The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes
Abstract
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that strongly activates dendritic cells (DC) and can initiate allergic inflammation. The factors inducing the production of human TSLP are not known. In this study, we show that proinflammatory (TNF-α or IL-1α) and Th2 (IL-4 or IL-13) cytokines synergized to induce the production of TSLP in human skin explants. TSLP production in situ was restricted to epidermal keratinocytes of the suprabasal layer. TSLP production could not be inhibited by factors regulating Th2 inflammation, such as IL-10, TGF-β, or IFN-γ. Cytokine-treated skin culture supernatants induced the maturation of blood CD11c+ DC in a TSLP-dependent manner. Our data provide the first evidence of TSLP induction and subsequent DC activation in human skin. Blocking TSLP-inducing cytokines could represent a novel strategy for the treatment of allergic diseases.
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Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
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Self-citationCytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets
O'Garra, A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80533-6 · Cited by 1,533
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Ito, T., Wang, Y.-H., Duramad, O., Hori, T., Delespesse, G. J., Watanabe, N., Qin, F. X.-F., Yao, Z., Cao, W., & Liu, Y.-J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051135 · Cited by 1,129
IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS
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γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
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Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
Zhou, B., Comeau, M. R., Smedt, T. D., Liggitt, H. D., Dahl, M. E., Lewis, D. B., Gyarmati, D., Aye, T., Campbell, D. J., & Ziegler, S. F. (2005) · Nature Immunology · doi:10.1038/ni1247 · Cited by 819
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Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
Hammad, H., & Lambrecht, B. N. (2008) · Nature Reviews Immunology · doi:10.1038/nri2275 · Cited by 666
Th2 Cytokines and Atopic Dermatitis
B. Brandt, E. (2011) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000110 · Cited by 655
Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
Hill, D. A., & Artis, D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101330 · Cited by 586
Saenz, S. A., Taylor, B. C., & Artis, D. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00713.x · Cited by 484
Metadata
- Authors
- Bogiatzi, S. I., Fernandez, I., Bichet, J.-C., Marloie-Provost, M.-A., Volpe, E., Sastre, X., & Soumelis, V.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03
- Volume
- 178
- Issue
- 6
- Pages
- 3373-3377
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1822726093
- Cited by
- 272
- References
- 29
- FWCI
- 21.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes. https://app.cochat.ai/papers/10.4049/jimmunol.178.6.3373
- The paper
- Bogiatzi, S. I., Fernandez, I., Bichet, J.-C., Marloie-Provost, M.-A., Volpe, E., Sastre, X., & Soumelis, V. (2007). Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.6.3373
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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