The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Hyperglycemia as a Risk Factor for Cancer Progression
Open accessAbstract
As the prevalence of diabetes mellitus is substantially increasing worldwide, associated diseases such as renal failure, cardiovascular diseases, fatty liver, and cancers have also increased. A number of cancers such as pancreatic, liver, breast, and female reproductive cancers have shown an increased prevalence and a higher mortality rate in diabetic patients compared to healthy subjects. Thus, this suggests an association between diabetes, especially type 2 diabetes and cancer incidence and progression. Recent studies have suggested that hyperinsulinemia, chronic inflammation and hyperglycemia, all frequently seen in diabetics, may lead to increased tumor growth; the underlying molecular mechanisms of this association are not fully understood. In particular, chronic hyperglycemic episodes could serve as a direct or indirect mediator of the increase in tumor cell growth. Here, we will discuss our current understanding how hyperglycemia and cancer risk may be linked, and what the implications are for the treatment of diabetic cancer patients.
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Cited by
Challenges and Perspectives in the Treatment of Diabetes Associated Breast Cancer
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Metadata
- Authors
- Ryu, T. Y., Park, J., & Scherer, P. E.
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2014
- Volume
- 38
- Issue
- 5
- Pages
- 330
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- OpenAlex
- W2138121862
- Cited by
- 331
- References
- 62
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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