The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages
Open accessAbstract
Alveolar macrophages are a unique type of mononuclear phagocytes that populate the external surface of the lung cavity. Early studies have suggested that alveolar macrophages originate from tissue-resident, local precursors, whereas others reported their derivation from blood-borne cells. However, the role of circulating monocytes as precursors of alveolar macrophages was never directly tested. In this study, we show through the combined use of conditional cell ablation and adoptive cell transfer that alveolar macrophages originate in vivo from blood monocytes. Interestingly, this process requires an obligate intermediate stage, the differentiation of blood monocytes into parenchymal lung macrophages, which subsequently migrate into the alveolar space. We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate.
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“These results support the findings that the origin of the AM pool is mainly through differentiation of intermediate lung macrophages rather than self-proliferation (24).”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [24]
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2 retracted
Induction of a Homeostatic Circuit in Lung Tissue by Microbial Compounds
Takabayshi, K., Corr, M., Hayashi, T., Redecke, V., Beck, L., Guiney, D. G., Sheppard, D., & Raz, E. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.011 · Cited by 89
RetractedRETRACTED: Induction of a Homeostatic Circuit in Lung Tissue by Microbial Compounds
Takabayshi, K., Corr, M., Hayashi, T., Redecke, V., Beck, L., Guiney, D. G., Sheppard, D., & Raz, E. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.008 · Cited by 76
RetractedMonocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Self-citationJung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Self-citationJung, S., Unutmaz, D., Wong, P., Sano, G., Santos, K. D. L., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00365-5 · Cited by 1,953
Self-citationKitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783
THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
van Furth, R., & Cohn, Z. A. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.128.3.415 · Cited by 1,564
van Rijt, L. V., Jung, S., KleinJan, A., Vos, N., Willart, M., Duez, C., Hoogsteden, H., & Lambrecht, B. (2005) · Journal of Experimental Medicine · doi:10.1084/jem.20042311 · Cited by 704
Self-citationNaglich, J. G., Metherall, J. E., Russell, D. W., & Eidels, L. (1992) · Cell · doi:10.1016/0092-8674(92)90623-k · Cited by 557
Research works printed but not linked: 49
- 2005, Proc. Am. Thorac. Soc., 403
- 2003, Nat. Rev. Immunol., 994
- 1996, Am. J. Pathol., 657
- 1993, J. Exp. Med., 397
- 2002, Immunity, 271
- 1991, Eur. J. Immunol., 2845
- 1989, J. Exp. Med., 499
- 2004, Am. J. Respir. Cell Mol. Biol., 22
- 2004, EMBO J., 969
- 2006, Immunity, 475
- 1972, J. Exp. Med., 630
- 1976, Science, 1016
- 1987, J. Leukocyte Biol., 443
- 2004, J. Immunol. Methods, 25
- 1980, Am. J. Pathol., 365
- 2006, Am. J. Respir. Cell Mol. Biol., 227
- 1999, Bone Marrow Transplant., 589
- 1995, Transplantation, 672
- 1968, J. Exp. Med., 415
- 1973, J. Exp. Med., 1314
- 1992, Glia, 301
- 2005, Nat. Rev. Immunol., 953
- 1980, Lab. Invest., 511
- 1990, J. Exp. Med., 159
- 1982, Lab. Invest., 165
- 1996, J. Leukocyte Biol., 133
- 2007, J. Immunol., 2000
- 2003, Immunity, 71
- 2002, Immunity, 211
- 2000, Mol. Cell. Biol., 4106
- 1991, Nature, 423
- 1973, Oncology, 385
- 2003, J. Immunol., 3128
- 2004, Cytometry A, 170
- 2005, J. Exp. Med., 981
- 1992, Cell, 1051
- 2003, J. Immunol., 4416
- 2004, Cancer Immunol. Immunother., 1041
- 1995, Annu. Rev. Biophys. Biomol. Struct., 405
- 1979, J. Exp. Med., 1504
- 1991, Cancer Res., 4570
- 1992, Histopathology, 591
- 1989, Curr. Top. Pathol., 125
- 1999, Blood, 667
- 1986, J. Leukocyte Biol., 347
- 1984, J. Exp. Med., 1273
- 1978, J. Exp. Med., 1
- 1980, Lab. Invest., 518
- 1992, Int. J. Radiat. Oncol. Biol. Phys., 93
Cited by
Sorted by citations
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
Self-citationMonocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,745
Repertoire of microglial and macrophage responses after spinal cord injury
David, S., & Kroner, A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3053 · Cited by 1,297
Guilliams, M., de Kleer, I., Henri, S., Post, S., Vanhoutte, L., Prijck, S. D., Deswarte, K., MALISSEN, B., Hammad, H., & Lambrecht, B. N. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131199 · Cited by 1,342
Metadata
- Authors
- Landsman, L., & Jung, S.
- Affiliations
- Weizmann Institute of Science (IL)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09
- Volume
- 179
- Issue
- 6
- Pages
- 3488-3494
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2170851221
- Cited by
- 258
- References
- 51
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 23 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 17 · 2017: 11 · 2016: 27 · 2015: 11 · 2014: 23 · 2013: 20 · 2012: 18
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- alveolar macrophages, lung macrophages, blood monocytes, monocyte-to-macrophage differentiation, monocyte-derived macrophages, macrophage proliferation, adoptive cell transfer
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Diphtheria Toxin, Growth Inhibitors, Lung, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, Monocytes, Stem Cells, Bone Marrow Transplantation, Macrophages, Alveolar, Adoptive Transfer, Cell Proliferation, Mice
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