The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Leptin-Deficient Mice Exhibit Impaired Host Defense in Gram-Negative Pneumonia
Abstract
Leptin is an adipocyte-derived hormone that is secreted in correlation with total body lipid stores. Serum leptin levels are lowered by the loss of body fat mass that would accompany starvation and malnutrition. Recently, leptin has been shown to modulate innate immune responses such as macrophage phagocytosis and cytokine synthesis in vitro. To determine whether leptin plays a role in the innate host response against Gram-negative pneumonia in vivo, we compared the responses of leptin-deficient and wild-type mice following an intratracheal challenge of Klebsiella pneumoniae. Following K. pneumoniae administration, we observed increased leptin levels in serum, bronchoalveolar lavage fluid, and whole lung homogenates. In a survival study, leptin-deficient mice, as compared with wild-type mice, exhibited increased mortality following K. pneumoniae administration. The increased susceptibility to K. pneumoniae in the leptin-deficient mice was associated with reduced bacterial clearance and defective alveolar macrophage phagocytosis in vitro. The exogenous addition of very high levels of leptin (500 ng/ml) restored the defect in alveolar macrophage phagocytosis of K. pneumoniae in vitro. While there were no differences between wild-type and leptin-deficient mice in lung homogenate cytokines TNF-α, IL-12, or macrophage-inflammatory protein-2 after K. pneumoniae administration, leukotriene synthesis in lung macrophages from leptin-deficient mice was reduced. Leukotriene production was restored by the addition of exogenous leptin (500 ng/ml) to macrophages in vitro. This study demonstrates for the first time that leptin-deficient mice display impaired host defense in bacterial pneumonia that may be due to a defect in alveolar macrophage phagocytosis and leukotriene synthesis.
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Leptin in Human Physiology and Pathophysiology
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Leptin and hyperleptinemia - from friend to foe for cardiovascular function
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Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines
Zhao, Y., Sun, R., You, L., Gao, C., & Tian, Z. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02838-3 · Cited by 229
Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice
Dong, F., Zhang, X., Yang, X., Esberg, L. B., Yang, H., Zhang, Z., Culver, B., & Ren, J. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06241 · Cited by 155
Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation
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Metadata
- Authors
- Mancuso, P., Gottschalk, A., Phare, S. M., Peters-Golden, M., Lukacs, N. W., & Huffnagle, G. B.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04
- Volume
- 168
- Issue
- 8
- Pages
- 4018-4024
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1485601868
- Cited by
- 359
- References
- 3
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- closed
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