Behavioral effects of deep brain stimulation of the anterior nucleus of thalamus, entorhinal cortex and fornix in a rat model of Alzheimer’s disease
Open accessAbstract
BACKGROUND: Recent clinical and preclinical studies have suggested that deep brain stimulation (DBS) can be used as a tool to enhance cognitive functions. The aim of the present study was to investigate the impact of DBS at three separate targets in the Papez circuit, including the anterior nucleus of thalamus (ANT), the entorhinal cortex (EC), and the fornix (FX), on cognitive behaviors in an Alzheimer's disease (AD) rat model. METHODS: Forty-eight rats were subjected to an intrahippocampal injection of amyloid peptides 1-42 to induce an AD model. Rats were divided into six groups: DBS and sham DBS groups of ANT, EC, and FX. Spatial learning and memory were assessed by the Morris water maze (MWM). Recognition memory was investigated by the novel object recognition memory test (NORM). Locomotor and anxiety-related behaviors were detected by the open field test (OF). By using two-way analysis of variance (ANOVA), behavior differences between the six groups were analyzed. RESULTS: In the MWM, the ANT, EC, and FX DBS groups performed differently in terms of the time spent in the platform zone (F(2,23) = 6.04, P < 0.01), the frequency of platform crossing (F(2,23) = 11.53, P < 0.001), and the percent time spent within the platform quadrant (F(2,23) = 6.29, P < 0.01). In the NORM, the EC and FX DBS groups spent more time with the novel object, although the ANT DBS group did not (F(2,23) = 10.03, P < 0.001). In the OF, all of the groups showed a similar total distance moved (F (1,42) = 1.14, P = 0.29) and relative time spent in the center (F(2,42) = 0.56, P = 0.58). CONCLUSIONS: Our results demonstrated that DBS of the EC and FX facilitated hippocampus-dependent spatial memory more prominently than ANT DBS. In addition, hippocampus-independent recognition memory was enhanced by EC and FX DBS. None of the targets showed side-effects of anxiety or locomotor behaviors.
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Electrical stimulation of the EC facilitated NOP memory and water maze spatial navigation in rats infused with amyloid peptides 1-42 into the hippocampus, as a model of Alzheimer's disease.
“Furthermore, electrical stimulation of EC facilitated NOP memory and water maze spatial navigation in rats infused with the amyloid peptides 1–42 into the hippocampus, as a model of Alzheimer’s disease (Zhang et al., 2015), suggestive of close connections between the EC and hippocampus-dependent functions.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Zhang et al., 2015
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Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
- Authors
- Zhang, C., Hu, W.-H., Wu, D.-L., Zhang, K., & Zhang, J.-G.
- Affiliations
- Capital Medical University (CN)
- Xiamen University (CN)
- Corresponding author
- Zhang, Chao
- Zhang, Kai
- Venue
- Chinese Medical Journal
- Published
- 2015-05-05
- Volume
- 128
- Issue
- 9
- Pages
- 1190-1195
- ISSN
- 0366-6999 (ISSN-L)
- PMC
- PMC4831546
- OpenAlex
- W1550155560
- Cited by
- 42
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 1 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 5
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Chinese Medical Journal (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- deep brain stimulation, Alzheimer's disease, entorhinal cortex, fornix, Papez circuit, amyloid-beta 42, spatial learning and memory, recognition memory, anxiety, locomotor behavior, rat model
- MeSH terms
- Alzheimer Disease, Animals, Male, Memory, Rats, Sprague-Dawley, Entorhinal Cortex, Anterior Thalamic Nuclei, Fornix, Brain, Deep Brain Stimulation, Rats, Spatial Learning
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