B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

Inducible Gene Targeting in Mice

Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,915 · see citing works

Age-related changes in lymphocyte development and function

Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,175 · see citing works

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · see citing works

Antibody response to influenza vaccination in the elderly: A quantitative review

GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064 · see citing works

Infant mortality statistics from the 2004 period linked birth/infant death data set.

Mathews, T. J., & MacDorman, M. F. (2007) · PubMed · doi:10.13016/v2ql-unmj · Cited by 1,044 · see citing works

Stems Cells and the Pathways to Aging and Cancer

Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.036 · Cited by 895 · see citing works

Cellular Niches Controlling B Lymphocyte Behavior within Bone Marrow during Development

Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B.-I., & Nagasawa, T. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.001 · Cited by 796 · see citing works

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

Beerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000834107 · Cited by 711 · see citing works

A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus

Chan, O. T. M., Hannum, L. G., Haberman, A. M., Madaio, M. P., & Shlomchik, M. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.10.1639 · Cited by 698 · see citing works

Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy

Gong, Q., Ou, Q., Ye, S., Lee, W. P., Cornelius, J., Diehl, L. J., Lin, W. Y., Hu, Z., Lu, Y., Chen, Y., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.817 · Cited by 542 · see citing works

Deaths: Leading Causes for 2017.

Heron, M. P. (2019) · PubMed · Cited by 519 · see citing works

B-cell targeting in rheumatoid arthritis and other autoimmune diseases

Edwards, J., & Cambridge, G. (2006) · Nature reviews. Immunology · doi:10.1038/nri1838 · Cited by 508 · see citing works

Aging of the Immune System: How Much Can the Adaptive Immune System Adapt?

Weng, N. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.001 · Cited by 476 · see citing works

B‐cell diversity decreases in old age and is correlated with poor health status

Gibson, K. L., Wu, Y., Barnett, Y., Duggan, O., Vaughan, R., Kondeatis, E., Nilsson, B., Wikby, A., Kipling, D., & Dunn‐Walters, D. K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00443.x · Cited by 433 · see citing works

Dendritic cell homeostasis

Merad, M., & Manz, M. G. (2009) · Blood · doi:10.1182/blood-2008-12-180646 · Cited by 395 · see citing works

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

Cho, R. H., Sieburg, H. B., & Muller-Sieburg, C. E. (2008) · Blood · doi:10.1182/blood-2007-11-123547 · Cited by 377 · see citing works

TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology

Sasaki, Y., Casola, S. S., Kutok, J. L., Rajewsky, K., & Schmidt‐Supprian, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2245 · Cited by 365 · see citing works

Peripheral deletion of self-reactive B cells

Russell, D. M., Dembić, Z., Morahan, G., Miller, J. F. A. P., Bürki, K., & Nemazee, D. A. (1991) · Nature · doi:10.1038/354308a0 · Cited by 352 · see citing works

The Decline in B Lymphopoiesis in Aged Mice Reflects Loss of Very Early B-Lineage Precursors

Miller, J. P., & Allman, D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2326 · Cited by 255 · see citing works

Depletion of B Cells in Murine Lupus: Efficacy and Resistance

Ahuja, A., Shupe, J., Dunn, R., Kashgarian, M. J., Kehry, M. R., & Shlomchik, M. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3351 · Cited by 239 · see citing works

Immunosenescence and germinal center reaction

Zheng, B. Q., Han, S., Takahashi, Y., & Kelsoe, G. H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01028.x · Cited by 229 · see citing works

Age-related epigenetic changes and the immune system

Issa, J. J. (2003) · Clinical Immunology · doi:10.1016/s1521-6616(03)00203-1 · Cited by 181 · see citing works

Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells

Hannum, L. G., Haberman, A. M., Anderson, S. M., & Shlomchik, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.931 · Cited by 178 · see citing works

Deaths: leading causes for 2003.

Heron, M. P., & Smith, B. L. (2007) · PubMed · Cited by 175 · see citing works

B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

Kline, G. H., Hayden, T. A., & Klinman, N. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3342 · Cited by 170 · see citing works

Red blood cells

Klinken, S. P. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00087-0 · Cited by 160 · see citing works

Age-related decline in immunity: implications for vaccine responsiveness

Kumar, R., & Burns, E. A. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.4.467 · Cited by 156 · see citing works

Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity.

Johnson, S. A., & Cambier, J. C. (2004) · Arthritis Research · doi:10.1186/ar1180 · Cited by 150 · see citing works

Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase

Frasca, D., Van der Put, E., Riley, R. L., & Blomberg, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2155 · Cited by 150 · see citing works

Aging-Dependent Exclusion of Antigen-Inexperienced Cells from the Peripheral B Cell Repertoire

Johnson, S. A., Rozzo, S. J., & Cambier, J. C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5014 · Cited by 134 · see citing works

Effects of Aging on the Common Lymphoid Progenitor to Pro-B Cell Transition

Min, H., Montecino-Rodriguez, E., & Dorshkind, K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1007 · Cited by 126 · see citing works

Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging

Guerrettaz, L., Johnson, S. A., & Cambier, J. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805498105 · Cited by 99 · see citing works

Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

Frasca, D., Landin, A. M., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2741 · Cited by 97 · see citing works

Aging of hematopoietic stem cells is regulated by the stem cell niche

Wagner, W., Horn, P., Bork, S., & Ho, A. D. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.007 · Cited by 97 · see citing works

Independent homeostatic regulation of B cell compartments

Agenès, F., Rosado, M. M., & Freitas, A. A. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270731 · Cited by 80 · see citing works

Multiple prethymic defects underlie age-related loss of T progenitor competence

Zediak, V. P., Maillard, I., & Bhandoola, A. (2007) · Blood · doi:10.1182/blood-2007-01-071605 · Cited by 79 · see citing works

Decreased E47 in Senescent B Cell Precursors Is Stage Specific and Regulated Posttranslationally by Protein Turnover

der Put, E. V., Frasca, D., King, A. M., Blomberg, B. B., & Riley, R. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.818 · Cited by 76 · see citing works

Reduced EBF expression underlies loss of B‐cell potential of hematopoietic progenitors with age

Lescale, C., Dias, S., Maës, J., Cumano, A., Szabo, P., Charron, D. J., Weksler, M. E., Dosquet, C., Vieira, P., & Goodhardt, M. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00566.x · Cited by 61 · see citing works

Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered

Bachmann, M. F., Gallimore, A., Jones, E., Ecabert, B., Acha‐Orbea, H., & Köpf, M. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200102)31:2 · Cited by 60 · see citing works

Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells☆

Whisler, R. L., & Grants, I. S. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90033-n · Cited by 54 · see citing works

Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody

Rouzière, A., Kneitz, C., Palanichamy, A., Dörner, T., & Tony, H. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1731 · Cited by 54 · see citing works

Donor age‐related differences in PBPC mobilization with rHuG–CSF

de la Rubia, J., Díaz, M. Á., Verdeguer, A., Pascual, M. J., Arbona, C., Arrieta, R., Brunet, S., Bargay, J., Martı́nez, C., Espigado, I., et al. (2001) · Transfusion · doi:10.1046/j.1537-2995.2001.41020201.x · Cited by 52 · see citing works

Bone Marrow Precursor Cells from Aged Mice Generate CD4 T Cells That Function Well in Primary and Memory Responses

Eaton, S. M., Maue, A. C., Swain, S. L., & Haynes, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4825 · Cited by 45 · see citing works

AID−/−μs−/− Mice Are Agammaglobulinemic and Fail to Maintain B220−CD138+ Plasma Cells

Kumazaki, K., Tirosh, B., Maehr, R., Boes, M. L., Honjo, T., & Ploegh, H. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2192 · Cited by 45 · see citing works

B Cells of Aged Mice Show Decreased Expansion in Response to Antigen, But Are Normal in Effector Function

Dailey, R. W., Eun, S.-Y., Russell, C. E., & Vogel, L. A. (2001) · Cellular Immunology · doi:10.1006/cimm.2001.1894 · Cited by 42 · see citing works

B cell maturation and selection at the marrow-periphery interface

Cancro, M. P., Allman, D., Hayes, C. E., Lentz, V. M., FIELDS, R. G., Sah, A. P., & Tomayko, M. M. (1998) · Immunologic Research · doi:10.1007/bf02786425 · Cited by 32 · see citing works

Regulation and Localization of Lymphocyte Production in the Bone Marrow

Osmond, D. G., Fahlman, M. T. E., Fulop, G. M., & Rahal, D. M. (1981) · Novartis Foundation symposium · doi:10.1002/9780470720660.ch5 · Cited by 30 · see citing works

Post-irradiation regeneration of early B-lymphocyte precursor cells in mouse bone marrow.

Park, Y. H., & Osmond, D. G. (1989) · PubMed · Cited by 28 · see citing works

Correction of age-associated deficiency in germinal center response by immunization with immune complexes

Zheng, B. Q., Switzer, K. C., Marinova, E., Wansley, D. L., & Han, S. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.04.017 · Cited by 16 · see citing works

Spontaneous Class Switch Recombination in B Cell Lymphopoiesis Generates Aberrant Switch Junctions and Is Increased after VDJ Rearrangement

Edry, E., Koralov, S. B., Rajewsky, K., & Melamed, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6555 · Cited by 14 · see citing works

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

Shalapour, S., Font-Burgada, J., Di Caro, G., Zhong, Z., Sanchez-Lopez, E., Dhar, D., Willimsky, G., Ammirante, M., Strasner, A., Hansel, D. E., et al. (2015) · Nature · doi:10.1038/nature14395 · Cited by 611 · see citing works

Age-Associated B Cells

Cancro, M. P. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-092419-031130 · Cited by 464 · see citing works

The bone marrow at the crossroads of blood and immunity

Mercier, F., Ragu, C., & Scadden, D. T. (2011) · Nature reviews. Immunology · doi:10.1038/nri3132 · Cited by 338 · see citing works

Interconnections between Inflammageing and Immunosenescence during Ageing

Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 310 · see citing works

Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

Lu, Y., Zhao, Q., Liao, J., Song, E., Xia, Q., Pan, J., Li, Y., Li, J., Zhou, B., Ye, Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.015 · Cited by 281 · see citing works

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

Rubtsova, K., Rubtsov, A. V., Cancro, M. P., & Marrack, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501209 · Cited by 246 · see citing works

Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

Ross, J., Myers, L. M., Noh, J. J., Collins, M. M., Carmody, A., Messer, R. J., Dhuey, E., Hasenkrug, K. J., & Weissman, I. L. (2024) · Nature · doi:10.1038/s41586-024-07238-x · Cited by 241 · see citing works

Immune System Dysfunction in the Elderly

Eduardo Fuentes, Q., FUENTES, M., Alarcón, M. A., & Palomo, I. F. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160487 · Cited by 234 · see citing works

Targeting immune dysfunction in aging

Borgoni, S., Kudryashova, K. S., Burka, K., & de Magalhães, J. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101410 · Cited by 227 · see citing works

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

Camell, C. D., Günther, P. S., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.006 · Cited by 215 · see citing works

B-cell subpopulations in humans and their differential susceptibility to depletion with anti-CD20 monoclonal antibodies

Leandro, M. J. (2013) · Arthritis Research & Therapy · doi:10.1186/ar3908 · Cited by 214 · see citing works

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

Schweighoffer, E., Vanes, L., Nys, J. A., Cantrell, D. A., McCleary, S., Smithers, N. N., & Tybulewicz, V. L. J. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.015 · Cited by 207 · see citing works

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Roberti, M. P., Yonekura, S., Duong, C. P. M., Picard, M., Ferrere, G., Tidjani Alou, M., Rauber, C., Iebba, V., Lehmann, C. H. K., Amon, L., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0882-8 · Cited by 208 · see citing works

Hallmarks of aging and immunosenescence: Connecting the dots

Rodrigues, L. P., Teixeira, V. R., Alencar‐Silva, T., Simonassi-Paiva, B., Pereira, R. W., Pogue, R. E., & Carvalho, J. L. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.006 · Cited by 190 · see citing works

In senescence, age‐associated B cells secrete TNF α and inhibit survival of B‐cell precursors*

Ratliff, M., Alter, S., Frasca, D., Blomberg, B. B., & Riley, R. L. (2013) · Aging Cell · doi:10.1111/acel.12055 · Cited by 183 · see citing works

Pericardial Adipose Tissue Regulates Granulopoiesis, Fibrosis, and Cardiac Function After Myocardial Infarction

Horckmans, M., Bianchini, M., Santovito, D., Megens, R. T. A., Springael, J., Negri, I., Vacca, M., Eusanio, M. D., Moschetta, A., Weber, C., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.028833 · Cited by 171 · see citing works

B cell maintenance and function in aging

Kogut, I., Scholz, J. L., Cancro, M. P., & Cambier, J. C. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.004 · Cited by 166 · see citing works

Immunosenescence: Aging and Immune System Decline

Goyani, P., Christodoulou, R. C., & Vassiliou, E. K. (2024) · Vaccines · doi:10.3390/vaccines12121314 · Cited by 177 · see citing works

Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans

Shen-Orr, S. S., Furman, D., Kidd, B. A., Hadad, F., Lovelace, P., Huang, Y.-W., Rosenberg-Hasson, Y., Mackey, S., Grisar, F. A. G., Pickman, Y., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.009 · Cited by 154 · see citing works

Age‐associated B cells: key mediators of both protective and autoreactive humoral responses

Naradikian, M. S., Hao, Y., & Cancro, M. P. (2015) · Immunological Reviews · doi:10.1111/imr.12380 · Cited by 152 · see citing works

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

Ma, S., Ji, Z., Zhang, B., Geng, L., Cai, Y., Nie, C., Li, J., Zuo, Y., Sun, Y., Xu, G., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.019 · Cited by 162 · see citing works

The Dynamics of B Cell Aging in Health and Disease

de Mol, J., Kuiper, J., Tsiantoulas, D., & Foks, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733566 · Cited by 155 · see citing works

B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice

Ortega, S. B., Torres, V. O., Latchney, S. E., Whoolery, C. W., Noorbhai, I., Poinsatte, K., Selvaraj, U. M., Benson, M. A., Meeuwissen, A., Plautz, E. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913292117 · Cited by 137 · see citing works

Plasma cells are obligate effectors of enhanced myelopoiesis in aging bone marrow

Pioli, P. D., Casero, D., Montecino-Rodriguez, E., Morrison, S. L., & Dorshkind, K. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.006 · Cited by 131 · see citing works

Immune aging in diabetes and its implications in wound healing

Moura, J., Madureira, P., Leal, E. C., Fonseca, A. C., & Carvalho, E. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.02.002 · Cited by 116 · see citing works

Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions

Salminen, A. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02123-w · Cited by 124 · see citing works

The Satb1 Protein Directs Hematopoietic Stem Cell Differentiation toward Lymphoid Lineages

Satoh, Y., Yokota, T., Sudo, T., Kondo, M., Lai, A. Y., Kincade, P. W., Kouro, T., Iida, R., Kokame, K., Miyata, T., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.014 · Cited by 115 · see citing works

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

Richner, J. M., Gmyrek, G. B., Govero, J., Tu, Y., van der Windt, G. J. W., Metcalf, T. U., Haddad, E. K., Textor, J. C., Miller, M. J., & Diamond, M. S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005027 · Cited by 109 · see citing works

Reversible CD8 T cell–neuron cross-talk causes aging-dependent neuronal regenerative decline

Zhou, L., Kong, G., Palmisano, I., Cencioni, M. T., Danzi, M. C., Virgiliis, F. D., Chadwick, J., Crawford, G., Yu, Z., de Winter, F., et al. (2022) · Science · doi:10.1126/science.abd5926 · Cited by 105 · see citing works

A comparative review of aging and B cell function in mice and humans

Scholz, J. L., Diaz, A., Riley, R. L., Cancro, M. P., & Frasca, D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.006 · Cited by 103 · see citing works

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke

Courties, G., Frodermann, V., Honold, L., Zheng, Y. Z., Hérisson, F., Schloss, M. J., Sun, Y., Présumey, J., Sévère, N., Engblom, C., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314518 · Cited by 87 · see citing works

Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues

Tabibian‐Keissar, H., Hazanov, L., Schiby, G., Rosenthal, N., Rakovsky, A., Michaeli, M., Shahaf, G. L., Pickman, Y., Rosenblatt, K., Melamed, D., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201545586 · Cited by 84 · see citing works

Reversing T cell immunosenescence: why, who, and how

Lang, P. O., Govind, S., & Aspinall, R. (2012) · AGE · doi:10.1007/s11357-012-9393-y · Cited by 76 · see citing works

Fate Mapping and Quantitation of Hematopoiesis In Vivo

Höfer, T., Busch, K., Klapproth, K., & Rodewald, H.-R. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112019 · Cited by 67 · see citing works

Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis

Säwén, P., Lang, S., Mandal, P. K., Rossi, D. J., Soneji, S., & Bryder, D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.073 · Cited by 60 · see citing works

Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity

Lee-Chang, C., Bodogai, M., Moritoh, K., Olkhanud, P. B., Chan, A. C., Croft, M., Mattison, J. A., Holst, P. J., Gress, R. E., Ferrucci, L., et al. (2014) · Blood · doi:10.1182/blood-2014-03-563940 · Cited by 58 · see citing works

Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age

Riley, R. L., Khomtchouk, K. M., & Blomberg, B. B. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.04.008 · Cited by 56 · see citing works

Immune Senescence and Vaccination in the Elderly

Lang, P. O., Govind, S., ten Bokum, A., Kenny, N., Matas, E., Pitts, D. G., & Aspinall, R. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113136660181 · Cited by 54 · see citing works

B Cell Development in the Bone Marrow Is Regulated by Homeostatic Feedback Exerted by Mature B Cells

Shahaf, G. L., Zisman‐Rozen, S., Benhamou, D., Melamed, D., & Mehr, R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00077 · Cited by 55 · see citing works

Peripheral B cells repress B-cell regeneration in aging through a TNF-α/IGFBP-1/IGF-1 immune-endocrine axis

Dowery, R., Benhamou, D., Ben‐Chetrit, E., Harel, O., Nevelsky, A., Zisman‐Rozen, S., Braun‐Moscovici, Y., Balbir‐Gurman, A., Avivi, I. M., Shechter, A., et al. (2021) · Blood · doi:10.1182/blood.2021012428 · Cited by 50 · see citing works

Impaired B lymphopoiesis in old age: a role for inflammatory B cells?

Riley, R. L. (2013) · Immunologic Research · doi:10.1007/s12026-013-8444-5 · Cited by 48 · see citing works

The role of cellular senescence in aging through the prism of Koch-like criteria

Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45 · see citing works

B cells in the aging immune system: time to consider B‐1 cells

Holodick, N. E., & Rothstein, T. L. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12825 · Cited by 43 · see citing works

CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage

Ren, H., Yan, P., Wang, D., Hao, H., Han, R., Qi, C., Zhang, W., He, W., Shi, F., & Liu, Q. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106912 · Cited by 39 · see citing works

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice

van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O., Vermeij, W. P., Brandt, R. M. C., Barnhoorn, S., Hoeijmakers, J. H. J., de Vos, P., et al. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1hi0216-062rr · Cited by 36 · see citing works

Depletion of B cells rejuvenates the peripheral B‐cell compartment but is insufficient to restore immune competence in aging

Avivi, I. M., Zisman‐Rozen, S., Naor, S., Dai, I., Benhamou, D., Shahaf, G. L., Tabibian‐Keissar, H., Rosenthal, N., Rakovsky, A., Ammuri, H., et al. (2019) · Aging Cell · doi:10.1111/acel.12959 · Cited by 30 · see citing works

Reversing B cell aging

Mehr, R., & Melamed, D. (2011) · Aging · doi:10.18632/aging.100313 · Cited by 27 · see citing works

Haematopoietic ageing in health and lifespan

Andersson, R., Mejía-Ramírez, E., & Florian, M. C. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01739-1 · Cited by 24 · see citing works

Anti-mesothelin immunotoxin induces mesothelioma eradication, anti-tumor immunity, and the development of tertiary lymphoid structures

Liu, W., Tai, C., Liu, X., & Pastan, I. H. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214928119 · Cited by 22 · see citing works

In aged mice, low surrogate light chain promotes pro‐ B ‐cell apoptotic resistance, compromises the P re BCR checkpoint, and favors generation of autoreactive, phosphorylcholine‐specific B cells

Ratliff, M., Alter, S., McAvoy, K., Frasca, D., Wright, J. A., Zinkel, S. S., Khan, W. N., Blomberg, B. B., & Riley, R. L. (2015) · Aging Cell · doi:10.1111/acel.12302 · Cited by 22 · see citing works

Chronic B Cell Deficiency from Birth Prevents Age-Related Alterations in the B Lineage

Zohar, K., Averbuch, D., Shahaf, G. L., Zisman‐Rozen, S., Golan, K., Itkin, T., Lapidot, T., Mehr, R., & Melamed, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100999 · Cited by 21 · see citing works

Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications

Chen, Z., Mao, Z., Tang, W., Shi, Y., Liu, J., & You, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00517-1 · Cited by 21 · see citing works

Aging and neoteny in the B lineage

Melamed, D., & Scott, D. W. (2012) · Blood · doi:10.1182/blood-2012-07-444711 · Cited by 19 · see citing works

Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non–Muscle Invasive Bladder Cancer

Yolmo, P., Rahimi, S., Chenard, S. W., Conseil, G., Jenkins, D., Sachdeva, K., Emon, I. M., Hamilton, J., Xu, M., Rangachari, M., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-1114 · Cited by 18 · see citing works

Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives

Ganguly, P., Toghill, B. J., & Pathak, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212225 · Cited by 17 · see citing works

Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets

Stanton, S. E., Gad, E. A., Corulli, L. R., Lu, H., & Disis, M. L. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.05.024 · Cited by 18 · see citing works

Early events in lymphopoiesis

Zhang, Q., Iida, R., Yokota, T., & Kincade, P. W. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283612628 · Cited by 17 · see citing works

CD19 as a therapeutic target in a spontaneous autoimmune polyneuropathy

Abraham, P. M., Quan, S., Dukala, D., & Soliven, B. C. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12215 · Cited by 17 · see citing works

Myc-Interacting Zinc Finger Protein 1 (Miz-1) Is Essential to Maintain Homeostasis and Immunocompetence of the B Cell Lineage

Piskor, E.-M., Ross, J., Möröy, T., & Kosan, C. (2022) · Biology · doi:10.3390/biology11040504 · Cited by 13 · see citing works

Rituximab Therapy for Treatment of Pemphigus in Southeast Asians

Kanokrungsee, S., Anuntrangsee, T., Tankunakorn, J., Srisuwanwattana, P., Suchonwanit, P., & Chanprapaph, K. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s306046 · Cited by 14 · see citing works

Nucleic acid vaccines: innovations, efficacy, and applications in at-risk populations

Konopka, E., Edgerton, A. O., & Kutzler, M. A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1584876 · Cited by 13 · see citing works

B-Cell-Targeted 3DNA Nanotherapy Against Indoleamine 2,3-Dioxygenase 2 (IDO2) Ameliorates Autoimmune Arthritis in a Preclinical Model

Merlo, L. M. F., Bowers, J., Stefanoni, T., Getts, R. C., & Mandik‐Nayak, L. (2020) · Clinical Pathology · doi:10.1177/2632010x20951812 · Cited by 12 · see citing works

Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice

Krambs, J. R., Monlish, D. A., Gao, F., Schuettpelz, L. G., & Link, D. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767267 · Cited by 11 · see citing works

Anti-CD20-Mediated B Cell Depletion Is Associated With Bone Preservation in Lymphoma Patients and Bone Mass Increase in Mice

Kolomansky, A., Kaye, I., Ben‐Califa, N., Gorodov, A., Awida, Z., Sadovnic, O., Ibrahim, M., Liron, T., Hiram‐Bab, S., Oster, H. S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.561294 · Cited by 11 · see citing works

Cell signaling and the aging of B cells

Labi, V., & Derudder, E. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110985 · Cited by 9 · see citing works

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

Bertoni, G., Ristori, S., & Monti, D. (2026) · Cells · doi:10.3390/cells15080657 · Cited by 9 · see citing works

Replenishing B lymphocytes in health and disease

Zhang, Q., Iida, R., Shimazu, T., & Kincade, P. W. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.12.007 · Cited by 10 · see citing works

Photodynamic Therapy‐Induced Cyclooxygenase 2 Expression in Tumor‐Draining Lymph Nodes Regulates B‐Cell Expression of Interleukin 17 and Neutrophil Infiltration

Falk‐Mahapatra, R., & Gollnick, S. O. (2022) · Photochemistry and Photobiology · doi:10.1111/php.13601 · Cited by 8 · see citing works

Interaction of aging and Immunosenescence: New therapeutic targets of aging

Liao, S., Ning, Q., Chen, Y., Zhao, X., & Tang, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109397 · Cited by 8 · see citing works

Immunseneszenz

Peters, T. (2011) · Der Hautarzt · doi:10.1007/s00105-011-2134-9 · Cited by 8 · see citing works

Gastric DLBCL clonal evolution as function of patient age

Iosselevitch, I., Tabibian‐Keissar, H., Barshack, I., & Mehr, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.957170 · Cited by 8 · see citing works

Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies

Doshi, B. S., Markmann, C., Novak, N. C., Rojas, S. J., Davidson, R. J., Chau, J. Q., Wang, W., Carrig, S., Rus, C. M., Samelson‐Jones, B. J., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.003 · Cited by 8 · see citing works

Inflammatory immune cells may impair the preBCR checkpoint, reduce new B cell production, and alter the antibody repertoire in old age

Riley, R. L., Khomtchouk, K. M., & Blomberg, B. B. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.023 · Cited by 6 · see citing works

A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Konturek-Cieśla, A., Zhang, Q., Kharazi, S., & Bryder, D. (2025) · Nature Communications · doi:10.1038/s41467-025-60464-3 · Cited by 5 · see citing works

The Influence of Heterochronic Non-Myeloablative Bone Marrow Transplantation on the Immune System, Frailty, General Health, and Longevity of Aged Murine Recipients

Jazbec, K., Jež, M., Švajger, U., Smrekar, B., Miceska, S., Rajčević, U., Justin, M., Završnik, J., Malovrh, T., Švara, T., et al. (2022) · Biomolecules · doi:10.3390/biom12040595 · Cited by 5 · see citing works

The pathophysiological mechanisms of immunosenescence in coronary artery disease

Bie, H., & Tao, Z. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1686947 · Cited by 4 · see citing works

Immunseneszenz. Bestandsaufnahme und molekulare Grundlagen

Peters, T. (2011) · Der Hautarzt · Cited by 4 · see citing works

[The effect of deep branches of cervical nerve on motorial function of trapezius muscle].

Wang, F., Wen, Y., & Li, L. (2003) · PubMed · Cited by 4 · see citing works

Atypical B cells mediate poor response to Bacillus Calmette Guérin immunotherapy in non-muscle invasive bladder cancerPreprint

Yolmo, P., Rahimi, S., Chenard, S. W., Conseil, G., Jenkins, D., Sachdeva, K., Emon, I. M., Hamilton, J., Xu, M., Rangachari, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.30.522127 · Cited by 4 · see citing works

Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses

Zhu, D. Y., Du, Y., Zhao, M., Ablikim, D., Huang, H., Pan, W., Zeng, X., Xu, C., Lu, M., Sutter, K., et al. (2024) · Hepatology International · doi:10.1007/s12072-024-10753-8 · Cited by 3 · see citing works

Progress of immune senescence in multiple myeloma treatment resistance

Jia, Y., Yan, L., Fan, C., Sun, H., Zhou, X., & Shi, Z. (2025) · Discover Oncology · doi:10.1007/s12672-025-02136-8 · Cited by 3 · see citing works

ICOS+CD4+ T cells define a high susceptibility to anti–PD-1 therapy–induced lung pathogenesis

Yokoi, M., Murakami, K., Yaguchi, T., Chamoto, K., Ozasa, H., Yoshida, H., Shirakashi, M., Ito, K., Komohara, Y., Fujiwara, Y., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.186483 · Cited by 3 · see citing works

B cells talk to their progenitors

Broeck, A. V. D., & Cambier, J. C. (2011) · Blood · doi:10.1182/blood-2011-02-332544 · Cited by 2 · see citing works

B cells and aging: a historical perspective

Cancro, M. P. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf025 · Cited by 2 · see citing works

Understanding the Mechanisms of Immune System Aging: Immune System Cell Development and Antibody Repertoires

Shahaf, G. L., Hazanov, H., Averbuch, D., Amu, S., Ademokun, A., Wu, Y.-C. B., Dunn‐Walters, D. K., Chiodi, F., & Mehr, R. (2014) · International perspectives on aging · doi:10.1007/978-3-319-06650-9_4 · Cited by 2 · see citing works

Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination

Kunath, P., Pflumm, D., Moehrle, B., Sakk, V., Seidel, A., Münch, J., Geiger, H., & Schirmbeck, R. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00507-x · Cited by 1 · see citing works

Development of a broadly reactive vaccine for highly pathogenic H5N1 influenza

Giles, B. M. (2011) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1 · see citing works

1st French-Israeli International Conference on B Cells and therapeutic antibodies

Reynaud, C., Moutel, S., Dieu‐Nosjean, M., Laskov, R., & Teillaud, J. (2012) · mAbs · doi:10.4161/mabs.20289

Dietary manipulation of natural killer cell biology through refeeding of previously calorically restricted mice

Clinthorne, J. F. (2013) · Michigan State University Libraries · doi:10.25335/m5zq68

Hematopoietic Stem Cell Aging and Leukemogenesis

Henry, C. J., Rozhok, A. I., & DeGregori, J. V. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_13

Rejuvenation of Aged Hematopoietic Stem Cells

Greenshpan, Y., & Gazit, R. (2016) · Journal of Clinical & Medical Genomics · doi:10.4172/2472-128x.1000142

The aging immune system and nutritional interventions

van Beek, A. A. (2017) · doi:10.18174/392235

B Cell Repertoire Changes in Mouse Models of Aging

Scholz, J. L., Hao, Y., Quinn, W. J., & Cancro, M. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_20-1

B Cell Repertoire Changes in Mouse Models of Aging

Scholz, J. L., Hao, Y., Quinn, W. J., & Cancro, M. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_20

The Effects of Aging on Solid Organ Transplantation—Characteristics and Consequences of Immunosenescence

Rollenhagen, C., & Maltzman, J. S. (2023) · Current Transplantation Reports · doi:10.1007/s40472-023-00405-5

Molecular Mechanisms Behind Organ-Related Aging and Regulatory Effects of Natural Therapeutics

Abaidullah, R., Ali, S., Summer, M., & Tahir, H. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01792-5

Selective Immune Silencing by Targeted TGF-β MimicsPreprint

Sun, Q., Ogishi, M., Barrett, A. K., Jiang, H., Yan, H., Solà, E., Zhang, J., Xiao, P., Lyu, H., Salehi, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.700410

CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection

He, Y., Vijayamahantesh, V., Jiang, L., Huerter, H., Jung, K. I., McKenna, S., Studstill, C. J., Xu, D. H., & Hahm, B. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag183

Synergistic effects of physical and psychological distress on immunesenescence

Duggal, N. A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)

Depletion of B cells rejuvenates the peripheral B‐cell compartment but is insufficient to restore immune competence in aging

Avivi, I. M., Zisman‐Rozen, S., Naor, S., Dai, I., Benhamou, D., Shahaf, G. L., Tabibian‐Keissar, H., Rosenthal, N., Rakovsky, A., Ammuri, H., et al. (2019) · Aging Cell · doi:10.1111/acel.12959 · Cited by 30 · see citing works

Reversing B cell aging

Mehr, R., & Melamed, D. (2011) · Aging · doi:10.18632/aging.100313 · Cited by 27 · see citing works

Homeostatic Regulation of Aging and Rejuvenation in the B Lineage Cells

Melamed, D. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013006907 · Cited by 6 · see citing works

Reversing B cell aging Research Perspective

Mehr, R., & Melamed, D. (2013)

Intra‐bone marrow bone marrow transplantation rejuvenates the B‐cell lineage in aged mice

Hida, D., Ishiguro, N., Haneda, M., Ishida, Y., Suzuki, H., & Isobe, K. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.69 · Cited by 6 · see citing works