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Fasting levels of hepatic p-S6 are increased in old mice
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“Altered mTORC1 signaling with age has also been reported in other tissues of mice, with most studies reporting increased mTORC1 activity with age 39,97,106–108.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [107]
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646
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Cited by
Sorted by citations
The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging
Kennedy, B. K., & Lamming, D. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.009 · Cited by 544
Targeting the biology of aging with mTOR inhibitors
Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372
Fasting and rapamycin: diabetes versus benevolent glucose intolerance
Blagosklonny, M. V. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1822-8 · Cited by 74
Self-citation
Metadata
- Authors
- Leontieva, O. V., Paszkiewicz, G. M., & Blagosklonny, M. V.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2014-09-02
- Volume
- 13
- Issue
- 17
- Pages
- 2656-2659
- ISSN
- 1538-4101
- 1551-4005
- Cited by
- 19
- References
- 10
- Language
- en
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