Dopamine Concentrations and Dopamine Receptor Gene Expression in Emotion-Related Brain Structures of Female Adult Rats Exposed to Stress of Chronic Isolation from Weaning
Open accessAbstract
It is known that early-life stress events induce profound consequences on emotional brain regions including amygdala, involved in emotional processing and the ventral tegmental area (VTA), which contains neuron cell bodies of the mesolimbic dopaminergic system. The aim of this study is to test the hypothesis that stress induced by long-term social isolation from weaning in female rats is associated with alterations in amygdalar dopamine receptor gene expression and VTA dopamine concentrations. Rats were weaned on postnatal day 21 and then exposed to stress of chronic isolation for 9 weeks. Control animals were housed socially. Amygdalar dopamine D1 but not D2 receptor gene expression was decreased in isolated rats compared to controls. Dopamine concentrations in the VTA were enhanced following chronic isolation. A negative correlation was observed between amygdalar D1 gene expression and dopamine concentrations in the VTA. In conclusion, a reduction of dopamine D1 receptor gene expression in the amygdala in response to stress induced by chronic isolation in female rats was accompanied by an increase in dopamine concentration in the VTA. Further studies are needed to understand the physiological significance, if any, of negative association of amygdalar dopamine receptor D1 gene expression and dopamine concentrations in the VTA.
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Chronic isolation in female rats reduced the DRD1 gene expression in the amygdala, while increasing dopamine concentration in the VTA.
“For instance, chronic isolation in female rats reduced the DRD1 gene expression in the amygdala, while increasing dopamine concentration in the VTA.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [121]
Genetic variability in the NRCAM gene influences stress responses in humans exposed to abusive supervision.
“Social defeat stress in male rats affected pituitary gland gene expression related to neuron morphogenesis and communication, with genetic variability in the NRCAM gene influencing stress responses in humans exposed to abusive supervision [43,121].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [121]
Environmental stressors such as social defeat and isolation significantly alter gene expression in the brain.
“In laboratory settings, environmental stressors such as social defeat and isolation significantly alter gene expression in the brain.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [121]
Social defeat stress in male rats affected pituitary gland gene expression related to neuron morphogenesis and communication.
“Social defeat stress in male rats affected pituitary gland gene expression related to neuron morphogenesis and communication, with genetic variability in the NRCAM gene influencing stress responses in humans exposed to abusive supervision [43,121].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [121]
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- Authors
- Karailiev, P., Hlavacova, N., Chomanic, P., Riecansky, I., & Jezova, D.
- Affiliations
- Slovak Academy of Sciences (SK)
- Venue
- General Physiology and Biophysics
- Publisher
- AEPress, s.r.o.
- Published
- 2020
- Volume
- 39
- Issue
- 04
- Pages
- 393-398
- ISSN
- 0231-5882 (ISSN-L)
- 1338-4325
- OpenAlex
- W3070524247
- Cited by
- 3
- References
- 28
- Citations by year
- 2024: 2 · 2023: 1
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- General Physiology and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Slovenská Akadémia Vied
- Agentúra na Podporu Výskumu a Vývoja (APVV-18?, APVV-18-0283)
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- early life stress, chronic social isolation, dopamine D1 receptor, dopamine D2 receptor, amygdala, ventral tegmental area, mesolimbic dopamine system, dopamine concentration, gene expression, female rats
- MeSH terms
- Animals, Dopamine, Emotions, Female, Social Isolation, Stress, Psychological, Weaning, Receptors, Dopamine D2, Ventral Tegmental Area, Rats
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