Systemic adaptation to oxidative challenge induced by regular exercise

Radak, Zsolt; Chung, Hae Young; Goto, Sataro

doi:10.1016/j.freeradbiomed.2007.01.029

Cited by 623Exercise and Physiological ResponsesAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Systemic adaptation to oxidative challenge induced by regular exercise

Radak, Zsolt, Chung, Hae Young, Goto, Sataro·2008·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2007.01.029

Open this paper in CoChat — free account

Abstract

Exercise is associated with increased ATP need and an enhanced aerobic and/or anaerobic metabolism, which results in an increased formation of reactive oxygen species (ROS). Regular exercise seems to decrease the incidence of a wide range of ROS-associated diseases, including heart disease, type II diabetes, rheumatic arthritis, Alzheimer and Parkinson diseases, and certain cancers. The preventive effect of regular exercise, at least in part, is due to oxidative stress-induced adaptation. The oxidative challenge-related adaptive process of exercise is probably not just dependent upon the generated level of ROS but primarily on the increase in antioxidant and housekeeping enzyme activities, which involves the oxidative damage repair enzymes. Therefore, the effects of exercise resemble the characteristics of hormesis. In addition, it seems that the oxidative challenge-related effects of exercise are systemic. Skeletal muscle, liver, and brain have very different metabolic rates and functions during exercise, but the adaptive response is very similar: increased antioxidant/damage repair enzyme activity, lower oxidative damage, and increased resistance to oxidative stress, due to the changes in redox homeostasis. Hence, it is highly possible that the well-known beneficial effects of exercise are due to the capability of exercise to produce increased levels of ROS. Or in other words, it seems that the vulnerability of the body to oxidative stress and diseases is significantly enhanced in a sedentary compared to a physically active lifestyle.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2007.01.029

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Moderate-intensity activities done for durations of less than 1 min might not be long enough to induce pronounced changes to the coronary vasculature when compared with longer bouts.
“Moderate-intensity activities done for durations of less than 1 min might not be long enough to induce pronounced changes to the coronary vasculature when compared with longer bouts.28,29”
From Brief bouts of device-measured intermittent lifestyle physical activity and its association with major adverse cardiovascular events and mortality in people who do not exercise: A prospective cohort study (2023) · cites this paper as [29]
The levels of reactive oxygen species produced during moderate exercise bring about beneficial adaptations in a number of cell types.
“and the levels produced during moderate exercise have been proven to bring about beneficial adaptations in a number of cell types (Ji et al. 2006; Powers and Jackson 2008; Radak et al. 2008).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Radak et al. 2008
Optimal reactive oxygen species production is critical for cell function, especially immune cells.
“Optimal reactive oxygen species production is critical for cell function, especially immune cells”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Radak et al. 2008

Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women
Blair, S. N. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540030039029 · Cited by 1,819 · see citing works
Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739 · see citing works
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works
Ageing and neuronal vulnerability
Mattson, M. P., & Magnus, T. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1886 · Cited by 1,075 · see citing works
Protein Oxidation
Stadtman, E. R., & Levine, R. L. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06187.x · Cited by 1,037 · see citing works
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885 · see citing works
VEGF is necessary for exercise‐induced adult hippocampal neurogenesis
Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., Kuo, C. J., & Palmer, T. D. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03041.x · Cited by 861 · see citing works
Degradation of oxidized proteins in mammalian cells
Grune, T., Reinheckel, T., & Davies, K. J. A. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212076 · Cited by 835 · see citing works
Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease
Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 806 · see citing works
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.
Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works
Toxicology rethinks its central belief
Calabrese, E. J., & Baldwin, L. A. (2003) · Nature · doi:10.1038/421691a · Cited by 721 · see citing works
Carbonyl modified proteins in cellular regulation, aging, and disease2,3 2Guest Editor: Earl Stadtman 3This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.
Levine, R. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00765-7 · Cited by 657 · see citing works
Free Radical Theory of Aging: An Update: Increasing the Functional Life Span
HARMAN, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.003 · Cited by 601 · see citing works
Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways
Olson, A. K., Eadie, B. D., Ernst, C., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20157 · Cited by 565 · see citing works
Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.
Forster, M. J., Dubey, A., Dawson, K. M., Stutts, W. A., Lal, H., & Sohal, R. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4765 · Cited by 494 · see citing works
Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance
Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478 · see citing works
Decreasing xanthine oxidase‐mediated oxidative stress prevents useful cellular adaptations to exercise in rats
Gómez‐Cabrera, M. C., Borrás, C., Pallardó, F. V., Sastre, J., Ji, L. L., & Viña, J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080564 · Cited by 477 · see citing works
Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase
Ushio‐Fukai, M., & Alexander, R. W. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000044378.09409.b5 · Cited by 473 · see citing works
Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus
Berchtold, N. C., Chinn, G., Chou, M., Kesslak, J. P., & Cotman, C. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.026 · Cited by 471 · see citing works
Oxidative modification of proteins during aging
Levine, R. L., & Stadtman, E. R. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00135-8 · Cited by 466 · see citing works
Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer
Navarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 460 · see citing works
Aging and acute exercise enhance free radical generation in rat skeletal muscle
Bejma, J., & Ji, L. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.465 · Cited by 445 · see citing works
Ubiquitin Conjugation Is Not Required for the Degradation of Oxidized Proteins by Proteasome
Shringarpure, R., Grune, T., Mehlhase, J., & Davies, K. J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206279200 · Cited by 438 · see citing works
Energy supply and muscle fatigue in humans
SAHLIN, K., TONKONOGI, M., & SÖDERLUND, K. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0298f.x · Cited by 419 · see citing works
Exercise and hormesis: oxidative stress-related adaptation for successful aging
Radak, Z. O., Chung, H. Y., & Goto, S. (2005) · Biogerontology · doi:10.1007/s10522-004-7386-7 · Cited by 413 · see citing works
Self-citation
Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity
Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.001 · Cited by 396 · see citing works
Exercise Enhances and Protects Brain Function
Cotman, C. W., & Engesser‐Cesar, C. (2002) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200204000-00006 · Cited by 388 · see citing works
Regular exercise improves cognitive function and decreases oxidative damage in rat brain
Radak, Z. O., Kaneko, T., Tahara, S., Nakamoto, H., Pucsok, J. M., Sasvári, M., Nyakas, C. J., & Goto, S. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00063-2 · Cited by 373 · see citing works
Self-citation
Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors
Rechsteiner, M., & Hill, C. P. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.11.003 · Cited by 372 · see citing works
Role of Oxidant Species in Aging
Stadtman, E. R. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365341 · Cited by 368 · see citing works
Lipid peroxidation and scavenger enzymes during exercise: adaptive response to training
Alessio, H. M., & Goldfarb, A. H. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.4.1333 · Cited by 362 · see citing works
Adaptation to exercise-induced oxidative stress: from muscle to brain.
Radak, Z. O., Taylor, A. W., Ohno, H., & Goto, S. (2001) · PubMed · Cited by 292 · see citing works
Self-citation
Acute exercise activates nuclear factor (NF)‐ΚB signaling pathway in rat skeletal muscle
Ji, L. L., Gómez‐Cabrera, M. C., Steinhafel, N. W., & Viña, J. (2004) · The FASEB Journal · doi:10.1096/fj.04-1846com · Cited by 279 · see citing works
Regulation of DNA repair by ubiquitylation
Huang, T. T., & D’Andrea, A. D. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1908 · Cited by 273 · see citing works
The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes
Radak, Z. O., Kaneko, T., Tahara, S., Nakamoto, H., Ohno, H., Sasvári, M., Nyakas, C. J., & Goto, S. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00038-6 · Cited by 273 · see citing works
Self-citation
Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle
Radák, Z., Naito, H., Kaneko, T., Tahara, S., Nakamoto, H., Takahashi, R., Cardozo-Pelaez, F., & Goto, S. (2002) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-002-0918-6 · Cited by 269 · see citing works
Self-citation
A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin
Mattson, M. P., Maudsley, S. R., & Martin, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.08.001 · Cited by 266 · see citing works
Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression
Adlard, P. A., & Cotman, C. W. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.039 · Cited by 265 · see citing works
The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain
Radak, Z. O., Toldy, A., Szabo, Z., Siamilis, S., Nyakas, C. J., Silye, G., Jakus, J., & Goto, S. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.02.004 · Cited by 254 · see citing works
Self-citation
Extracellular matrix adaptation of tendon and skeletal muscle to exercise
Kjær, M., Magnusson, S. P., Krogsgaard, M. R., Bojsen‐Møller, J., Olesen, J. L., Heinemeier, K. M., Hansen, M., Haraldsson, B. T., Koskinen, S., Esmarck, B., et al. (2006) · Journal of Anatomy · doi:10.1111/j.1469-7580.2006.00549.x · Cited by 249 · see citing works
Do mitochondrial DNA fragments promote cancer and aging?
Richter, C. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81018-4 · Cited by 226 · see citing works
Molecular adaptations of neuromuscular disease‐associated proteins in response to eccentric exercise in human skeletal muscle
Féasson, L., Stockholm, D., Freyssenet, D. G., Richard, I., Duguez, S., Beckmann, J. S., & Denis, C. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.018689 · Cited by 224 · see citing works
Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells
Shringarpure, R., Grune, T., & Davies, K. J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000787 · Cited by 217 · see citing works
Hormesis: a revolution in toxicology, risk assessment and medicine
Calabrese, E. J. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400222 · Cited by 217 · see citing works
Selectivity of protein oxidative damage during aging in Drosophila melanogaster
Nilanjana, D. A. S., Levine, R. L., Orr, W. C., & Sohal, R. S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600209 · Cited by 186 · see citing works
Branched-Chain Amino Acids as Fuels and Anabolic Signals in HumanMuscle
Rennie, M. J., Bohé, J., Smith, K., Wackerhage, H., & Greenhaff, P. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.264s · Cited by 185 · see citing works
Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age
Vasilaki, A., McArdle, F., Iwanejko, L. M., & McArdle, A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.08.004 · Cited by 182 · see citing works
Contractile response to low peroxide concentrations: myofibrillar calcium sensitivity as a likely target for redox‐modulation of skeletal muscle function
Andrade, F. H., Reid, M. B., & Westerblad, H. (2000) · The FASEB Journal · doi:10.1096/fj.00-0507fje · Cited by 181 · see citing works
Voluntary Wheel Running Improves Recovery from a Moderate Spinal Cord Injury
Engesser‐Cesar, C., Anderson, A. J., Basso, D. M., Edgerton, V. R., & Cotman, C. W. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.157 · Cited by 180 · see citing works
Age‐associated increases in oxidative stress and nuclear transcription factor κB activation are attenuated in rat liver by regular exercise
Radak, Z. O., Chung, H. Y., Naıto, H., Takahashi, R., Jung, K. J., Kim, H., & Goto, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0509fje · Cited by 173 · see citing works
Self-citation
Oxidative stress, aging and the proteasomal system
Grune, T. (2000) · Biogerontology · doi:10.1023/a:1010037908060 · Cited by 171 · see citing works
Proteasome‐dependent degradation of oxidized proteins in MRC‐5 fibroblasts
Sitte, N., Merker, K., & Grune, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01495-1 · Cited by 171 · see citing works
Hormesis and the Antiaging Action of Dietary Restriction
Masoro, E. J. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00071-5 · Cited by 167 · see citing works
Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise
Radak, Z. O., Asano, K., Inoue, M., et al. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.1.129 · Cited by 158 · see citing works
Self-citation
A Redox Signaling Mechanism for Density-dependent Inhibition of Cell Growth
Pani, G., Colavitti, R., Bedogni, B., Anzevino, R., Borrello, S., & Galeotti, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007319200 · Cited by 156 · see citing works
Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain
Devi, S. A., & Kiran, T. R. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00112-x · Cited by 154 · see citing works
The Genetics of Human Longevity
Capri, M., Salvioli, S., Sevini, F., Valensin, S., Celani, L., Monti, D., Pawelec, G., Benedictis, G. D., Gonos, E. S., & Franceschi, C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.033 · Cited by 153 · see citing works
Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women
Blair, S. N. (1996) · JAMA · doi:10.1001/jama.276.3.205 · Cited by 150 · see citing works
The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain
Ogonovszky, H., Berkes, I., Kumagai, S., Kaneko, T., Tahara, S., Goto, S., & Radak, Z. O. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.02.009 · Cited by 149 · see citing works
Self-citation
Evidence of myofibrillar protein oxidation induced by postischemic reperfusion in isolated rat hearts
Canton, M., Neverova, I., Menabò, R., Eyk, J. E. V., & Lisa, F. D. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00714.2003 · Cited by 148 · see citing works
Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle
Radak, Z. O., Pucsok, J. M., Mecseki, S., Csont, T., & Ferdinandy, P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00309-8 · Cited by 135 · see citing works
Self-citation
Protein oxidation and degradation during postmitotic senescence
Grune, T., Merker, K., Jung, T., Sitte, N., & Davies, K. J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.009 · Cited by 117 · see citing works
Marathon running alters the DNA base excision repair in human skeletal muscle
Radak, Z. O., Apor, P., Pucsok, J. M., Berkes, I., Ogonovszky, H., Pavlik, G., Nakamoto, H., & Goto, S. (2003) · Life Sciences · doi:10.1016/s0024-3205(02)02476-1 · Cited by 115 · see citing works
Self-citation
The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain
Toldy, A., Stadler, K., Sasvári, M., Jakus, J., Jung, K. J., Chung, H. Y., Berkes, I., Nyakas, C. J., & Radak, Z. O. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.02.028 · Cited by 106 · see citing works
Self-citation
Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats
Nakamoto, H., Kaneko, T., Tahara, S., Hayashi, E., Naıto, H., Radak, Z. O., & Goto, S. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.11.006 · Cited by 105 · see citing works
Self-citation
The Effects of Moderate, Strenuous, and Overtraining on Oxidative Stress Markers and DNA Repair in Rat Liver
Ogonovszky, H., Sasvári, M., Dosek, A., Berkes, I., Kaneko, T., Tahara, S., Nakamoto, H., Goto, S., & Radak, Z. O. (2005) · Canadian Journal of Applied Physiology · doi:10.1139/h05-114 · Cited by 101 · see citing works
Self-citation
Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain
Radak, Z. O., Sasvári, M., Nyakas, C. J., Kaneko, T., Tahara, S., Ohno, H., & Goto, S. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00003-1 · Cited by 97 · see citing works
Self-citation
Exercise Preconditioning against Hydrogen Peroxide-Induced Oxidative Damage in Proteins of Rat Myocardium
Radak, Z. O., Sasvári, M., Nyakas, C. J., Pucsok, J. M., Nakamoto, H., & Goto, S. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1719 · Cited by 91 · see citing works
Self-citation
Proteasome mediates removal of proteins oxidized during myocardial ischemia
Divald, A., & Powell, S. R. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.09.022 · Cited by 90 · see citing works
High Altitude Training Increases Reactive Carbonyl Derivatives But Not Lipid Peroxidation in Skeletal Muscle of Rats
Radak, Z. O., Asano, K., Lee, K.-C., Ohno, H., Nakamura, A., Nakamoto, H., & Goto, S. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00350-4 · Cited by 88 · see citing works
Self-citation
The effect of exercise on brain antioxidant status of diabetic rats.
Özkaya, Y. G., Ağar, A., Yargiçoğlu, P., et al. (2002) · PubMed · Cited by 84 · see citing works
On Radiation, Paradigms, and Hormesis
Sagan, L. A. (1989) · Science · doi:10.1126/science.2669125 · Cited by 81 · see citing works
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-5 · Cited by 77 · see citing works
8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats
Radak, Z. O., Kumagai, S., Nakamoto, H., & Goto, S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01051.2006 · Cited by 72 · see citing works
Self-citation
Exercise training alters kinetics of antioxidant enzymes in rat tissues.
Somani, S. M., & Husain, K. M. (1996) · PubMed · Cited by 72 · see citing works
Superoxide dismutase derivative prevents oxidative damage in liver and kidney of rats induced by exhausting exercise
k, Z. R., Asano, K., Inoue, M., Kizaki, T., Oh‐ishi, S., Suzuki, K., Taniguchi, N., & Ohno, H. (1996) · European Journal of Applied Physiology · doi:10.1007/bf00838637 · Cited by 69 · see citing works
Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise
Iemitsu, M., Maeda, S., Jesmin, S., et al. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00392.2005 · Cited by 65 · see citing works
Regular Training Modulates the Accumulation of Reactive Carbonyl Derivatives in Mitochondrial and Cytosolic Fractions of Rat Skeletal Muscle
Radak, Z. O., Sasvári, M., Nyakas, C. J., Taylor, A. W., Ohno, H., Nakamoto, H., & Goto, S. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2042 · Cited by 65 · see citing works
Self-citation
Additive effect between NF-κB subunits and p53 protein for transcriptional activation of human p53 promoter
Benoît, V., Hellin, A., Huygen, S., GIELEN, J. E., Bours, V., & Merville, M.-P. (2000) · Oncogene · doi:10.1038/sj.onc.1203831 · Cited by 52 · see citing works
The effects of vitamin C supplementation on oxidative stress and antioxidant content in the brains of chronically exercised rats
Cevher, Ş. C., Gönül, B., Güzel, N. A., & Balabanlı, B. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-8421-y · Cited by 52 · see citing works
A Healthful Dab of Radiation?
Kaiser, J. (2003) · Science · doi:10.1126/science.302.5644.378 · Cited by 40 · see citing works
Acute bout of exercise does not alter the antioxidant enzyme status and lipid peroxidation of rat hippocampus and cerebellum
Radak, Z. O., Asano, K., Kizaki, T., et al. (1995) · Pathophysiology · doi:10.1016/0928-4680(95)00045-9 · Cited by 26 · see citing works
Self-citation
DNA Joining in Mammalian CellsPreprint
Lindahl, T. L., Prigent, C., Barnes, D. E., et al. (1993) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1993.058.01.068 · Cited by 19 · see citing works

Flagged first, then by citations

Sorted by citations

Physical activity and depression: towards understanding the antidepressant mechanisms of physical activity
Kandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309 · see citing works
Sirtuins, a promising target in slowing down the ageing process
Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · see citing works
Antioxidant Supplementation during Exercise Training: Beneficial or Detrimental?
Peternelj, T.-T., & Coombes, J. S. (2011) · Sports Medicine · doi:10.2165/11594400-000000000-00000 · Cited by 314 · see citing works
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
Koltai, E., Szabo, Z., Atalay, M., Boldogh, I., Naito, H., Goto, S., Nyakas, C., & Radak, Z. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.11.002 · Cited by 283 · see citing works
Self-citation
Neurobiological effects of exercise on major depressive disorder: A systematic review
Schuch, F. B., Deslandes, A. C., Stubbs, B., Gosmann, N. P., Silva, C. T. B. D., & Fleck, M. P. D. A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.012 · Cited by 279 · see citing works
Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy
Chen, M., Wang, Y., Deng, S., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.964130 · Cited by 187 · see citing works
Brief bouts of device-measured intermittent lifestyle physical activity and its association with major adverse cardiovascular events and mortality in people who do not exercise: A prospective cohort study
Ahmadi, M. N., Hamer, M., Gill, J. M. R., Murphy, M., Sanders, J. P., Doherty, A., & Stamatakis, E. (2023) · The Lancet Public Health · doi:10.1016/s2468-2667(23)00183-4 · Cited by 172 · see citing works
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works
Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against <scp>A</scp>lzheimer's Disease
Bernardo, T. C., Marques‐Aleixo, I., Beleza, J., Oliveira, P. J., Ascensão, A., & Magalhães, J. (2016) · Brain Pathology · doi:10.1111/bpa.12403 · Cited by 108 · see citing works
Does exercise reduce brain oxidative stress? A systematic review
Camiletti‐Moirón, D., Aparicio, V. A., Aranda, P., & Radak, Z. (2013) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12065 · Cited by 104 · see citing works
Self-citation
Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“controversies about this matter, since some studies supported the protective role of exercise against oxidative stress, while others demonstrated increased oxidative stress markers after acute aerobic [310, 311] and anaerobic exercise [313, 314].”
Result
High intensity interval training and molecular adaptive response of skeletal muscle
Torma, F., Gombos, Z., Jokai, M., Takeda, M., Mimura, T., & Radak, Z. (2019) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2019.08.003 · Cited by 95 · see citing works
Self-citation
Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise
Ra, S.-G., Miyazaki, T., Ishikura, K., Nagayama, H., Komine, S., Nakata, Y., Maeda, S., Matsuzaki, Y., & Ohmori, H. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-51 · Cited by 94 · see citing works
Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment
Pusic, K. M., Pusic, A. D., Kemme, J., & Kraig, R. P. (2014) · Glia · doi:10.1002/glia.22672 · Cited by 85 · see citing works
Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues
Bayod, S., del Valle, J., Lalanza, J. F., Sanchez-Roige, S., de Luxán-Delgado, B., Coto-Montes, A., Canudas, A. M., Camins, A., Escorihuela, R. M., & Pallàs, M. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.08.004 · Cited by 77 · see citing works
Endurance exercise is protective for mice with mitochondrial myopathy
Wenz, T., Diaz, F., Hernandez, D., & Moraes, C. T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91571.2008 · Cited by 78 · see citing works
Retracted
Attenuation of Long-Term Rhodiola rosea Supplementation on Exhaustive Swimming-Evoked Oxidative Stress in the Rat
Huang, S.-C. (2009) · The Chinese Journal of Physiology · doi:10.4077/cjp.2009.amh029 · Cited by 73 · see citing works
Prolonged Depletion of Antioxidant Capacity after Ultraendurance Exercise
TURNER, J. E., HODGES, N. J., BOSCH, J. A., & ALDRED, S. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821240bb · Cited by 49 · see citing works
An active lifestyle induces positive antioxidant enzyme modulation in peripheral blood mononuclear cells of overweight/obese postmenopausal women
Farinha, J. B., De Carvalho, N. R., Steckling, F. M., De Vargas, L. D. S., Courtes, A. A., Stefanello, S. T., Martins, C. C., Bresciani, G., Dos Santos, D. L., & Soares, F. A. A. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.11.022 · Cited by 19 · see citing works

Authors: Radak, Z., Chung, H. Y., & Goto, S.
Affiliations: Semmelweis University (HU)
Pusan National University (KR)
Toho University (JP)
Corresponding author: Radak, Zsolt
ORCID: Radak, Zsolt
Chung, Hae Young
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2008-01
Volume: 44
Issue: 2
Pages: 153-159
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2007.01.029
OpenAlex: W2076515148
Cited by: 623
References: 86
Citations by year: 2026: 21 · 2025: 19 · 2024: 17 · 2023: 11 · 2022: 66 · 2021: 30 · 2020: 29 · 2019: 31 · 2018: 39 · 2017: 39 · 2016: 35 · 2015: 40 · 2014: 43 · 2013: 50 · 2012: 43
FWCI: 3.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Hungarian Science Foundation
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: physical activity, oxidative stress, reactive oxygen species, hormesis, antioxidant enzymes, redox homeostasis, oxidative damage repair, exercise adaptation, sedentary lifestyle, disease prevention, skeletal muscle, liver, brain
MeSH terms: Adaptation, Physiological, Animals, Brain, Humans, Liver, Models, Biological, Periodicity, Physical Conditioning, Animal, Exercise, Oxidative Stress, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Systemic adaptation to oxidative challenge induced by regular exercise

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks