p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

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In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

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Aggresomes, inclusion bodies and protein aggregation

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Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

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Guidelines for the use and interpretation of assays for monitoring autophagy

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

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Oxidative stress response and Nrf2 signaling in aging

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Huntingtin functions as a scaffold for selective macroautophagy

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Biological aging processes underlying cognitive decline and neurodegenerative disease

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Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

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Autophagy in Huntington disease and huntingtin in autophagy

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Insect Antiviral Innate Immunity: Pathways, Effectors, and Connections

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Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

Tanik, S. A., Schultheiss, C. E., Volpicelli-Daley, L. A., Brunden, K. R., & Lee, V. M. Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457408 · Cited by 326

The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

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Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance inDrosophila

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Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila

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A Double‐Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury

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ADrosophilaModel of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

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The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain

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p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy

Danieli, A., & Martens, S. (2018) · Journal of Cell Science · doi:10.1242/jcs.214304 · Cited by 144

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

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Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

Sato, S., Uchihara, T., Fukuda, T., Noda, S., Kondo, H., Saiki, S., Komatsu, M., Uchiyama, Y., Tanaka, K., & Hattori, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-21325-w · Cited by 125

Role of Cigarette Smoke–Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis

Tran, I., Ji, C. H., Ni, I., Min, T., Tang, D., & Vij, N. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0107oc · Cited by 120

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

Thellung, S., Corsaro, A., Nizzari, M., Barbieri, F., & Florio, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040901 · Cited by 117

How and why to study autophagy in Drosophila: It’s more than just a garbage chute

Nagy, P., Varga, Á., Kovács, A. L., Takáts, S., & Juhász, G. (2015) · Methods · doi:10.1016/j.ymeth.2014.11.016 · Cited by 115

Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint

Zheng, K., Li, Y., Wang, S., Wang, X., Liao, C., Hu, X., Fan, L., Kang, Q., Zeng, Y., Wu, X., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1192751 · Cited by 114

This old heart: Cardiac aging and autophagy

Linton, P., Gurney, M. A., Sengstock, D. M., Mentzer, R. M., & Gottlieb, R. A. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.12.017 · Cited by 115

Lipid peroxidation dysregulation in ischemic stroke: Plasma 4-HNE as a potential biomarker?

Lee, W., Wong, H.-Y., Chai, Y.-Y., Shi, C.-W., Amino, N., Kikuchi, S., & Huang, S.-H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.08.002 · Cited by 114

DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway

Bouchè, V., Perez, A. M., Leone, L., Sardiello, M., Ballabio, A., & Botas, J. (2016) · Autophagy · doi:10.1080/15548627.2015.1134081 · Cited by 116

Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

Song, P., Li, S., Wu, H., Gao, R., Rao, G., Wang, D., Chen, Z., Ma, B., Wang, H., Sui, N., et al. (2016) · Protein & Cell · doi:10.1007/s13238-015-0230-9 · Cited by 107

Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway

Yang, Y., Wang, Q., Song, D., Zen, R., Zhang, L., Wang, Y., Yang, H., Zhang, D., Jia, J., Zhang, J., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01701-z · Cited by 102

Autophagy in neuronal cells: general principles and physiological and pathological functions

Daμμe, M., Suntio, T., Säftig, P., & Eskelinen, E. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1361-4 · Cited by 102

Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models

Anderson, E. N., Gochenaur, L., Singh, A., Grant, R., Patel, K., Watkins, S., Wu, J. Y., & Pandey, U. B. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy047 · Cited by 96

Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model

Zhu, P., Sieben, C. J., Xu, X., Harris, P. C., & Lin, X. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw376 · Cited by 95

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice

Noda, S., Sato, S., Fukuda, T., Tada, N., Uchiyama, Y., Tanaka, K., & Hattori, N. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104717 · Cited by 94

Emerging role of the Hippo pathway in autophagy

Wang, D., He, J., Huang, B., Liu, S., Zhu, H., & Xu, T. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03069-6 · Cited by 89

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

Dialynas, G. K., Shrestha, O. K., Ponce, J., Zwerger, M., Thiemann, D. A., Young, G. H., Moore, S. A., Yu, L. P., Lammerding, J., & Wallrath, L. L. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005231 · Cited by 87

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury

Barekat, A., Gonzalez, A., Mauntz, R. E., Kotzebue, R. W., Molina, B., El-Mecharrafie, N., Conner, C. J., Garza, S., Melkani, G. C., Joiner, W. J., et al. (2016) · Scientific Reports · doi:10.1038/srep25252 · Cited by 87

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases

Tanji, K., Maruyama, A., Odagiri, S., Mori, F., Itoh, K., Kakita, A., Takahashi, H., & Wakabayashi, K. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31827b5713 · Cited by 80

The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy

Lin, Q., Dai, Q., Meng, H., Sun, A., Wei, J., Peng, K., Childress, C., Chen, M., Shao, G., & Yang, W. (2017) · Journal of Cell Science · doi:10.1242/jcs.207068 · Cited by 79

Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms

Park, S.-H., Baek, K., Shin, I., & Shin, I. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.06.010 · Cited by 76

Mitochondrial Autophagy Involving Renal Injury and Aging Is Modulated by Caloric Intake in Aged Rat Kidneys

Cui, J., Shi, S., Sun, X., Cai, G., Cui, S., Hong, Q., Chen, X., & Bai, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069720 · Cited by 73

p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB

Jain, A., Rusten, T. E., Katheder, N. S., Elvenes, J., Bruun, J., Sjøttem, E., Lamark, T., & Johansen, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656116 · Cited by 70

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, J., Abeliovich, H., Acevedo‐Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Kölner Universitäts PublikationsServer (Universität zu Köln) · doi:10.5167/uzh-131237 · Cited by 69

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

Gal, J., Bang, Y., & Choi, H. J. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.07.010 · Cited by 69

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

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Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

Swamy, S., Rajasekaran, N. S., & Thannickal, V. J. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.02.022 · Cited by 67

Assays to Monitor Autophagy Progression in Cell Cultures

Orhon, I., & Reggiori, F. (2017) · Cells · doi:10.3390/cells6030020 · Cited by 67

The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB

DeVorkin, L., Go, N. E., Hou, Y. C., Moradian, A., Morin, G. B., & Gorski, S. M. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201303144 · Cited by 68

Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats

Yu, W., Lyu, J., Jia, L., Sheng, M., Yu, H., & Du, H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7385458 · Cited by 61

Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death

Moon, J.-H., Eo, S. K., Lee, J. H., & Park, S. (2015) · Oncology Reports · doi:10.3892/or.2015.3991 · Cited by 61

Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain

Tanji, K., Miki, Y., Ozaki, T., Maruyama, A., Yoshida, H., Mimura, J., Matsumiya, T., Mori, F., Imaizumi, T., Itoh, K., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-50 · Cited by 59

S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia

Oh, C.-K., Dolatabadi, N., Cieplak, P., Diaz-Meco, M. T., Moscat, J., Nolan, J. P., Nakamura, T., & Lipton, S. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1508-21.2022 · Cited by 58

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease

Kinghorn, K. J., Asghari, A., & Castillo-Quan, J. I. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.202934 · Cited by 58

Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Zhang, Z., Yung, K. K. L., & Ko, J. K.-S. (2022) · Antioxidants · doi:10.3390/antiox11071349 · Cited by 57

The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells

Yan, S., Yang, X., Chen, T., Xi, Z., & Jiang, X. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2014.16 · Cited by 57

Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia

Mattè, A., Federti, E., Winter, M., Koerner, A., Harmeier, A., Mazer, N. A., Tomka, T., Paolo, M. L. D., Falco, L. D., Andolfo, I., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.130111 · Cited by 54

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Wong, B. K. Y., Ehrnhoefer, D. E., Graham, R. K., Martin, D. D. O., Ladha, S., Uribe, V., Stanek, L. M., Franciosi, S., Qiu, X., Deng, Y., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.030 · Cited by 50

Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast

Bak, A. M., Møller, A. B., Vendelbo, M. H., Nielsen, T. S., Viggers, R., Rungby, J., Pedersen, S. B., Jørgensen, J. O. L., Jessen, N., & Møller, N. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2015 · Cited by 49

Short-term heat stress results in increased apoptotic signaling and autophagy in oxidative skeletal muscle in Sus scrofa

Ganesan, S., Pearce, S., Gabler, N. K., Baumgard, L. H., Rhoads, R. P., & Selsby, J. T. (2018) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2018.01.003 · Cited by 49

Heat stress causes dysfunctional autophagy in oxidative skeletal muscle

Brownstein, A. J., Ganesan, S., Summers, C. M., Pearce, S., Hale, B. J., Ross, J. W., Gabler, N. K., Seibert, J. T., Rhoads, R. P., Baumgard, L. H., et al. (2017) · Physiological Reports · doi:10.14814/phy2.13317 · Cited by 48

Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s Ataxia

Edenharter, O., Schneuwly, S., & Navarro, J. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00038 · Cited by 44

Short-term heat stress causes altered intracellular signaling in oxidative skeletal muscle1

Ganesan, S., Summers, C. M., Pearce, S., Gabler, N. K., Valentine, R. J., Baumgard, L. H., Rhoads, R. P., & Selsby, J. T. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1233 · Cited by 47

Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit

Vaughen, J. P., Theisen, E. K., Rivas‐Serna, I. M., Berger, A. B., Kalakuntla, P. R., Anreiter, I., Mazurak, V. C., Rodriguez, T. P., Mast, J. D., Hartl, T. A., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.016 · Cited by 49

Prodigiosin impairs autophagosome-lysosome fusion that sensitizes colorectal cancer cells to 5-fluorouracil-induced cell death

Zhao, C., Qiu, S., He, J., Peng, Y., Xu, H., Feng, Z., Huang, H., Du, Y., Zhou, Y., & Nie, Y. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.03.010 · Cited by 46

p 62 Deficiency Enhances α‐Synuclein Pathology in Mice

Tanji, K., Odagiri, S., Miki, Y., Maruyama, A., Nikaido, Y., Mimura, J., Mori, F., Warabi, E., Yanagawa, T., Ueno, S., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12214 · Cited by 46

SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages

Shi, B., Huang, Q.-Q., Birkett, R., Doyle, R., Dorfleutner, A., Stehlik, C., He, C., & Pope, R. M. (2016) · Autophagy · doi:10.1080/15548627.2016.1261238 · Cited by 45

Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death

Wu, M., Lao, Y., Xu, N., Wang, X., Tan, H., Fu, W., Lin, Z., & Xu, H. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.06.008 · Cited by 45

Monitoring Autophagic Flux Using Ref(2)P, the Drosophila p62 OrthologPreprint

DeVorkin, L., & Gorski, S. M. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot080333 · Cited by 45

The Putative HORMA Domain Protein Atg101 Dimerizes and Is Required for Starvation-Induced and Selective Autophagy inDrosophila

Hegedűs, K., Nagy, P., Gáspári, Z., & Juhász, G. (2014) · BioMed Research International · doi:10.1155/2014/470482 · Cited by 47

Conserved regulators of cognitive aging: From worms to humans

Arey, R. N., & Murphy, C. T. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.035 · Cited by 41

Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer

Wang, J., Garbutt, C. C., Ma, H., Gao, P., Hornicek, F. J., Kan, Q., Shi, H., & Duan, Z. (2018) · Gynecologic Oncology · doi:10.1016/j.ygyno.2018.04.557 · Cited by 43

Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities?

Jacomin, A., Taillebourg, E., & Fauvarque, M. (2018) · Cells · doi:10.3390/cells7080112 · Cited by 44

The role of insulin-like growth factor 1 in ALS cell and mouse models: A mitochondrial protector

Wen, D., Cui, C., Duan, W., Wang, W., Wang, Y., Liu, Y., Li, Z., & Li, C. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.09.015 · Cited by 43

Combined Inhibition of Autophagy and Caspases Fails to Prevent Developmental Nurse Cell Death in the Drosophila melanogaster Ovary

Peterson, J. S., & McCall, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076046 · Cited by 42

Raspberry Ketone Reduced Lipid Accumulation in 3T3-L1 Cells and Ovariectomy-Induced Obesity in Wistar Rats by Regulating Autophagy Mechanisms

Leu, S., Chen, Y., Tsai, Y.-C., Hung, Y.-W., Hsu, C., Lee, Y., & Cheng, P. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b03831 · Cited by 41

Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors

Ratliff, E. P., Mauntz, R. E., Kotzebue, R. W., Gonzalez, A., Achal, M., Barekat, A., Finley, K. A., Sparhawk, J. M., Robinson, J. E., Herr, D. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132768 · Cited by 42

The Protective Effect of Cordycepin on D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury

Li, J., Zhong, L., Zhu, H., & Wang, F. (2017) · Mediators of Inflammation · doi:10.1155/2017/3946706 · Cited by 39

Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells

Chatterjee, S., Ambegaokar, S. S., Jackson, G. R., & Mudher, A. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00801 · Cited by 40

Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice

Sato, S., Noda, S., Torii, S., Amo, T., Ikeda, A., Funayama, M., Yamaguchi, J., Fukuda, T., Kondo, H., Tada, N., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab057 · Cited by 38

Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway

Shi, Z.-Y., Deng, J.-X., Fu, S., Wang, L., Wang, Q., Liu, B., Li, Y., & Deng, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3158 · Cited by 37

Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction

Moon, J.-H., Lee, J., Lee, Y.-J., & Park, S. (2016) · Oncotarget · doi:10.18632/oncotarget.13730 · Cited by 36

Lysosome-targeted fluorescence probe for discriminating cysteine from homocysteine/glutathione and assessing autophagy in drug-induced liver injury

Zeng, J., Yang, T., Liu, M., Li, S., Cheng, D., & He, L. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.134616 · Cited by 35

A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila

Jacomin, A.-C., Fauvarque, M.-O., & Taillebourg, E. (2016) · BMC Cell Biology · doi:10.1186/s12860-016-0115-7 · Cited by 36

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

Ribot, C., Soler, C., Chartier, A., Hayek, S. A., Naït-Saïdi, R., Barbezier, N., Coux, O., & Simonelig, M. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010015 · Cited by 36

The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila

Jacomin, A.-C., Bescond, A., Soleilhac, E., Gallet, B., Schoehn, G., Fauvarque, M.-O., & Taillebourg, E. (2015) · PLOS ONE · doi:10.1371/journal.pone.0143078 · Cited by 30

Long live the queen, the king and the commoner? Transcript expression differences between old and young in the termite Cryptotermes secundus

Kuhn, J. M. M., Meusemann, K., & Korb, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210371 · Cited by 33

p62 works as a hub modulation in the ageing process

Fan, X., Huang, T., Tong, Y., Fan, Z., Yang, Z., Yang, D., Mao, X., & Yang, M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101538 · Cited by 31

The inhibition of IGF‐1 signaling promotes proteostasis by enhancing protein aggregation and deposition

Moll, L., Ben‐Gedalya, T., Reuveni, H., & Cohen, E. (2015) · The FASEB Journal · doi:10.1096/fj.15-281675 · Cited by 29

Loss of miR‐34 in Drosophila dysregulates protein translation and protein turnover in the aging brain

Srinivasan, A. R., Tran, T., & Bonini, N. M. (2022) · Aging Cell · doi:10.1111/acel.13559 · Cited by 29

ALDH2 and Stroke: A Systematic Review of the Evidence

Xu, H., Zhang, Y., & Ren, J. T. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-6260-6_11 · Cited by 28

Drosophila immunity against natural and nonnatural viral pathogens

Tafesh‐Edwards, G., & Eleftherianos, I. (2019) · Virology · doi:10.1016/j.virol.2019.12.001 · Cited by 28

UM-6 induces autophagy and apoptosis via the Hippo-YAP signaling pathway in cervical cancer

Wang, D., He, J., Dong, J., Wu, S., Liu, S., Zhu, H., & Xu, T. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.020 · Cited by 31

Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

del Caño-Espinel, M., Acebes, J. R., Sánchez, D., & Ganfornina, M. D. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0009-8 · Cited by 28

Organelle aging: Lessons from model organisms

Bouska, M. J., Huang, K., Kang, P., & Bai, H. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.03.011 · Cited by 27

Molecular mechanisms of selective autophagy in Drosophila

Gohel, R., Kournoutis, A., Petridi, S., & Nezis, I. P. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2019.08.003 · Cited by 27

Autophagy and Akt-mTOR signaling display periodic oscillations during torpor-arousal cycles in oxidative skeletal muscle of Daurian ground squirrels (Spermophilus dauricus)

Chang, H., Peng, X., Xia, Y., Zhang, J., Xu, S., Wang, H., Wang, Z., Ma, X., & Gao, Y. (2019) · Journal of Comparative Physiology B · doi:10.1007/s00360-019-01245-5 · Cited by 31

Detrimental effects of proteasome inhibition activity in Drosophila melanogaster: implication of ER stress, autophagy, and apoptosis

Velentzas, P. D., Velentzas, A. D., Mpakou, V., Antonelou, M. H., Margaritis, L. H., Papassideri, I. S., & Stravopodis, D. J. (2012) · Cell Biology and Toxicology · doi:10.1007/s10565-012-9235-9 · Cited by 29

Prolonged environment-induced hyperthermia alters autophagy in oxidative skeletal muscle in Sus scrofa

Ganesan, S., Brownstein, A. J., Pearce, S., Hudson, M. B., Gabler, N. K., Baumgard, L. H., Rhoads, R. P., & Selsby, J. T. (2018) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2018.03.007 · Cited by 26

Inhibition of ERα/ERK/P62 cascades induces “autophagic switch” in the estrogen receptor-positive breast cancer cells exposed to gemcitabine

Shen, P., Chen, M., He, M., Chen, L., Song, Y., Xiao, P., Wan, X., Dai, F., Pan, T. S., & Wang, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.10363 · Cited by 25

Involvement of the p62/Nrf2/HO-1 pathway in the browning effect of irisin in 3T3-L1 adipocytes

Tsai, Y.-C., Wang, C.-W., Wen, B.-Y., Hsieh, P., Lee, Y., Yen, M., & Cheng, P. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110915 · Cited by 25

Hinokitiol protects primary neuron cells against prion peptide-induced toxicity via autophagy flux regulated by hypoxia inducing factor-1

Moon, J.-H., Lee, J., Lee, Y.-J., & Park, S. (2016) · Oncotarget · doi:10.18632/oncotarget.8670 · Cited by 24

mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells

Gordeev, S. A., Bykova, T. V., Zubova, S. G., Bystrova, O. A., Martynova, M. G., Pospelov, V. A., & Pospelova, T. V. (2015) · Oncotarget · doi:10.18632/oncotarget.6457 · Cited by 23

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

Nezis, I. P., Simonsen, A., Sagona, A. P., Finley, K., Gaumer, S., Contamine, D., Rusten, T. E., Stenmark, H., & Brech, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711108 · Cited by 370

Assays to Monitor Aggrephagy in Drosophila Brain

Jacomin, A., & Nezis, I. P. (2018) · Methods in molecular biology · doi:10.1007/7651_2018_157 · Cited by 2

Monitoring Autophagic Flux Using Ref(2)P, the Drosophila p62 OrthologPreprint

DeVorkin, L., & Gorski, S. M. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot080333 · Cited by 45

Chapter Thirty‐Five Quantitative Analysis of Autophagic Activity in Drosophila Neural Tissues by Measuring the Turnover Rates of Pathway Substrates

Cumming, R. C., Simonsen, A., & Finley, K. D. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03235-7 · Cited by 21

The autophagic biomarker p62 as a tool for monitoring age-dependent cellular responses

Carvalho, A. V. A. (2019) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)