Effect of Jyotiṣmatī seed oil on spatial and fear memory using scopolamine induced amnesia in mice
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BACKGROUND: Treatment of memory impairment associated with dementia such as Alzheimer's disease is still inadequate and requires development of new drugs. OBJECTIVE: The objective was to evaluate the memory enhancing effect of Celastrus paniculatus seed oil. MATERIALS AND METHODS: C. paniculatus seed oil was mixed with equal amount of pure ghee and administered orally to mice in the dose of 200 mg/kg/day. Piracetam was used as a standard nootropic. Elevated plus maze and passive avoidance tests were used as a models to test spatial and fear memory respectively. Scopolamine (3 mg/kg, i.p.), was used as an amnestic agent. RESULTS: Mice receiving C. paniculatus showed significant memory enhancement as compared to scopolamine group. The effect of C. paniculatus and combination of C. paniculatus with piracetam was comparable to that with piracetam alone. CONCLUSION: The present study demonstrates that C. paniculatus seed oil has memory enhancing effect and hence can be developed as a potential drug in the treatment of dementia.
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C. paniculatus seed oil treatment showed memory improvement in scopolamine induced amnesia in mice.
“Furthermore, C. paniculatus seed oil treatment showed memory improvement in scopolamine induced amnesia in mice [182].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [182]
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- Authors
- Jadhav, K., Raut, S., Parekar, R., Marathe, P., & Rege, N.
- Affiliations
- King Edward Memorial Hospital and Seth G.S. Medical College (IN)
- ORCID
- Rege, NirmalaN
- Venue
- Ancient Science of Life
- Published
- 2015
- Volume
- 34
- Issue
- 3
- Pages
- 130
- ISSN
- 0257-7941 (ISSN-L)
- PMC
- PMC4458902
- OpenAlex
- W1571591883
- Cited by
- 26
- References
- 9
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 4 · 2018: 1 · 2017: 1 · 2016: 2
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Ancient Science of Life (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Celastrus paniculatus, seed oil, memory enhancement, spatial memory, fear memory, scopolamine-induced amnesia, piracetam, nootropic drugs, dementia, Alzheimer's disease, elevated plus maze, passive avoidance
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