Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: A diffusion tensor imaging study
Abstract
Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus may play a role in the pathophysiology of schizophrenia. The cingulum bundles (CBs; posterior and anterior) are the most prominent white matter tracts in the limbic system, furnishing both input and output to the cingulate gyrus . In previous diffusion tensor imaging (DTI) studies, abnormal integrity has been demonstrated in the anterior CB portion, but not the posterior, in schizophrenia. As well, the relationships between the abnormalities of CB integrity and the psychopathology of schizophrenia remain to be elucidated. Using DTI acquired on a 3 T MRI machine, we examined fractional anisotropy (FA) in the anterior and posterior CBs of 42 patients with schizophrenia and 24 group-matched controls. Moreover, we investigated the relationships between CB abnormalities and the psychopathology of schizophrenia. Bilaterally reduced FA was demonstrated in both anterior and posterior CBs in schizophrenia patients. However, the pattern of FA reduction was different between anterior and posterior CBs: the reduction in FA was left-accentuated in anterior CBs, while no such lateralized abnormality was found in posterior ones. Finally, FA in posterior CBs correlated with positive symptom scores in patients with schizophrenia. These findings suggest that CB abnormalities in schizophrenia are not restricted to the anterior CB, but include the posterior as well. Pathology in the posterior CB would be one of the possible neural underpinnings of positive symptoms in schizophrenia.
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In schizophrenia, primary sensorimotor fasciculi appear comparatively unaffected, while structural abnormalities are consistently reported in frontal fasciculi connecting the frontal lobe with the rest of the brain, including the uncinate, arcuate, superior longitudinal, and cingulum bundle.
“Specifically, while the primary sensorimotor fasciculi appear to be comparatively unaffected in patients in schizophrenia, structural abnormalities have consistently been reported in the fasciculi connecting the frontal lobe with the rest of the brain, such as the uncinate fasciculus, 25,26 arcuate fasciculus, 27,28 superior longitudinal fasciculus, 29,30 and cingulum bundle.31,32”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [28]
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- Authors
- Fujiwara, H., Namiki, C., Hirao, K., Miyata, J., Shimizu, M., Fukuyama, H., Sawamoto, N., Hayashi, T., & Murai, T.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Fujiwara, Hironobu
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 95
- Issue
- 1-3
- Pages
- 215-222
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2094634860
- Cited by
- 126
- References
- 33
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 10
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Kobayashi Magobe Memorial Medical Foundation (18020014)
- Uehara Memorial Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, cingulum
- MeSH terms
- Adult, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Neural Pathways, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Anisotropy, Age of Onset, Diffusion Magnetic Resonance Imaging
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