The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The Role of Advanced Glycation End Products in Diabetic Vascular Complications
Open accessAbstract
In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Endogenous AGEs represent adducts that are produced and slowly accumulated within the body during the normal aging process and under the oxidative stress, inflammatory, and hyperglycemic (high blood sugar) conditions often observed in diabetes and other metabolic syndromes1,4,12,13.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751
Advanced glycation end-products: A review
Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597
Advanced Glycation End Products and Diabetic Complications
Singh, V. P., Bali, A., Singh, N., & Jaggi, A. S. (2014) · The Korean Journal of Physiology & Pharmacology · doi:10.4196/kjpp.2014.18.1.1 · Cited by 1,518
Advanced glycation end products in foods and a practical guide to their reduction in the diet
Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., & Vlassara, H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.03.018 · Cited by 1,289
Bucala, R., Tracey, K. J., & Cerami, A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115014 · Cited by 1,162
Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2003) · JAMA · doi:10.1001/jama.290.16.2159 · Cited by 1,009
Diabetes and advanced glycation endproducts
Vlassara, H., & Palace, M. R. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.00932.x · Cited by 723
YONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716
Lo, T. W. C., Westwood, M. E., McLellan, A. C., Selwood, T., & Thornalley, P. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31635-1 · Cited by 695
Bierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 554
Research works printed but not linked: 1
- Soulis-Liparota, 1991, Diabetes, 40, 1328, 10.2337/diab.40.10.1328 · DOI
Cited by
Sorted by citations
Items 201–273 of 273
Phan, T.-C.-L., Chiang, Y.-S., Su, M., Liang, Y.-J., & Juang, S.-J. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46060339 · Cited by 2
Emami, L., Hoshyar, S., Bina, S., Zare, F., Mardaneh, P., Haghshenas, M., Poustforoosh, A., Firouzabadi, N., & Rashedinia, M. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.140824 · Cited by 2
Gandhi, T., Patel, A., & Purohit, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90583-1.00034-9 · Cited by 2
Influence of melatonin on the kidneys of rats with experimental diabetes mellitus type 2
Semenko, A. V., Murdasov, Y. V., Кириченко, С. В., Zhylіuk, V. I., & Ушакова, Г. А. (2020) · Regulatory Mechanisms in Biosystems · doi:10.15421/022059 · Cited by 2
Hussein, L. K. (2020) · Indian Journal of Forensic Medicine & Toxicology · doi:10.37506/ijfmt.v14i1.117 · Cited by 2
Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats
Seresht, H. R., Mansouri, E., Milani, M. D., Vahidianfar, B., Shahi, A. R., Namazi, M. J., Moallaei, H., Latifnia, M., & Abdizadeh, M. F. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0308 · Cited by 1
Salarizadeh, N., Shojai, S., Pebdeni, A. B., Nojoki, F., Zargar, S. J., & Habibi-Rezaei, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90222-9.00020-0 · Cited by 1
AGE-RAGE Pathway as a Potential Therapeutic Target
Ahmed, F. T., & Ali, S. H. (2025) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v9i1.2108 · Cited by 1
Borymska, W., Borymski, S., Zych, M., Dudek, S., & Kaczmarczyk‐Sedlak, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311252 · Cited by 1
Qaisrani, R. N., Niaz, S. I., Chaman, S., Dar, E., Akram, M., & Amin, A. (2025) · Main Group Chemistry · doi:10.1177/10241221251394675 · Cited by 1
Shen, F., Zhu, Z., Kong, X., Qu, Y., Dai, Y., Wang, T., & Li, Y. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.179979 · Cited by 1
Ahmmed, R., Antu, U. S., Noor, T., Faysal, M. F., Akter, M. T., Nesa, M., & Mollah, M. N. H. (2026) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2026.109036 · Cited by 1
Yang, H., Gong, X., Wang, N., Chen, S., Chen, W., & Zheng, Z. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.112738 · Cited by 1
Akinlade, O. M., Owoyele, B. V., & Soladoye, O. A. (2020) · PubMed Central · Cited by 1
Biological variation of glycated albumin, glucose and albumin in healthy Turkish subjects
Oğuz, O., Mercan, H., & Hocaoglu-Emre, F. S. (2021) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2020-0115 · Cited by 1
Тkachuk, S. S., Hryniuk, M. I., & Ткачук, О. В. (2023) · Clinical & experimental pathology · doi:10.24061/1727-4338.xxii.3.85.2023.07 · Cited by 1
Insights into COVID-19 in age-related macular degeneration
Torres, R. J. D. A. (2023) · The Pan-American Journal of Ophthalmology · doi:10.4103/pajo.pajo_71_22 · Cited by 1
A Recent Update on Candidate Biomarkers in the Pathogenesis of Diabetic Retinopathy
Shakthiya, T., Chand, L., & Annamalai, R. (2025) · The Open Biomarkers Journal · doi:10.2174/0118753183372247250213110930 · Cited by 2
Bai, Z., Lin, X., Wang, B., Li, Z., Qu, X., & Hou, Y. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1843576 · Cited by 1
Schaerffenberg, E. (2021) · Springer eBooks · doi:10.1007/978-3-662-62300-8_12 · Cited by 1
Measures of Endothelial Function in Type 2 Diabetes: A Focus on Circulatory Biomarkers
Hoong, C. W. S. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-08014-2_68 · Cited by 1
DF-5 COMPOUND DELAYS DEVELOPMENT OF DIABETIC NEPHROPATHY IN RATS
Спасов, А. А., Zhukovskaya, O. N., Rashchenko, A. I., Brigadirova, A. A., Litvinov, R., Гурова, Н. А., Smirnov, A. V., Паньшин, Н. Г., Abbas, H. S. A., & Морковник, А. С. (2023) · Pharmacy & Pharmacology · doi:10.19163/2307-9266-2022-10-6-549-561 · Cited by 2
Rock, C. A., Keeney, S. J., Zakharchenko, A., Takano, H., Spiegel, D. A., Krieger, A. Μ., Ferrari, G. M., & Levy, R. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.28.117739 · Cited by 1
Pathogenesis of Diabetic Neuropathy and the Treatment Efforts for it
Elshourbagy, T. (2019) · Acta Scientific Neurology · doi:10.31080/asne.2019.02.0089
Aly, W. W., Monier, M. M., Elsheikh, D. H. H., Amer, M. S., Omar, O. H., & Mahmoud, R. M. (2019) · Aging Medicine and Healthcare · doi:10.33879/amh.2019.1904
Advanced Glycation Endproducts (AGEs) in Food: Health Implications and Mitigation Strategies
Birch, C., & Bonwick, G. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788016438-00191
The Roles of HIFs in the Complications of Diabetes
Yazıhan, N., & Kocak, M. K. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_8
Xing, G., Huo, P., Zhang, X., Chen, Z., Wang, L., & Liu, Y. (2020) · Research Square · doi:10.21203/rs.3.rs-122889/v1
Arvilla, F. (2021) · Saintika Medika · doi:10.22219/sm.vol17.smumm1.12150
Abubakar, A., Nazifi, A. B., Maje, I. M., Tanko, Y., Anuka, J. A., & Abdurahman, E. M. (2021) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmdi-2021-0129 · Cited by 1
Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A. R., Yates, N., Baumann, C. G., Parkin, A., et al. (2021) · ChemRxiv · doi:10.26434/chemrxiv.14731779.v1
A collector of distinction: Sir William Holburne (1793-1874)
White, L. D. (2003) · Apollo: The international magazine of arts
Main molecular mechanisms for noncommunicable diseases
Geraldi, M. V., Filho, P. S. L., Baseggio, A. M., Cazarin, C. B. B., & Maróstica, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823569-0.00002-3
Mačáková, D., Plchová, M., Cibičková, Ľ., Krystyník, O., Karásek, D., & Zadražil, J. (2021) · BioMed · doi:10.3390/biomed2010001
Bansode, S. B., Joshi, R. S., Giri, A. P., & Kulkarni, M. J. (2022) · Chronicle of Diabetes Research and Practice · doi:10.4103/cdrp.cdrp_8_21
Pathogenesis of Microvascular Complications
Shore, A. C. (2022) · doi:10.1093/med/9780198870197.003.0275
Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A. D., Yates, N., Baumann, C. G., Parkin, A., et al. (2021) · ChemRxiv · doi:10.26434/chemrxiv.14731779
Measures of Endothelial Function in Type 2 Diabetes: A Focus on Circulatory Biomarkers
Hoong, C. W. S. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81303-1_68-1
Tétard, C., Poullenot, F., Pellet, G., Clouzeau, H., Rebouissoux, L., Wilsius, E., Kerlogot, L., Chevrier, C., Laharie, D., Lamireau, T., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1938892/v1
Ткачук, О. В., Тkachuk, S. S., Povar, M. A., Anokhina, S. I., Yasinska, O. V., & Vadziuk, S. N. (2022) · Fìzìologìčnij žurnal · doi:10.15407/fz68.04.040
谭, 娟. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.12101321
Shalaby, A., Al-Gholam, M. A.-S., Elfiky, S., & Elgarawany, G. E. (2022) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2022.8810
Hussein, K. S. (2022) · Pharmacophore · doi:10.51847/qt3qwqvjjk
Phytochemical investigation and Antidiabetic activity screening of Bennincas Hispida (THUNB.)
Uma, P., Ramya, M., Rani, B., Reddy, S. R., Saraswathi, A. Y., & Shreshta, R. (2023) · International Journal of Multidisciplinary Research and Growth Evaluation · doi:10.54660/.ijmrge.2023.4.1.395-400
Effect of Diet Patterns in the Prevention of Alzheimer’s Disease
Cosio, D. S., Rodriguez, S., Jayakumar, A. R., & Paidas, M. J. (2023) · Nutritional neurosciences · doi:10.1007/978-981-99-0677-2_13
Efeito do metilglioxal na função miccional em camundongos
de Oliveira, Á. L. (2023) · doi:10.47749/t/unicamp.2023.1374803
Mitigating diabetic cardiomyopathy
D’Haese, S. (2024) · Research Publications (Maastricht University) · doi:10.26481/dis.20241014sh
Samuel, P. G. M., Wantania, F. E. N., & Sedli, B. P. (2024) · Medical Scope Journal · doi:10.35790/msj.v7i1.58526
Chen, P., & Xie, Y. (2024) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-024-01432-3
The process of blood coagulation in individuals with diabetes mellitus
Ahmad, N. H., Agrilista, C. C., Yuda, Z. F., & Diyatri, I. (2024) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2024.24.3.3981
Historical insights of polyphenols in human health
Quero, J., López, V., Les, F., Cásedas, G., Delgado‐Machuca, M., Beas, Ó., & Rodriguez‐Yoldi, M. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13821-8.00001-9
Ahmadirad, H., Farhadnejad, H., Norouzzadeh, M., Jahromi, M. K., Mokhtari, E., Omrani, M., Teymoori, F., Sadeghi, R., Mirmiran, P., & Bagherian, M. (2025) · Cancer Epidemiology · doi:10.1016/j.canep.2025.102807
Zawadzka, M., Gil, W., Konieczny, A., Krakowska, K., Kijewska, M., & Stefanowicz, P. (2025) · ACS Omega · doi:10.1021/acsomega.5c02738
Al-sayed, R. M., Hasan, M. M., Hussein, S., Mohammed, A. M., Abdelazem, A. S., Abdelghany, E. M. A., EL-sayed, Y. M., & Mohammed, E. A. R. (2025) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-025-00184-8
Wang, H., Ma, X., Zhang, D., Liu, S., Ma, X., & Zhao, X. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07405-x · Cited by 1
Martínez, J. P. Q., & Campos, M. R. S. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10169-8
The Role of Metabolic and Environmental Factors in the Formation of Advanced Glycation End Products
Erim, B. (2025) · Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi · doi:10.46413/boneyusbad.1551266
Chayaratanasin, P., Adisakwattana, S., & Thilavech, T. (2021) · Figshare · doi:10.6084/m9.figshare.14140561
Advanced Glycation End Products— Physiology and Pathological Activity: A Literature Review
Ali, S. H., & Mhaibes, S. H. (2026) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v10i1.2593
Eberendu, E., Kizito., O., Ifeoma, U. V., Hyacint Chinenye, E., Aka Beatrice, L., Okoronkwo, K. C., & Ejezie Michael, U. (2026) · Research Journal of Science and Technology · doi:10.52711/2349-2988.2026.00002
Meher, N., Kisan, B., Swain, S. K., Mohanty, S., & Sahoo, A. K. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121447
Noreen, Z., Mondal, T., Johnson, J., Sahota, J., Loffredo, C. A., Nunlee-Bland, G. L., Korba, B. A., Bhatti, A., Chandra, V., & Ghosh, S. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251403462
Han, H., Hou, L., Lu, J., Sun, H., Ning, W., Liang, Y., Gu, Y., Yin, H., & Gao, Q. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1809245
Nalini, M., Sri, M. T., Gowri, G., Bandaru, N., & Latha, S. M. (2026) · Toxicology International · doi:10.18311/ti/2026/v33i1/47232
Therapeutic Role of Oxidative Stress in Diabetes
Saha, S., Karande, A. V., Nair, G. G., & Srivastava, N. (2026) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-032-19837-2_7
Xin, Q., Ma, L., Yu, X., & Du, G. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1854135
Abreu, L. L. D. C., Oliveira, N. C. C. A., Soares, T., Mendes, V. R., Macedo, J. L., Oliveira, A. S. D. S. S., da Silva, J. K. M., BARROS, M. M., Amorim, J. A., & Martins, M. D. C. D. C. E. (2026) · Nutrire · doi:10.1186/s41110-026-00523-x
Lan, N. T., & Duc, T. M. (2025) · Journal of Applied Pharmaceutical Technologies and Systems · doi:10.68159/p948328217
Seidu, S., Kunutsor, S. K., & Khunti, K. K. (2026) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2026.100756
Torres, Á., Montoya-Muñoz, S., Montes-Vanegas, M., Cappelli, C., Árias, I., Cancino, C. J., Quezada, C., Alarcón, S., Guerrero, B., Silva, P., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188171
Metadata
- Authors
- Rhee, S. Y., & Kim, Y. S.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Kim, Young Seol
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2018
- Volume
- 42
- Issue
- 3
- Pages
- 188
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC6015964
- OpenAlex
- W2806671364
- Cited by
- 274
- References
- 52
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 20 · 2023: 25 · 2022: 44 · 2021: 58 · 2020: 46 · 2019: 24 · 2018: 3
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Health and Welfare (HI10C2020)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- advanced glycation end products, diabetic vascular complications, chronic hyperglycemia, AGE receptor, AGE formation, glycemic control, diabetes complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
