-9 Induces VEGF Secretion from Human Mast Cells and IL-9/IL-9 Receptor Genes Are Overexpressed in Atopic Dermatitis

Sismanopoulos, N., Delivanis, D. A., Alysandratos, K., Angelidou, A., Vasiadi, M., Therianou, A., & Theoharides, T. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033271 · Cited by 82

Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease

Zheng, H., Zhang, X., Castillo, E. F., Luo, Y., Liu, M., & Yang, X. O. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.743187 · Cited by 82

The transcription factor network in Th9 cells

Kaplan, M. H. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0600-2 · Cited by 84

The DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells

Nakatsukasa, H., Zhang, D., Maruyama, T., Chen, H., Cui, K., Ishikawa, M., Deng, L., Zanvit, P., Tu, E., Jin, W., et al. (2015) · Nature Immunology · doi:10.1038/ni.3252 · Cited by 80

Cutting Edge: Smad2 and Smad4 Regulate TGF-β–Mediated Il9 Gene Expression via EZH2 Displacement

Wang, A., Pan, D., Lee, Y., Martínez, G., Feng, X., & Dong, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300433 · Cited by 80

Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain

Donninelli, G., Saraf‐Sinik, I., Mazziotti, V., Capone, A., Grasso, M. G., Battistini, L., Reynolds, R., Magliozzi, R., & Volpe, E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01770-z · Cited by 79

IL-9: Basic Biology, Signaling Pathways in CD4+ T Cells and Implications for Autoimmunity

Li, H., & Rostami, A. M. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9186-y · Cited by 77

Human Vδ2 T cells are a major source of interleukin-9

Peters, C., Häsler, R., Wesch, D., & Kabelitz, D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607136113 · Cited by 82

The many lives of IL-9: a question of survival?

Wilhelm, C., Turner, J., Snick, J. V., & Stockinger, B. (2012) · Nature Immunology · doi:10.1038/ni.2303 · Cited by 77

IL-9, a local growth factor for synovial T cells in inflammatory arthritis

Kundu‐Raychaudhuri, S., Abria, C. J., & Raychaudhuri, S. P. (2016) · Cytokine · doi:10.1016/j.cyto.2015.12.020 · Cited by 72

The Unique Features of Th9 Cells and their Products

Tan, C., & Gery, I. (2012) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v32.i1.10 · Cited by 72

The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator

Richard, A. C., Ferdinand, J. R., Meylan, F., Hayes, E. T., Gabay, O., & Siegel, R. M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0315-095r · Cited by 72

Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation

Xiao, X., Fan, Y., Li, J., Zhang, X., Lou, X., Dou, Y., Shi, X., Lan, P., Xiao, Y., Minze, L. J., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20170928 · Cited by 71

EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells

Roy, S., Rizvi, Z. A., Clarke, A. J., Macdonald, F., Pandey, A., Zaiss, D. M. W., Simon, A. K., & Awasthi, A. (2021) · Nature Communications · doi:10.1038/s41467-021-23042-x · Cited by 69

Nitric oxide enhances Th9 cell differentiation and airway inflammation

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Transforming growth factor-β inhibits IL-4 and IFN-γ production by stimulated human T cells

Hotter, W., Kalthoff, F., Pickl, W. F., Ebner, C., Majdic, O., Kraft, D., & Knapp, W. (1994) · International Immunology · doi:10.1093/intimm/6.3.469 · Cited by 34

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