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Cited by 61

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Safety and Efficacy of Tocilizumab for the Treatment of Rheumatoid Arthritis

Ogata, Atsushi, Hirano, Toru, Hishitani, Yoshihiro, Tanaka, Toshio·2012·Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
DOI 10.4137/cmamd.s7371PMC PMC3306224
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Abstract

Because of the pathological role of IL-6 in rheumatoid arthritis (RA), tocilizumab (TCZ), a humanized anti-IL-6 receptor monoclonal antibody, was expected to improve inflammation and joint destruction of RA. Indeed, randomized clinical trials demonstrated the clinical efficacy of TCZ as monotherapy or combined with methotrexate (MTX) for RA patients with inadequate responses to disease-modifying antirheumatic drugs, MTX or tumor necrosis factor (TNF) inhibitors. Although long-term tolerability for TCZ is superior to that for TNF inhibitors, information regarding the potency of drug free remission of TCZ is limited at present. In terms of its safety profile, the general risk of infection when using TCZ is comparable to that of TNF inhibitors. TCZ has some advantage in RA patients who can not use MTX and are non-responders to TNF inhibitors. In conclusion, TCZ is one of the most prospective next generation biologics for the treatment of RA.

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Crossref · 10.4137/cmamd.s7371

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Citations

Cites

Research works printed but not linked: 8

  1. Ogata A., 2011, Joint Bone Spine.
  2. Nishimoto N., 2003, J Rheumatol., 30, 1426
  3. Singh J.A., 2010, Cochrane Database Syst Rev., 70, CD008331
  4. Yazici Y., 2011, Ann Rheum Dis.
  5. Hoshi D., 2011, Mod Rheumatol.
  6. Okada M., 2011, Clin Dev Immunol., 404929
  7. Hirao M., 2011, Rheumatol Int.
  8. Singh J.A., 2011, Cochrane Database Syst Rev., CD008794

Cited by

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Metadata

Authors
Ogata, A., Hirano, T., Hishitani, Y., & Tanaka, T.
Affiliations
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan.
Venue
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
Publisher
SAGE Publications
Published
2012-01
Volume
5
Pages
CMAMD.S7371
ISSN
1179-5441
DOI
10.4137/cmamd.s7371
PMC
PMC3306224
Cited by
61
References
86
Language
en
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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