Cited by 484Bone Metabolism and DiseasesNeurogenesis and neuroplasticity mechanismsBone health and osteoporosis research

Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions

Open access
Oury, Franck, Khrimian, Lori, Denny, Christine A., Gardin, Antoine, Chamouni, Alexandre, Goeden, Nick, Huang, Yung-yu, Lee, Hojoon +8 more·2013·Cell

Abstract

The powerful regulation of bone mass exerted by the brain suggests the existence of bone-derived signals modulating this regulation or other functions of the brain. We show here that the osteoblast-derived hormone osteocalcin crosses the blood-brain barrier, binds to neurons of the brainstem, midbrain, and hippocampus, enhances the synthesis of monoamine neurotransmitters, inhibits GABA synthesis, prevents anxiety and depression, and favors learning and memory independently of its metabolic functions. In addition to these postnatal functions, maternal osteocalcin crosses the placenta during pregnancy and prevents neuronal apoptosis before embryos synthesize this hormone. As a result, the severity of the neuroanatomical defects and learning and memory deficits of Osteocalcin(-/-) mice is determined by the maternal genotype, and delivering osteocalcin to pregnant Osteocalcin(-/-) mothers rescues these abnormalities in their Osteocalcin(-/-) progeny. This study reveals that the skeleton via osteocalcin influences cognition and contributes to the maternal influence on fetal brain development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cell.2013.08.042

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Osteocalcin stimulates monoamine neurotransmitter synthesis in hippocampus and inhibits GABA synthesis, improving learning and memory.

    “Osteocalcin also stimulates the synthesis of monoamine neurotransmitters in the hippocampus and inhibits gamma-aminobutyric acid (GABA) synthesis, improving learning and memory skills [207].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 58 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Oury, F., Khrimian, L., Denny, C. A., Gardin, A., Chamouni, A., Goeden, N., Huang, Y.-Y., Lee, H., Srinivas, P., Gao, X.-B., Suyama, S., Langer, T., Mann, J. J., Horvath, T. L., Bonnin, A., & Karsenty, G.
Affiliations
  • Columbia University (US)
  • University of Southern California (US)
  • New York State Psychiatric Institute (US)
  • Yale University (US)
  • Sanofi (Germany) (DE)
Venue
Cell
Publisher
Elsevier BV
Published
2013-09
Volume
155
Issue
1
Pages
228-241
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2017975043
Cited by
484
References
58
Citations by year
2026: 33 · 2025: 43 · 2024: 40 · 2023: 39 · 2022: 40 · 2021: 45 · 2020: 77 · 2019: 35 · 2018: 31 · 2017: 25 · 2016: 27 · 2015: 17 · 2014: 28 · 2013: 4
FWCI
11.34
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Sanofi
  • National Institutes of Health
  • National Institute on Aging (P01AG032959)
  • National Institute of General Medical Sciences (T32GM007088)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045548)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
osteocalcin, blood-brain barrier, GABA synthesis, anxiety, depression, learning and memory, neuronal apoptosis, placental transfer, maternal genotype, fetal brain development
MeSH terms
Aging, Animals, Brain, Female, Fetus, Pregnancy, Signal Transduction, Osteocalcin, Neurotransmitter Agents, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review