The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses
Open accessAbstract
The DExD/H box RNA helicase retinoic acid-inducible gene I (RIG-I) and the melanoma differentiation-associated gene 5 (MDA5) are key intracellular receptors that recognize virus infection to produce type I IFN. A third helicase gene, Lgp2, is homologous to Rig-I and Mda5 but lacks a caspase activation and recruitment domain. We generated Lgp2-deficient mice and report that the loss of this gene greatly sensitizes cells to cytosolic polyinosinic/polycytidylic acid-mediated induction of type I IFN. However, negative feedback inhibition of IFN-β transcription was found to be normal in the absence of LGP2, indicating that LGP2 is not the primary negative regulator of type I IFN production. Our data further indicate that Lgp2−/− mice exhibited resistance to lethal vesicular stomatitis virus infection, a virus whose replicative RNA intermediates are recognized specifically by RIG-I rather than by MDA5 to trigger the production of type I IFN. However, mice lacking LGP2 were observed to exhibit a defect in type I IFN production in response to infection by the encephalomyocarditis virus, the replication of which activates MDA5-dependent innate immune responses. Collectively, our data indicate a disparate regulatory role for LGP2 in the triggering of innate immune signaling pathways following RNA virus infection.
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Cites
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Cited by
Immune Signaling by RIG-I-like Receptors
Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875
Signaling in innate immunity and inflammation
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RIG-I and Other RNA Sensors in Antiviral Immunity
Chow, K. T., Gale, M., & Loo, Y.-M. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053309 · Cited by 429
Ten Strategies of Interferon Evasion by Viruses
García-Sastre, A. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.012 · Cited by 423
Metadata
- Authors
- Venkataraman, T., Valdes, M., Elsby, R., Kakuta, S., Caceres, G., Saijo, S., Iwakura, Y., & Barber, G. N.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05
- Volume
- 178
- Issue
- 10
- Pages
- 6444-6455
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2141425521
- Cited by
- 401
- References
- 45
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses. https://app.cochat.ai/papers/10.4049/jimmunol.178.10.6444
- The paper
- Venkataraman, T., Valdes, M., Elsby, R., Kakuta, S., Caceres, G., Saijo, S., Iwakura, Y., & Barber, G. N. (2007). Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.10.6444
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