The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells
Open accessAbstract
The early involvement of marginal zone (MZ) B lymphocytes in T-independent immune responses is well established. In this study we compared the abilities of MZ and follicular (FO) B cells to collaborate with T cells. After immunization with soluble hen egg lysozyme, both MZ and FO B cells captured Ag and migrated to T cell areas in the response to hen egg lysozyme. MZ B cells were far superior to FO B cells in inducing CD4+ T cell expansion both in vitro and in vivo. MZ, but not FO, B cells, after interaction with T cells, differentiated into plasma cells, and in addition they stimulated Ag-specific CD4+ T cells to produce high levels of Th1-like cytokines upon primary stimulation in vitro. These results indicate that MZ B cells rapidly and effectively capture soluble Ag and activate CD4+ T cells to become effector T cells. The enhanced capacity of MZ B cells to prime T cells in this study appeared to be intrinsic to MZ B cells, as both MZ and FO B cell populations express an identical Ag receptor.
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Cites
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Cited by
Thien, M., Phan, T. G., Gardam, S., Amesbury, M., Basten, A., Mackay, F., & Brink, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.010 · Cited by 746
Allman, D., & Pillai, S. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.014 · Cited by 536
Hoffman, W., Lakkis, F. G., & Chalasani, G. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09430915 · Cited by 482
Pillai, S., Cariappa, A., & Moran, S. T. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115728 · Cited by 466
Marginal Zone B-Cells, a Gatekeeper of Innate Immunity
Zouali, M., & Richard, Y. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00063 · Cited by 112
Metadata
- Authors
- Attanavanich, K., & Kearney, J. F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01
- Volume
- 172
- Issue
- 2
- Pages
- 803-811
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1526178344
- Cited by
- 276
- References
- 82
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Attanavanich, K., & Kearney, J. F. (2004). Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.172.2.803
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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