Hot topics in aging research: protein translation and TOR signaling, 2010

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677 · see citing works

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123 · see citing works

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works

Influence of TOR kinase on lifespan in C. elegans

Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057 · see citing works

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057 · see citing works

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Spilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., Richardson, A., Strong, R., & Galvan, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009979 · Cited by 1,033 · see citing works

Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982 · see citing works

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923 · see citing works

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881 · see citing works

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Hansen, M., Taubert, S., Crawford, D. K., Libina, N., Lee, S., & Kenyon, C. J. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 877 · see citing works

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874 · see citing works

Drosophila S6 kinase: a regulator of cell size.

Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S., & Thomas, G. (1999) · Science · doi:10.1126/science.285.5436.2126 · Cited by 785 · see citing works

Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

Jorgensen, P., Nishikawa, J. L., Breitkreutz, B., & Tyers, M. (2002) · Science · doi:10.1126/science.1070850 · Cited by 753 · see citing works

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 706 · see citing works

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chen, C., Liu, Y., Liu, Y., & Zheng, P. (2009) · Science Signaling · doi:10.1126/scisignal.2000559 · Cited by 680 · see citing works

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 664 · see citing works

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644 · see citing works

Two neurons mediate diet-restriction-induced longevity in C. elegans

Bishop, N. A., & Guarente, L. (2007) · Nature · doi:10.1038/nature05904 · Cited by 643 · see citing works

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in <i>C. elegans</i>

Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes &amp; Development · doi:10.1101/gad.1255404 · Cited by 643 · see citing works

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 574 · see citing works

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M., Lu, T. A., Benzer, S., & Kapahi, P. (2009) · Cell · doi:10.1016/j.cell.2009.07.034 · Cited by 537 · see citing works

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen

Hansen, M., Hsu, A., Dillin, A. G., & Kenyon, C. J. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010017 · Cited by 533 · see citing works

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J., & Kapahi, P. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00266.x · Cited by 491 · see citing works

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Rüegg, M. A., & Hall, M. N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.003 · Cited by 480 · see citing works

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

Steffen, K. K., MacKay, V. L., Kerr, E. O., Tsuchiya, M., Hu, D., Fox, L. A., Dang, N., Johnston, E. D., Oakes, J. A., Tchao, B. N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.037 · Cited by 465 · see citing works

Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

Malagelada, C., Jin, Z. H., Jackson-Lewis, V. R., Przedborski, S., & Greene, L. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3944-09.2010 · Cited by 458 · see citing works

Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice

Pende, M., Kozma, S. C., Jaquet, M., Oorschot, V. M. J., Burcelin, R., MARCHAND‐BRUSTEL, Y. L., Klumperman, J., Thorens, B., & Thomas, G. W. (2000) · Nature · doi:10.1038/35050135 · Cited by 452 · see citing works

The TOR pathway comes of age

Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. R., & Kennedy, B. K. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.007 · Cited by 339 · see citing works

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

An, W.-L., Cowburn, R. F., Li, L., Braak, H., Alafuzoff, I., Iqbal, K., Iqbal, I.-G., Winblad, B., & Pei, J.-J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63687-5 · Cited by 312 · see citing works

MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

Medvedik, O., Lamming, D. W., Kim, K. D., & Sinclair, D. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050261 · Cited by 308 · see citing works

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf‐1 ‐dependent mechanism in Caenorhabditis elegans

Steinkraus, K. A., Smith, E. D., Davis, C., Carr, D. T., Pendergrass, W. R., Sutphin, G. L., Kennedy, B. K., & Kaeberlein, M. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00385.x · Cited by 265 · see citing works

Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l -DOPA–Induced Dyskinesia

Santini, E., Heiman, M., Greengard, P., Valjent, E., & Fisone, G. (2009) · Science Signaling · doi:10.1126/scisignal.2000308 · Cited by 256 · see citing works

Reversal of Alzheimer’s-like pathology and behavior in human APP transgenic mice by mutation of Asp664

Galvan, V., Gorostiza, O. F., Banwait, S., Ataie, M., Logvinova, A. V., Sitaraman, S., Carlson, E., Sagi, S. A., Chevallier, N., Jin, K., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509695103 · Cited by 239 · see citing works

Aging networks in Caenorhabditis elegans : AMP‐activated protein kinase ( aak‐2 ) links multiple aging and metabolism pathways

Curtis, R., O'Connor, G., & DiStefano, P. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00205.x · Cited by 215 · see citing works

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

Rose, C., Menzies, F. M., Renna, M., Acevedo‐Arozena, A., Corrochano, S., Sadiq, O., Brown, S. D. M., & Rubinsztein, D. C. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq093 · Cited by 200 · see citing works

mTOR‐dependent signalling in Alzheimer's disease

Pei, J., & Hugon, J. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00509.x · Cited by 190 · see citing works

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

Wang, J., Robida-Stubbs, S., Tullet, J. M. A., Rual, J.-F. M., Vidal, M., & Blackwell, T. K. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001048 · Cited by 167 · see citing works

An RNA‐dependent protein kinase is involved in tunicamycin‐induced apoptosis and Alzheimer's disease

Onuki, R., Bando, Y., Suyama, E., Katayama, T., Kawasaki, H., Baba, T., Tohyama, M., & Taira, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600049 · Cited by 163 · see citing works

Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice

Chang, G., Chiu, Y., Wu, Y., Chen, W., Liao, J., Chao, T., & Mao, F. C. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08215fp · Cited by 146 · see citing works

TOR on the brain

Garelick, M. G., & Kennedy, B. K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.030 · Cited by 119 · see citing works

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

McColl, G., Rogers, A. N., Alavez, S., Hubbard, A., Melov, S., Link, C. D., Bush, A. I., Kapahi, P., & Lithgow, G. J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.004 · Cited by 117 · see citing works

TOR signaling never gets old: Aging, longevity and TORC1 activity

Evans, D. S., Kapahi, P., Hsueh, W., & Kockel, L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.001 · Cited by 117 · see citing works

Long‐term Administration of Rapamycin Reduces Adiposity, but Impairs Glucose Tolerance in High‐Fat Diet‐fed KK/HlJ Mice

Chang, G., Wu, Y., Chiu, Y., Chen, W., Liao, J., Hsu, H., Chao, T., Hung, S., & Mao, F. C. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00427.x · Cited by 113 · see citing works

Resveratrol and rapamycin: are they anti‐aging drugs?

Kaeberlein, M. R. (2010) · BioEssays · doi:10.1002/bies.200900171 · Cited by 93 · see citing works

Raptor is Phosphorylated by cdc2 during Mitosis

Gwinn, D. M., Asara, J. M., & Shaw, R. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009197 · Cited by 60 · see citing works

A midlife longevity drug?

Kaeberlein, M. R., & Kennedy, B. K. (2009) · Nature · doi:10.1038/460331a · Cited by 55 · see citing works

Hot topics in aging research: protein translation, 2009

Kennedy, B. K., & Kaeberlein, M. R. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00522.x · Cited by 54 · see citing works

Protein translation, 2007

Kaeberlein, M. R., & Kennedy, B. K. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00341.x · Cited by 51 · see citing works

drr‐2 encodes an eIF4H that acts downstream of TOR in diet‐restriction‐induced longevity of C. elegans

Ching, T., Paal, A. B., Mehta, A., Zhong, L., & Hsu, A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00580.x · Cited by 47 · see citing works

Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control

Mehta, R., Chandler-Brown, D., Ramos, F. J., Shamieh, L. S., & Kaeberlein, M. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-7002-2_2 · Cited by 44 · see citing works

Regulation of Protein Turnover by Longevity Pathways

Vellai, T., & Takács‐Vellai, K. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7002-2_7 · Cited by 38 · see citing works

Aging Is RSKy Business

Kaeberlein, M. R., & Kapahi, P. (2009) · Science · doi:10.1126/science.1181034 · Cited by 30 · see citing works

Protein translation, 2008

Kaeberlein, M. R., & Kennedy, B. K. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00439.x · Cited by 29 · see citing works

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works

Redox control of senescence and age-related disease.

Chandrasekaran, A., Idelchik, M. D. P. S., & Melendez, J. A. (2017) · Redox Biology · doi:10.1016/j.redox.2016.11.005 · Cited by 360 · see citing works

Small nucleoli are a cellular hallmark of longevity

Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Späth, M., Suchiman, H. E. D., Müller, R.-U., Slagboom, P. E., et al. (2017) · Nature Communications · doi:10.1038/ncomms16083 · Cited by 287 · see citing works

Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through e<scp>IF</scp>2α activation

Tardif, N., Salles, J., Guillet, C., Tordjman, J., Reggio, S., Landrier, J., Giraudet, C., Patrac, V., Bertrand‐Michel, J., Migne, C., et al. (2014) · Aging Cell · doi:10.1111/acel.12263 · Cited by 186 · see citing works

Mitogen-Independent Phosphorylation of S6K1 and Decreased Ribosomal S6 Phosphorylation in Senescent Human Fibroblasts

Zhang, H., Hoff, H. B., Marinucci, T., Cristofalo, V. J., & Sell, C. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4965 · Cited by 29 · see citing works

Faculty Opinions recommendation of Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

Toker, A. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.5714957.5695055

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., García‐Martínez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lang, F. J. W., Lipina, C., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02032-07 · Cited by 131 · see citing works

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Pearce, L. R., Alton, G., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C., & Alessi, D. R. (2010) · Biochemical Journal · doi:10.1042/bj20101024 · Cited by 267 · see citing works

ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase

Lee, S. B., Kim, S., Lee, J., Park, J., Lee, G., Kim, Y., Kim, J., & Chung, J. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400917 · Cited by 140 · see citing works