National Trends in Long-Term Use of Antidepressant Medications: Results From the US National Health and Nutrition Examination Survey

Mojtabai, Ramin; Olfson, Mark

doi:10.4088/jcp.13m08443

Cited by 247Mental Health Treatment and AccessTreatment of Major DepressionOpioid Use Disorder Treatment

National Trends in Long-Term Use of Antidepressant Medications: Results From the US National Health and Nutrition Examination Survey

Mojtabai, Ramin, Olfson, Mark·2014·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.13m08443

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Abstract

Article AbstractObjective: To assess the trend in long-term use of antidepressants by persons aged ≥ 18 years, and the correlates of such use, in the United States from 1999 to 2010. Method: We examined trends in duration of antidepressant use and correlates of long-term use in data from 6 waves of the cross-sectional National Health and Nutrition Examination Survey (N = 35,379), a representative survey of the general population. Results: The overall prevalence of antidepressant use increased from 6.5% in 1999-2000 to 10.4% in 2009-2010 (odds ratio = 1.54; 95% CI, 1.31-1.81; P < .001). This included an increase from 3.0% to 6.9% in long-term use (≥ 24 months; OR = 2.12; 95% CI, 1.75-2.57; P < .001). Medium-term (6 to < 24 months; from 1.3% to 1.6%) and short-term use (< 6 months; from 2.2% to 1.8%) of antidepressants did not change appreciably in this period. The increasing trend in long-term antidepressant use was limited to adults who received their care from general medical providers (adjusted OR = 3.86; 95% CI, 2.57-5.80; P < .001). Conclusions: From 1999 to 2010, there was a marked increase in long-term use of antidepressant medications in the United States, explaining the overall increasing trend in antidepressant use. This trend calls for greater vigilance in prescribing antidepressants for long periods of time. J Clin Psychiatry © Copyright 2013 Physicians Postgraduate Press, Inc. Submitted: February 26, 2013; accepted July 9, 2013. Online ahead of print: December 10, 2013 (doi:10.4088/JCP.13m08443). Corresponding author: Ramin Mojtabai, MD, PhD, MPH, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Hampton House/Room 797, Baltimore, MD 21205 (rmojtaba@jhsph.edu).

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The increase in long-term prescriptions of antidepressant monotherapy was also observed by other studies.
“Our data suggested that there was dramatic increase in long-term prescriptions of antidepressant monotherapy, which was also observed by some other studies (29, 30).”
From National prescription patterns of antidepressants in the treatment of adults with major depression in the us between 1996 and 2015: a population representative survey based analysis (2020) · cites this paper as [30]
Many people in receipt of long-term antidepressant medication do not necessarily require maintenance treatment.
“Research further indicates that many people in receipt of long-term antidepressant medication do not necessarily require maintenance treatment.7,9,10”
From Protracted withdrawal syndrome after stopping antidepressants: a descriptive quantitative analysis of consumer narratives from a large internet forum (2020) · cites this paper as [7]

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Authors: Mojtabai, R., & Olfson, M.
Affiliations: Johns Hopkins University (US)
Columbia University (US)
Corresponding author: Mojtabai, Ramin
ORCID: Mojtabai, Ramin
Olfson, Mark
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2013-12-10
Volume: 75
Issue: 02
Pages: 169-177
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.13m08443
OpenAlex: W2075265772
Cited by: 247
References: 0
Citations by year: 2026: 10 · 2025: 16 · 2024: 27 · 2023: 16 · 2022: 22 · 2021: 18 · 2020: 28 · 2019: 21 · 2018: 17 · 2017: 26 · 2016: 22 · 2015: 13 · 2014: 11
FWCI: 22.95
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (NCT01528839.)
Topics: Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords: antidepressant use, long-term antidepressant use, antidepressant prescribing trends, depression, general medical care, prescribing patterns, United States adults, NHANES, mental health service utilization, insurance status
MeSH terms: Adult, Aged, Antidepressive Agents, Cross-Sectional Studies, Drug Utilization, Female, Humans, Male, Middle Aged, Nutrition Surveys, Drug Prescriptions, Time Factors, United States, Prevalence, Young Adult

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National Trends in Long-Term Use of Antidepressant Medications: Results From the US National Health and Nutrition Examination Survey

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