The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Roles and regulation of the mucus barrier in the gut
Open accessAbstract
The gastrointestinal tract is coated by a thick layer of mucus that forms the front line of innate host defense. Mucus consists of high molecular weight glycoproteins called mucins that are synthesized and secreted by goblet cells and functions primarily to lubricate the epithelium and protect it from damage by noxious substances. Recent studies have also suggested the involvement of goblet cells and mucins in complex immune functions such as antigen presentation and tolerance. Under normal physiological conditions, goblet cells continually produce mucins to replenish and maintain the mucus barrier; however, goblet cell function can be disrupted by various factors that can affect the integrity of the mucus barrier. Some of these factors such as microbes, microbial toxins and cytokines can stimulate or inhibit mucin production and secretion, alter the chemical composition of mucins or degrade the mucus layer. This can lead to a compromised mucus barrier and subsequently to various pathological conditions like chronic inflammatory diseases. Insight into how these factors modulate the mucus barrier in the gut is necessary in order to develop strategies to combat these disorders.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762 · cited 2×
“In particular, IL-10 has been shown to regulate the mucus barrier by inhibiting ER stress and protein misfolding.126 IL-10 is a Th2 cytokine with anti-inflammatory functions and also inhibits the synthesis of pro-inflammatory cytokines such as IL-1b, IL-6 and TNFa.162,163 The effect of IL-10 on ER stress was investiga…”
BackgroundIL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Mediators of endoplasmic reticulum stress-induced apoptosis
Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400779 · Cited by 2,345
Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80330-5 · Cited by 2,021
Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · cited 1×
“This correlated to increases in specific mucolytic bacteria, particularly the Ruminococcus family.(138) Fecal samples collected from patients with UC have greater mucinase activity than controls or CD patients.”
BackgroundTravassos, L. H., Carneiro, L. A. M., Ramjeet, M., Hussey, S., Kim, Y.-G., Magalhães, J. G., Yuan, L., Soares, F., Chea, E., Le Bourhis, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1823 · Cited by 1,306
One step at a time: endoplasmic reticulum-associated degradation
Vembar, S. S., & Brodsky, J. L. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2546 · Cited by 1,299
The indigenous gastrointestinal microflora
Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153 · cited 3×
“Mannose and N-acetylglucosamine decreased linearly while fucose increased linearly with increasing probiotic treatment.25 The microbial communities also contribute significantly in host nutrient metabolism providing folate, vitamin K and SCFAs.26,27 A major function of gut microbiota is to break down non-digestible ca…”
BackgroundMicrobiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
Ng, K. M., Ferreyra, J. A., Higginbottom, S. K., Lynch, J. B., Kashyap, P. C., Gopinath, S., Naidu, N., Choudhury, B., Weimer, B. C., Monack, D. M., et al. (2013) · Nature · doi:10.1038/nature12503 · Cited by 1,035
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Hua, S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00524 · Cited by 527
Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720696115 · Cited by 400
Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242
Burclaff, J., Bliton, R. J., Breau, K. A., Ok, M. T., Gomez-Martinez, I., Ranek, J. S., Bhatt, A. P., Purvis, J. E., Woosley, J. T., & Magness, S. T. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.02.007 · Cited by 242
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Zhang, X., Liu, H., Hashimoto, K., Yuan, S., & Zhang, J. (2022) · Critical Care · doi:10.1186/s13054-022-04090-1 · Cited by 200
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Wells, A. I., & Coyne, C. B. (2019) · Viruses · doi:10.3390/v11050460 · Cited by 109
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Van Kaer, L., & Olivares-Villagómez, D. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701704 · Cited by 101
Cheng, C., Tan, J., Qian, W., Zhang, L., & Hou, X. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.017 · Cited by 86
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Fekete, E., Allain, T., Siddiq, A., Sosnowski, O., & Buret, A. G. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.618106 · Cited by 86
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Solaymani-Mohammadi, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.817468 · Cited by 43
Banić, M., Uroić, K., Leboš Pavunc, A., Novak, J., Zorić, K., Durgo, K., Petković, H., Jamnik, P., Kazazić, S., Kazazić, S., et al. (2018) · LWT · doi:10.1016/j.lwt.2018.03.054 · Cited by 35
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Covello, C., Becherucci, G., Di Vincenzo, F., Del Gaudio, A., Pizzoferrato, M., Cammarota, G., Gasbarrini, A., Scaldaferri, F., & Mentella, M. C. (2024) · Nutrients · doi:10.3390/nu16142288 · Cited by 21
Akhtar, A., Lata, M., Sunsunwal, S., Yadav, A., LNU, K., Subramanian, S., & Ramya, T. N. C. (2023) · Communications Biology · doi:10.1038/s42003-023-04718-0 · Cited by 9
Metadata
- Authors
- Cornick, S., Tawiah, A., & Chadee, K.
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2015-01-15
- Volume
- 3
- Issue
- 1-2
- Pages
- e982426
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- OpenAlex
- W2141300346
- Cited by
- 526
- References
- 21
- FWCI
- 13.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
