Cited by 258Immune cells in cancerPhagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

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Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages

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Landsman, Limor, Jung, Steffen·2007·The Journal of Immunology

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Abstract

Alveolar macrophages are a unique type of mononuclear phagocytes that populate the external surface of the lung cavity. Early studies have suggested that alveolar macrophages originate from tissue-resident, local precursors, whereas others reported their derivation from blood-borne cells. However, the role of circulating monocytes as precursors of alveolar macrophages was never directly tested. In this study, we show through the combined use of conditional cell ablation and adoptive cell transfer that alveolar macrophages originate in vivo from blood monocytes. Interestingly, this process requires an obligate intermediate stage, the differentiation of blood monocytes into parenchymal lung macrophages, which subsequently migrate into the alveolar space. We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate.

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2 retracted

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Retracted
RETRACTED: Induction of a Homeostatic Circuit in Lung Tissue by Microbial Compounds
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Authors: Landsman, L., & Jung, S.
Affiliations: Weizmann Institute of Science (IL)
ORCID: Landsman, Limor
Jung, Steffen
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2007-09
Volume: 179
Issue: 6
Pages: 3488-3494
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.179.6.3488
OpenAlex: W2170851221
Cited by: 258
References: 51
Citations by year: 2026: 6 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 23 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 17 · 2017: 11 · 2016: 27 · 2015: 11 · 2014: 23 · 2013: 20 · 2012: 18
FWCI: 4.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: alveolar macrophages, lung macrophages, blood monocytes, monocyte-to-macrophage differentiation, monocyte-derived macrophages, macrophage proliferation, adoptive cell transfer
MeSH terms: Animals, Cell Differentiation, Cell Movement, Diphtheria Toxin, Growth Inhibitors, Lung, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, Monocytes, Stem Cells, Bone Marrow Transplantation, Macrophages, Alveolar, Adoptive Transfer, Cell Proliferation, Mice

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Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages

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