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Cited by 271

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death

Zhang, Huang-Ge, Liu, Cunren, Su, Kaihun, Yu, Shaohua, Zhang, Liming, Zhang, Shuangqin, Wang, Jianhua, Cao, Xu, Grizzle, William, Kimberly, Robert P·2006·The Journal of Immunology
DOI 10.4049/jimmunol.176.12.7385
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Abstract

In common with many other cell types, synovial fibroblasts produce exosomes. In this study, we show that the exosomes produced by synovial fibroblasts obtained from individuals with rheumatoid arthritis (RASF), but not exosomes produced by synovial fibroblasts obtained from individuals with osteoarthritis, contain a membrane bound form of TNF-α as demonstrated by colloidal gold immunostaining of TNF-α and confirmed by both Western blot and mass spectrometry. The RASF-derived exosomes, but not exosomes derived from fibroblasts obtained from individuals with osteoarthritis, are cytotoxic for the L929 cell, a TNF-α-sensitive cell line, and stimulate activation of NF-κB and induction of collagenase-1 in RASF. These effects are blocked by addition of soluble TNFR1 (sTNFbp), suggesting that a TNF-α-signaling pathway mediates these biological activities. sTNFbp also reduced the production of exosomes by RASF, suggesting the interruption of a positive amplification loop. Exosomes can transmit signals between cells, and RASF exosomes, effectively taken up by anti-CD3-activated T cells, activated AKT and NF-κB and rendered these activated T cells resistant to apoptosis. Neutralization of exosomal membrane TNF-α by sTNFbp partially reversed this resistance, suggesting that not only TNF-α but also additional exosomal proteins may contribute to the development of apoptosis resistance.

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Metadata

Authors
Zhang, H.-G., Liu, C., Su, K., Yu, S., Zhang, L., Zhang, S., Wang, J., Cao, X., Grizzle, W., & Kimberly, R. P.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2006-06
Volume
176
Issue
12
Pages
7385-7393
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.176.12.7385
OpenAlex
W1533291299
Cited by
271
References
59
FWCI
2.58
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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CoChat. (2026). Citation check: A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death. https://app.cochat.ai/papers/10.4049/jimmunol.176.12.7385
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Zhang, H.-G., Liu, C., Su, K., Yu, S., Zhang, L., Zhang, S., Wang, J., Cao, X., Grizzle, W., & Kimberly, R. P. (2006). A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death. The Journal of Immunology. https://doi.org/10.4049/jimmunol.176.12.7385

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