The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Accelerated Telomere Erosion Is Associated with a Declining Immune Function of Caregivers of Alzheimer’s Disease Patients
Open accessAbstract
Caregivers of Alzheimer’s disease patients endure chronic stress associated with a decline of immune function. To assess the psychological and immunological changes of caregivers, we compared depressive symptoms, PBMC composition, in vitro activation-induced proliferation and cytokine production, and telomere length and telomerase activity of 82 individuals (41 caregivers and 41 age- and gender-matched controls). We found depressive symptoms were significantly higher in caregivers than in controls (p < 0.001). Correspondingly, caregivers had significantly lower T cell proliferation but higher production of immune-regulatory cytokines (TNF-α and IL-10) than controls in response to stimulation in vitro. We examined the impact of these changes on cellular replicative lifespan and found that caregivers had significantly shorter telomere lengths in PBMC than controls (6.2 and 6.4 kb, respectively, p < 0.05) with similar shortening in isolated T cells and monocytes and that this telomere attrition in caregivers was not due to an increase of shorter telomere possessing T cell subsets in PBMC. Finally, we showed that basal telomerase activity in PBMC and T cells was significantly higher in caregivers than in controls (p < 0.0001), pointing to an unsuccessful attempt of cells to compensate the excessive loss of telomeres in caregivers. These findings demonstrate that chronic stress is associated with altered T cell function and accelerated immune cell aging as suggested by excessive telomere loss.
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Citations
Cites
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Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
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Cited by
Happy People Live Longer: Subjective Well‐Being Contributes to Health and Longevity
Diener, E., & Chan, M. Y. (2011) · Applied Psychology: Health and Well-Being · doi:10.1111/j.1758-0854.2010.01045.x · Cited by 2,260
Family Caregiving for Older Adults
Schulz, R., Beach, S. R., Czaja, S. J., Martire, L. M., & Monin, J. K. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-010419-050754 · Cited by 754
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A systematic review of leukocyte telomere length and age in adults
Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.003 · Cited by 474
Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820573b6 · Cited by 430
Self-citation
Metadata
- Authors
- Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt-Glaser, J. K., Nguyen, H., Laskowski, B., Zou, Y., Beversdorf, D. Q., & Weng, N.-P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09
- Volume
- 179
- Issue
- 6
- Pages
- 4249-4254
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2164808240
- Cited by
- 413
- References
- 10
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Accelerated Telomere Erosion Is Associated with a Declining Immune Function of Caregivers of Alzheimer’s Disease Patients. https://app.cochat.ai/papers/10.4049/jimmunol.179.6.4249
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- Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt-Glaser, J. K., Nguyen, H., Laskowski, B., Zou, Y., Beversdorf, D. Q., & Weng, N.-P. (2007). Accelerated Telomere Erosion Is Associated with a Declining Immune Function of Caregivers of Alzheimer’s Disease Patients. The Journal of Immunology. https://doi.org/10.4049/jimmunol.179.6.4249
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
