Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats

Nalini, K.; Karanth, K.S.; Rao, A.; Aroor, A.R.

doi:10.1016/0378-8741(95)01264-e

Cited by 81Medicinal Plants and NeuroprotectionMedicinal Plant Extracts EffectsMedicinal Plant Research

Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats

Nalini, K., Karanth, K.S., Rao, A., Aroor, A.R.·1995·Journal of Ethnopharmacology

DOI 10.1016/0378-8741(95)01264-e

Open this paper in CoChat — free account

Abstract

The effects of an indigenous drug, Celastrus oil, extracted from the seeds of Celastrus paniculatus on learning and memory in a two compartment passive avoidance task was studied in albino rats. The effects on the contents of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in the brain and on the levels of their metabolites both in the brain and urine were also assessed. Significant improvement was observed in the retention ability of the drug treated rats compared with the saline administered controls. The contents of NE, DA and 5-HT and their metabolites in the brain were significantly decreased in the drug treated group. The urinary metabolite levels were also significantly decreased except for total 3-methoxy-4-hydroxyphenyl glycol. These data indicate that Celastrus oil causes an overall decrease in the turnover of all the three central monoamines and implicate the involvement of these aminergic systems in the learning and memory process.

Integrity signals

Registry

Crossref · 10.1016/0378-8741(95)01264-e

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Centella asiatica aqueous leaf extract improves learning and memory in rats and modulates dopamine, 5-hydroxytryptamine and noradrenaline systems in the rat brain in-vivo.
“C. asiatica aqueous leaf extract showed improvement in learning and memory in rats, and modulated dopamine, 5-hydroxytryptamine (5-HT) and noradrenaline systems in the rat brain in-vivo [56].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [56]
Rats treated with 850 mg/kg of C. paniculatus oil for 15 days had significantly improved retention in two passive avoidance tasks.
“In another study, rats treated with 850 mg/kg of C. paniculatus oil for 15 days had significantly improved retention in two passive avoidance tasks [56].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [56]

ON THE COLORIMETRIC DETERMINATION OF CREATININE BY THE JAFFE REACTION
Bonsnes, R. W., & Taussky, H. H. (1945) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51334-5 · Cited by 2,006 · see citing works
Psychopharmacology : a generation of progress
Lipton, M. A., DiMascio, A., & Killam, K. F. (1978) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,208 · see citing works
The role of dopamine in locomotor activity and learning
Beninger, R. J. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90038-3 · Cited by 848 · see citing works
Antiepileptic Drug Development: II. Anticonvulsant Drug Screening
Krall, R. L., PENRY, J. K., WHITE, B. G., Kupferberg, H. J., & Swinyard, E. A. (1978) · Epilepsia · doi:10.1111/j.1528-1157.1978.tb04507.x · Cited by 825 · see citing works
Screening Methods in Pharmacology
(1971) · Elsevier eBooks · doi:10.1016/c2013-0-11630-3 · Cited by 789 · see citing works
Psychopharmacology: A generation of progress
LADER, M. H. (1978) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(78)90014-4 · Cited by 771 · see citing works
Catecholamine metabolism: basic aspects and clinical significance.
Kopin, I. J. (1985) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06859-0 · Cited by 582 · see citing works
Involvement of Hormonal and Neuromodulatory Systems in the Regulation of Memory Storage
McGaugh, J. L. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.001351 · Cited by 562 · see citing works
Simultaneous Determination of 3,4‐Dihydroxyphenylalanine, 5‐Hydroxytryptophan, Dopamine, 4‐Hydroxy‐3‐Methoxyphenylalanine, Norepinephrine, 3,4‐Dihydroxyphenylacetic Acid, Homovanillic Acid, Serotonin, and 5‐Hydroxyindoleacetic Acid in Rat Cerebrospinal Fluid and Brain by High‐Performance Liquid Chromatography with Electrochemical Detection
Wagner, J., Vitali, P., Palfreyman, M. G., Zraika, M. M., & Huot, S. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb07897.x · Cited by 345 · see citing works
Biology of serotonergic transmission
Gray, E. G. (1983) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(83)90123-8 · Cited by 203 · see citing works
Posttraining brain norepinephrine concentrations: Correlation with retention performance of avoidance training and with peripheral epinephrine modulation of memory processing
Gold, P. E., & van Buskirk, R. (1978) · Behavioral Biology · doi:10.1016/s0091-6773(78)91614-0 · Cited by 191 · see citing works
Nadkarni's Indian Materia Medica.
Nadkarni, A. (1954) · Cited by 178 · see citing works
Cortical spreading depression as a memory disturbing factor.
Bureš, J., & Burešová, O. (1963) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0045749 · Cited by 170 · see citing works
SOME BEHAVIORAL EFFECTS OF SEROTONIN DEPLETION DEPEND ON METHOD: A COMPARISON OF 5,7‐DIHYDROXYTRYPTAMINE, p‐CHLOROPHENYLALANINE, p‐CHLOROAMPHETAMINE, AND ELECTROLYTIC RAPHE LESIONS*
Lorens, S. A. (1978) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1978.tb31547.x · Cited by 133 · see citing works
Catecholamines and behaviour
Mason, S. T. (1984) · Cambridge University Press eBooks · Cited by 102 · see citing works
Catecholamines and behaviour
Dantzer, R. (1985) · Neuropsychologia · doi:10.1016/0028-3932(85)90057-0 · Cited by 61 · see citing works
What should a biochemistry of learning and memory be about?
Rose, S. P. R. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90164-0 · Cited by 59 · see citing works
Brain noradrenergic responses to training and to amnestic frontal cortex stimulation
Gold, P. E., & Murphy, J. M. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90082-9 · Cited by 46 · see citing works
Different temporal effects of serotonergic antagonists on passive avoidance retention
Altman, H. J., & Normile, H. J. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90452-7 · Cited by 44 · see citing works
Studies on biogenic amines and their metabolites in mentally retarded children on celastrus oil therapy
Nalini, K., Ar, A., Kb, K., & Rao, A. (1986) · Cited by 23 · see citing works
Self-citation
A spectrophotometric method for the estimation of 3-methoxy-4-hydroxyphenylglycol in urine.
Bigelow, L. B., Neal, S. P., & Weil‐Malherbe, H. (1971) · PubMed · Cited by 20 · see citing works
Improved colorimetry of urinary 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid).
Knight, J. A., & Haymond, R. E. (1977) · Clinical Chemistry · doi:10.1093/clinchem/23.11.2007 · Cited by 15 · see citing works
Colorimetric assay of urinary 5-hydroxy-3-indoleacetic acid
Shihabi, Z. K., & Wilson, E. L. (1982) · Clinical Biochemistry · doi:10.1016/s0009-9120(82)96125-2 · Cited by 11 · see citing works
A semi automated procedure for the measurement of 3-methoxy-4 hydroxy mandelic acid
Siddiqui, S. A., & Craig, A. (1978) · Clinical Biochemistry · doi:10.1016/s0009-9120(78)90758-0 · Cited by 3 · see citing works

Flagged first, then by citations

Sorted by citations

Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function
Howes, M. R., & Houghton, P. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00128-x · Cited by 443 · see citing works
Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders
Zhang, Z. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.014 · Cited by 345 · see citing works
Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature
Adams, M. A., Gmünder, F., & Hamburger, M. O. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.07.016 · Cited by 328 · see citing works
Neuroprotective Herbs for the Management of Alzheimer’s Disease
Gregory, J., Vengalasetti, Y. V., Bredesen, D. E., & Rao, R. V. (2021) · Biomolecules · doi:10.3390/biom11040543 · Cited by 238 · see citing works
Clitoria ternatea and the CNS
Jain, N., Ohal, C. C., Shroff, S. K., Bhutada, R. H., Somani, R., Kasture, V. S., & Kasture, S. B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00130-8 · Cited by 194 · see citing works
Journal of Global Trends in Pharmaceutical Sciences
Rao, A., Korim, R., Reddy, D. S., & Mujavar, E. (2014) · Cited by 142 · see citing works
Self-citation
Ethnomedicinal plants used for digestive system disorders by the Karen of northern Thailand
Tangjitman, K., Wongsawad, C., Kamwong, K., Sukkho, T., & Trisonthi, C. (2015) · Journal of Ethnobiology and Ethnomedicine · doi:10.1186/s13002-015-0011-9 · Cited by 135 · see citing works
Antioxidant property of Celastrus paniculatus Willd.: A possible mechanism in enhancing cognition
Kumar, M. H. V., & Gupta, Y. K. (2002) · Phytomedicine · doi:10.1078/0944-7113-00136 · Cited by 133 · see citing works
Neuropharmacological profile of Eclipta alba (Linn.) Hassk
Thakur, V., & Mengi, S. A. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.05.037 · Cited by 133 · see citing works
The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease
Divino da Rocha, M., Pereira Dias Viegas, F., Cristina Campos, H., Carolina Nicastro, P., Calve Fossaluzza, P., Alberto Manssour Fraga, C., J. Barreiro, E., & Viegas, C. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794480429 · Cited by 126 · see citing works
Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
“paniculatus oil for 15 days had significantly improved retention in two passive avoidance tasks [56].”
Background
Hippocampal brain amines in methotrexate-induced learning and memory deficit
Madhyastha, S., Somayaji, S. N., Rao, M. S. R., Nalini, K., & Bairy, L. K. (2002) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y02-135 · Cited by 102 · see citing works
Self-citation
Nootropic activity ofCelastrus paniculatusseed
Bhanumathy, M., Harish, M. S., Shivaprasad, H. N., & Sushma, G. (2010) · Pharmaceutical Biology · doi:10.3109/13880200903127391 · Cited by 88 · see citing works
Reversal of Scopolamine-Induced Deficits in Navigational Memory Performance by the Seed Oil of Celastrus paniculatus
Gattu, M., Boss, K. L., Terry, A. V., & Buccafusco, J. J. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00391-7 · Cited by 79 · see citing works
Effect ofConvulvulus pluricaulisChoisy. on learning behaviour and memory enhancement activity in rodents
Nahata, A., Patil, U. K., & Dixit, V. K. (2008) · Natural Product Research · doi:10.1080/14786410802214199 · Cited by 74 · see citing works
Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells
Godkar, P. B., Gordon, R. K., Ravindran, A., & Doctor, B. P. (2006) · Phytomedicine · doi:10.1016/j.phymed.2003.11.011 · Cited by 72 · see citing works
GC–MS analysis of the essential oil of Celastrus paniculatus Willd. seeds and antioxidant, anti-inflammatory study of its various solvent extracts
Arora, N., & Rai, S. P. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.07.025 · Cited by 67 · see citing works
Nootropic activity of Albizzia lebbeck in mice
Chintawar, S., Somani, R., Kasture, V. S., & Kasture, S. B. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00140-x · Cited by 65 · see citing works
Effect of leaves of Butea frondosa on stress, anxiety, and cognition in rats
Soman, I. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.05.022 · Cited by 62 · see citing works
Ameliorating effect ofCelastrus paniculatusstandardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism
Malik, J., Karan, M., & Dogra, R. (2017) · Pharmaceutical Biology · doi:10.1080/13880209.2017.1285945 · Cited by 62 · see citing works
Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment
Bhagya, V. R., Christofer, T., & Rao, B. S. S. (2016) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.194853 · Cited by 60 · see citing works
Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain
Godkar, P. B., Gordon, R. K., Ravindran, A., & Doctor, B. P. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.03.051 · Cited by 54 · see citing works
Effect of Jyotishmati (Celastrus paniculatus) seeds in mouse models of pain and inflammation
Kulkarni, Y. A., Agarwal, S., & Garud, M. S. (2014) · Journal of Ayurveda and Integrative Medicine · doi:10.4103/0975-9476.146540 · Cited by 50 · see citing works
Potent relaxant effect of a Celastrus paniculatus extract in the rat and human ileum
Borrelli, F., Borbone, N., Capasso, R., Montesano, D., Marino, S. D., Aviello, G., Aprea, G., Masone, S., & Izzo, A. A. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.02.003 · Cited by 46 · see citing works
Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour
Rajkumar, R., Kumar, E. P., Suresh, S., & Suresh, B. (2006) · Fitoterapia · doi:10.1016/j.fitote.2006.09.028 · Cited by 39 · see citing works
Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria
Qassadi, F. I., Zhu, Z., & Monaghan, T. M. (2023) · Pathogens · doi:10.3390/pathogens12020333 · Cited by 41 · see citing works
Chemical and Pharmacological Studies of the Plants from Genus Celastrus
Su, X., Zhang, M., Wen-hong, Z., Huo, C., Shi, Q., Gu, Y., & Kiyota, H. (2009) · Chemistry & Biodiversity · doi:10.1002/cbdv.200700403 · Cited by 37 · see citing works
PHYTO-PHARMACOLOGY OF CELASTRUS PANICULATUS: AN OVERVIEW
Bhanumathy, M., Chandrasekar, S. B., Chandur, U., & Somasundaram, T. C. (2010) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2010.020303 · Cited by 36 · see citing works
Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide-induced oxidative injury
Godkar, P., Gordon, R. K., Ravindran, A., & Doctor, B. P. (2003) · Fitoterapia · doi:10.1016/s0367-326x(03)00190-4 · Cited by 32 · see citing works
(M)- and (P)-Bicelaphanol A, Dimeric Trinorditerpenes with Promising Neuroprotective Activity from Celastrus orbiculatus
Wang, L., Wu, J., Yang, Z., Wang, X.-J., Fu, Y., Liu, S.-Z., Wang, H., Zhu, W., Zhang, H., & Zhao, W. (2013) · Journal of Natural Products · doi:10.1021/np3008182 · Cited by 29 · see citing works
Neuroprotective effect ofManasamitra vatakamagainst aluminium induced cognitive impairment and oxidative damage in the cortex and hippocampus of rat brain
Thirunavukkarasu, S., Venkataraman, S., Sundararajan, R., & Upadhyay, L. (2011) · Drug and Chemical Toxicology · doi:10.3109/01480545.2011.589442 · Cited by 28 · see citing works
Effect of Jyotiṣmatī seed oil on spatial and fear memory using scopolamine induced amnesia in mice
Jadhav, K., Raut, S., Parekar, R., Marathe, P., & Rege, N. (2015) · Ancient Science of Life · doi:10.4103/0257-7941.157149 · Cited by 26 · see citing works
CELASTRUS PANICULATUS, AN ENDANGERED INDIAN MEDICINAL PLANT WITH MIRACULOUS COGNITIVE AND OTHER THERAPEUTIC PROPERTIES: AN OVERVIEW
Rai, S. P. (2012) · International Journal of Pharma and Bio Sciences · Cited by 26 · see citing works
An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd
Nagpal, K., Garg, M., Arora, D., Dubey, A., & Grewal, A. S. (2022) · Phytotherapy Research · doi:10.1002/ptr.7424 · Cited by 23 · see citing works
Psychoactive Herbs in Veterinary Behavior Medicine
Schwartz, S. (2005) · Wiley eBooks · doi:10.1002/9780470344644 · Cited by 24 · see citing works
Traditional Medicine for Memory Enhancement
Howes, M. R., & Houghton, P. J. (2008) · Springer eBooks · doi:10.1007/978-3-540-79116-4_15 · Cited by 21 · see citing works
Anti-alzheimer and antioxidant activity of celastrus paniculatus seed
Badrul, A., & Ekramul, H. (2011) · BRAC University Institutional Repository (BRAC University) · Cited by 20 · see citing works
Phytochemistry and pharmacology of Celastrus paniculatus Wild.: a nootropic drug
Aleem, M. A. (2021) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2021-0251 · Cited by 17 · see citing works
Neuroprotective potential of Celastrus paniculatus seeds against common neurological ailments: a narrative review
Sankaramourthy, D., Sankaranarayanan, L., Subramanian, K., & Sadras, S. R. (2022) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2021-0448 · Cited by 17 · see citing works
Anti-stress and nootropic activity of drugs affecting the renin-angiotensin system in rats based on indirect biochemical evidence
Kumar, K. A., Nagwar, S., Thyloor, R., & Satyanarayana, S. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320313516173 · Cited by 16 · see citing works
Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model
Faldu, K. G., Patel, S. S., & Shah, J. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01186-7 · Cited by 14 · see citing works
Application of Green Technologies in Design-Based Extraction of Celastrus paniculatus (Jyotishmati) Seeds, SEM, GC-MS Analysis, and Evaluation for Memory Enhancing Potential
Arya, A., Kaushik, D. K., Almeer, R., BUNGAU, S. G., Sayed, A. A., Abdel‐Daim, M. M., Bhatia, S., & Mittal, V. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.871183 · Cited by 14 · see citing works
Effect of intracerebroventricular methotrexate on brain amines.
Madhyastha, S., Somayaji, S. N., Rao, M. S., Nalini, K., & Bairy, K. L. (2005) · PubMed · Cited by 12 · see citing works
Self-citation
Nootropic Activity of Caralluma fimbriata Extract in Mice
Rajendran, R., Ambikar, D. B., Khandare, R. A., Sannapuri, V. D., Vyawahare, N., & Clayton, P. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.52019 · Cited by 11 · see citing works
Therapeutic potentiality of a new flavonoid against ketamine induced glutamatergic dysregulation in schizophrenia: In vivo and in silico approach
Venkataramaiah, C., Payani, S., Priya, B. L., & Pradeepkiran, J. A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111453 · Cited by 11 · see citing works
The Role of Natural Products in Alzheimer's and Parkinson's Disease
Khatoon, S. S., Rehman, M. U., & Rahman, A. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64058-1.00003-0 · Cited by 10 · see citing works
Medicinal Plants from Deccan Ecoregion, India: Traditional Knowledge, Ethnopharmacology, Cultivation, Utilization, Conservation and Biotechnology - Opportunities and Impediments
Prasad, M. N. V., Padmalatha, K. V., Jayaram, K. M., & da Silva, J. A. T. (2007) · Cited by 10 · see citing works
Herbal Remedies to Treat Anxiety Disorders
Bhagya, V. R., Bettadapura, N., & Rao, B. S. S. (2011) · InTech eBooks · doi:10.5772/23511 · Cited by 9 · see citing works
Nootropic (medhya) plants from ayurvedic pharmacopoeia
Maciuk, A., Bouchet, M.-J., Mazars, G., Um, B., & Anton, R. (2002) · IRD Éditions eBooks · doi:10.4000/books.irdeditions.7273 · Cited by 9 · see citing works
NEUROPHARMACOLOGICAL PROFILE OF PIPER BETEL LEAVES EXTRACT IN MICE
Vyawahare, N. S., & Bodhankar, S. L. (2007) · Cited by 7 · see citing works
The Disease‐Preventive Potential of Some Popular and Underutilized Seeds
Bhat, R. (2011) · doi:10.1002/9780470960844.ch7 · Cited by 7 · see citing works
In vitro effect of selected medicinal plants on β-amyloid induced toxicity in neuroblastoma cells
Adewusi, E. A. (2012) · UpSpace Institutional Repository (University of Pretoria) · Cited by 7 · see citing works
Phytochemical Composition, Pharmacological Properties, and Therapeutic Applications of Celastrus paniculatus
Kandikattu, H. K., Amruta, N., Khanum, F., Narayana, V. V. P. C., & Srinivasulu, D. (2020) · Current Traditional Medicine · doi:10.2174/2215083806666200218111155 · Cited by 6 · see citing works
Neuropharmacological and Cognitive Effects of Celastrus paniculatus – A Comprehensive Review
Bhagya, V. R., & Jaideep, S. (2020) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2020.v65i01.013 · Cited by 6 · see citing works
ROLE OF MEDICINAL PLANTS IN NEURODEGENERATIVE DISEASES WITH SPECIAL EMPHASIS TO ALZHEIMER'S DISEASE
Abdel, M., Hassan, G., Balasubramanian, R., Masoud, A. D., Burkan, Z. E., Sughir, A. A., & Raju, S. K. (2014) · Cited by 6 · see citing works
Pharmacognosy, phytochemistry and clinical applications of traditional medicinal plants as memory booster
Gudalwar, B. R., Panchale, W. A., Manwar, J. V., Nimbalwar, M. G., Badukale, N. A., & Bakal, R. L. (2021) · GSC Advanced Research and Reviews · doi:10.30574/gscarr.2021.8.2.0155 · Cited by 6 · see citing works
Natural products as cognition enhancing agents
Wesnes, K. A., Zangara, A., Scholey, A. B., & Kennedy, D. O. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7867-8_10 · Cited by 6 · see citing works
Biological activities and therapeutic effects of Celastrus paniculatus seed oil
Chan, K. W., Chin, V. K., Ismail, N., Ooi, D. J., Khong, N. M. H., & Esa, N. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824135-6.00024-6 · Cited by 5 · see citing works
A STUDY ON NOOTROPIC ACTIVITY OF CELASTRUS PANICULATA WILLD WHOLE PLANT METHANOLIC EXTRACT IN RATS
Jakka, A. L. (2016) · Asian Journal of Pharmaceutical and Clinical Research · Cited by 5 · see citing works
Neuropharmacology of Celastrus paniculatus Willd.
Saroya, A. S., & Singh, J. (2018) · Springer eBooks · doi:10.1007/978-981-13-0289-3_12 · Cited by 5 · see citing works
AN ANCIENT APPROACH BUT TURNING INTO FUTURE POTENTIAL SOURCE OF THERAPEUTICS IN ALZHEIMER’S DISEASE
Singh, V. (2015) · International Research Journal of Pharmacy · doi:10.7897/2230-8407.0614 · Cited by 4 · see citing works
Gas chromatography‐mass spectrophotometric profile of cold‐pressed Celastrus paniculatus seed oil and its high‐performance thin‐layer chromatographic analysis emphasizing squalene content
Jarande, S. S., & Damle, M. C. (2024) · Separation Science Plus · doi:10.1002/sscp.202300179 · Cited by 3 · see citing works
Future Evolution of the Human Brain
Saniotis, A., & Henneberg, M. (2011) · Cited by 3 · see citing works
NEUROPHARMACOLOGICAL PROFILE OF ETHANOLIC EXTRACT OF DALBERGIA LATIFOLIA ROXB IN SWISS ALBINO MICE
Prasad, D. R. P. D. S. P. E., & Chandran, R. V. (2013) · Cited by 3 · see citing works
Natural Medicines Enhancing Neurite Growth in Central Nervous System Disorders: A Review
Sudha, M., Sundaram, R., Annapondian, V., Abhirama, B., Vazhayil, B. K., Gomathi, S., Geethapriya, C., & Patel, D. (2015) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2016/21881 · Cited by 1 · see citing works
Effect of Isolated Fraction from Biophytum reinwardtii on Dexamethasone Induced Insulin Resistance in Rats
Bandaru, N., Rao, A. N., Deepika, Y., Ketha, A., Thathipudi, D., & Laxmi, N. (2023) · Toxicology International · doi:10.18311/ti/2023/v30i1/26258 · Cited by 1 · see citing works
Self-citation
Celastrus paniculatus Willd. (Celastraceae)
Akbar, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-16807-0_59 · Cited by 1 · see citing works
Celastrus paniculatus and memantine prevent alcohol dependence and improve decision making in alcohol dependent C57BL6 mice
Pooja, S., Raut, S. B., Kamat, S. K., Satam, S., Marathe, P. A., & Rege, N. N. (2023) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20230383 · Cited by 1 · see citing works
Ayurvedic Psychoactive Herbs
Schwartz, S. (2005) · doi:10.1002/9780470344644.ch3
Review article AYURVEDIC MEDICINAL PLANTS AS PSYCHOTHERAPEUTIC AGENTS-A REVIEW
Sharma, M., Sahu, S. K., Khemani, N., & Kaur, R. (2014)
EUROPHARMACOLOGICAL PROFILE OF TRICHOLEPIS GLABERRIMA EXTRACT IMICE
Khadabadi, S. S., Deore, S. L., & Hadke, S. P. (2009)
Comparison of Fatty Acid and Alkaloid Contents in Celastrus paniculatus Willd. Seed Oil
Kaewsopak, O., Naphrom, D., & Supapornhemin, P. (2013)
OIL ACCUMULATION IN FRUIT CELASTRUS RUGOSUS
Trusov, N. A. (2011) · CyberLeninK (CyberLeninka)
Papel de receptores monoaminérgicos, colinérgicos e glutamatérgicos no efeito pro-mnéstico de Ptychopetalum olacoides Bentham (Olacaceae).
Saúde, B. D. (2006)
ATTENUATION OF STRESS INDUCED URINARY BIOCHEMICAL CHANGES AND SCOPOLAMINE-INDUCED MEMORY LOSS BY HYDROALCOHOLIC SEED EXTRACT OF CELASTRUS PANICULATUS WILLD. IN RAT MODEL
V., A. K. K., Vimala, N., Rama, T., & Sreemanthula, S. (2021) · INDIAN DRUGS · doi:10.53879/id.58.07.12639
Pharmacognosy Phytochemistry and Clinical Applications of Medicinal Plant as Nervine Tonic
Nagre, B. G., Manwar, G. G., Kohale, N. B., Rathod, S. B., Tiwari, K. S., & Deshmukh, A. O. (2023) · International Journal of Advanced Research in Science Communication and Technology · doi:10.48175/ijarsct-8840
Effect of Celastrus paniculatus on Alcohol-Elicited Conditioned Place Preference and Alcohol Withdrawal-Induced Anxiety in Mice
Satam, S., Raut, S., Shetty, Y., Marathe, P., Mulkalwar, A., Raut, A., & Rege, N. (2025) · Cureus · doi:10.7759/cureus.81962 · Cited by 1 · see citing works
Unveiling the Cognitive Enhancer: A Comprehensive Review of Celastrus paniculatus
Kolambkar, S. V., Beerwala, F. A., Samant, S. S., Hurkadale, P. J., & Harish, D. R. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898814380126070007
DNA Barcoding, GC-MS Analysis, and Biological Activity Prediction of Bioactive Compounds in the Seeds of Celastrus paniculatus: A Source of Lead Compounds for Neurological Disorders
Nadh, A. G., Mohan, A., Sajal, H., Arya, K. R., & Raju, R. (2026) · Journal of Natural Remedies · doi:10.18311/jnr/2026/55143
Ayurveda and Mental Health – A Systemic Review Study
Patel, P., Patel, R., & Raskar, S. C. (2026) · Studies in Rhythm Engineering · doi:10.1007/978-3-032-19974-4_16

Effect of Celastrus Paniculatus on Learning, Memory and Serum Biochemistry of Aging Albino Rats
Younus, M., & Agarwal, M. (2013) · Journal of Chemistry and Chemical Engineering · Cited by 4 · see citing works
Studies on biogenic amines and their metabolites in mentally retarded children on celastrus oil therapy
Nalini, K., Ar, A., Kb, K., & Rao, A. (1986) · Cited by 23 · see citing works
Self-citation
Nootropic Effect of Celastrus paniculatus on Restraint Stress Induced Behavioral and Biochemical Changes in Wistar Albino Rats
Paul, J., Phazani Sankar, M., Ravishankar, N., & Rajan, R. (2024) · International Journal of Ayurvedic Medicine · doi:10.47552/ijam.v14i4.3903
Nootropic activity ofCelastrus paniculatusseed
Bhanumathy, M., Harish, M. S., Shivaprasad, H. N., & Sushma, G. (2010) · Pharmaceutical Biology · doi:10.3109/13880200903127391 · Cited by 88 · see citing works
A STUDY ON NOOTROPIC ACTIVITY OF CELASTRUS PANICULATA WILLD WHOLE PLANT METHANOLIC EXTRACT IN RATS
Jakka, A. L. (2016) · Asian Journal of Pharmaceutical and Clinical Research · Cited by 5 · see citing works

Authors: Nalini, K., Karanth, K. S., Rao, A., & Aroor, A. R.
Affiliations: Kasturba Medical College, Manipal (IN)
Kasturba Medical College Hospital (IN)
Corresponding author: Nalini, K.
ORCID: Nalini, K.
Rao, A.
Aroor, A.R.
Venue: Journal of Ethnopharmacology
Publisher: Elsevier BV
Published: 1995-07
Volume: 47
Issue: 2
Pages: 101-108
ISSN: 0378-8741 (ISSN-L)
DOI: 10.1016/0378-8741(95)01264-e
OpenAlex: W2031952773
Cited by: 81
References: 24
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 4 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 2
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Ethnopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Indian Council of Medical Research
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: Celastrus paniculatus, seed oil, passive avoidance, learning and memory, norepinephrine, dopamine, serotonin, monoamine metabolites, MHPG, aminergic systems, memory retention
MeSH terms: Animals, Avoidance Learning, Behavior, Animal, Biogenic Amines, Brain, Dopamine, Male, Methoxyhydroxyphenylglycol, Synaptic Transmission, Norepinephrine, Plant Extracts, Plant Oils, Plants, Medicinal, Seeds, Serotonin, Rats, Wistar, Pain Threshold, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks