Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala–Prefrontal Cortical Pathway

Floresco, Stan B.; Tse, Maric T.

doi:10.1523/jneurosci.5474-06.2007

Cited by 204Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala–Prefrontal Cortical Pathway

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Floresco, Stan B., Tse, Maric T.·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.5474-06.2007PMC PMC6673549

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Abstract

Projections from the basolateral amygdala (BLA) and dopamine (DA) input from the ventral tegmental area (VTA) converge in the medial prefrontal cortex (mPFC), forming a neural circuit implicated in certain cognitive and emotional processes. However, the role that DA plays in modulating activity in the BLA–mPFC pathway is unknown. The present study investigated the mechanisms by which DA modulates BLA-evoked changes in mPFC neural activity, using extracellular single-unit recordings in urethane-anesthetized rats. BLA stimulation evoked two distinct types of responses in separate populations of mPFC neurons: monosynaptic, excitatory responses and, more commonly, inhibition of spontaneous firing. Stimulation of the VTA or local iontophoretic application of DA attenuated BLA-evoked inhibition of PFC neuron firing. Administration of selective DA receptor agonists revealed that these effects were mediated by D 2 and D 4(but not D 1) receptors. In addition, VTA stimulation or DA application attenuated BLA-evoked firing of a separate population of mPFC neurons in a frequency-dependent manner; firing evoked by higher-frequency stimulation of the BLA was less inhibited than that evoked by single-pulse stimulation. Attenuation of BLA-evoked firing was also induced by of D 1(but not D 2 or D 4) receptor agonists. These data indicate that dissociable DA receptor mechanisms regulate the balance of excitatory and inhibitory transmission in BLA–mPFC circuits, biasing toward an increase in the excitatory influence that the BLA exerts over populations of mPFC neurons. These findings may have important implications for understanding the pathophysiology underlying emotional and cognitive disturbances present in disorders such as depression and drug addiction.

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Dopamine is crucial for communication between the accumbens, amygdala, and prefrontal cortex and signaling between these regions relies upon the fine balance between excitatory and inhibitory dopamine transmission.
“Animal studies have shown that dopamine is crucial for communication between the accumbens, amygdala, and prefrontal cortex and that signaling between these regions relies upon the fine balance between excitatory and inhibitory dopamine transmission (Floresco & Tse 2007; Grace et al. 2007; Jackson et al. 2001).”
From The Adolescent Brain (2008) · cites this paper as Floresco & Tse 2007
The Abstract reports that dopamine receptor mechanisms regulate the balance of excitatory and inhibitory transmission in basolateral amygdala–medial prefrontal cortex circuits. The Anatomical distributions section also identifies some prefrontal neurons receiving amygdala input that project to the nucleus accumbens. But the paper does not establish that signaling among all three regions relies on this balance, and it describes dopamine as regulating excitatory and inhibitory transmission—not as separate excitatory and inhibitory dopamine transmission. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Differences in baby face affect may have been a confounding factor in prior maternal response studies because the amygdala plays an important role in processing face affect and its response may be modulated by dopamine.
“Since the amygdala plays an important role in processing face affect (27), and its response may be modulated by dopamine (28;29), differences in baby face affect may have been a confounding factor.”
From What’s in a smile? Maternal brain responses to infant facial cues (2008) · cites this paper as [29]

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Authors: Floresco, S. B., & Tse, M. T.
Affiliations: University of British Columbia (CA)
ORCID: Floresco, Stan B.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-02-21
Volume: 27
Issue: 8
Pages: 2045-2057
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5474-06.2007
PMC: PMC6673549
OpenAlex: W1965930842
Cited by: 204
References: 80
Citations by year: 2026: 2 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 3 · 2020: 11 · 2019: 8 · 2018: 12 · 2017: 15 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 17 · 2012: 10
FWCI: 7.01
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dopamine, basolateral amygdala, medial prefrontal cortex, ventral tegmental area, dopamine D1 receptor, dopamine D2 receptor, dopamine D4 receptor, synaptic inhibition, excitatory synaptic transmission, frequency-dependent inhibition
MeSH terms: Amygdala, Animals, Dopamine, Electric Stimulation, Electrophysiology, Iontophoresis, Male, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neurons, Tegmentum Mesencephali, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Receptors, Dopamine D4, Rats

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Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala–Prefrontal Cortical Pathway

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