The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Roles and regulation of the mucus barrier in the gut
Open accessAbstract
The gastrointestinal tract is coated by a thick layer of mucus that forms the front line of innate host defense. Mucus consists of high molecular weight glycoproteins called mucins that are synthesized and secreted by goblet cells and functions primarily to lubricate the epithelium and protect it from damage by noxious substances. Recent studies have also suggested the involvement of goblet cells and mucins in complex immune functions such as antigen presentation and tolerance. Under normal physiological conditions, goblet cells continually produce mucins to replenish and maintain the mucus barrier; however, goblet cell function can be disrupted by various factors that can affect the integrity of the mucus barrier. Some of these factors such as microbes, microbial toxins and cytokines can stimulate or inhibit mucin production and secretion, alter the chemical composition of mucins or degrade the mucus layer. This can lead to a compromised mucus barrier and subsequently to various pathological conditions like chronic inflammatory diseases. Insight into how these factors modulate the mucus barrier in the gut is necessary in order to develop strategies to combat these disorders.
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Cites
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“In particular, IL-10 has been shown to regulate the mucus barrier by inhibiting ER stress and protein misfolding.126 IL-10 is a Th2 cytokine with anti-inflammatory functions and also inhibits the synthesis of pro-inflammatory cytokines such as IL-1b, IL-6 and TNFa.162,163 The effect of IL-10 on ER stress was investiga…”
BackgroundIL-10 inhibits cytokine production by activated macrophages
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“This correlated to increases in specific mucolytic bacteria, particularly the Ruminococcus family.(138) Fecal samples collected from patients with UC have greater mucinase activity than controls or CD patients.”
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BackgroundMicrobiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
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Cited by
Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health
Chambers, E. S., Preston, T., Frost, G., & Morrison, D. J. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0248-8 · Cited by 691
Hua, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00524 · Cited by 527
Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720696115 · Cited by 400
Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242
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Metadata
- Authors
- Cornick, S., Tawiah, A., & Chadee, K.
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2015-01-15
- Volume
- 3
- Issue
- 1-2
- Pages
- e982426
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- OpenAlex
- W2141300346
- Cited by
- 526
- References
- 21
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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