Skeletal muscle thermogenesis and its role in whole body energy metabolism
Open accessAbstract
Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.
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Even small increases in energy demand in skeletal muscle can have significant effects on total-body energy expenditure, even in the basal state.
“even small increases in the energy demand in SkM can have significant effects on total-body energy expenditure [37], even in the basal state.”
Skeletal muscle represents approximately half of total body mass, accounts for nearly 80% of insulin-stimulated glucose uptake, and is a major determinant of basal metabolic rate.
“considering that SkM represents approximately half of the total body mass, that it accounts for nearly 80% of insulin-stimulated glucose uptake, and that it is a major determinant of the basal metabolic rate”
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“Indeed, considering that SkM represents approximately half of the total body mass, that it accounts for nearly 80% of insulin-stimulated glucose uptake, and that it is a major determinant of the basal metabolic rate, even small increases in the energy demand in SkM can have significant effects on total-body energy exp…”
BackgroundSkeletal muscle energy metabolism in obesity
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- Authors
- Periasamy, M., Herrera, J. L., & Reis, F. C. G.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Periasamy, Muthu
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2017
- Volume
- 41
- Issue
- 5
- Pages
- 327
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC5663671
- OpenAlex
- W2765117536
- Cited by
- 230
- References
- 64
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 38 · 2023: 29 · 2022: 41 · 2021: 30 · 2020: 22 · 2019: 8 · 2018: 9
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01-HL 088555, R01 DK098240)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- skeletal muscle thermogenesis, non-shivering thermogenesis, sarcolipin, energy expenditure, obesity, diabetes mellitus, diet-induced thermogenesis, cold-induced thermogenesis, UCP1, brown adipose tissue, white adipose tissue, basal metabolic rate
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